The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Race and Alzheimer Disease Biomarkers: A Neglected Race
Open accessAbstract
Race is a social construct with profound consequences on health. Although race does not always segregate with genetic ancestry, some genetic variants are more frequently found in certain self-identified racial and ethnic groups. Differences in the epidemiology and the pathophysiology of Alzheimer disease (AD) and other neurodegenerative conditions have been described in certain racial groups. Unfortunately, most studies in the field of AD have mainly included non-Hispanic White (NHW) participants, with an underrepresentation of other populations. In the past few years, however, research on race and ethnic differences in AD has grown rapidly. Some studies indicate that African Americans (AA) have a greater risk for AD than NHW.1 The reasons hypothesized to account for this higher risk are certain genetic risk factors associated with AA, the higher prevalence of vascular risk factors in AA, and socioeconomic factors.2 In addition, some studies have reported a different pathophysiology and pattern of AD biomarkers. There is evidence that AA have lower concentrations of total-Tau, phosphorylated Tau, and neurofilament light in the CSF compared with NHW.3 The differences in AD pathophysiology in racial groups can be due to various factors, such as genetic variants associated with that race, but also with other environmental factors such as socioeconomic status, diet, or medical comorbidities. Another factor that could play a role in this association is a different innate immune response to AD pathology.
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“age‐, sex‐, race‐, and ethnicity‐based variations; the frequency of comorbidities; and the effects of genetic diversity must always be kept in mind, as observed already in AD and ALS, 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 but also within the FTD field. 158 , 159 , 160”
From New developments of biofluid‐based biomarkers for routine diagnosis and disease trajectories in frontotemporal dementia (2022) · cites this paper as [147]
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Systemic inflammation and disease progression in Alzheimer disease
Holmes, C., Cunningham, C., Zotova, E., Woolford, J., Dean, C., Kerr, S., Culliford, D., & Perry, V. H. (2009) · Neurology · doi:10.1212/wnl.0b013e3181b6bb95 · Cited by 1,139
Inequalities in dementia incidence between six racial and ethnic groups over 14 years
Mayeda, E. R., Glymour, M. M., Quesenberry, C. P., & Whitmer, R. A. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.12.007 · Cited by 883 · cited 4×
“In this issue of Neurology® Genetics, Schindler et al.4 take advantage of the racial and ethnical diversity of the Knight ADRC cohort to describe differences in soluble TREM2 (sTREM2) concentrations in the CSF in AA and NHW. AA participants had lower CSF sTREM2 concentrations, a difference that was mainly driven by th…”
BackgroundInfluentialTREM2 — a key player in microglial biology and Alzheimer disease
Ulland, T. K., & Colonna, M. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0072-1 · Cited by 735
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Self-citationEwers, M., Franzmeier, N., Suárez-Calvet, M., Morenas-Rodriguez, E., Caballero, M. A. A., Kleinberger, G., Piccio, L., Cruchaga, C., Deming, Y., Dichgans, M., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav6221 · Cited by 327
Self-citationSuárez-Calvet, M., Araque Caballero, M. Á., Kleinberger, G., Bateman, R. J., Fagan, A. M., Morris, J. C., Levin, J., Danek, A., Ewers, M., Haass, C., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aag1767 · Cited by 272
Self-citationHowell, J. C., Watts, K. D., Parker, M. W., Wu, J., Kollhoff, A. L., Wingo, T. S., Dorbin, C. D., Qiu, D., & Hu, W. T. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0315-1 · Cited by 198
Racial Differences in the Incidence of Cardiovascular Risk Factors in Older Black and White Adults
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African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants
Schindler, S. E., Cruchaga, C., Joseph, A., McCue, L. M., Farias, F., Wilkins, C. H., Deming, Y. K., Henson, R. L., Mikesell, R. J., Piccio, L. M., et al. (2021) · Neurology Genetics · doi:10.1212/nxg.0000000000000571 · Cited by 50
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del Campo, M., Zetterberg, H., Gandy, S., Onyike, C. U., Oliveira, F., Udeh‐Momoh, C., Lleó, A., Teunissen, C. E., & Pijnenburg, Y. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12643 · Cited by 52
Self-citationDementia Prevention in Clinical Practice
Niotis, K., Akiyoshi, K., Carlton, C., & Isaacson, R. (2022) · Seminars in Neurology · doi:10.1055/s-0042-1759580 · Cited by 26
Novel Alzheimer’s disease genes and epistasis identified using machine learning GWAS platform
Lundberg, M., Sng, L. M. F., Szul, P., Dunne, R. A., Bayat, A., Burnham, S. C., Bauer, D. C., Twine, N. A., & Initiative, T. A. D. N. (2023) · Scientific Reports · doi:10.1038/s41598-023-44378-y · Cited by 23
Roberg, B. L., Anzalone, C., Nicholson, J. D., Peruggia, P. E., & Buckley, T. (2022) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acac090 · Cited by 1
Moon, S. S., Anderson, L., Lee, J., & Moon, Y. (2023) · Journal of Social & Health Sciences · doi:10.58398/0001.000008
Metadata
- Authors
- Lleó, A., & Suárez-Calvet, M.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- From the Memory Unit (A.L.), Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau-Universitat Autònoma de Barcelona; Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED) (A.L.), Madrid; Barcelonaβeta Brain Research Center (BBRC) (M.S.-C.), Pasqual Maragall Foundation, Barcelona; Servei de Neurologia (M.S.-C.), Hospital del Mar, Barcelona; IMIM (Hospital del Mar Medical Research Institute) (M.S.-C.), Barcelona; and Centro...
- Corresponding author
- Lleó, Alberto
- Venue
- Neurology Genetics
- Published
- 2021-04
- Volume
- 7
- Issue
- 2
- Pages
- e574-e574
- ISSN
- 2376-7839 (ISSN-L)
- PMC
- PMC7938472
- OpenAlex
- W3133564118
- Cited by
- 5
- References
- 10
- Citations by year
- 2023: 2 · 2022: 3
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Neurology Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Social Sciences › Anthropology › Race, Genetics, and Society
- Keywords
- Alzheimer's disease, race, racial and ethnic disparities, Alzheimer's disease biomarkers, African Americans, non-Hispanic whites, cerebrospinal fluid, total tau, phosphorylated tau, neurofilament light chain, genetic ancestry, vascular risk factors, socioeconomic status, innate immune response, underrepresentation in clinical trials
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