CoChat
Sign Up
Cited by 1,260Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Religious Orders Study and Rush Memory and Aging Project

Open access
Bennett, David A., Buchman, Aron S., Boyle, Patricia A., Barnes, Lisa L., Wilson, Robert S., Schneider, Julie A.·2018·Journal of Alzheimer's Disease
DOI 10.3233/jad-179939PMC PMC6380522
Open this paper in CoChat — free account

Abstract

BACKGROUND: The Religious Orders Study and Rush Memory and Aging Project are both ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease (AD). OBJECTIVES: To summarize progress over the past five years and its implications for understanding neurodegenerative diseases. METHODS: Participants in both studies are older adults who enroll without dementia and agree to detailed longitudinal clinical evaluations and organ donation. The last review summarized findings through the end of 2011. Here we summarize progress and study findings over the past five years and discuss new directions for how these studies can inform on aging and AD in the future. RESULTS: We summarize 1) findings on the relation of neurobiology to clinical AD; 2) neurobiologic pathways linking risk factors to clinical AD; 3) non-cognitive AD phenotypes including motor function and decision making; 4) the development of a novel drug discovery platform. CONCLUSION: Complexity at multiple levels needs to be understood and overcome to develop effective treatments and preventions for cognitive decline and AD dementia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3233/jad-179939

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Genes associated with Alzheimer's disease progression are enriched in dopaminergic and inhibitory neuron subtypes, validated across two independent datasets.

    “This key finding, validated across two independent datasets [41, 100], points specifically to the enrichment of these progression genes in dopaminergic and inhibitory neuron subtypes.”

    From Genetic drivers of progression in Alzheimer’s disease are distinct from disease risk (2026) · cites this paper as [100]

    The Introduction (page unavailable) identifies the Religious Orders Study and Rush Memory and Aging Project as cohort studies and describes their datasets, supporting this paper as a citation for a data resource. The paper does not report that Alzheimer’s progression genes are enriched in dopaminergic or inhibitory neuron subtypes, or that this finding was validated across two datasets. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • All ROSMAP participants enrolled without known dementia and agreed to detailed clinical evaluation and brain donation at death.

    “All ROSMAP partici- pants enrolled without known dementia and agreed to detailed clinical evaluation and brain donation at death.”

    From PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia (2025) · cites this paper as [62]

  • Aged individuals can harbor a high burden of AD brain lesions at autopsy while remaining cognitively intact, indicating resilience to AD pathology.

    “several studies have revealed the existence of aged individuals harboring a high burden of brain lesions at autopsy while remaining cognitively intact, indicating resilience to AD pathology [3, 7, 21, 22, 56, 57, 68, 76, 78, 96].”

    From Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease (2024) · cites this paper as [7]

  • Some studies have identified selected overlaps in expression changes between AD mouse models and human brains.

    “Although some studies have identified selected overlaps in expression changes between AD mouse models and human brains (Bennett et al., 2018; Castillo et al., 2017; Mostafavi et al., 2018; Neuner et al., 2019; Rojo et al., 2017), other studies have questioned the overall degree of conservation (Burns et al., 2015; Galatro et al., 2017; Hargis and Blalock, 2017).”

    From Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models (2020) · cites this paper as Bennett et al., 2018

    The Results section on the novel drug and biomarker discovery pipeline discusses human-brain omics and an ex vivo model, but does not compare expression changes in AD mouse models with human brains. Searches for mouse models, cross-species comparisons, and overlapping expression changes found no passage in our copy reporting the claimed overlap; pages were not provided. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

  • miR-1908-5p is relevant to bipolar disorder despite its relatively low abundance.

    “Notable among those, miR-1908–5p was previously observed to be differentially expressed in blood in the acute bipolar state compared to remission state62, which suggests that miR-1908–5p is relevant to bipolar disorder despite its relatively low abundance.”

    From Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions (2024) · cites this paper as [62]

    The Materials section discusses miRNA data from the Religious Orders Study and Rush Memory and Aging Project, but does not identify miR-1908-5p or address bipolar disorder. Searches for miR-1908-5p, acute bipolar state versus remission, and low abundance found no passage supporting the observation attributed to this source. (LLM, conf=0.77)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 397

