The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index; none of the 31 sources its claims cite is checked for support yet.
Sleep architecture and the risk of incident dementia in the community
Open accessAbstract
OBJECTIVE: Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset. We examined the associations between sleep architecture and the prospective risk of incident dementia in the community-based Framingham Heart Study (FHS). METHODS: Our sample comprised a subset of 321 FHS Offspring participants who participated in the Sleep Heart Health Study between 1995 and 1998 and who were aged over 60 years at the time of sleep assessment (mean age 67 ± 5 years, 50% male). Stages of sleep were quantified using home-based polysomnography. Participants were followed for a maximum of 19 years for incident dementia (mean follow-up 12 ± 5 years). RESULTS: We observed 32 cases of incident dementia; 24 were consistent with Alzheimer disease dementia. After adjustments for age and sex, lower REM sleep percentage and longer REM sleep latency were both associated with a higher risk of incident dementia. Each percentage reduction in REM sleep was associated with approximately a 9% increase in the risk of incident dementia (hazard ratio 0.91; 95% confidence interval 0.86, 0.97). The magnitude of association between REM sleep percentage and dementia was similar following adjustments for multiple covariates including vascular risk factors, depressive symptoms, and medication use, following exclusions for persons with mild cognitive impairment at baseline and following exclusions for early converters to dementia. Stages of non-REM sleep were not associated with dementia risk. CONCLUSIONS: Despite contemporary interest in slow-wave sleep and dementia pathology, our findings implicate REM sleep mechanisms as predictors of clinical dementia.
Overview
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Written from the paper’s full text.
TL;DR
In community-dwelling Framingham Heart Study Offspring participants older than 60, lower REM sleep percentage and longer REM sleep latency were prospectively associated with higher incident dementia risk over a mean 12 years. Non-REM sleep stages were not associated with dementia risk, implicating REM sleep mechanisms rather than slow-wave sleep.
Key findings
- Among 321 participants (mean age 67 ± 5 years, 50% male; mean follow-up 12 ± 5 years, maximum 19 years), there were 32 incident all-cause dementia cases, including 24 Alzheimer disease (AD) dementia cases.
- Each 1% lower REM sleep percentage was associated with approximately a 9% higher risk of incident all-cause dementia: age/sex-adjusted HR 0.91 (95% CI 0.86–0.97, p = 0.004); fully adjusted HR 0.91 (95% CI 0.85–0.98, p = 0.01). AD dementia results were similar (age/sex-adjusted HR 0.92, 95% CI 0.86–0.99, p = 0.02).
- The lowest vs highest tertile of REM sleep latency was associated with lower all-cause dementia risk in model 1 (HR 0.37, 95% CI 0.14–0.97) and model 2 (HR 0.26, 95% CI 0.08–0.85). Higher wake after sleep onset was associated with increased risk only in model 2 (HR 2.08, 95% CI 1.02–4.23). Stages 1, 2, and slow-wave sleep were not significantly associated with dementia risk.
- Sensitivity analyses excluding MCI at baseline or early converters did not materially change the REM sleep association. Excluding persons with high REM arousals due to hypopnea attenuated the association (all-cause dementia HR 0.94, 95% CI 0.88–1.01, p = 0.09). An APOE ε4 by REM sleep percentage interaction was found for AD dementia (p = 0.05), with lower REM sleep associated in ε4 noncarriers (HR 0.88, 95% CI 0.80–0.96) but not carriers (HR 0.99, 95% CI 0.90–1.08), though the authors caution interpretation.
Methods
- Prospective cohort study using a subset of 321 Framingham Heart Study Offspring participants aged over 60 at the time of home-based polysomnography in the Sleep Heart Health Study (1995–1998); exclusions from 699 Offspring participants included age <60, prevalent dementia, no dementia follow-up, and missing PSG data.
- Sleep stages were scored in 30-second epochs using Rechtschaffen and Kales criteria; primary exposures were percentage of time in stage 1, stage 2, slow-wave sleep (stages 3 and 4 combined), and REM sleep, with secondary measures of sleep continuity, fragmentation, and sleep-disordered breathing.
