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Cited by 712Dementia and Cognitive Impairment ResearchDialysis and Renal Disease ManagementCancer-related cognitive impairment studies

The DOI matches its Crossref record; 47 of the 48 references it cites were found in a registry or an index.

Cognitive impairment in hemodialysis patients is common

Murray, A. M., Tupper, D. E., Knopman, D. S., Gilbertson, D. T., Pederson, S. L., Li, S., Smith, G. E., Hochhalter, A. K., Collins, A. J., Kane, R. L.·2006·Neurology
DOI 10.1212/01.wnl.0000225182.15532.40
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Abstract

BACKGROUND: Hemodialysis patients are at high risk for cognitive impairment due to their older age and high prevalence of stroke and cardiovascular risk factors. METHODS: Using a cross-sectional design, the authors measured cognitive function in 374 hemodialysis patients aged 55 years and older and an age-matched comparison group in Minneapolis and St. Paul, MN. Cognitive performance was measured in three domains: memory, executive function, and language. Subjects were classified as having no, mild, moderate, or severe cognitive impairment. RESULTS: Of 338 subjects who completed testing in at least two of the three cognitive domains, 13.9% (95% CI 10.4, 18.1) were classified with mild impairment, 36.1% (31.0, 41.5) with moderate impairment, 37.3% (32.1, 42.7) with severe impairment, and 12.7% (9.4, 16.8) with normal cognition. Only 2.9% had a documented history of cognitive impairment. Factors associated with severe cognitive impairment on adjusted logistic regression were stroke (adjusted OR [AOR] 1.95; 95% CI 1.08, 3.49; p < 0.03), equilibrated Kt/V > 1.2 (1.67; 1.01, 2.75; p < 0.05), and education >12 years (0.32; 0.14, 0.72; p < 0.01). The AOR for severe cognitive impairment in a random sample of 101 hemodialysis patients vs an age-matched comparison group was 3.54 (1.28, 9.78; p < 0.02). CONCLUSIONS: Moderate to severe cognitive impairment is common and undiagnosed in hemodialysis patients. Further studies are needed to determine whether dialysis exacerbates the cognitive impairment attributable to underlying disease. Cognitive testing in hemodialysis patients before dialysis initiation and periodically may be warranted.

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Crossref · 10.1212/01.wnl.0000225182.15532.40

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Research works printed but not linked: 4

  1. National Kidney Foundation. K/DOQI clinical practice guidelines for hemodialysis adequacy. Am J Kidney Dis 1997;30(suppl 2):S15–S66.
  2. Gilli P, De Bastiani P. Cognitive function and regular dialysis treatment. Clin Nephrol 1983;19:188–192.
  3. Kamata T. Morphologic abnormalities in the brain of chronically hemodialyzed patients without cerebrovascular disease. Am J Nephrol 2000;20:27–31.
  4. Beard CM, Kokmen E, O’Brien PC, Ania BJ, Melton LJ III. Risk of Alzheimer’s disease among elderly patients with anemia: population-based investigations in Olmsted County, Minnesota. Ann Epidemiol 1997;7:219–224.

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Metadata

Authors
Murray, A. M., Tupper, D. E., Knopman, D. S., Gilbertson, D. T., Pederson, S. L., Li, S., Smith, G. E., Hochhalter, A. K., Collins, A. J., & Kane, R. L.
Affiliations
University of Minnesota (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-07-25
Volume
67
Issue
2
Pages
216-223
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000225182.15532.40
OpenAlex
W2077510921
Cited by
712
References
48
Citations by year
2026: 26 · 2025: 31 · 2024: 50 · 2023: 44 · 2022: 42 · 2021: 41 · 2020: 55 · 2019: 46 · 2018: 41 · 2017: 38 · 2016: 32 · 2015: 34 · 2014: 39 · 2013: 44 · 2012: 28
FWCI
12.34
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (K021174A)
  • National Center for Research Resources (M01RR000400)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords
cognitive impairment, hemodialysis, end-stage renal disease, memory, executive function, language, stroke, older adults, cognitive screening
MeSH terms
Aged, Aged, 80 and over, Cognition Disorders, Cross-Sectional Studies, Female, Renal Dialysis, Humans, Kidney Failure, Chronic, Male, Middle Aged, Minnesota, Risk Factors, Cohort Studies, Comorbidity, Prevalence, Age Distribution, Sex Distribution, Risk Assessment

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