The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Individual Prognostication of Disease Activity and Disability Worsening in Multiple Sclerosis With Retinal Layer Thickness z Scores
Open accessAbstract
BACKGROUND AND OBJECTIVES: scores of OCT-derived measures to prognosticate future disease activity and disability worsening in people with MS (PwMS). METHODS: scores (pRNFL-z and GCIP-z) based on the reference data. Finally, we investigated the association of pRNFL-z or GCIP-z as predictors with future confirmed disability worsening (Expanded Disability Status Scale score increase) or disease activity (failing of the no evidence of disease activity [NEDA-3] criteria) as outcomes. Cox proportional hazards models or logistic regression analyses were applied according to the original studies. Optimal cutoffs were identified using the Akaike information criterion as well as location with the log-rank and likelihood-ratio tests. RESULTS: score approach with optimal cutoffs showed better performance in discrimination and calibration (higher Harrell's concordance index and lower integrated Brier score). DISCUSSION: scores that account for age, a major driver for disease progression in MS, to be a promising approach for creating OCT-derived measures useable across devices and toward individualized prognostication.
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“Several factors, including the stimulus parameters used, method of recording, and approaches for waveform analysis, influence VEPs, not only the recorded latencies, but also the sensitivity to optic nerve lesions.”
From The use of optical coherence tomography and visual evoked potentials in the 2024 McDonald diagnostic criteria for multiple sclerosis (2025) · cites this paper as [96]
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“In addition, reliability and reproducibility of recordings can be influenced by electrical noise, the choice and placement of electrodes, impedance, and the number of averages obtained per recording session, among other factors. 95,96”
From The use of optical coherence tomography and visual evoked potentials in the 2024 McDonald diagnostic criteria for multiple sclerosis (2025) · cites this paper as [96]
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Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Thompson, A. J., Banwell, B. L., Barkhof, F., Carroll, W. M., Coetzee, T., Comi, G., Correale, J., Fazekas, F., Filippi, M., Freedman, M. S., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30470-2 · Cited by 8,167
Reich, D. S., Lucchinetti, C. F., & Calabresi, P. A. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1401483 · Cited by 2,491
Self-citationThe OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment
Tewarie, P., Balk, L., Costello, F., Green, A., Martin, R., Schippling, S., & Petzold, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034823 · Cited by 627
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Saidha, S., Green, A. J., Leocani, L., Vidal-Jordana, A., Kenney, R. C., Bsteh, G., Outteryck, O., Thompson, A., Montalban, X., Coetzee, T., et al. (2025) · The Lancet Neurology · doi:10.1016/s1474-4422(25)00275-3 · Cited by 66
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Metadata
- Authors
- Lin, T.-Y., Motamedi, S., Asseyer, S., Chien, C., Saidha, S., Calabresi, P. A., Fitzgerald, K. C., Samadzadeh, S., Villoslada, P., Llufriu, S., Green, A. J., Preiningerova, J. L., Petzold, A., Leocani, L., Garcia-Martin, E., Oreja-Guevara, C., Outteryck, O., Vermersch, P., Balcer, L. J., Kenney, R., Albrecht, P., Aktas, O., Costello, F., Frederiksen, J., Uccelli, A., Cellerino, M., Frohman, E. M., Frohman, T. C., Bellmann-Strobl, J., Schmitz-Hübsch, T., Ruprecht, K., Brandt, A. U., Zimmermann, H. G., & Paul, F.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- From the Charité - Universitätsmedizin Berlin (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.); Experimental and Clinical Research Center (T.-Y.L., S.M., S.A., C.C., S. Samadzadeh, J.B.-S., T.S.-H., A.U.B., H.G.Z., F.P.), a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité - Universitätsmedizin Berlin; Max-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) (T.-Y.L., S.M., S.A., C.C., S....
- Corresponding author
- Zimmermann, Hanna G.
- Paul, Friedemann
- ORCID
- Lin, Ting-Yi
- Motamedi, Seyedamirhosein
- Asseyer, Susanna
- Chien, Claudia
- Saidha, Shiv
- Calabresi, Peter A.
- Fitzgerald, Kathryn C.
- Samadzadeh, Sara
- Villoslada, Pablo
- Llufriu, Sara
- Green, Ari J.
- Preiningerova, Jana Lizrova
- Petzold, Axel
- Leocani, Letizia
- Garcia-Martin, Elena
- Oreja-Guevara, Celia
- Outteryck, Olivier
- Vermersch, Patrick
- Balcer, Laura J.
- Kenney, Rachel
- Albrecht, Philipp
- Aktas, Orhan
- Costello, Fiona
- Frederiksen, Jette
- Uccelli, Antonio
- Cellerino, Maria
- Frohman, Elliot M.
- Bellmann-Strobl, Judith
- Ruprecht, Klemens
- Brandt, Alexander U.
- Zimmermann, Hanna G.
- Paul, Friedemann
- Venue
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2024-09
- Volume
- 11
- Issue
- 5
- Pages
- e200269-e200269
- ISSN
- 2332-7812 (ISSN-L)
- PMC
- PMC11214150
- OpenAlex
- W4400109826
- Cited by
- 12
- References
- 3
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 1
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Neurology Neuroimmunology & Neuroinflammation (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, cc-by)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (publishedVersion, cc-by-nc-nd)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (acceptedVersion, cc-by-nc-nd)
- HAL (submittedVersion, cc-by-nc-nd)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- LillOA (Université de Lille (University Of Lille)) (submittedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion, other-oa)
- Funders
- National Multiple Sclerosis Society
- Bristol-Myers Squibb
- Eli Lilly and Company (PE0000006)
- Sanofi
- Biogen (PE0000006)
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Celgene
- F. Hoffmann-La Roche (PE0000006)
- Guthy-Jackson Charitable Foundation
- Arthur Arnstein Stiftung
- Horizon Therapeutics
- Multiple Sclerosis Society of Canada
- National Institute for Health and Care Research
- Multiple Sclerosis Society
- European Commission (821,283-2, EU-FP7, PE0000006, 821283, 739534, project MNESYS (PE0000006)
- Bayer HealthCare
- Deutsche Forschungsgemeinschaft (DFG EXC-257, EXC257, PE0000006)
- Bundesministerium für Bildung und Forschung (821283-2)
- Stichting MS Research
- Stiftung Charité (Exc 257)
- Ipsen
- National Institutes of Health (PE0000006)
- Allergan
- Chugai Pharmaceutical
- Sanofi Genzyme
- Instituto de Salud Carlos III
- National Institute of Neurological Disorders and Stroke (R01NS082347)
- Cilag
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Health Sciences › Medicine › Ophthalmology › Drug-Induced Ocular Toxicity
- Keywords
- multiple sclerosis, retinal nerve fiber layer thickness, ganglion cell-inner plexiform layer thickness, optical coherence tomography, disease activity, disability progression, outcome prediction, no evidence of disease activity, Expanded Disability Status Scale, age adjustment, reference data
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Prognosis, Retina, Severity of Illness Index, Disease Progression, Tomography, Optical Coherence
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