The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Neuropsychological changes in asymptomatic persons with Alzheimer disease neuropathology
Open accessAbstract
OBJECTIVE: To determine whether asymptomatic persons with Alzheimer disease (AD) neuropathologic change differ in the trajectory of their cognitive performance compared to asymptomatic persons without AD neuropathologic change. METHODS: Longitudinal performance on standard neuropsychological tests was examined in participants who died within 2 years of their last cognitive assessment and who were never diagnosed with mild cognitive impairment or dementia (Clinical Dementia Rating global score of 0 at all assessments). Using cognitive and neuropathologic data collected between 2005 and 2013 from the 34 National Institute on Aging-sponsored Alzheimer's Disease Centers, cognitive trajectories were compared for persons with and without evidence of AD neuropathologic change. We evaluated rates of decline in 4 domains (episodic memory, language, attention/working memory, executive function). The significance of the differences (β) in rates of decline was tested using linear regression, adjusting for age, education, sex, and other neuropathologic lesions. RESULTS: Participants who had low to high levels of AD neuropathologic change (n = 131) showed a greater rate of decline on the attention/working memory domain score (β = -0.11; 95% confidence interval = -0.19, -0.02; p = 0.02) when compared to 80 participants who died without evidence of AD neuropathologic change. CONCLUSIONS: Clinically normal individuals who come to autopsy with AD neuropathologic change exhibit subtle evidence of declining cognitive trajectories for attention/working memory.
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“Since the publication of the 2011 guidelines, data have continued to accumulate indicating that the cognitive decline in AD occurs continuously over a long period [6–8]”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [8]
In the citing paper
“Clinicopathologic studies suggest that low levels of pathologic changes are associated with subtle cognitive deficits among CU persons [8,161].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [8]
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NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
Jack, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.018 · Cited by 10,537
“Clinicopathologic studies suggest that low levels of pathologic changes are associated with subtle cognitive deficits among CU persons [8,161].”
Religious Orders Study and Rush Memory and Aging Project
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Baker, J. E., Lim, Y. Y., Pietrzak, R. H., Hassenstab, J. J., Snyder, P. J., Masters, C. L., & Maruff, P. T. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.09.002 · Cited by 214
Self-citationCauses and Patterns of Dementia: An Update in the Era of Redefining Alzheimer's Disease
James, B. D., & Bennett, D. A. (2019) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-040218-043758 · Cited by 213
Detecting cognitive changes in preclinical Alzheimer's disease: A review of its feasibility
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Metadata
- Authors
- Monsell, S. E., Mock, C., Hassenstab, J., Roe, C. M., Cairns, N. J., Morris, J. C., & Kukull, W.
- Affiliations
- University of Washington (US)
- ORCID
- Venue
- Neurology
- Published
- 2014-07-29
- Volume
- 83
- Issue
- 5
- Pages
- 434-440
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC4132573
- OpenAlex
- W1974806875
- Cited by
- 71
- References
- 42
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 15 · 2015: 8 · 2014: 1
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (U01AG016976, P50AG005681, P01AG003991, P01AG026276)
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK094982)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, cognitive decline, episodic memory, language, executive function, autopsy, longitudinal cognitive trajectories
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Asymptomatic Diseases
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- CoChat. (2026). Citation check: Neuropsychological changes in asymptomatic persons with Alzheimer disease neuropathology. https://app.cochat.ai/papers/10.1212/wnl.0000000000000650
- The paper
- Monsell, S. E., Mock, C., Hassenstab, J., Roe, C. M., Cairns, N. J., Morris, J. C., & Kukull, W. (2014). Neuropsychological changes in asymptomatic persons with Alzheimer disease neuropathology. Neurology. https://doi.org/10.1212/wnl.0000000000000650