  1. [1]Maurer K, Volk S, Gerbaldo H (1997) Auguste D and Alzheimer’s disease. Lancet 349, 1546– 1549. 9167474
  2. [2]Amaducci LA, Rocca WA, Schoenberg BS (1986) Origin of the distinction between Alzheimer’s disease and senile dementia: how history can clarify nosology. Neurology 36, 1497– 1499. 3531918
  3. [3]Cairns NJ, Perrin RJ, Franklin EE, Carter D, Vincent B, Xie M, Bateman RJ, Benzinger T, Friedrichsen K, Brooks WS, Halliday GM, McLean C, Ghetti B, Morris JC (2015) Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN). Neuropathology 35, 390– 400. 25964057 PMC4521391
  4. [4]Toledo JB, Arnold SE, Raible K, Brettschneider J, Xie SX, Grossman M, Monsell SE, Kukull WA, Trojanowski JQ (2013) Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre. Brain 136, 2697– 2706. 23842566 PMC3858112
  5. [6]Snowdon DA (1997) Aging and Alzheimer’s disease: lessons from the Nun Study. Gerontologist 37, 150– 156. 9127971
  6. [7]White L, Launer L (2006) Relevance of cardiovascular risk factors and ischemic cerebrovascular disease to the pathogenesis of Alzheimer disease: a review of accrued findings from the Honolulu-Asia Aging Study. Alzheimer Dis Assoc Disord 20, S79– 83. 16917201
  7. [8]Shinkawa A, Ueda K, Kiyohara Y, Kato I, Sueishi K, Tsuneyoshi M, Fujishima M (1995) Silent cerebral infarction in a community-based autopsy series in Japan. The Hisayama Study. Stroke 26, 380– 385. 7886710
  8. [9]Zaccai J, Ince P, Brayne C (2006) Population-based neuropathological studies of dementia: design, methods and areas of investigation--a systematic review. BMC Neurol 6, 2. 16401346 PMC1397861
  9. [10]Bennett DA, Schneider JA, Buchman AS, Barnes LL, Boyle PA, Wilson RS (2012) Overview and Findings From the Rush Memory and Aging Project. Curr Alzheimer Res 9, 646– 663. 22471867 PMC3439198
  10. [11]Bennett DA, Schneider JA, Arvanitakis Z, Wilson RS (2012) Overview and findings from the religious orders study. Curr Alzheimer Res 9, 628– 645. 22471860 PMC3409291
  11. [12]Wilson RS, Mendes De Leon CF, Barnes LL, Schneider JA, Bienias JL, Evans DA, Bennett DA (2002) Participation in cognitively stimulating activities and risk of incident Alzheimer disease. Jama 287, 742– 748. 11851541
  12. [13]Wilson RS, Barnes LL, Mendes de Leon CF, Aggarwal NT, Schneider JS, Bach J, Pilat J, Beckett LA, Arnold SE, Evans DA, Bennett DA (2002) Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology 59, 364– 370. 12177369
  13. [15]Wilson R, Barnes L, Bennett D (2003) Assessment of lifetime participation in cognitively stimulating activities. J Clin Exp Neuropsychol 25, 634– 642. 12815501
  14. [16]Wilson RS, Bienias JL, Mendes de Leon CF, Evans DA, Bennett DA (2003) Negative affect and mortality in older persons. Am J Epidemiol 158, 827– 835. 14585760
  15. [17]Wilson RS, Evans DA, Bienias JL, Mendes de Leon CF, Schneider JA, Bennett DA (2003) Proneness to psychological distress is associated with risk of Alzheimer’s disease. Neurology 61, 1479– 1485. 14663028
  16. [18]Arvanitakis Z, Wilson RS, Bienias JL, Evans DA, Bennett DA (2004) Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 61, 661– 666. 15148141
  17. [20]Wilson RS, Scherr PA, Hoganson G, Bienias JL, Evans DA, Bennett DA (2005) Early life socioeconomic status and late life risk of Alzheimer’s disease. Neuroepidemiology 25, 8– 14. 15855799
  18. [21]Wilson RS, Barnes LL, Krueger KR, Hoganson G, Bienias JL, Bennett DA (2005) Early and late life cognitive activity and cognitive systems in old age. J Int Neuropsychol Soc 11, 400– 407. 16209420
  19. [22]Buchman AS, Wilson RS, Bienias JL, Shah RC, Evans DA, Bennett DA (2005) Change in body mass index and risk of incident Alzheimer disease. Neurology 65, 892– 897. 16186530
  20. [23]Shah RC, Wilson RS, Bienias JL, Arvanitakis Z, Evans DA, Bennett DA (2006) Relation of blood pressure to risk of incident Alzheimer’s disease and change in global cognitive function in older persons. Neuroepidemiology 26, 30– 36. 16254451
  21. [24]Wilson RS, Krueger KR, Arnold SE, Barnes LL, Mendes de Leon CF, Bienias JL, Bennett DA (2006) Childhood adversity and psychosocial adjustment in old age. Am J Geriatr Psychiatry 14, 307– 315. 16582039 PMC2740729
  22. [25]Wilson RS, Buchman AS, Arnold SE, Shah RC, Tang Y, Bennett DA (2006) Harm avoidance and disability in old age. Exp Aging Res 32, 243– 261. 16754467
  23. [26]Krueger KR, Wilson RS, Shah RC, Tang Y, Bennett DA (2006) Personality and incident disability in older persons. Age Ageing 35, 428– 433. 16788082
  24. [27]Park M, Comella CL, Leurgans SE, Fan W, Wilson RS, Bennett DA (2006) Association of daytime napping and Parkinsonian signs in Alzheimer’s disease. Sleep Med 7, 614– 618. 17023213
  25. [28]Wilson RS, Arnold SE, Schneider JA, Kelly JF, Tang Y, Bennett DA (2006) Chronic psychological distress and risk of Alzheimer’s disease in old age. Neuroepidemiology 27, 143– 153. 16974109
  26. [29]Barnes LL, Schneider JA, Boyle PA, Bienias JL, Bennett DA (2006) Memory complaints are related to Alzheimer disease pathology in older persons. Neurology 67, 1581– 1585. 17101887 PMC2740723
  27. [30]Wilson RS, Krueger KR, Arnold SE, Schneider JA, Kelly JF, Barnes LL, Tang Y, Bennett DA (2007) Loneliness and risk of Alzheimer disease. Arch Gen Psychiatry 64, 234– 240. 17283291
  28. [31]Buchman AS, Boyle PA, Wilson RS, Bienias JL, Bennett DA (2007) Physical activity and motor decline in older persons. Muscle Nerve 35, 354– 362. 17143881
  29. [32]Wilson RS, Schneider JA, Arnold SE, Tang Y, Boyle PA, Bennett DA (2007) Olfactory identification and incidence of mild cognitive impairment in older age. Arch Gen Psychiatry 64, 802– 808. 17606814
  30. [33]Wilson RS, Scherr PA, Schneider JA, Tang Y, Bennett DA (2007) Relation of cognitive activity to risk of developing Alzheimer disease. Neurology 69, 1911– 1920. 17596582
  31. [34]Wilson RS, Schneider JA, Arnold SE, Bienias JL, Bennett DA (2007) Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment. Arch Gen Psychiatry 64, 1204– 1212. 17909133
  32. [35]Wilson RS, Arnold SE, Beck TL, Bienias JL, Bennett DA (2008) Change in depressive symptoms during the prodromal phase of Alzheimer disease. Arch Gen Psychiatry 65, 439– 445. 18391132
  33. [36]Buchman AS, Boyle PA, Wilson RS, Gu L, Bienias JL, Bennett DA (2008) Pulmonary function, muscle strength and mortality in old age. Mech Ageing Dev 129, 625– 631. 18755207 PMC2677981
  34. [37]Buchman AS, Boyle PA, Wilson RS, Leurgans S, Shah RC, Bennett DA (2008) Respiratory muscle strength predicts decline in mobility in older persons. Neuroepidemiology 31, 174– 180. 18784416 PMC2741394
  35. [38]Buchman AS, Boyle PA, Wilson RS, Fleischman DA, Leurgans S, Bennett DA (2009) Association between late-life social activity and motor decline in older adults. Arch Intern Med 169, 1139– 1146. 19546415 PMC2775502
  36. [39]Buchman AS, Tanne D, Boyle PA, Shah RC, Leurgans SE, Bennett DA (2009) Kidney function is associated with the rate of cognitive decline in the elderly. Neurology 73, 920– 927. 19657107 PMC2754333
  37. [41]Boyle PA, Buchman AS, Barnes LL, James BD, Bennett DA (2010) Association between life space and risk of mortality in advanced age. J Am Geriatr Soc 58, 1925– 1930. 20831722 PMC3286640
  38. [42]Shah RC, Buchman AS, Boyle PA, Leurgans SE, Wilson RS, Andersson GB, Bennett DA (2011) Musculoskeletal pain is associated with incident mobility disability in community-dwelling elders. J Gerontol A Biol Sci Med Sci 66, 82– 88. 20966101 PMC3011961