- Incident dementia was ascertained through Framingham Heart Study surveillance, MMSE screening, neuropsychological/neurologic evaluations, and dementia review committee adjudication using DSM-IV; AD dementia used NINCDS-ADRDA criteria. Cox proportional hazards models were used: model 1 adjusted for age and sex; model 2 additionally adjusted for BMI, education, APOE ε4, systolic blood pressure, smoking, diabetes, heart disease, depressive symptoms, and medication use.
Limitations
- The paper states small sample size and small number of incident events, limiting power to detect weaker associations with other sleep exposures, including the AHI ≥15 threshold; the sample was of Caucasian descent, so generalizability to other ethnic groups is unclear.
- The paper states no information on shift work, preventing ascertainment of circadian rhythm sleep disorders.
- Evident from the text: the APOE ε4 interaction for AD dementia was based on small event counts and overlapping confidence intervals; the single baseline PSG cannot capture changes in sleep architecture over follow-up, and observational design leaves potential residual confounding.
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Claims the paper makes
22 Own result · 17 Sources not found · 5 Own method · 5 Own interpretation
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The exclusion of persons with a high number of arousals from REM sleep attenuated the HR linking REM sleep percentage to incident dementia”
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The magnitude of association between REM sleep percentage and dementia was similar following adjustments for multiple covariates including vascular risk factors, depressive symptoms, and medication use”
plainn = 32- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“no such APOE e4 by REM sleep percentage interaction was identified when predicting all-cause dementia.”
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“this attenuation appeared to be due to arousals resulting from hypopnea rather than obstructive apnea.”
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“following exclusions for persons with mild cognitive impairment at baseline”
plainn = 32- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“After adjustment for age and sex, each percentage decrease in REM sleep was associated with approximately a 9% increase in the risk of incident dementia.”
- Also stated in: § Abstract · plain
“Each percentage reduction in REM sleep was associated with approximately a 9% increase in the risk of incident dementia (hazard ratio 0.91; 95% confidence interval 0.86, 0.97).”
plaincorrelationaln = 32- Asserted: passes — The authors put it forward as true.
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- Also stated in: § Abstract · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Lower REM sleep percentage was associated with an increased risk of all-cause dementia across both statistical models (table 3).”
plaincorrelationaln = 32- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Stages of non-REM sleep were not associated with dementia risk.”
- Also stated in: § Sample overview. · plain
“Stages 1, 2, and SWS were not significantly associated with dementia risk.”
plainn = 32- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Sample overview. · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“following exclusions for early converters to dementia.”
plainn = 32- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Separate exclusions for those with an early or late chronotype resulted in minimal change to the observed association between REM sleep percentage and incident dementia (table 4).”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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- It may state two separate claims as one. 17
- The quote only partly states this claim. 1
- Probably not a substantial claim. 16
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“After stratifying the results, lower REM sleep percentage was associated with a higher risk of incident AD dementia in e4 noncarriers (HR 0.88, 95% CI 0.80-0.96,p 5 0.006, events/n 5 14/245) but not carriers (HR 0.99, 95% CI 0.90-1.08,p 5 0.75, events/n 5 10/71).”
plaincorrelationaln = 14 ·- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Sleep onset latency, sleep efficiency, and the AHI were not related to dementia incidence in our sample (table e-1 at Neurology.org).”
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Although higher total sleep time was associated with a lower risk of all-cause dementia (HR 0.994; 95% CI 0.989-0.999)and AD dementia (HR 0.993; 95% CI 0.987-0.999) in model 1, the effect sizes were small.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Higher wake after sleep onset was associated with an increased risk of incident allcause dementia in model 2 (HR 2.08; 95% CI 1.02-4.23)but not model 1 (HR 1.58; 95% CI 0.88-2.83).”
plaincorrelationaln = 32 ·- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Cases of dementia due to the synucleinopathies did not drive our results given that effect sizes were similar when examining incident all-cause dementia (which included 6 cases of dementia with Lewy bodies) and AD dementia (no cases of mixed AD with Lewy bodies, Parkinson disease, or multiple system atrophy).”
plainn = 6- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The effect sizes were similar for AD dementia.”
plainn = 32- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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The quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Results for absolute time in each sleep stage were consistent with our primary models, although effect sizes for time in REM sleep and dementia were less marked (table e-2).”
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Over a mean of 12 (SD 5) years of follow-up, we observed 32 cases of incident dementia, 24 of which were due to AD dementia.”
