Inflammatory mediators in the elderly
Abstract
Ageing is accompanied by 2-4-fold increases in plasma/serum levels of inflammatory mediators such as cytokines and acute phase proteins. A wide range of factors seems to contribute to this low-grade inflammation, including an increased amount of fat tissue, decreased production of sex steroids, smoking, subclinical infections (e.g. asymptomatic bacteriuria), and chronic disorders such as cardiovascular diseases and Alzheimer's disease. Furthermore, there is some evidence that ageing is associated with a dysregulated cytokine response following stimulation. Several inflammatory mediators such as tumour necrosis factor-alpha and interleukin-6 have the potential to induce/aggravate risk factors in age-associated pathology, providing a positive feedback mechanism. Thus, it is possible that inflammatory mediators constitute a link between life style factors, infections and physiological changes in the process of ageing on the one hand and risk factors for age-associated diseases on the other. Consistent with this, inflammatory mediators are strong predictors of mortality independently of other known risk factors and co-morbidity in elderly cohorts. A direct pathogenetic role of inflammatory mediators would be highly likely if longevity was shown to be associated with cytokine polymorphisms regulating cytokine production. Several studies support indeed this hypothesis but, unfortunately, findings in this area are conflicting, which probably reflects the complexity of the effect of cytokine polymorphisms and their interaction with the lifestyle and sex.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Circulating advanced glycation end products accumulate when renal function is impaired.
“In addition, circulating AGE accumulate when renal function is impaired (456 -459) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [459]
In long-term haemodialysis and peritoneal dialysis patients, circulating advanced glycation end products correlated significantly with the advanced glycation end product content of a regular diet and with blood urea nitrogen level.
“This study showed that circulating AGE correlated significantly with the AGE content of a regular diet, as estimated by means of 3 d dietary records and food questionnaires, as well as with blood urea N level (459) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [459]
Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907 · see citing works
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
C-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18921 · Cited by 4,576 · see citing works
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
C-reactive protein: a critical update
Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318921 · Cited by 3,436 · see citing works
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429 · see citing works
Fishman, D., Faulds, G., Jeffery, R., Mohamed-Ali, V, Yudkin, J. S., Humphries, S., & Woo, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2629 · Cited by 2,243 · see citing works
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777 · see citing works
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works
Albert Hofman, D., Ott, A., Breteler, M. M. B., Bots, M. L., Slooter, A. J. C., van Harskamp, F., van Duijn, C. M., Broeckhoven, C. V., & Grobbee, D. E. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09328-2 · Cited by 1,365 · see citing works
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365 · see citing works
Visser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294 · see citing works
Serum IL‐6 Level and the Development of Disability in Older Persons
Ferrucci, L., Harris, T. B., Guralnik, J. M., Tracy, R. P., Corti, M., Cohen, H. J., Penninx, B., Pahor, M., Wallace, R., & Havlik, R. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01583.x · Cited by 809 · see citing works
Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans
Starkie, R., Ostrowski, S. R., Jauffred, S., Febbraio, M., & Pedersen, B. K. (2003) · The FASEB Journal · doi:10.1096/fj.02-0670fje · Cited by 790 · see citing works
Inflammatory markers and cognition in well-functioning African-American and white elders
Yaffe, K., Lindquist, K., Penninx, B. W., Simonsick, E. M., Pahor, M., Kritchevsky, S., Launer, L., Kuller, L., Rubin, S., & Harris, T. (2003) · Neurology · doi:10.1212/01.wnl.0000073620.42047.d7 · Cited by 706 · see citing works
Increased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665 · see citing works
Ferrucci, L., Penninx, B. W. J. H., Volpato, S., Harris, T. B., Bandeen‐Roche, K., Balfour, J., Leveille, S. G., Fried, L. P., & Md, J. M. G. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50605.x · Cited by 618 · see citing works
Age-related inflammatory cytokines and disease
Brüünsgaard, H., & Pedersen, B. K. (2003) · Immunology and Allergy Clinics of North America · doi:10.1016/s0889-8561(02)00056-5 · Cited by 608 · see citing works
Penninx, B. W. J. H., Kritchevsky, S. B., Yaffe, K. S., Newman, A. B., Simonsick, E. M., Rubin, S. M., Ferrucci, L., Harris, T. B., & Pahor, M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01811-5 · Cited by 530 · see citing works
Etminan, M., Gill, S., & Samii, A. (2003) · BMJ · doi:10.1136/bmj.327.7407.128 · Cited by 511 · see citing works
Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices
Bauer, J., Strauss, S., Schreiter-Gasser, U., Ganter, U., Schlegel, P., Witt, I., Yolk, B., & Berger, M. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80737-n · Cited by 483 · see citing works
Interleukin‐6: A Cytokine for Gerontolgists
Ershler, W. B. (1993) · Journal of The American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb02054.x · Cited by 480 · see citing works
Total cholesterol and risk of mortality in the oldest old
Weverling-Rijnsburger, A. W., Blauw, G. J., Lagaay, A. M., Knock, D. L., Meinders, A. E., & Westendorp, R. G. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04430-9 · Cited by 474 · see citing works
A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians
Brüünsgaard, H., Andersen‐Ranberg, K., Jeune, B., Pedersen, B. K., Skinhøj, P., & Pedersen, B. K. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.7.m357 · Cited by 458 · see citing works
Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans
GREIWE, J. S., CHENG, B., RUBIN, D. C., YARASHESKI, K. E., & SEMENKOVICH, C. F. (2001) · The FASEB Journal · doi:10.1096/fj.00-0274com · Cited by 454 · cited 2× · see citing works
“Consistent with this, muscle protein synthesis was inversely related to local levels of TNF-a protein in skeletal muscles in a study of frail, very elderly humans (Greiwe et al., 2001).”