  39. [43]Buchman AS, Shah RC, Leurgans SE, Boyle PA, Wilson RS, Bennett DA (2010) Musculoskeletal pain and incident disability in community-dwelling older adults. Arthritis Care Res (Hoboken) 62, 1287– 1293. 20853470 PMC3445435
  40. [44]Wilson RS, Begeny CT, Boyle PA, Schneider JA, Bennett DA (2011) Vulnerability to stress, anxiety, and development of dementia in old age. Am J Geriatr Psychiatry 19, 327– 334. 21427641 PMC3078621
  41. [45]Shah RC, Buchman AS, Wilson RS, Leurgans SE, Bennett DA (2011) Hemoglobin level in older persons and incident Alzheimer disease: prospective cohort analysis. Neurology 77, 219– 226. 21753176 PMC3136057
  42. [46]Wilson RS, Boyle PA, Buchman AS, Yu L, Arnold SE, Bennett DA (2011) Harm avoidance and risk of Alzheimer’s disease. Psychosom Med 73, 690– 696. 21949425 PMC3304581
  43. [47]Buchman AS, Wilson RS, Bennett DA (2008) Total daily activity is associated with cognition in older persons. Am J Geriatr Psychiatry 16, 697– 701. 18669949
  44. [48]Lim AS, Yu L, Costa MD, Buchman AS, Bennett DA, Leurgans SE, Saper CB (2011) Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis. Sleep 34, 1569– 1581. 22043128 PMC3198212
  45. [49]Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, Schneider J, Wilson RS (2003) Dietary fats and the risk of incident Alzheimer disease. Arch Neurol 60, 194– 200. 12580703
  46. [50]De Jager PL, Shulman JM, Chibnik LB, Keenan BT, Raj T, Wilson RS, Yu L, Leurgans SE, Tran D, Aubin C, Anderson CD, Biffi A, Corneveaux JJ, Huentelman MJ, Rosand J, Daly MJ, Myers AJ, Reiman EM, Bennett DA, Evans DA (2012) A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiol Aging 33, 1017 e1011–1015. PMC3307898 22054870
  47. [52]Bennett DA, Schneider JA, Wilson RS, Bienias JL, Arnold SE (2004) Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch Neurol 61, 378– 384. 15023815
  48. [54]Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS (2006) The effect of social networks on the relation between Alzheimer’s disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol 5, 406– 412. 16632311
  49. [57]Schneider JA, Li JL, Li Y, Wilson RS, Kordower JH, Bennett DA (2006) Substantia nigra tangles are related to gait impairment in older persons. Ann Neurol 59, 166– 173. 16374822
  50. [59]Schneider JA, Arvanitakis Z, Leurgans SE, Bennett DA (2009) The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol 66, 200– 208. 19743450 PMC2812870
  51. [60]Arvanitakis Z, Leurgans SE, Wang Z, Wilson RS, Bennett DA, Schneider JA (2011) Cerebral amyloid angiopathy pathology and cognitive domains in older persons. Ann Neurol 69, 320– 327. 21387377 PMC3228518
  52. [61]Wilson RS, Yu L, Trojanowski JQ, Chen EY, Boyle PA, Bennett DA, Schneider JA (2013) TDP-43 pathology, cognitive decline, and dementia in old age. JAMA Neurol 70, 1418– 1424. 24080705 PMC3830649
  53. [63]Fleischman DA, Arfanakis K, Kelly JF, Rajendran N, Buchman AS, Morris MC, Barnes LL, Bennett DA (2010) Regional brain cortical thinning and systemic inflammation in older persons without dementia. J Am Geriatr Soc 58, 1823– 1825. 20863359 PMC2945260
  54. [64]Dawe RJ, Bennett DA, Schneider JA, Vasireddi SK, Arfanakis K (2009) Postmortem MRI of human brain hemispheres: T2 relaxation times during formaldehyde fixation. Magn Reson Med 61, 810– 818. 19189294 PMC2713761
  55. [65]Dawe RJ, Bennett DA, Schneider JA, Arfanakis K (2011) Neuropathologic correlates of hippocampal atrophy in the elderly: a clinical, pathologic, postmortem MRI study. PLoS One 6, e26286. 22043314 PMC3197137
  56. [66]Wilson RS, Beckett LA, Barnes LL, Schneider JA, Bach J, Evans DA, Bennett DA (2002) Individual differences in rates of change in cognitive abilities of older persons. Psychol Aging 17, 179– 193. 12061405
  57. [67]Wilson RS, Bennett DA (2005) Assessment of cognitive decline in old age with brief tests amenable to telephone administration. Neuroepidemiology 25, 19– 25. 15855801
  58. [68]Wilson RS, Arnold SE, Tang Y, Bennett DA (2006) Odor identification and decline in different cognitive domains in old age. Neuroepidemiology 26, 61– 67. 16352908
  59. [69]Bennett DA, Shannon KM, Beckett LA, Goetz CG, Wilson RS (1997) Metric properties of nurses’ ratings of parkinsonian signs with a modified Unified Parkinson’s Disease Rating Scale. Neurology 49, 1580– 1587. 9409350
  60. [70]Bennett DA, Shannon KM, Beckett LA, Wilson RS (1999) Dimensionality of parkinsonian signs in aging and Alzheimer’s disease. J Gerontol A Biol Sci Med Sci 54, M191– 196. 10219010
  61. [71]Wilson RS, Schneider JA, Beckett LA, Evans DA, Bennett DA (2002) Progression of gait disorder and rigidity and risk of death in older persons. Neurology 58, 1815– 1819. 12084882
  62. [72]Boyle PA, Wilson RS, Aggarwal NT, Arvanitakis Z, Kelly J, Bienias JL, Bennett DA (2005) Parkinsonian signs in subjects with mild cognitive impairment. Neurology 65, 1901– 1906. 16380610
  63. [73]Buchman AS, Wilson RS, Boyle PA, Bienias JL, Bennett DA (2007) Change in motor function and risk of mortality in older persons. J Am Geriatr Soc 55, 11– 19. 17233680
  64. [74]Buchman AS, Wilson RS, Boyle PA, Bienias JL, Bennett DA (2007) Grip strength and the risk of incident Alzheimer’s disease. Neuroepidemiology 29, 66– 73. 17925596
  65. [75]Buchman AS, Wilson RS, Boyle PA, Tang Y, Fleischman DA, Bennett DA (2007) Physical activity and leg strength predict decline in mobility performance in older persons. J Am Geriatr Soc 55, 1618– 1623. 17697103
  66. [76]Boyle PA, Buchman AS, Wilson RS, Leurgans SE, Bennett DA (2009) Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons. Arch Neurol 66, 1339– 1344. 19901164 PMC2838435
  67. [77]Buchman AS, Wilson RS, Bienias JL, Bennett DA (2005) Gender differences in motor performance of older persons. Geriatrics Gerontology International 5, 59– 65. 25782068
  68. [78]Dawe RJ, Leurgans SE, Yang J, Bennett JM, Hausdorff JM, Lim AS, Gaiteri C, Bennett DA, Buchman AS (2017) Association between Quantitative Gait and Balance Measures and Total Daily Physical Activity in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. PMC5905609 28957994
  69. [79]Weiss A, Mirelman A, Giladi N, Barnes LL, Bennett DA, Buchman AS, Hausdorff JM (2016) Transition Between the Timed up and Go Turn to Sit Subtasks: Is Timing Everything? J Am Med Dir Assoc 17, 864 e869–864.e815. PMC5004894 27569715
  70. [80]Mirelman A, Weiss A, Buchman AS, Bennett DA, Giladi N, Hausdorff JM (2014) Association between performance on Timed Up and Go sub-tasks and Mild Cognitive Impairment: Further insights into the cognitive aspects of the TUG. Journal of the American Geriatrics Society 62, 673– 678. 24635699 PMC3989433
  71. [81]Buchman AS, Leurgans SE, Weiss A, VanderHorst V, Mirelman A, Dawe R, Barnes LL, Wilson RS, Hausdorff JM, Bennett DA (2014) Associations between Quantitative Mobility Measures Derived from Components of Conventional Mobility Testing and Parkinsonian Gait in Older Adults. PLoS ONE 9, e86262. 24465997 PMC3899223
  72. [82]Weiss A, Mirelman A, Buchman AS, Bennett DA, Hausdorff JM (2013) Using a body-fixed sensor to identify subclinical gait difficulties in older adults with IADL disability: maximizing the output of the timed up and go. PLoS One 8, e68885. 23922665 PMC3726691
  73. [84]James BD, Boyle PA, Bennett JS, Bennett DA (2012) The impact of health and financial literacy on decision making in community-based older adults. Gerontology 58, 531– 539. 22739454 PMC3491105
