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Cited by 153Cardiac Health and Mental HealthAcute Ischemic Stroke ManagementStroke Rehabilitation and Recovery

Prospective study of depressive symptoms and risk of stroke among Japanese

Ohira, Tetsuya, Iso, Hiroyasu, Satoh, Shinji, Sankai, Tomoko, Tanigawa, Takeshi, Ogawa, Yuka, Imano, Hironori, Sato, Shinichi +2 more·2001·Stroke
DOI 10.1161/01.str.32.4.903
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Abstract

Background and Purpose —We sought to examine the relationship between depressive symptoms and the incidence of stroke among Japanese men and women. Methods —A 10.3-year prospective study on the relationship between depressive symptoms and the incidence of stroke was conducted with 901 men and women aged 40 to 78 years in a rural Japanese community. Depressive symptoms were measured at baseline with the use of the Zung Self-Rating Depression Scale (SDS). The incidence of stroke was ascertained under systematic surveillance. Results —During the 10-year follow-up, 69 strokes (39 ischemic strokes, 10 intracerebral hemorrhages, 10 subarachnoid hemorrhages, and 10 unclassified strokes) occurred. Age- and sex-adjusted prevalence of mild depression (SDS scores ≥40) at baseline was 25% among subjects with incident stroke and 12% among subjects without stroke ( P <0.01). Persons with SDS scores in the high tertile had twice the age- and sex-adjusted relative risk of total stroke as those with scores in the low tertile. The excess risk was confined to ischemic stroke. After we adjusted for body mass index, systolic blood pressure level, serum total cholesterol level, cigarette smoking, current treatment with antihypertensive medication, and history of diabetes mellitus, these relative risks remained statistically significant for total stroke (1.9; 95% CI, 1.1 to 3.5) and ischemic stroke (2.7; 95% CI, 1.2 to 6.0). Conclusions —Depressive symptoms predict the risk of stroke, specifically ischemic stroke among Japanese.

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  • Major depressive disorder is a consistent predictor of the subsequent first onset of coronary artery disease, stroke, diabetes, heart attacks, and certain types of cancer, though evidence about major depressive disorder as a cause of physical disorders is spotty.

    “we know from meta-analyses of longitudinal studies that MDD is a consistent predictor of the subsequent first onset of coronary artery disease,97, 98 stroke,99 diabetes,100 heart attacks ,101, 102 and certain types of cancer.103”

    From The Costs of Depression (2012) · cites this paper as [98]

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  1. Pisa Z, Uemura K. Trends of mortality from ischaemic heart disease and other cardiovascular diseases in 27 countries, 1968 -1977. World Health Stat Q. 1982;35:11-47.
  2. Iso H, Shimamoto T, Sankai T, Yokota K, Harada M, Ohki M, Miyagaki T, Fukuuchi K, Kitamura A, Sato S, Komachi Y. Effectiveness of a community-based education program on blood pressure reduction for cardiovascular disease prevention [in Japanese]. Jpn J Public Health. 1993;40:147-158.
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  6. Nakamura M, Morita M, Yabuuchi E, Yukami M, Kuruma S, Kuritani C, Kanasu Y, Nishiwaki E, Ueshima H, Iida M, Komachi Y. The evaluation and the results of cooperative cholesterol and triglyceride standardization program by WHO-CDC [in Japanese]. Rinsho Byori. 1982;30:325-332.
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  10. Everson SA, Roberts RE, Goldberg DE, Kaplan GA. Depressive symptoms and increased risk of stroke mortality over a 29-year period. Arch Intern Med. 1998;158:1133-1138.
  11. Simons LA, McCallum J, Friedlander Y, Simons J. Risk factors for ischemic stroke: Dubbo Study of the Elderly. Stroke. 1998;29:1341-1346.
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Authors
Ohira, T., Iso, H., Satoh, S., Sankai, T., Tanigawa, T., Ogawa, Y., Imano, H., Sato, S., Kitamura, A., & Shimamoto, T.
Affiliations
University of Tsukuba (JP)
ORCID
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-04
Volume
32
Issue
4
Pages
903-908
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.32.4.903
OpenAlex
W1641471140
Cited by
153
References
36
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 8 · 2012: 10
FWCI
6.09
Type
journal article
Language
en
Open access
closed
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
Keywords
depressive symptoms, stroke incidence, ischemic stroke, depression, Zung Self-Rating Depression Scale, Japanese population, rural communities, cardiovascular risk factors, body mass index, blood pressure, serum cholesterol, smoking, antihypertensive drugs, diabetes mellitus
MeSH terms
Adult, Aged, Blood Pressure, Depression, Female, Follow-Up Studies, Humans, Japan, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Psychological Tests, Risk, Risk Factors, Rural Population, Comorbidity, Body Mass Index, Incidence, Prevalence, Age Distribution, Sex Distribution, Stroke

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