BackgroundToward an Understanding of Frailty
Hamerman, D. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-11-199906010-00022 · Cited by 441 · see citing works
Cardiovascular Disease, Interleukin-6, and Risk of Mortality in Older Women
Volpato, S., Guralnik, J. M., Ferrucci, L., Balfour, J. L., Chaves, P. H. M., Fried, L. P., & Harris, T. B. (2001) · Circulation · doi:10.1161/01.cir.103.7.947 · Cited by 434 · see citing works
Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation
Roubenoff, R., Harris, T. B., Abad, L. W., Wilson, P. W. F., Dallal, G. E., & Dinarello, C. A. (1998) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/53a.1.m20 · Cited by 418 · see citing works
Ageing, tumour necrosis factor-alpha (TNF- α ) and atherosclerosis
Brüünsgaard, H., Skinhøj, P., Pedersen, B. K., Schroll, M., & Pedersen, B. K. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01281.x · Cited by 402 · see citing works
Increase of plasma IL-6 concentration with age in healthy subjects
Wei, J., Xu, H., Davies, J. L., & Hemmings, G. P. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90112-3 · Cited by 402 · see citing works
Licastro, F., Pedrini, S., Caputo, L., Annoni, G., Davis, L. J., Ferri, C., Casadei, V. M., & Grimaldi, L. M. E. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00226-x · Cited by 400 · see citing works
Humphries, S. E. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2678 · Cited by 388 · see citing works
Avital, A., Goshen, I., Kamsler, A., Segal, M., Iverfeldt, K., Richter‐Levin, G., & Yirmiya, R. (2003) · Hippocampus · doi:10.1002/hipo.10135 · Cited by 375 · see citing works
Interleukin-6 ( IL-6 ) and the Prognosis of Abdominal Aortic Aneurysms
Jones, K. G., Brull, D. J., Brown, L. C., Sian, M., Greenhalgh, R. M., Humphries, S. E., & Powell, J. T. (2001) · Circulation · doi:10.1161/01.cir.103.18.2260 · Cited by 369 · see citing works
Pedersen, M., Bruunsgaard, H., Weis, N., Hendel, H. W., Andreassen, B. U., Eldrup, E., Dela, F., & Pedersen, B. K. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00027-7 · Cited by 342 · see citing works
Self-citation(1993) · PubMed · Cited by 330 · see citing works
Elevated levels of tumor necrosis factor alpha and mortality in centenarians
Bruunsgaard, H., Andersen-Ranberg, K., Hjelmborg, J. V. B., Pedersen, B. K., & Jeune, B. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00329-2 · Cited by 325 · see citing works
Andersen‐Ranberg, K., Schroll, M., & Jeune, B. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49180.x · Cited by 316 · see citing works
Catabolism of aging: is it an inflammatory process?
