Cited by 363Dementia and Cognitive Impairment ResearchPhysical Activity and HealthCardiovascular and exercise physiology

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Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.

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Burns, J. M., Cronk, B. B., Anderson, H. S., Donnelly, J. E., Thomas, G. P., Harsha, A., Brooks, W. M., Swerdlow, R. H.·2008·Neurology

DOI 10.1212/01.wnl.0000317094.86209.cbPMC PMC2657657

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Abstract

OBJECTIVE: To examine the correlation of cardiorespiratory fitness with brain atrophy and cognition in early-stage Alzheimer disease (AD). BACKGROUND: In normal aging physical fitness appears to mitigate functional and structural age-related brain changes. Whether this is observed in AD is not known. METHODS: Subjects without dementia (n = 64) and subjects with early-stage AD (n = 57) had MRI and standard clinical and psychometric evaluations. Peak oxygen consumption (VO(2)(peak)), the standard measure of cardiorespiratory fitness, was assessed during a graded treadmill test. Normalized whole brain volume, a brain atrophy estimate, was determined by MRI. Pearson correlation and linear regression were used to assess fitness in relation to brain volume and cognitive performance. RESULTS: Cardiorespiratory fitness (VO(2)(peak)) was modestly reduced in subjects with AD (34.7 [5.0] mL/kg/min) vs subjects without dementia (38.1 [6.3] mL/kg/min, p = 0.002). In early AD, VO(2)(peak) was associated with whole brain volume (beta = 0.35, p = 0.02) and white matter volume (beta = 0.35, p = 0.04) after controlling for age. Controlling for additional covariates of sex, dementia severity, physical activity, and physical frailty did not attenuate the relationships. VO(2)(peak) was associated with performance on delayed memory and digit symbol in early AD but not after controlling for age. In participants with no dementia, there was no relationship between fitness and brain atrophy. Fitness in participants with no dementia was associated with better global cognitive performance (r = 0.30, p = 0.02) and performance on Trailmaking A and B, Stroop, and delayed logical memory but not after controlling for age. CONCLUSIONS: Increased cardiorespiratory fitness is associated with reduced brain atrophy in Alzheimer disease (AD). Cardiorespiratory fitness may moderate AD-related brain atrophy or a common underlying AD-related process may impact both brain atrophy and cardiorespiratory fitness.

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Authors: Burns, J. M., Cronk, B. B., Anderson, H. S., Donnelly, J. E., Thomas, G. P., Harsha, A., Brooks, W. M., & Swerdlow, R. H.
Affiliations: University of Kansas (US)
ORCID: Burns, J. M.
Donnelly, J. E.
Thomas, G. P.
Brooks, W. M.
Swerdlow, R. H.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-07-15
Volume: 71
Issue: 3
Pages: 210-216
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/01.wnl.0000317094.86209.cb
PMC: PMC2657657
OpenAlex: W1963796716
Cited by: 363
References: 44
Citations by year: 2026: 7 · 2025: 10 · 2024: 14 · 2023: 10 · 2022: 17 · 2021: 13 · 2020: 24 · 2019: 23 · 2018: 15 · 2017: 23 · 2016: 24 · 2015: 21 · 2014: 29 · 2013: 34 · 2012: 24
FWCI: 17.52
Type: journal article
Language: en
Open access: green
pmc.ncbi.nlm.nih.gov
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
Funders: U.S. Public Health Service (C76HF00201)
National Institute on Aging (AG026482, R21AG029615, R03AG026374, R21AG026482)
National Institute of Mental Health (R01 MH71940, R01MH071940)
National Institute of Neurological Disorders and Stroke (NS 039123, K23NS058252, R01NS039123)
National Center for Research Resources (P41RR013642, U54RR021813, M01RR023940)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: cardiorespiratory fitness, brain atrophy, early Alzheimer's disease, peak oxygen uptake, total brain volume, white matter volume, cognitive performance, normal aging
MeSH terms: Aged, Aged, 80 and over, Aging, Alzheimer Disease, Atrophy, Brain, Cognition, Cross-Sectional Studies, Exercise Test, Female, Humans, Male, Physical Fitness, Time Factors, Respiratory Mechanics

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Cardiorespiratory fitness and brain atrophy in early Alzheimer disease.

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