- Also stated in: § Abstract · plain
“We observed 32 cases of incident dementia; 24 were consistent with Alzheimer disease dementia.”
plainn = 32- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
- Also stated in: § Abstract · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, even after excluding persons with a high number of arousals from REM sleep, each percentage reduction in REM sleep percentage was associated a nonstatistically significant 6% increase in all-cause dementia risk, suggesting contributions from other unmeasured factors.”
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“A populationbased study using PSG recently demonstrated that time in REM sleep is reduced in those with as compared to without cognitive impairment, perhaps as a result of sleep-disordered breathing.21”
What the sources say
- Not matchedcites [21]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
boostedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
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None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“Thus, loss of cholinergic function may underpin the association between reduced REM sleep and dementia risk, i.e., a healthy cholinergic system maintains REM sleep metrics better than a slowly degenerating cholinergic system.”
What the sources say
- Not matchedcites [25]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
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- Not matchedcites [27]
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hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
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None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“On the other hand, REM sleep is thought to promote synaptic consolidation and to upregulate the activity of immediate early genes implicated in synaptic plasticity.27,32”
What the sources say
- Not matchedcites [27]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [32]
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hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
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What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Model 1 included adjustments for age and sex.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Limitations of the current study include the small sample size and a small number of incident events.Consequently, we had limited power to detect weaker but potentially important associations with other sleep-related exposures and dementia.”
plain- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“After confirming the proportionality of hazards assumption, we used SAS software V9.4 (SAS Institute, Cary, NC) to estimate Cox proportional hazards regression models.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“AD is well-known to be associated with loss of cholinergic function, from the degeneration of cholinergic projections in the basal forebrain and changes in acetylcholine release, high-affinity choline uptake, and acetylcholine receptor expression.28,29”
What the sources say
- Not matchedcites [28]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [29]
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boostedcorrelational- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Second, as our sample was of Caucasian decent, it is unclear how our results generalize to other ethnic groups.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“Current research on sleep and AD is mostly focused on SWS.4,19,20”
What the sources say
- Not matchedcites [4]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [19]
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- Not matchedcites [20]
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plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The effect between REM sleep percentage and dementia was attenuated after excluding persons with a high number of arousals from REM sleep due to hypopneas, suggesting a possible contributing role of sleep-disordered breathing.”
hedgedconditional- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“REM sleep behavior disorder has been associated with dementia and is clinically diagnostic of dementia due to the synucleinopathies.24”
What the sources say
- Not matchedcites [24]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaincorrelational- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Not matched
In the paper
“REM sleep latency is also longer in patients with AD dementia as compared to controls with latency appearing to increase across categories of AD severity.3”
What the sources say
- Not matchedcites [3]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaincorrelational- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Not matched
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, our findings implicate less REM sleep, and not SWS, with the risk of dementia.”
- Also stated in: § Abstract · plain
“our findings implicate REM sleep mechanisms as predictors of clinical dementia.”
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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It may state two separate claims as one.
- Also stated in: § Abstract · plain
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Strengths of the current study include the population-based sample, rigorous surveillance for incident dementia, long duration of follow-up, and use of PSG to measure sleep architecture.”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“Cholinergic neurons are important determinants of REM sleep, 25,26 with cholinergic activity low during SWS and high during REM sleep.27”
What the sources say
- Not matchedcites [25]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [26]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [27]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaindirect- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
- Not matched
In the paper
“Briefly, sleep stages were scored in 30-second epochs by the criteria outlined by Rechtschaffen and Kales.11”
What the sources say
- Not matchedcites [11]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“Thus, REM sleep may also buffer against synaptic loss and cognitive decline by assisting in the production of new connections and networks.”
What the sources say
- Not matchedcites [27]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Not matchedcites [32]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
None of the sources cited for this claim could be matched to a paper in Crossref, so there is nothing to check it against.
In the paper
“The methods, including scoring guidelines and reliability, have been published previously.[8][9][10]”
What the sources say
- Not matchedcites [8]
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- Not matchedcites [9]
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- Not matchedcites [10]
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plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
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What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Model 2 included additional adjustments for body mass index, education (dichotomized at the level of college degree attainment), positivity for an APOE e4 allele, systolic blood pressure, current smoking, prevalent diabetes, prevalent heart disease, depressive symptoms”
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“In the same study, REM sleep percentage was positively correlated with CSF levels of Ab1-42 in 48 patients with AD.”