Roubenoff, R. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000068965.34812.62 · Cited by 307 · see citing works
Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people
BRUUNSGAARD, H., LADELUND, S., PEDERSEN, A. N., SCHROLL, M., JØRGENSEN, T., & PEDERSEN, B. K. (2003) · Clinical and Experimental Immunology · doi:10.1046/j.1365-2249.2003.02137.x · Cited by 300 · see citing works
Reuben, D. B., Cheh, A. I., Harris, T. B., Ferrucci, L., Rowe, J. W., Tracy, R. P., & Seeman, T. E. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50157.x · Cited by 296 · see citing works
Plasma tumour necrosis factor-α and early carotid atherosclerosis in healthy middle-aged men
Skoog, T. (2002) · European Heart Journal · doi:10.1053/euhj.2001.2805 · Cited by 275 · see citing works
Vickers, M. A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00534-x · Cited by 252 · see citing works
Jenny, N. S., Tracy, R. P., Ogg, M. S., Luong, L. A., Kuller, L. H., Arnold, A. M., Sharrett, A. R., & Humphries, S. E. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000040224.49362.60 · Cited by 243 · see citing works
Gender-specific association between −1082 IL-10 promoter polymorphism and longevity
Lio, D., Scola, L., Crivello, A., Colonna‐Romano, G., Candore, G., Bonafè, M., Cavallone, L., Franceschi, C., & Caruso, C. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363827 · Cited by 227 · see citing works
Cerebral pattern of pro- and anti-inflammatory cytokines in dementias
Tarkowski, E., Liljeroth, A.-M., Minthon, L., Tarkowski, A., Wallin, A., & Blennow, K. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00088-1 · Cited by 219 · see citing works
Albumin levels as a predictor of mortality in the healthy elderly
Klonoff-Cohen, H. S., Barrett-Connor, E. L., & Edelstein, S. L. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90080-7 · Cited by 210 · see citing works
Advancing age and insulin resistance: role of plasma tumor necrosis factor-α
Paolisso, G., Rizzo, M. R., Mazziotti, G., Tagliamonte, M. R., Gambardella, A., Rotondi, M., Carella, C., Giugliano, D., Varricchio, M., & D’Onofrio, F. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e294 · Cited by 208 · see citing works
Low levels of circulating inflammatory cytokines—Do they affect human brain functions?
Pollmächer, T., Haack, M., Schuld, A., Reichenberg, A., & Yirmiya, R. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00004-1 · Cited by 202 · see citing works
Interleukin‐6 release from the human brain during prolonged exercise
Nybo, L., Nielsen, B., Pedersen, B. K., Møller, K., & Secher, N. H. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.022285 · Cited by 196 · see citing works
Association of an interleukin 1α polymorphism with Alzheimer’s disease
Du, Y., Dodel, R. C., Eastwood, B. J., Bales, K. R., Gao, F., Lohmüller, F., Müller, U., Kurz, A., Zimmer, R., Evans, R. M., et al. (2000) · Neurology · doi:10.1212/wnl.55.4.480 · Cited by 195 · see citing works
McCusker, S. M., Curran, M. D., Dynan, K., McCullagh, C. D., Urquhart, D., Middleton, D., Patterson, C. C., McIlroy, S. P., & Passmore, A. P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04008-3 · Cited by 191 · see citing works
Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype
Gibson, G. E., Haroutunian, V. H., Zhang, H., Park, L. C. H., Shi, Q., LESSER, M. L., Mohs, R. C., Sheu, R., & Blass, J. P. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200009)48:3 · Cited by 184 · see citing works
Licastro, F., Grimaldi, L. M. E., Bonafè, M., Martina, C., Olivieri, F., Cavallone, L., Giovanietti, S., Masliah, E., & Franceschi, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00013-7 · Cited by 182 · see citing works
Baggio, G., Donazzan, S., Monti, D., Mari, D., Martini, S., Gabelli, C., Vestra, M. D., Previato, L., Guido, M., Pigozzo, S., et al. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.6.433 · Cited by 180 · see citing works
Jan Born, A., Uthgenannt, D., Dodt, C., Nünninghoff, D., Ringvolt, E., Wagner, T., & Fehm, H. (1995) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(95)01638-4 · Cited by 174 · see citing works
O’Mahony, L., Holland, J., Jackson, J., Feighery, C., Hennessy, T. P. J., & Mealy, K. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00641.x · Cited by 173 · see citing works
Interleukin-6 and selected plasma proteins in healthy persons of different ages
Häger, K., Machein, U., Krieger, S., Platt, D., Seefried, G., & Bauer, J. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90066-3 · Cited by 172 · see citing works
Basso, F., Lowe, G. D. O., Rumley, A., McMahon, A. D., & Humphries, S. E. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000013283.84306.1a · Cited by 172 · see citing works
Interleukin-6 Production Does Not Increase With Age
Beharka, A. A., Meydani, M., Wu, D., Leka, L. S., Meydani, A., & Meydani, S. N. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.2.b81 · Cited by 169 · see citing works
