The DOI matches its Crossref record; 67 of the 68 references it cites were found in a registry or an index.
Involvement of the nucleus accumbens and dopamine system in chronic pain
Abstract
Chronic pain syndrome is a complex disorder that includes not only the presence of spontaneous pain and exaggerated responses to painful and nonpainful stimuli but also the development of a negative affective, motivational, and cognitive state and the persistent desire to eliminate pain. Recent evidence indicates that chronic pain shares basic mechanisms with reward-based learning and drug addiction1–3 and that the transition from acute to chronic pain reflects functional reorganization of this reward/motivational circuitry.4
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“The NAc, a key hub in the dopaminergic system, is thought to mediate motivational, affective, and self‐regulatory aspects of chronic pain (Benarroch 2016) and sensorimotor function.”
Citations
Cites
How do you feel — now? The anterior insula and human awareness
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Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry
Basbaum, A. I., & Fields, H. L. (1984) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.07.030184.001521 · Cited by 2,687
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629 · cited 1×
“The somatosensory cortices (S1 and S2) encode information about pain features, including its location and duration(12); the insula is important for the subjective experience of pain,(13) and together with the dorsal anterior cingulate (midcingulate) cortex encodes emotional and motivational aspects of pain.(14) Both t…”
BackgroundCognitive and emotional control of pain and its disruption in chronic pain
Bushnell, M. C., Čeko, M., & Low, L. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3516 · Cited by 2,076
Lamm, C., Decety, J., & Singer, T. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.014 · Cited by 2,016
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
Modulation of Striatal Projection Systems by Dopamine
Gerfen, C. R., & Surmeier, D. J. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113641 · Cited by 1,700
An fMRI-Based Neurologic Signature of Physical Pain
Wager, T. D., Atlas, L. Y., Lindquist, M. A., Roy, M., Woo, C.-W., & Kross, E. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1204471 · Cited by 1,597
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1 of the 68 references couldn’t be matched to a known paper.
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- 10.1016/j.rapm.2007.01.001 · DOI · Paper page
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Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior
Markovic, T., Pedersen, C. E., Massaly, N., Vachez, Y. M., Ruyle, B. C., Murphy, C. A., Abiraman, K., Shin, J. H., Garcia, J. J., Yoon, H. J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00924-3 · Cited by 129
Role of Descending Dopaminergic Pathways in Pain Modulation
Li, C., Liu, S., Lu, X., & Tao, F. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190430102531 · Cited by 103
Reward Circuitry Plasticity in Pain Perception and Modulation
DosSantos, M. F. H., Moura, B. D. S., & DaSilva, A. F. M. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00790 · Cited by 71
Chung, G., Kim, C. Y., Yun, Y.-C., Yoon, S. H., Kim, M., Kim, Y. K., & Kim, S. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-09991-8 · Cited by 67
Association between Chronic Pain and Alterations in the Mesolimbic Dopaminergic System
Yang, S., Boudier‐Revéret, M., Choo, Y. J., & Chang, M. C. (2020) · Brain Sciences · doi:10.3390/brainsci10100701 · Cited by 65
Metadata
- Authors
- Benarroch, E. E.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Benarroch, Eduardo E.
- Venue
- Neurology
- Published
- 2016-10-18
- Volume
- 87
- Issue
- 16
- Pages
- 1720-1726
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2522550648
- Cited by
- 52
- References
- 68
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 1
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- chronic pain, nucleus accumbens, dopaminergic system, reward learning, drug addiction, negative affect, cognitive states, acute to chronic pain transition, functional reorganization
- MeSH terms
- Aged, Animals, Dopamine, Humans, Male, Motivation, Nucleus Accumbens, Mice, Pain Perception, Chronic Pain
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