  74. [86]Gamble K, Boyle P, Yu L, Bennett D (2015) Aging and Financial Decision Making. Manage Sci 61, 2603– 2610. 26622068 PMC4662381
  75. [87]Bennett DA, Schneider JA, Aggarwal NT, Arvanitakis Z, Shah RC, Kelly JF, Fox JH, Cochran EJ, Arends D, Treinkman AD, Wilson RS (2006) Decision rules guiding the clinical diagnosis of Alzheimer’s disease in two community-based cohort studies compared to standard practice in a clinic-based cohort study. Neuroepidemiology 27, 169– 176. 17035694
  76. [89]Schneider JA, Bienias JL, Wilson RS, Berry-Kravis E, Evans DA, Bennett DA (2005) The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons. Stroke 36, 954– 959. 15774818
  77. [90]Wilson RS, Schneider JA, Bienias JL, Arnold SE, Evans DA, Bennett DA (2003) Depressive symptoms, clinical AD, and cortical plaques and tangles in older persons. Neurology 61, 1102– 1107. 14581672
  78. [91]Buracchio T, Arvanitakis Z, Leurgans S, Bennett DA (2010) Parkinsonian signs and incident falls in older persons without Parkinson’s disease. J Am Geriatr Soc 58, 205– 206. 20122072 PMC3629945
  79. [92]James BD, Leurgans SE, Hebert LE, Scherr PA, Yaffe K, Bennett DA (2014) Contribution of Alzheimer disease to mortality in the United States. Neurology 82, 1045– 1050. 24598707 PMC3962992
  80. [93]Mungas D, Tractenberg R, Schneider JA, Crane PK, Bennett DA (2014) A 2-process model for neuropathology of Alzheimer’s disease. Neurobiol Aging 35, 301– 308. 24080173 PMC3977862
  81. [94]Crystal HA, Schneider JA, Bennett DA, Leurgans S, Levine SR (2014) Associations of cerebrovascular and Alzheimer’s disease pathology with brain atrophy. Curr Alzheimer Res 11, 309– 316. 24597507 PMC4401460
  82. [95]Wilson RS, Segawa E, Boyle PA, Anagnos SE, Hizel LP, Bennett DA (2012) The natural history of cognitive decline in Alzheimer’s disease. Psychol Aging 27, 1008– 1017. 22946521 PMC3534850
  83. [96]Nag S, Yu L, Capuano AW, Wilson RS, Leurgans SE, Bennett DA, Schneider JA (2015) Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease. Ann Neurol 77, 942– 952. 25707479 PMC4447563
  84. [97]Boyle PA, Yu L, Nag S, Leurgans S, Wilson RS, Bennett DA, Schneider JA (2015) Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons. Neurology 85, 1930– 1936. 26537052 PMC4664125
  85. [98]Arvanitakis Z, Capuano AW, Leurgans SE, Buchman AS, Bennett DA, Schneider JA (2017) The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts. Brain Pathol 27, 77– 85. 26844934 PMC4974145
  86. [99]Arvanitakis Z, Capuano AW, Leurgans SE, Bennett DA, Schneider JA (2016) Relation of cerebral vessel disease to Alzheimer’s disease dementia and cognitive function in elderly people: a cross-sectional study. Lancet Neurol 15, 934– 943. 27312738 PMC4969105
  87. [100]James BD, Wilson RS, Boyle PA, Trojanowski JQ, Bennett DA, Schneider JA (2016) TDP-43 stage, mixed pathologies, and clinical Alzheimer’s-type dementia. Brain 139, 2983– 2993. 27694152 PMC5091047
  88. [101]Nag S, Yu L, Wilson RS, Chen EY, Bennett DA, Schneider JA (2017) TDP-43 pathology and memory impairment in elders without pathologic diagnoses of AD or FTLD. Neurology 88, 653– 660. 28087828 PMC5317379
  89. [103]Fleischman DA, Leurgans S, Arfanakis K, Arvanitakis Z, Barnes LL, Boyle PA, Han SD, Bennett DA (2014) Gray-matter macrostructure in cognitively healthy older persons: associations with age and cognition. Brain Struct Funct 219, 2029– 2049. 23955313 PMC3926914
  90. [104]Arvanitakis Z, Fleischman DA, Arfanakis K, Leurgans SE, Barnes LL, Bennett DA (2016) Association of white matter hyperintensities and gray matter volume with cognition in older individuals without cognitive impairment. Brain Struct Funct 221, 2135– 2146. 25833685 PMC4592368
  91. [105]Dawe RJ, Yu L, Leurgans SE, Schneider JA, Buchman AS, Arfanakis K, Bennett DA, Boyle PA (2016) Postmortem MRI: a novel window into the neurobiology of late life cognitive decline. Neurobiol Aging 45, 169– 177. 27459937 PMC5003419
  92. [106]Yu L, Dawe RJ, Buchman AS, Boyle PA, Schneider JA, Arfanakis K, Bennett DA (2017) Ex vivo MRI transverse relaxation in community based older persons with and without Alzheimer’s dementia. Behav Brain Res 322, 233– 240. 27596378 PMC5325779
  93. [107]Dawe RJ, Bennett DA, Schneider JA, Leurgans SE, Kotrotsou A, Boyle PA, Arfanakis K (2014) Ex vivo T2 relaxation: associations with age-related neuropathology and cognition. Neurobiol Aging 35, 1549– 1561. 24582637 PMC3989898
  94. [108]Kotrotsou A, Schneider JA, Bennett DA, Leurgans SE, Dawe RJ, Boyle PA, Golak T, Arfanakis K (2015) Neuropathologic correlates of regional brain volumes in a community cohort of older adults. Neurobiol Aging 36, 2798– 2805. 26195068 PMC4562889
  95. [109]Kotrotsou A, Bennett DA, Schneider JA, Dawe RJ, Golak T, Leurgans SE, Yu L, Arfanakis K (2014) Ex vivo MR volumetry of human brain hemispheres. Magn Reson Med 71, 364– 374. 23440751 PMC3664651
  96. [110]Evia AM, Kotrotsou A, Tamhane AA, Dawe RJ, Kapasi A, Leurgans SE, Schneider JA, Bennett DA, Arfanakis K (2017) Ex-vivo quantitative susceptibility mapping of human brain hemispheres. PLoS One 12, e0188395. 29261693 PMC5737971
  97. [111]Bennett DA, Wilson RS, Boyle PA, Buchman AS, Schneider JA (2012) Relation of neuropathology to cognition in persons without cognitive impairment. Ann Neurol 72, 599– 609. 23109154 PMC3490232
  98. [112]Yang FM, Grigorenko A, Tommet D, Farias ST, Mungas D, Bennett DA, Jones RN, Crane PK (2013) AD pathology and cerebral infarctions are associated with memory and executive functioning one and five years before death. J Clin Exp Neuropsychol 35, 24– 34. 23205616 PMC3605227
  99. [113]Schneider JA, Arvanitakis Z, Yu L, Boyle PA, Leurgans SE, Bennett DA (2012) Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies. Brain 135, 3005– 3014. 23065790 PMC3470712
  100. [114]Wilson RS, Boyle PA, Yu L, Barnes LL, Sytsma J, Buchman AS, Bennett DA, Schneider JA (2015) Temporal course and pathologic basis of unawareness of memory loss in dementia. Neurology 85, 984– 991. 26311746 PMC4567465
  101. [115]Wilson RS, Capuano AW, Bennett DA, Schneider JA, Boyle PA (2016) Temporal course of neurodegenerative effects on cognition in old age. Neuropsychology 30, 591– 599. 27111293 PMC4988317
  102. [116]Capuano AW, Wilson RS, Leurgans SE, Dawson JD, Bennett DA, Hedeker D (2016) Sigmoidal mixed models for longitudinal data. Stat Methods Med Res. PMC5503801 27130491
  103. [117]Boyle PA, Yu L, Fleischman DA, Leurgans S, Yang J, Wilson RS, Schneider JA, Arvanitakis Z, Arfanakis K, Bennett DA (2016) White matter hyperintensities, incident mild cognitive impairment, and cognitive decline in old age. Ann Clin Transl Neurol 3, 791– 800. 27752514 PMC5048389
  104. [118]Boyle PA, Yang J, Yu L, Leurgans SE, Capuano AW, Schneider JA, Wilson RS, Bennett DA (2017) Varied effects of age-related neuropathologies on the trajectory of late life cognitive decline. Brain 140, 804– 812. 28082297 PMC5837473
  105. [119]Jansen WJ, Wilson RS, Visser PJ, Nag S, Schneider JA, James BD, Leurgans SE, Capuano AW, Bennett DA, Boyle PA (2018) Age and the association of dementia-related pathology with trajectories of cognitive decline. Neurobiol Aging 61, 138– 145. 29078129 PMC5721665
  106. [120]Fleischman DA, Yu L, Arfanakis K, Han SD, Barnes LL, Arvanitakis Z, Boyle PA, Bennett DA (2013) Faster cognitive decline in the years prior to MR imaging is associated with smaller hippocampal volumes in cognitively healthy older persons. Front Aging Neurosci 5, 21. 23760360 PMC3672675