Elderly Humans Show Prolonged In Vivo Inflammatory Activity during Pneumococcal Infections
Bruunsgaard, H., Skinhøj, P., Qvist, J., & Pedersen, B. K. (1999) · The Journal of Infectious Diseases · doi:10.1086/314873 · Cited by 167 · see citing works
Self-citationQuantitative and Qualitative Alterations of Acute-phase Proteins in Healthy Elderly Persons
Ballou, S. P., LOZANSKI, G. B., Hodder, S., Rzewnicki, D., MION, L. C., Sipe, J. D., Ford, A. B., & Kushner, I. (1996) · Age and Ageing · doi:10.1093/ageing/25.3.224 · Cited by 167 · see citing works
Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians
Gerli, R., Monti, D., Bistoni, O., M. Mazzone, A., Peri, G., Cossarizza, A., Di Gioacchino, M., E. F. Cesarotti, M., Doni, A., Mantovani, A., et al. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00195-0 · Cited by 162 · see citing works
Brüünsgaard, H., Pedersen, B. K., Schroll, M., Skinhøj, P., & Pedersen, B. K. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.01045.x · Cited by 158 · see citing works
Ageing Is Associated with a Prolonged Fever Response in Human Endotoxemia
Krabbe, K. S., Brüünsgaard, H., Hansen, C. M., Møller, K., Fonsmark, L., Qvist, J., Madsen, P. L., Kronborg, G., Andersen, H. Ø., Skinhøj, P., et al. (2001) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.8.2.333-338.2001 · Cited by 140 · see citing works
Self-citationBlood levels of histamine, IL-1β, and TNF-α in patients with mild to moderate alzheimer disease
Alvarez, X. A., Franco, A., Fernández-Novoa, L., & Cacabelos, R. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815005 · Cited by 139 · see citing works
Kilpinen, S. K., Hulkkonen, J., Wang, X. Y., & Hurme, M. (2001) · PubMed · Cited by 128 · see citing works
Gon, Y., Hashimoto, S., Hayashi, S., Koura, T., Matsumoto, K., & Horie, T. (1996) · PubMed · Cited by 127 · see citing works
Zinc supplementation reconstitutes the production of interferon-α by leukocytes from elderly persons
CAKMAN, I., KIRCHNER, H., & RINK, L. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.469 · Cited by 121 · see citing works
Rea, I. M., Stewart, M., Campbell, P., et al. (2009) · Gerontology · doi:10.1159/000213775 · Cited by 112 · see citing works
Bruunsgaard, H., Bjerregaard, E., Schroll, M., & Pedersen, B. K. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52061.x · Cited by 109 · see citing works
Self-citationSerum IL-1β levels in health and disease: a population-based study. ‘The InCHIANTI study’
Iorio, A. D., Ferrucci, L., Sparvieri, E., Cherubini, A., Volpato, S., Corsi, A., Bonafè, M., Franceschi, C., Abate, G., & Paganelli, R. (2003) · Cytokine · doi:10.1016/s1043-4666(03)00152-2 · Cited by 108 · see citing works
Antitumoral properties of aged human monocytes.
McLachlan, J. A., Serkin, C. D., Morrey, K. M., & Bakouche, O. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.2.832 · Cited by 96 · see citing works
Overproduction of monokines by leukocytes after stimulation with lipopolysaccharide in the elderly
Gabriel, P., Cakman, I., & Rink, L. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00189-9 · Cited by 96 · see citing works
The −174 C/G locus affects in vitro/in vivo IL-6 production during aging
Olivieri, F., Bonafè, M., Cavallone, L., Giovagnetti, S., Marchegiani, F., Cardelli, M., Mugianesi, E., Giampieri, C., Moresi, R., Stecconi, R., et al. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00197-8 · Cited by 94 · see citing works
Genetic polymorphisms in the cathespin D and interleukin-6 genes and the risk of Alzheimer's disease
Bhojak, T., DeKosky, S. T., Ganguli, M., & Kamboh, M. I. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01185-x · Cited by 94 · see citing works
Wang, X., Hurme, M., Jylhä, M. K., & Hervonen, A. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00338-4 · Cited by 91 · see citing works
Age-Related Differences in Cytokine Secretion
Riancho, J. A., Zarrabeitia, M. T., Amado, J. A., Olmos, J. M., & González-Macı́as, J. (2009) · Gerontology · doi:10.1159/000213568 · Cited by 88 · see citing works
Serum Albumin, Coronary Heart Disease Risk, and Mortality in an Elderly Cohort
Weijenberg, M. P., Feskens, E. J. M., Souverijn, J. H. M., & Kromhout, D. (1997) · Epidemiology · doi:10.1097/00001648-199701000-00014 · Cited by 88 · see citing works
Cytokine Antagonists in Aged Subjects and Their Relation With Cellular Immunity
Catania, A. P., Airaghi, L., Motta, P., Manfredi, M. G., Annoni, G., Pettenati, C., Brambilla, F., & Lipton, J. M. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.2.b93 · Cited by 85 · see citing works
Interleukin-1B polymorphism is associated with age at onset of Alzheimer’s disease
Sciacca, F. L., Ferri, C., Licastro, F., Veglia, F., Biunno, I., Gavazzi, A., Calabrese, E., Boneschi, F. M., Sorbi, S., Mariani, C. B., et al. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00011-3 · Cited by 82 · see citing works
Rea, I. M., Ross, O. A., Armstrong, M., McNerlan, S., Alexander, D. H., Curran, M. D., & Middleton, D. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00036-8 · Cited by 80 · see citing works
