The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2′dG
Abstract
In a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe. Serum and brain creatine concentrations increased in the creatine-treated group and returned to baseline after washout. Serum 8-hydroxy-2'-deoxyguanosine (8OH2'dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment.
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“We found that oral administration of creatine at a dose of 8 g/day for 16 weeks is well tolerated, safe and bioavailable to the brain, and it decreased serum 8-hydroxy-2-deoxyguanosine levels, a marker for oxidative stress.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [134]
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Cites
Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease
Ferrante, R. J., Andreassen, O. A., Jenkins, B. G., Dedeoglu, A., Kuemmerle, S., Kubilus, J. K., Kaddurah-Daouk, R., Hersch, S. M., & Beal, M. F. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04389.2000 · Cited by 522
Self-citationIncreased oxidative damage to DNA in ALS patients
Bogdanov, M. B., Brown, R. H., Matson, W. R., Smart, R. J., Hayden, D. L., O’Donnell, H. C., Beal, M. F., & Cudkowicz, M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00349-x · Cited by 334
Self-citationOxidative stress in patients with Friedreich ataxia
Schulz, J. B., Dehmer, T., Schöls, L. J., Mende, H. E., Hardt, C., Vorgerd, M., Bürk, K., Matson, W. R., DICHGANS, J., Beal, M. F., et al. (2000) · Neurology · doi:10.1212/wnl.55.11.1719 · Cited by 305
Self-citationAndreassen, O. A., Dedeoglu, A., Ferrante, R. J., Jenkins, B. G., Ferrante, K. L., Thomas, M., Friedlich, A., Browne, S. E., Schilling, G., Borchelt, D. R., et al. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0406 · Cited by 293
Self-citationIncrease of total creatine in human brain after oral supplementation of creatine-monohydrate
Dechent, P., Pouwels, P. J. W., Wilken, B., Hanefeld, F., & Frahm, J. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.3.r698 · Cited by 221
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Self-citationDedeoglu, A., Kubilus, J. K., Yang, L., Ferrante, K. L., Hersch, S. M., Beal, M. F., & Ferrante, A. R. J. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01706.x · Cited by 169
Self-citationCreatine supplementation in Huntington’s disease
Verbessem, P., Lemiere, J., Eijnde, B. O., Swinnen, S. P., Vanhees, L., Leemputte, M. V., Hespel, P., & Dom, R. (2003) · Neurology · doi:10.1212/01.wnl.0000090629.40891.4b · Cited by 163
Creatine therapy for Huntington’s disease: Clinical and MRS findings in a 1-year pilot study
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Items 301–313 of 313
Proteomics in Huntington’s Disease Biomarker Discovery
Červenka, J., Budkova, K., Suchá, R., Vodička, P., & Voukali, E. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-32815-2_9
THE RELATIONSHIP BETWEEN OXIDATIVE STRESS AND NEUROLOGICAL DISORDERS: MINI REVIEW
Kulbayeva, Z., Klyuyev, D. A., Sh, S. K. (., & Muratbek, A. A. (2024) · Farmaciâ Kazahstana · doi:10.53511/pharmkaz.2024.36.46.010
Vicente, L. S. (2024) · Repositorio Institucional de la Universidad de Burgos (University of Burgos) · doi:10.36443/10259/9239
Creatina e seus benefícios preventivos contra doenças cognitivas e neurodegenerativas
Costa, P. A., Colacite, J., Penteado, C. V. D. S., & Machado, N. S. (2025) · DELOS Desarrollo Local Sostenible · doi:10.55905/rdelosv18.n68-167
E3 Ubiquitin Ligases in Huntington’s Disease
Monsalvo-Maraver, L. Á., Galván‐Arzate, S., Chavarría, A., López-Goerne, T. M., Túnez, I., Tinkov, A. A., Aschner, M., & Santamarı́a, A. (2026) · Springer eBooks · doi:10.1007/978-981-95-6099-8_11
Étude de l'implication potentielle des marqueurs du striatum dans la maladie de Huntington
Galvan, L. (2011) · theses.fr (ABES) · doi:10.70675/ebf9c275z3ce2z474dz8d5az68c2c35df509
Trotier-Faurion, A. (2013) · theses.fr (ABES) · doi:10.70675/88744a8azcb26z49dbz977az6bf9162d955c
Králová, A., Kuorikoski, V., Anamea, L., Tampio, J., Tonduru, A. K., Cui, H., Leinonen, H., Rysä, J., Poso, A., Terasaki, T., et al. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00484
Vojdanitalab, K., Naderi, M., Samadi, R., Govari, D. A., & Gholami, S. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s645228
Benech, H., Krebs-Drouot, L., Viardot, G., Bertaina‐Anglade, V., Lhotellier, C., Flament, V., Roucairol, C., Mabondzo, A., Pinquier, J., & Joudinaud, T. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1940627
Huntingtin Nuclear Localization: Current Insights into Mechanism and Regulation
Desmond, C. R. (2012) · MacSphere (McMaster University) · doi:10.71548/9066
Metadata
- Authors
- Hersch, S. M., Gevorkian, S., Marder, K., Moskowitz, C., Feigin, A., Cox, M., Como, P., Zimmerman, C., Lin, M., Zhang, L., Ulug, A. M., Beal, M. F., Matson, W., Bogdanov, M., Ebbel, E., Zaleta, A., Kaneko, Y., Jenkins, B., Hevelone, N., Zhang, H., Yu, H., Schoenfeld, D., Ferrante, R., & Rosas, H. D.
- Affiliations
- Harvard University (US)
- From the Departments of Neurology, (S.M.H., S.G., A.Z., N.H., H.Z., H.Y., H.D.R.) and Biostatistics (D.S.), MassGeneral Institute for Neurodegenerative Disease, MGH-NMR Center and Athinoula A. Martinos Center for Biomedical Imaging (A.Z., B.J., N.H., H.D.R.), Massachusetts General Hospital and Harvard Medical School, Charlestown, MA; Center for Parkinson's Disease and Other Movement Disorders (K.M., C.M.), Department of Neurology, Sergievsky Center and Taub Institute for Research on Alzheimer's...
- ORCID
- Venue
- Neurology
- Published
- 2006-01-24
- Volume
- 66
- Issue
- 2
- Pages
- 250-252
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2163827910
- Cited by
- 313
- References
- 10
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 13 · 2023: 10 · 2022: 11 · 2021: 14 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 8 · 2016: 14 · 2015: 13 · 2014: 21 · 2013: 20 · 2012: 22
- FWCI
- 8.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS042861, NS 35255, R01NS035255)
- National Center for Research Resources (M01RR001066, M01-RR01066, M01RR000645, M01 RR00645)
- National Center for Complementary and Integrative Health (AT00613)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
- Keywords
- creatine, Huntington's disease, 8-hydroxy-2'-deoxyguanosine, oxidative DNA damage, drug safety and tolerability, neuroprotection
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Adult, Biological Availability, Brain, Creatine, Deoxyguanosine, Double-Blind Method, Female, Humans, Huntington Disease, Male, Middle Aged, Biomarkers
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