The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis
Open accessAbstract
OBJECTIVE: To determine the frequency and nature of leptomeningeal contrast enhancement in multiple sclerosis (MS) via in vivo 3-tesla postcontrast T2-weighted, fluid-attenuated inversion recovery (FLAIR) MRI and 7-tesla postmortem MRI-pathology correlation. METHODS: Brain MRI, using the postcontrast T2-weighted, FLAIR technique, was prospectively collected in 299 MS cases and 37 age-matched neurologically healthy controls. Expert raters evaluated focal gadolinium enhancement in the leptomeningeal compartment. Two progressive MS cases came to autopsy after in vivo MRI characterization. Pathologic and immunohistochemical examination assessed the association of enhancement with leptomeningeal inflammation and adjacent cortical demyelination. RESULTS: Focal contrast enhancement was detected in the leptomeningeal compartment in 74 of 299 MS cases (25%) vs 1 of 37 neurologically healthy controls (2.7%; p = 0.001). Enhancement was nearly twice as frequent (p = 0.009) in progressive MS (39/118 cases, 33%) as in relapsing-remitting MS (35/181, 19%). Enhancing foci generally remained stable throughout the evaluation period (up to 5.5 years). Pathology showed perivascular lymphocytic and mononuclear infiltration in the enhancing areas in association with flanking subpial cortical demyelination. CONCLUSION: Leptomeningeal contrast enhancement occurs frequently in MS and is a noninvasive, in vivo marker of inflammation and associated subpial demyelination. It might therefore enable testing of new treatments aimed at eliminating this inflammation and potentially arresting progressive MS.
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“Similar considerations may hold with active leptomeningeal inflammation (Howell et al., 2011; Absinta et al., 2015).”
From A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis (2019) · cites this paper as Absinta et al., 2015
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Cites
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New Multiple Sclerosis Phenotypic Classification
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Self-citationNeonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition
Goldbach‐Mansky, R. T., Garnes, N. D., Canna, S., Gelabert, A., Jones, J. H., Rubin, B. I., Kim, H. J., Brewer, C. C., Zalewski, C. K., Wiggs, E. A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055137 · Cited by 923
Self-citationLymphoid neogenesis in chronic inflammatory diseases
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Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis
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Reich, D. S., Lucchinetti, C. F., & Calabresi, P. A. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1401483 · Cited by 2,491
Self-citationHow neuroinflammation contributes to neurodegeneration
Ransohoff, R. M. (2016) · Science · doi:10.1126/science.aag2590 · Cited by 1,967
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Self-citationAbsinta, M., Ha, S.-K., Nair, G., Sati, P., Luciano, N. J., Palisoc, M., Louveau, A., Zaghloul, K. A., Pittaluga, S., Kipnis, J., et al. (2017) · eLife · doi:10.7554/elife.29738 · Cited by 643
“They provide an alternate conduit for drainage of immune cells and cerebrospinal fluid (CSF) from the brain, beyond previously described pathways of flow: via arachnoid granulations into the dural venous sinuses, and via the cribriform plate into the ethmoid region (Weller et al., 2009).”
BackgroundMethodInfluentialSelf-citationJakimovski, D., Bittner, S., Zivadinov, R., Morrow, S. A., Benedict, R. H. B., Zipp, F., & Weinstock‐Guttman, B. (2023) · The Lancet · doi:10.1016/s0140-6736(23)01473-3 · Cited by 695
Metadata
- Authors
- Absinta, M., Vuolo, L., Rao, A., Nair, G., Sati, P., Cortese, I. C. M., Ohayon, J., Fenton, K., Reyes-Mantilla, M. I., Maric, D., Calabresi, P. A., Butman, J. A., Pardo, C. A., & Reich, D. S.
- Affiliations
- National Institutes of Health (US)
- From the Translational Neuroradiology Unit (M.A., L.V., A.R., G.N., P.S., D.S.R.), Neuroimmunology Clinic (I.C.M.C., J.O., K.F.), and Flow Cytometry Core Facility (D.M.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD; Neuroimaging Research Unit (M.A.), Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan; Department of Neurology and Radiology (L.V.), University of Florence, Italy;...
- ORCID
- Venue
- Neurology
- Published
- 2015-07-07
- Volume
- 85
- Issue
- 1
- Pages
- 18-28
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC4501940
- OpenAlex
- W2169159041
- Cited by
- 296
- References
- 36
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 32 · 2023: 30 · 2022: 27 · 2021: 32 · 2020: 32 · 2019: 31 · 2018: 28 · 2017: 27 · 2016: 26 · 2015: 6
- FWCI
- 23.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Keywords
- multiple sclerosis, leptomeningeal inflammation, gadolinium-enhancing lesions, progressive multiple sclerosis, relapsing-remitting multiple sclerosis, perivascular lymphocytic infiltrate, cortical demyelination, MRI-pathology correlation, 7T MRI
- MeSH terms
- Gadolinium, Humans, Magnetic Resonance Imaging, Meninges, Meningitis, Multiple Sclerosis, Relapsing-Remitting
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