Association between the TNFα‐308 A/G polymorphism and the onset‐age of Alzheimer disease
Álvarez, V., Mata, I. F., González, P., Lahoz, C., Martínez, C., Peña, J., Guisasola, L. M., & Coto, E. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10515 · Cited by 75 · see citing works
Bruunsgaard, H., Pedersen, B. K., Poulsen, H. E., Nyyssönen, K., Kaikkonen, J., & Salonen, J. T. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.4.1170 · Cited by 70 · see citing works
Pola, R., Flex, A., Gaetani, E., Lago, A. D., Gerardino, L., Pola, P., & Bernabei, R. (2002) · Neuroreport · doi:10.1097/00001756-200209160-00015 · Cited by 70 · see citing works
AN IMBALANCE BETWEEN PRO- AND ANTI-INFLAMMATORY CYTOKINES, A CHARACTERISTIC FEATURE OF OLD AGE
Saurwein-Teissl, M., Blasko, I., Zisterer, K., Neuman, B., Lang, B., & Grubeck-Loebenstein, B. (2000) · Cytokine · doi:10.1006/cyto.2000.0679 · Cited by 69 · see citing works
McNerlan, S., Rea, I. M., & Alexander, H. D. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00188-7 · Cited by 69 · see citing works
Interleukin‐6–174 G/C Promoter Gene Polymorphism C Allele Reduces Alzheimer's Disease Risk
Faltraco, F., Bürger, K., Zill, P., et al. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51177.x · Cited by 60 · see citing works
The Effect of Aging on Circulating Levels of Proinflammatory Cytokines During Septic Shock
Marik, P. E., Zaloga, G. P., & and the Norasept II Study Investigators (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49003.x · Cited by 60 · see citing works
Peterson, P. K., Chao, C. C., Carson, P., et al. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/19.6.1158 · Cited by 55 · see citing works
Effect of patient age on tests of the acute-phase response.
Caswell, M., Pike, L. A., Bull, B. S., et al. (1993) · PubMed · Cited by 54 · see citing works
TNF gene polymorphism and its relation to intracerebral production of TNFα and TNFβ in AD
Tarkowski, E., Liljeroth, A., Nilsson, A. M., Ricksten, A., Davidsson, P., Minthon, L., & Blennow, K. (2000) · Neurology · doi:10.1212/wnl.54.11.2077 · Cited by 53 · see citing works
Are interleukin-1 gene polymorphisms risk factors or disease modifiers in AD?
Green, E., Harris, J. M., Lemmon, H. A., Lambert, J., Chartier‐Harlin, M., Clair, D. S., Mann, D. M. A., Iwatsubo, T., & Lendon, C. L. (2002) · Neurology · doi:10.1212/wnl.58.10.1566 · Cited by 51 · see citing works
Mooradian, A. D., Reed, R. L., Osterweil, D., & Scuderi, P. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb04456.x · Cited by 47 · see citing works
Brüünsgaard, H., Christiansen, L., Pedersen, A. N., Schroll, M., Jørgensen, T., & Pedersen, B. K. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.012 · Cited by 46 · see citing works
The Tumor Necrosis Factor Alpha −308G>A Polymorphism Is Associated with Dementia in the Oldest Old
Brüünsgaard, H., Benfield, T., Andersen‐Ranberg, K., Hjelmborg, J., Pedersen, A. N., Schroll, M., Pedersen, B. K., & Jeune, B. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52369.x · Cited by 43 · see citing works
Sandmand, M., Brüünsgaard, H., Kemp, K., Andersen‐Ranberg, K., Schroll, M., & Jeune, B. (2003) · Gerontology · doi:10.1159/000069174 · Cited by 35 · see citing works
Interleukin-1 Production by Human Monocytes in Ageing and Disease
Rudd, A. G., & Banerjee, D. K. (1989) · Age and Ageing · doi:10.1093/ageing/18.1.43 · Cited by 33 · see citing works
Terreni, L., Fogliarino, S., Quadri, P., et al. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00434-8 · Cited by 25 · see citing works
Infante, J., Llorca, J., Berciano, J., et al. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00453-6 · Cited by 22 · see citing works
Combarros, O., Llorca, J., Sánchez-Guerra, M., et al. (2003) · Journal of Neurology · doi:10.1007/s00415-003-1136-7 · Cited by 21 · see citing works
The Soluble Interleukin‐2 Receptor Predicts Mortality in Older Hospitalized Men
Rosenthal, A. J., McMurtry, C. T., Sanders, K. M., Jacobs, M., Thompson, D., & Adler, R. A. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb02937.x · Cited by 16 · see citing works
Inflammation in atherosclerosis: causal or casual? The need for randomized trials
Meir, K. S., Leitersdorf, E., & Hennekens, C. H. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00226-6 · Cited by 2 · see citing works
Cann, S. A. H., Netten, J. P. V., & Netten, C. V. (2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200003)47:3
Flagged first, then by citations
Cited by
Sorted by citations
Immune modulation of learning, memory, neural plasticity and neurogenesis
Yirmiya, R., & Goshen, I. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.015 · Cited by 1,483 · see citing works
Molecular inflammation: Underpinnings of aging and age-related diseases
Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203 · see citing works
Why does COVID-19 disproportionately affect older people?