  107. [121]Yu L, Boyle PA, Leurgans S, Schneider JA, Kryscio RJ, Wilson RS, Bennett DA (2015) Effect of common neuropathologies on progression of late life cognitive impairment. Neurobiol Aging 36, 2225– 2231. 25976345 PMC4457559
  108. [123]Wang D, Schultz T, Novak GP, Baker S, Bennett DA, Narayan VA (in press). Longitudinal Modeling of Functional Decline associated with pathologic Alzheimer’s disease in older persons without cognitive impairment. JAD. PMC6195203 29480187
  109. [124]Boyle PA, Yu L, Wilson RS, Schneider JA, Bennett DA (2013) Relation of neuropathology with cognitive decline among older persons without dementia. Front Aging Neurosci 5, 50. 24058343 PMC3766823
  110. [126]Sadleir KR, Bennett DA, Schneider JA, Vassar R (2013) Elevated Abeta42 in aged, non-demented individuals with cerebral atherosclerosis. Curr Alzheimer Res 10, 785– 789. 23919773 PMC4041148
  111. [127]Tremblay C, Francois A, Delay C, Freland L, Vandal M, Bennett DA, Calon F (2017) Association of Neuropathological Markers in the Parietal Cortex With Antemortem Cognitive Function in Persons With Mild Cognitive Impairment and Alzheimer Disease. J Neuropathol Exp Neurol. PMC7526851 28158844
  112. [128]Larson ME, Sherman MA, Greimel S, Kuskowski M, Schneider JA, Bennett DA, Lesne SE (2012) Soluble alpha-synuclein is a novel modulator of Alzheimer’s disease pathophysiology. J Neurosci 32, 10253– 10266. 22836259 PMC3425439
  113. [129]Larson M, Sherman MA, Amar F, Nuvolone M, Schneider JA, Bennett DA, Aguzzi A, Lesne SE (2012) The complex PrP(c)-Fyn couples human oligomeric Abeta with pathological tau changes in Alzheimer’s disease. J Neurosci 32, 16857– 16871a. 23175838 PMC3568961
  114. [130]Lesne SE, Sherman MA, Grant M, Kuskowski M, Schneider JA, Bennett DA, Ashe KH (2013) Brain amyloid-beta oligomers in ageing and Alzheimer’s disease. Brain 136, 1383– 1398. 23576130 PMC3634198
  115. [131]Sherman MA, LaCroix M, Amar F, Larson ME, Forster C, Aguzzi A, Bennett DA, Ramsden M, Lesne SE (2016) Soluble Conformers of Abeta and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci 36, 9647– 9658. 27629715 PMC5039246
  116. [132]Yu L, Boyle PA, Segawa E, Leurgans S, Schneider JA, Wilson RS, Bennett DA (2015) Residual decline in cognition after adjustment for common neuropathologic conditions. Neuropsychology 29, 335– 343. 25495832 PMC4420708
  117. [134]Wilson RS, Nag S, Boyle PA, Hizel LP, Yu L, Buchman AS, Schneider JA, Bennett DA (2013) Neural reserve, neuronal density in the locus ceruleus, and cognitive decline. Neurology 80, 1202– 1208. 23486878 PMC3691778
  118. [135]Ramos-Miguel A, Hercher C, Beasley CL, Barr AM, Bayer TA, Falkai P, Leurgans SE, Schneider JA, Bennett DA, Honer WG (2015) Loss of Munc18–1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample. Mol Neurodegener 10, 65. 26628003 PMC4667524
  119. [136]Buchman AS, Yu L, Boyle PA, Schneider JA, De Jager PL, Bennett DA (2016) Higher brain BDNF gene expression is associated with slower cognitive decline in older adults. Neurology 86, 735– 741. 26819457 PMC4763800
  120. [137]Ramos-Miguel A, Sawada K, Jones AA, Thornton AE, Barr AM, Leurgans SE, Schneider JA, Bennett DA, Honer WG (2017) Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer’s disease. Acta Neuropathol 133, 395– 407. 27866231 PMC6542594
  121. [138]Mostafavi S, Gaiteri C, Sullivan S, White C, Takasi S, Xu J, Taga M, Klein H, Patrick E, Komashko V, McCable C, Smith R, Bradshaw E, Root D, Yu L, Regev A, Chibnik L, Schneider J, Young-Pearse T, Bennett D, De Jager P, A molecular network of the aging brain implicates INPPL1 and PLXNB1 in Alzheimer’s disease, https://www.biorxiv.org/content/early/2017/10/19/205807,
  122. [139]Wilson RS, Capuano AW, Sytsma J, Bennett DA, Barnes LL (2015) Cognitive aging in older Black and White persons. Psychol Aging 30, 279– 285. 25961876 PMC4481321
  123. [140]Wilson RS, Capuano AW, Marquez DX, Amofa P, Barnes LL, Bennett DA (2016) Change in Cognitive Abilities in Older Latinos. J Int Neuropsychol Soc 22, 58– 65. 26553103 PMC4990203
  124. [141]Barnes LL, Yumoto F, Capuano A, Wilson RS, Bennett DA, Tractenberg RE (2016) Examination of the Factor Structure of a Global Cognitive Function Battery across Race and Time. J Int Neuropsychol Soc 22, 66– 75. 26563713 PMC4763720
  125. [142]Yu L, Boyle P, Wilson RS, Segawa E, Leurgans S, De Jager PL, Bennett DA (2012) A random change point model for cognitive decline in Alzheimer’s disease and mild cognitive impairment. Neuroepidemiology 39, 73– 83. 22814083 PMC3484884
  126. [143]Valant V, Keenan BT, Anderson CD, Shulman JM, Devan WJ, Ayres AM, Schwab K, Goldstein JN, Viswanathan A, Greenberg SM, Bennett DA, De Jager PL, Rosand J, Biffi A (2012) TOMM40 in Cerebral Amyloid Angiopathy Related Intracerebral Hemorrhage: Comparative Genetic Analysis with Alzheimer’s Disease. Transl Stroke Res 3, 102– 112. 24323865 PMC4054941
  127. [144]Yu L, Lutz MW, Wilson RS, Burns DK, Roses AD, Saunders AM, Yang J, Gaiteri C, De Jager PL, Barnes LL, Bennett DA (2017) APOE epsilon4-TOMM40 ‘523 haplotypes and the risk of Alzheimer’s disease in older Caucasian and African Americans. PLoS One 12, e0180356. 28672022 PMC5495438
  128. [145]Yu L, Lutz MW, Wilson RS, Burns DK, Roses AD, Saunders AM, Gaiteri C, De Jager PL, Barnes LL, Bennett DA (2017) TOMM40’523 variant and cognitive decline in older persons with APOE epsilon3/3 genotype. Neurology 88, 661– 668. 28108637 PMC5317377
  129. [146]Yu L, Lutz MW, Farfel JM, Wilson RS, Burns DK, Saunders AM, De Jager PL, Barnes LL, Schneider JA, Bennett DA (2017) Neuropathologic features of TOMM40 ‘523 variant on late-life cognitive decline. Alzheimers Dement 13, 1380– 1388. 28624335 PMC5723540
  130. [147]Barnes LL, Arvanitakis Z, Yu L, Kelly J, De Jager PL, Bennett DA (2013) Apolipoprotein E and change in episodic memory in blacks and whites. Neuroepidemiology 40, 211– 219. 23364031 PMC3645297
  131. [148]Yu L, Boyle P, Schneider JA, Segawa E, Wilson RS, Leurgans S, Bennett DA (2013) APOE epsilon4, Alzheimer’s disease pathology, cerebrovascular disease, and cognitive change over the years prior to death. Psychol Aging 28, 1015– 1023. 23647000 PMC3766432
  132. [149]Yu L, Boyle PA, Nag S, Leurgans S, Buchman AS, Wilson RS, Arvanitakis Z, Farfel JM, De Jager PL, Bennett DA, Schneider JA (2015) APOE and cerebral amyloid angiopathy in community-dwelling older persons. Neurobiol Aging 36, 2946– 2953. 26341746 PMC4609607
  133. [150]Yu L, Boyle PA, Leurgans S, Schneider JA, Bennett DA (2014) Disentangling the effects of age and APOE on neuropathology and late life cognitive decline. Neurobiol Aging 35, 819– 826. 24199961 PMC3882071
  134. [151]Farfel JM, Yu L, De Jager PL, Schneider JA, Bennett DA (2016) Association of APOE with tau-tangle pathology with and without beta-amyloid. Neurobiol Aging 37, 19– 25. 26481403 PMC4716785
  135. [153]Keenan BT, Shulman JM, Chibnik LB, Raj T, Tran D, Sabuncu MR, Allen AN, Corneveaux JJ, Hardy JA, Huentelman MJ, Lemere CA, Myers AJ, Nicholson-Weller A, Reiman EM, Evans DA, Bennett DA, De Jager PL (2012) A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline. Hum Mol Genet 21, 2377– 2388. 22343410 PMC3335317
  136. [154]Biffi A, Shulman JM, Jagiella JM, Cortellini L, Ayres AM, Schwab K, Brown DL, Silliman SL, Selim M, Worrall BB, Meschia JF, Slowik A, De Jager PL, Greenberg SM, Schneider JA, Bennett DA, Rosand J (2012) Genetic variation at CR1 increases risk of cerebral amyloid angiopathy. Neurology 78, 334– 341. 22262751 PMC3280047
