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Cited by 183Cardiac Health and Mental HealthAcute Ischemic Stroke ManagementMental Health Treatment and Access

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Psychological distress, major depressive disorder, and risk of stroke

Surtees, P. G., Wainwright, N.W.J., Luben, R. N., Wareham, N. J., Bingham, S. A., Khaw, K.-T·2008·Neurology
DOI 10.1212/01.wnl.0000304109.18563.81
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Abstract

BACKGROUND: Studies have suggested that mood status is associated with an increased risk of stroke, though mostly based on measures of depression defined by symptoms alone rather than diagnostic criteria representative of clinically important distress and impairment. We investigated this association based upon a large population-based prospective cohort study. METHODS: Baseline assessment of major depressive disorder (MDD) and of mental health well-being (defined by the Mental Health Inventory, MHI-5) was completed by 20,627 stroke-free participants, aged 41 to 80 years, in the United Kingdom European Prospective Investigation into Cancer-Norfolk study. RESULTS: During 8.5 years of follow-up, 595 incident (fatal and nonfatal) stroke endpoints were recorded. Neither past year nor lifetime MDD was associated with stroke. A one SD decrease in MHI-5 scale score (representing greater emotional distress) was associated with an 11% increased risk of stroke after adjustment for age, sex, cigarette smoking, systolic blood pressure, cholesterol, obesity, preexisting myocardial infarction, diabetes, social class, education, hypertension treatment, family history of stroke, and antidepressant medication use (hazard ratio 1.11, 95% CI 1.00 to 1.22). This association was consistent for men and for women, for fatal and nonfatal stroke, and conformed to a dose-response relationship. CONCLUSIONS: Findings from this large prospective cohort study suggest that increased psychological distress is associated with elevated stroke risk. Episodic major depressive disorder was not associated with incident stroke in this study.

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Crossref · 10.1212/01.wnl.0000304109.18563.81

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Citations

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Research works printed but not linked: 2

  1. Ware JE Snow KK Kosinski M Gandek B. SF-36 Health Survey: Manual and Interpretation Guide. Boston: Nimrod Press 1993.
  2. 10.1037/0022-006X.51.5.730 · DOI

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Metadata

Authors
Surtees, P. G., Wainwright, N. W. J., Luben, R. N., Wareham, N. J., Bingham, S. A., & Khaw, K.-T.
Affiliations
MRC Elsie Widdowson Laboratory (GB)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2008-03-04
Volume
70
Issue
10
Pages
788-794
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/01.wnl.0000304109.18563.81
OpenAlex
W1986822607
Cited by
183
References
35
Citations by year
2026: 3 · 2025: 6 · 2024: 15 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 6 · 2019: 11 · 2018: 4 · 2017: 6 · 2016: 9 · 2015: 5 · 2014: 10 · 2013: 18 · 2012: 16
FWCI
10.67
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords
psychological distress, major depressive disorder, stroke risk, Mental Health Inventory, emotional distress, incident stroke, sex differences, dose-response relationship, EPIC-Norfolk cohort
MeSH terms
Adult, Aged, Aged, 80 and over, Major Depressive Disorder, Female, United Kingdom, Health Status, Humans, Male, Mass Screening, Middle Aged, Prospective Studies, Risk Factors, Stress, Psychological, Cohort Studies, Comorbidity, Incidence, Survival Rate, Sex Distribution, Stroke, Risk Reduction Behavior

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