Mueller, A. L., McNamara, M. S., & Sinclair, D. A. (2020) · Aging · doi:10.18632/aging.103344 · Cited by 1,128 · see citing works
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies.
Valkanova, V., Ebmeier, K. P., & Allan, C. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.004 · Cited by 972 · see citing works
Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773 · see citing works
Cytokines and their relationship to the symptoms and outcome of cancer
Seruga, B., Zhang, H., Bernstein, L. J., & Tannock, I. F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2507 · Cited by 652 · see citing works
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Aging, adiposity, and calorie restriction
Fontana, L. (2007) · JAMA · doi:10.1001/jama.297.9.986 · Cited by 526 · see citing works
Cellular and molecular biology of aging endothelial cells
Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538 · see citing works
Stimulation of systemic low-grade inflammation by psychosocial stress.
Rohleder, N. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000049 · Cited by 497 · see citing works
Ravussin, E., Redman, L. M., Rochon, J., Das, S. K., Fontana, L., Kraus, W. E., Romashkan, S., Williamson, D. A., Meydani, S. N., Villareal, D. T., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv057 · Cited by 489 · see citing works
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C., & Caruso, C. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-8 · Cited by 453 · see citing works
The immune system and aging: A review
Castelo-Branco, C., & Soveral, I. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2013.852531 · Cited by 449 · see citing works
Inflammatory markers and the risk of Alzheimer disease: The Framingham Study
Tan, Z. S., Beiser, A. S., Vasan, R. S., Roubenoff, R., Dinarello, C. A., Harris, T. B., Benjamin, E. J., Au, R., Kiel, D. P., Wolf, P. A., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000263217.36439.da · Cited by 440 · see citing works
A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies
Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425 · see citing works
(Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease
Buford, T. W. (2017) · Microbiome · doi:10.1186/s40168-017-0296-0 · Cited by 409 · see citing works
Chronic low-grade inflammation and age-related sarcopenia
Beyer, I., Mets, T., & Bautmans, I. (2012) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32834dd297 · Cited by 400 · see citing works
Forel, J.-M., Roch, A., Marin, V., Michelet, P., Demory, D., Blache, J.-L., Perrin, G., Gainnier, M., Bongrand, P., & Papazian, L. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000239435.87433.0d · Cited by 400 · see citing works
Inflammation and frailty measures in older people
Hubbard, R. E., O’Mahony, M. S., Savva, G. M., Calver, B. L., & Woodhouse, K. W. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00733.x · Cited by 393 · see citing works
Interleukin-6 Covaries Inversely with Hippocampal Grey Matter Volume in Middle-Aged Adults
Marsland, A. L., Gianaros, P. J., Abramowitch, S. M., Manuck, S. B., & Hariri, A. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.016 · Cited by 348 · see citing works
Stress, age, and immune function: toward a lifespan approach
Graham, J. E., Christian, L. M., & Kiecolt-Glaser, J. K. (2006) · Journal of Behavioral Medicine · doi:10.1007/s10865-006-9057-4 · Cited by 329 · see citing works
Brain morphology links systemic inflammation to cognitive function in midlife adults
Marsland, A. L., Gianaros, P. J., Kuan, D. C.-H., Sheu, L. K., Krajina, K., & Manuck, S. B. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.015 · Cited by 321 · see citing works
Endocrine and inflammatory markers as predictors of frailty
Puts, M. T. E., Visser, M., Twisk, J. W. R., Deeg, D. J. H., & Lips, P. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02355.x · Cited by 316 · see citing works
Brinkley, T. E., Leng, X., Miller, M. E., Kitzman, D. W., Pahor, M., Berry, M. J., Marsh, A. P., Kritchevsky, S. B., & Nicklas, B. J. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gln038 · Cited by 311 · see citing works
Elahy, M., Jackaman, C., Mamo, J. C., Lam, V., Dhaliwal, S. S., Giles, C., Nelson, D., & Takechi, R. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0029-9 · Cited by 300 · see citing works
Hubackova, S., Krejcikova, K., Bartek, J., & Hodny, Z. (2012) · Aging · doi:10.18632/aging.100520 · Cited by 272 · see citing works
Impaired functions of peripheral blood monocyte subpopulations in aged humans
Nyugen, J., Agrawal, S., Gollapudi, S., & Gupta, S. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9448-8 · Cited by 249 · see citing works
Social relationships, sleep quality, and interleukin-6 in aging women