  137. [155]Felsky D, Szeszko P, Yu L, Honer WG, De Jager PL, Schneider JA, Malhotra AK, Lencz T, Ikuta T, Pipitone J, Chakravarty MM, Lobaugh NJ, Mulsant BH, Pollock BG, Kennedy JL, Bennett DA, Voineskos AN (2014) The SORL1 gene and convergent neural risk for Alzheimer’s disease across the human lifespan. Mol Psychiatry 19, 1125– 1132. 24166411 PMC4004725
  138. [158]Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, Bradshaw EM, De Jager PL (2015) CD33 modulates TREM2: convergence of Alzheimer loci. Nat Neurosci 18, 1556– 1558. 26414614 PMC4682915
  139. [159]Raj T, Shulman JM, Keenan BT, Chibnik LB, Evans DA, Bennett DA, Stranger BE, De Jager PL (2012) Alzheimer disease susceptibility loci: evidence for a protein network under natural selection. Am J Hum Genet 90, 720– 726. 22482808 PMC3322230
  140. [160]Farfel JM, Yu L, Buchman AS, Schneider JA, De Jager PL, Bennett DA (2016) Relation of genomic variants for Alzheimer disease dementia to common neuropathologies. Neurology 87, 489– 496. 27371493 PMC4970661
  141. [161]Yu L, Chibnik LB, Srivastava GP, Pochet N, Yang J, Xu J, Kozubek J, Obholzer N, Leurgans SE, Schneider JA, Meissner A, De Jager PL, Bennett DA (2015) Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease. JAMA Neurol 72, 15– 24. 25365775 PMC4344367
  142. [162]Chibnik LB, Yu L, Eaton ML, Srivastava G, Schneider JA, Kellis M, Bennett DA, De Jager PL (2015) Alzheimer’s loci: epigenetic associations and interaction with genetic factors. Ann Clin Transl Neurol 2, 636– 647. 26125039 PMC4479524
  143. [163]Benedet AL, Yu L, Labbe A, Mathotaarachchi S, Pascoal TA, Shin M, Kang MS, Gauthier S, Rouleau GA, Poirier J, Bennett DA, Rosa-Neto P (2018) CYP2C19 variant mitigates Alzheimer s disease pathophysiology in vivo & post mortem. Neurology Genetics In Press. PMC5820598 29473050
  144. [164]Yu L, Shulman JM, Chibnik L, Leurgans S, Schneider JA, De Jager PL, Bennett DA (2012) The CETP I405V polymorphism is associated with an increased risk of Alzheimer’s disease. Aging Cell 11, 228– 233. 22122979 PMC3306495
  145. [165]Replogle JM, Chan G, White CC, Raj T, Winn PA, Evans DA, Sperling RA, Chibnik LB, Bradshaw EM, Schneider JA, Bennett DA, De Jager PL (2015) A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Ann Neurol 77, 469– 477. 25545807 PMC4461024
  146. [166]Hohman TJ, Chibnik L, Bush WS, Jefferson AL, De Jaeger PL, Thornton-Wells TA, Bennett DA, Schneider JA (2015) GSK3beta Interactions with Amyloid Genes: An Autopsy Verification and Extension. Neurotox Res 28, 232– 238. 26194614 PMC4625986
  147. [167]Chou SY, Shulman JM, Keenan BT, Secor EA, Buchman AS, Schneider J, Bennett DA, De Jager PL (2013) Genetic susceptibility for ischemic infarction and arteriolosclerosis based on neuropathologic evaluations. Cerebrovasc Dis 36, 181– 188. 24135527 PMC3871868
  148. [168]Barral S, Habeck C, Gazes E, De Jager PL, Bennett DA, Stern Y (2017) A Dopamine Receptor genetic variant enhances perceptual speed in cognitive healthy subjects. Alzheimers Dement (N Y) 3, 254– 261. 28993814 PMC5630172
  149. [169]Chibnik LB, White CC, Mukherjee S, Raj T, Yu L, Larson EB, Montine TJ, Keene CD, Sonnen J, Schneider JA, Crane PK, Shulman JM, Bennett DA, De Jager PL (2017) Susceptibility to neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies. Mol Psychiatry. PMC5608624 28322283
  150. [170]Dubal DB, Yokoyama JS, Zhu L, Broestl L, Worden K, Wang D, Sturm VE, Kim D, Klein E, Yu GQ, Ho K, Eilertson KE, Yu L, Kuro-o M, De Jager PL, Coppola G, Small GW, Bennett DA, Kramer JH, Abraham CR, Miller BL, Mucke L (2014) Life extension factor klotho enhances cognition. Cell Rep 7, 1065– 1076. 24813892 PMC4176932
  151. [171]Yokoyama JS, Sturm VE, Bonham LW, Klein E, Arfanakis K, Yu L, Coppola G, Kramer JH, Bennett DA, Miller BL, Dubal DB (2015) Variation in longevity gene KLOTHO is associated with greater cortical volumes. Ann Clin Transl Neurol 2, 215– 230. 25815349 PMC4369272
  152. [172]White CC, Yang HS, Yu L, Chibnik LB, Dawe RJ, Yang J, Klein HU, Felsky D, Ramos-Miguel A, Arfanakis K, Honer WG, Sperling RA, Schneider JA, Bennett DA, De Jager PL (2017) Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data. PLoS Med 14, e1002287. 28441426 PMC5404753
  153. [173]Yang HS, White CC, Chibnik LB, Klein HU, Schneider JA, Bennett DA, De Jager PL (2017) UNC5C variants are associated with cerebral amyloid angiopathy. Neurol Genet 3, e176. 28761931 PMC5515600
  154. [174]Hall DA, Bennett DA, Filley CM, Shah RC, Kluger B, Ouyang B, Berry-Kravis E (2014) Fragile X gene expansions are not associated with dementia. Neurobiol Aging 35, 2637– 2638. 24958193 PMC4273643
  155. [175]Shulman JM, Chen K, Keenan BT, Chibnik LB, Fleisher A, Thiyyagura P, Roontiva A, McCabe C, Patsopoulos NA, Corneveaux JJ, Yu L, Huentelman MJ, Evans DA, Schneider JA, Reiman EM, De Jager PL, Bennett DA (2013) Genetic susceptibility for Alzheimer disease neuritic plaque pathology. JAMA Neurol 70, 1150– 1157. 23836404 PMC3773291
  156. [176]Roostaei T, Nazeri A, Felsky D, De Jager PL, Schneider JA, Pollock BG, Bennett DA, Voineskos AN (2017) Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer’s disease. Mol Psychiatry 22, 287– 295. 27021820 PMC5042808
  157. [177]Yu L, De Jager PL, Yang J, Trojanowski JQ, Bennett DA, Schneider JA (2015) The TMEM106B locus and TDP-43 pathology in older persons without FTLD. Neurology 84, 927– 934. 25653292 PMC4351662
  158. [178]Wilson RS, Boyle PA, Yang J, James BD, Bennett DA (2015) Early life instruction in foreign language and music and incidence of mild cognitive impairment. Neuropsychology 29, 292– 302. 25110933 PMC4324380
  159. [179]Marquine MJ, Segawa E, Wilson RS, Bennett DA, Barnes LL (2012) Association between cognitive activity and cognitive function in older Hispanics. J Int Neuropsychol Soc 18, 1041– 1051. 22676914 PMC3515684
  160. [180]Wilson RS, Segawa E, Boyle PA, Bennett DA (2012) Influence of late-life cognitive activity on cognitive health. Neurology 78, 1123– 1129. 22491864 PMC3320053
  161. [181]Wilson RS, Boyle PA, Yu L, Barnes LL, Schneider JA, Bennett DA (2013) Life-span cognitive activity, neuropathologic burden, and cognitive aging. Neurology 81, 314– 321. 23825173 PMC3772831
  162. [182]Arfanakis K, Wilson RS, Barth CM, Capuano AW, Vasireddi A, Zhang S, Fleischman DA, Bennett DA (2016) Cognitive activity, cognitive function, and brain diffusion characteristics in old age. Brain Imaging Behav 10, 455– 463. 25982658 PMC4646719
  163. [183]Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA (2012) Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology 78, 1323– 1329. 22517108 PMC3335448
  164. [185]Tangney CC, Li H, Wang Y, Barnes L, Schneider JA, Bennett DA, Morris MC (2014) Relation of DASH- and Mediterranean-like dietary patterns to cognitive decline in older persons. Neurology 83, 1410– 1416. 25230996 PMC4206157
  165. [186]Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT (2015) MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement 11, 1007– 1014. 25681666 PMC4532650
  166. [188]Morris MC, Wang Y, Barnes LL, Bennett DA, Dawson-Hughes B, Booth SL (2017) Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study. Neurology. PMC5772164 29263222
  167. [189]van de Rest O, Wang Y, Barnes LL, Tangney C, Bennett DA, Morris MC (2016) APOE epsilon4 and the associations of seafood and long-chain omega-3 fatty acids with cognitive decline. Neurology 86, 2063– 2070. 27164694 PMC4891213