Friedman, E. M., Hayney, M. S., Love, G. D., Urry, H. L., Rosenkranz, M. A., Davidson, R. J., Singer, B. H., & Ryff, C. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509281102 · Cited by 247 · see citing works
Dose-dependent effects of endotoxin on neurobehavioral functions in humans
Grigoleit, J.-S., Kullmann, J. S., Wolf, O. T., Hammes, F., Wegner, A., Jablonowski, S., Engler, H., Gizewski, E., Oberbeck, R., & Schedlowski, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028330 · Cited by 241 · see citing works
Kiecolt-Glaser, J. K., Belury, M. A., Andridge, R., Malarkey, W. B., Hwang, B. S., & Glaser, R. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.05.011 · Cited by 233 · see citing works
The Th17/Treg balance is disturbed during aging
Schmitt, V., Rink, L., & Uciechowski, P. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.09.003 · Cited by 235 · see citing works
The Influence of Latent Viral Infection on Rate of Cognitive Decline over 4 Years
Aiello, A. E., Haan, M. N., Blythe, L., Moore, K., Gonzalez, J. M., & Jagust, W. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00796.x · Cited by 210 · see citing works
Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse
Scott, K. A., Ida, M., Peterson, V. L., Prenderville, J. A., Moloney, G. M., Izumo, T., Murphy, K., Murphy, A., Ross, R. P., Stanton, C., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.02.004 · Cited by 202 · see citing works
Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging
Ravaglia, G., Forti, P., Maioli, F., Chiappelli, M., Montesi, F., Tumini, E., Mariani, E., Licastro, F., & Patterson, C. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.012 · Cited by 198 · see citing works
Telomeres and human aging: facts and fibs
Aviv, A. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.51.pe43 · Cited by 198 · see citing works
Sarcopenic obesity and endocrinal adaptation with age
Sakuma, K., & Yamaguchi, A. (2013) · International Journal of Endocrinology · doi:10.1155/2013/204164 · Cited by 189 · see citing works
Low-dose endotoxemia and human neuropsychological functions
Krabbe, K. S., Reichenberg, A., Yirmiya, R., Smed, A., Pedersen, B. K., & Bruunsgaard, H. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.04.010 · Cited by 189 · see citing works
Self-citationSpeisman, R. B., Kumar, A., Rani, A., Foster, T. C., & Ormerod, B. K. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.09.013 · Cited by 187 · see citing works
Marchetti, B., & Abbracchio, M. P. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.08.007 · Cited by 175 · see citing works
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.11.004 · Cited by 173 · see citing works
Dugan, L. L., Ali, S. S., Shekhtman, G., Roberts, A. J., Lucero, J., Quick, K. L., & Behrens, M. M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005518 · Cited by 165 · see citing works
Goronzy, J. J., Li, G., Yu, M., & Weyand, C. M. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.003 · Cited by 134 · see citing works
Immunology of the ageing kidney
Sato, Y., & Yanagita, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0185-9 · Cited by 126 · see citing works
Adipose tissue inflammation in aging
Mau, T., & Yung, R. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.014 · Cited by 110 · see citing works
Sharma, G., Hanania, N. A., & Shim, Y. M. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200904-022rm · Cited by 105 · see citing works
Measuring Systemic Inflammatory Regulation in Older Adults: Evidence and Utility
Bandeen-Roche, K., Walston, J. D., Huang, Y., Semba, R. D., & Ferrucci, L. (2009) · Rejuvenation Research · doi:10.1089/rej.2009.0883 · Cited by 94 · see citing works
Biochemical changes in response to intensive resistance exercise training in the elderly
Bautmans, I., Njemini, R., Vasseur, S., Chabert, H., Moens, L., Demanet, C., & Mets, T. (2005) · Gerontology · doi:10.1159/000085122 · Cited by 98 · see citing works
Dynamic alteration of soluble serum biomarkers in healthy aging
Shurin, G. V., Yurkovetsky, Z. R., Chatta, G. S., Tourkova, I. L., Shurin, M. R., & Lokshin, A. E. (2007) · Cytokine · doi:10.1016/j.cyto.2007.06.006 · Cited by 95 · see citing works
Ortmann, W., & Kolaczkowska, E. (2018) · Cell and Tissue Research · doi:10.1007/s00441-017-2751-4 · Cited by 80 · see citing works
The Oxygen Paradox, the French Paradox, and age-related diseases
Davies, J. M. S., Cillard, J., Friguet, B., Cadenas, E., Cadet, J., Cayce, R., Fishmann, A., Liao, D., Bulteau, A.-L., Derbré, F., et al. (2017) · GeroScience · doi:10.1007/s11357-017-0002-y · Cited by 82 · see citing works
“Elevated serum levels of pro-inflammatory cytokines such as IL-1, IL6, IL-18, TNFα, and CRP have been shown to increase with ageing (Krabbe et al. 2004; Cesari et al. 2004).”
BackgroundA paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis
Gupta, S., Agrawal, A., Agrawal, S., Su, H., & Gollapudi, S. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-5 · Cited by 77 · see citing works
Role of NFκB in age-related vascular endothelial dysfunction in humans
Donato, A. J., Pierce, G. L., Lesniewski, L. A., & Seals, D. R. (2009) · Aging · doi:10.18632/aging.100080 · Cited by 73 · see citing works
Khalafi, M., Akbari, A., Symonds, M. E., Pourvaghar, M. J., Rosenkranz, S. K., & Tabari, E. (2023) · Cytokine · doi:10.1016/j.cyto.2023.156303 · Cited by 69 · see citing works
Denollet, J., Vrints, C. J., & Conraads, V. M. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.10.015 · Cited by 58 · see citing works
Dangers, and benefits of the cytokine mediated response to injury and infection
Soeters, P. B., & Grimble, R. F. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.05.014 · Cited by 57 · see citing works
Hughes, A., Kumari, M., McMunn, A., & Bartley, M. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.012 · Cited by 47 · see citing works
The inflammatory response to social defeat is increased in older mice
Kinsey, S. G., Bailey, M. T., Sheridan, J. F., & Padgett, D. A. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.003 · Cited by 48 · see citing works
Depressive symptoms are associated with reduced neutrophil function in hip fracture patients
Duggal, N. A., Upton, J., Phillips, A. C., Hampson, P., & Lord, J. M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.07.004 · Cited by 39 · see citing works
Immune senescence and biomarkers profile of Bambuí aged population-based cohort
Torres, K. C. L., Rezende, V. B. D., Lima-Silva, M. L., Santos, L. J. D. S., Costa, C. G., Mambrini, J. V. D. M., Peixoto, S. V., Tarazona-Santos, E., Martins Filho, O. A., Lima-Costa, M. F., et al. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.006 · Cited by 30 · see citing works
Giunta, S., Wei, Y., Xu, K., & Xia, S. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13686 · Cited by 27 · see citing works
Ramírez-Vélez, R., García-Hermoso, A., Martínez-Velilla, N., Zambom-Ferraresi, F., L. Sáez de Asteasu, M., Recarey, A. E., & Izquierdo, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10020290 · Cited by 11 · see citing works
- Authors
- Krabbe, K. S., Pedersen, M., & Bruunsgaard, H.
- Affiliations
- University of Copenhagen (DK)
- Corresponding author
- Krabbe, Karen Suárez
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 39
- Issue
- 5
- Pages
- 687-699
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2092404576
- Cited by
- 928
- References
- 105
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 26 · 2023: 34 · 2022: 34 · 2021: 46 · 2020: 30 · 2019: 40 · 2018: 43 · 2017: 43 · 2016: 46 · 2015: 50 · 2014: 52 · 2013: 54 · 2012: 67
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- low-grade inflammation, aging, older adults, inflammatory mediators, cytokines, acute phase proteins, TNF-α, interleukin-6, adiposity, sex steroids, smoking, asymptomatic infection, cardiovascular disease, Alzheimer's disease, mortality, longevity, cytokine gene polymorphisms, lifestyle factors
- MeSH terms
- Aged, Aging, Arteriosclerosis, Chronic Disease, Cognition Disorders, Humans, Inflammation, Life Style, Mortality, Risk Factors, Cytokines, Frail Elderly
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