  168. [190]Samieri C, Morris MC, Bennett DA, Berr C, Amouyel P, Dartigues JF, Tzourio C, Chasman DI, Grodstein F (2017) Fish intake, genetic predisposition to alzheimer’s disease and decline in global cognition and memory in five cohorts of older persons. Am J Epidemiol. PMC5928461 29053784
  169. [191]Cunnane SC, Schneider JA, Tangney C, Tremblay-Mercier J, Fortier M, Bennett DA, Morris MC (2012) Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer’s disease. J Alzheimers Dis 29, 691– 697. 22466064 PMC3409580
  170. [192]Morris MC, Brockman J, Schneider JA, Wang Y, Bennett DA, Tangney CC, van de Rest O (2016) Association of Seafood Consumption, Brain Mercury Level, and APOE epsilon4 Status With Brain Neuropathology in Older Adults. Jama 315, 489– 497. 26836731 PMC5460535
  171. [193]Morris MC, Schneider JA, Li H, Tangney CC, Nag S, Bennett DA, Honer WG, Barnes LL (2015) Brain tocopherols related to Alzheimer’s disease neuropathology in humans. Alzheimers Dement 11, 32– 39. 24589434 PMC4148466
  172. [194]Wilson RS, Capuano AW, Boyle PA, Hoganson GM, Hizel LP, Shah RC, Nag S, Schneider JA, Arnold SE, Bennett DA (2014) Clinical-pathologic study of depressive symptoms and cognitive decline in old age. Neurology 83, 702– 709. 25080520 PMC4150132
  173. [195]Wilson RS, Boyle PA, Capuano AW, Shah RC, Hoganson GM, Nag S, Bennett DA (2016) Late-life depression is not associated with dementia-related pathology. Neuropsychology 30, 135– 142. 26237627 PMC4740262
  174. [196]Wilson RS, Nag S, Boyle PA, Hizel LP, Yu L, Buchman AS, Shah RC, Schneider JA, Arnold SE, Bennett DA (2013) Brainstem aminergic nuclei and late-life depressive symptoms. JAMA Psychiatry 70, 1320– 1328. 24132763 PMC3856195
  175. [197]Wilson RS, Beckett LA, Bienias JL, Evans DA, Bennett DA (2003) Terminal decline in cognitive function. Neurology 60, 1782– 1787. 12796531
  176. [198]Wilson RS, Beck TL, Bienias JL, Bennett DA (2007) Terminal cognitive decline: accelerated loss of cognition in the last years of life. Psychosom Med 69, 131– 137. 17327212
  177. [199]Wilson RS, Boyle PA, Yu L, Segawa E, Sytsma J, Bennett DA (2015) Conscientiousness, dementia related pathology, and trajectories of cognitive aging. Psychol Aging 30, 74– 82. 25664558 PMC4361241
  178. [200]Wilson RS, Boyle PA, Segawa E, Yu L, Begeny CT, Anagnos SE, Bennett DA (2013) The influence of cognitive decline on well-being in old age. Psychol Aging 28, 304– 313. 23421323 PMC3692607
  179. [201]Boyle PA, Buchman AS, Wilson RS, Yu L, Schneider JA, Bennett DA (2012) Effect of purpose in life on the relation between Alzheimer disease pathologic changes on cognitive function in advanced age. Arch Gen Psychiatry 69, 499– 505. 22566582 PMC3389510
  180. [202]Yu L, Boyle PA, Wilson RS, Levine SR, Schneider JA, Bennett DA (2015) Purpose in life and cerebral infarcts in community-dwelling older people. Stroke 46, 1071– 1076. 25791714 PMC4461202
  181. [203]Wilson RS, Capuano AW, James BD, Amofa P, Arvanitakis Z, Shah R, Bennett DA, Boyle PA (2017) Purpose in Life and Hospitalization for Ambulatory Care-Sensitive Conditions in Old Age. Am J Geriatr Psychiatry. PMC5773406 28780129
  182. [204]Wilson RS, Boyle PA, Levine SR, Yu L, Anagnos SE, Buchman AS, Schneider JA, Bennett DA (2012) Emotional neglect in childhood and cerebral infarction in older age. Neurology 79, 1534– 1539. 22993291 PMC3475630
  183. [205]Wilson RS, Boyle PA, Levine SR, Yu L, Hoganson GM, Buchman AS, Schneider JA, Bennett DA (2014) Harm avoidance and cerebral infarction. Neuropsychology 28, 305– 311. 24364391 PMC4061767
  184. [206]Gaynes BI, Shah R, Leurgans S, Bennett D (2013) Neuroticism modifies the association of vision impairment and cognition among community-dwelling older adults. Neuroepidemiology 40, 142– 146. 23221773 PMC4836446
  185. [207]Canli T, Yu L, Yu X, Zhao H, Fleischman D, Wilson RS, De Jager PL, Bennett DA (2018) Loneliness five years ante-mortem is associated with disease-related differential gene expression in postmortem dorsolateral prefrontal cortex. Translational Psychiatry In Press. PMC5802527 29317593
  186. [208]Canli T, Wen R, Wang X, Mikhailik A, Yu L, Fleischman D, Wilson RS, Bennett DA (2017) Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Mol Psychiatry 22, 1069– 1078. 27801889 PMC5411331
  187. [209]Arvanitakis Z, Capuano AW, Bennett DA, Barnes LL (2017) Body mass index and decline in cognitive function in older black and white persons. J Gerontol A Biol Sci Med Sci. PMC5861969 28961897
  188. [210]Shah RC, Schneider JA, Leurgans S, Bennett DA (2012) Association of lower hemoglobin level and neuropathology in community-dwelling older persons. J Alzheimers Dis 32, 579– 586. 22869465 PMC3496930
  189. [211]Arvanitakis Z, Brey RL, Rand JH, Schneider JA, Capuano AW, Yu L, Leurgans SE, Bennett DA, Levine SR (2015) Relation of antiphospholipid antibodies to postmortem brain infarcts in older people. Circulation 131, 182– 189. 25301832 PMC4293251
  190. [212]Roostaei T, Felsky D, Nazeri A, De Jager PL, Schneider JA, Bennett DA, Voineskos AN (2018) Genetic influence of plasma homocysteine on Alzheimer’s disease. Neurobiol Aging 62, 243 e247–243.e214. PMC6953632 29102475
  191. [213]Pruzin JJ, Schneider JA, Capuano AW, Leurgans SE, Barnes LL, Ahima RS, Arnold SE, Bennett DA, Arvanitakis Z (2017) Diabetes, Hemoglobin A1C, and Regional Alzheimer Disease and Infarct Pathology. Alzheimer Dis Assoc Disord 31, 41– 47. 27755004 PMC5321787
  192. [214]Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, Fuino RL, Kawaguchi KR, Samoyedny AJ, Wilson RS, Arvanitakis Z, Schneider JA, Wolf BA, Bennett DA, Trojanowski JQ, Arnold SE (2012) Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 122, 1316– 1338. 22476197 PMC3314463
  193. [215]Shah RC, Janos AL, Kline JE, Yu L, Leurgans SE, Wilson RS, Wei P, Bennett DA, Heilman KM, Tsao JW (2013) Cognitive decline in older persons initiating anticholinergic medications. PLoS One 8, e64111. 23741303 PMC3669362
  194. [216]Barnes LL, Capuano AW, Aiello AE, Turner AD, Yolken RH, Torrey EF, Bennett DA (2015) Cytomegalovirus infection and risk of Alzheimer disease in older black and white individuals. J Infect Dis 211, 230– 237. 25108028 PMC4326304
  195. [217]Lurain NS, Hanson BA, Martinson J, Leurgans SE, Landay AL, Bennett DA, Schneider JA (2013) Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease. J Infect Dis 208, 564– 572. 23661800 PMC3719902
  196. [218]Sivam A, Wroblewski KE, Alkorta-Aranburu G, Barnes LL, Wilson RS, Bennett DA, Pinto JM (2016) Olfactory Dysfunction in Older Adults is Associated with Feelings of Depression and Loneliness. Chem Senses 41, 293– 299. 26809485 PMC5006107
  197. [219]Foveau B, Albrecht S, Bennett DA, Correa JA, LeBlanc AC (2016) Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment. Acta Neuropathol Commun 4, 127. 27931265 PMC5146837
  198. [221]Yarchoan M, James BD, Shah RC, Arvanitakis Z, Wilson RS, Schneider J, Bennett DA, Arnold SE (2017) Association of Cancer History with Alzheimer’s Disease Dementia and Neuropathology. J Alzheimers Dis 56, 699– 706. 28035936 PMC5928782
  199. [222]Arfanakis K, Fleischman DA, Grisot G, Barth CM, Varentsova A, Morris MC, Barnes LL, Bennett DA (2013) Systemic inflammation in non-demented elderly human subjects: brain microstructure and cognition. PLoS One 8, e73107. 23991174 PMC3753267
  200. [223]Lim AS, Yu L, Costa MD, Leurgans SE, Buchman AS, Bennett DA, Saper CB (2012) Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals. Sleep 35, 633– 640b. 22547889 PMC3321422

200 of 397 shown

Cited by

Sorted by citations

Authors
Bennett, D. A., Buchman, A. S., Boyle, P. A., Barnes, L. L., Wilson, R. S., & Schneider, J. A.
Affiliations
Rush University Medical Center (US)
Corresponding author
Bennett, David A.
ORCID
Venue
Journal of Alzheimer's Disease
Publisher
SAGE Publications
Published
2018-06-12
Volume
64
Issue
s1
Pages
S161-S189
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
DOI
10.3233/jad-179939
PMC
PMC6380522
OpenAlex
W2809330972
Cited by
1,260
References
50
Citations by year
2026: 160 · 2025: 249 · 2024: 194 · 2023: 181 · 2022: 169 · 2021: 127 · 2020: 88 · 2019: 75 · 2018: 12 · 2017: 1 · 2013: 1
FWCI
11.67
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG043379, R01AG017917, R01AG056352, R01AG042210, RF1AG022018, U01AG046152, R01AG036042, R01AG015819, P30AG010161, R01AG040039, R01AG047976, RF1AG054057, RF1AG015819, RF1AG036042, R01AG033678, R01AG034374, R01AG022018)
  • National Institute of Neurological Disorders and Stroke (UH3NS100599, UH2NS100599, R01NS078009, UF1NS100599)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, aging
MeSH terms
Aging, Alzheimer Disease, Humans, Memory, United States, Religious Personnel

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review