What the sources say
- Not matchedcites [3]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaincorrelationaln = 48- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Not matched
The paper relies on this without support.
Sleep disturbance is common in dementia.
“Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset.”
The paper relies on this without support.
It is unclear whether differences in sleep architecture precede dementia onset.
“Sleep disturbance is common in dementia, although it is unclear whether differences in sleep architecture precede dementia onset.”
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,852
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,766
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,007
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
Cited by
Sorted by citations
Xu, W., Tan, C., Zou, J., Cao, X., & Tan, L. (2019) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-321896 · Cited by 349
Sharma, R. A., Varga, A. W., Bubu, O. M., Pirraglia, E., Kam, K., Parekh, A., Wohlleber, M. E., Miller, M. D., Andrade, A. G., Lewis, C., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201704-0704oc · Cited by 259
The Relationship between Obstructive Sleep Apnea and Alzheimer’s Disease
Andrade, A. G., Bubu, O. M., Varga, A. W., & Osorio, R. S. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-179936 · Cited by 216
della Monica, C., Johnsen, S., Atzori, G., Groeger, J. A., & Dijk, D. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00255 · Cited by 194
Macro and micro sleep architecture and cognitive performance in older adults
Djonlagic, I. E., Mariani, S., Fitzpatrick, A. L., van der Klei, V. M. G. T. H., Johnson, D. A., Wood, A. C., Seeman, T. E., Nguyen, H. T., Prerau, M. J., Luchsinger, J. A., et al. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-00964-y · Cited by 184
Obstructive Sleep Apnea and Longitudinal Alzheimer's Disease Biomarker Changes
Bubu, O. M., Pirraglia, E., Andrade, A. G., Sharma, R. A., Giménez, S., Umasabor‐Bubu, O. Q., Hogan, M. M., Shim, A., Mukhtar, F., Sharma, N. K., et al. (2018) · SLEEP · doi:10.1093/sleep/zsz048 · Cited by 176
Objective measurement of sleep in mild cognitive impairment: A systematic review and meta-analysis
D'Rozario, A. L., Chapman, J. L., Phillips, C. L., Palmer, J. R., Hoyos, C. M., Mowszowski, L., Duffy, S. L., Marshall, N. S., Benca, R. M., Mander, B. A., et al. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101308 · Cited by 147
The relationship between sleep duration, cognition and dementia: a Mendelian randomization study
Henry, A., Katsoulis, M., Masi, S., Fatemifar, G., Denaxas, S., Acosta, D., Garfield, V., & Dale, C. E. (2019) · International Journal of Epidemiology · doi:10.1093/ije/dyz071 · Cited by 139
Sleep Architecture, Obstructive Sleep Apnea, and Cognitive Function in Adults
Pase, M. P., Harrison, S. L., Misialek, J. R., Kline, C. E., Cavuoto, M. G., Baril, A., Yiallourou, S. R., Bisson, A., Himali, D., Leng, Y., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.25152 · Cited by 134
Self-citationSteele, T. A., Louis, E. K. S., Videnović, A., & Auger, R. R. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01031-8 · Cited by 128
Slow Wave Sleep Is a Promising Intervention Target for Alzheimer’s Disease
Lee, Y. F., Gerashchenko, D., Timofeev, I., Bacskai, B. J., & Kastanenka, K. V. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00705 · Cited by 127
Svensson, T., Madhawa, K., Nt, H., Chung, U., & Svensson, A. K. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.01.020 · Cited by 123
Obstructive sleep apnoea and Alzheimer’s disease: In search of shared pathomechanisms
Polšek, D., Gildeh, N., Cash, D., Winsky‐Sommerer, R., Williams, S., Turkheimer, F., Leschziner, G. D., Morrell, M. J., & Rosenzweig, I. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.12.004 · Cited by 114
Stressful Life Events and Racial Disparities in Cognition Among Middle-Aged and Older Adults
Zuelsdorff, M. L., Okonkwo, O. C., Norton, D., Barnes, L. L., Graham, K. L., Clark, L. R., Wyman, M. F., Benton, S. F., Gee, A., Lambrou, N. H., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190439 · Cited by 111
Mullins, A. E., Kam, K., Parekh, A., Bubu, O. M., Osorio, R. S., & Varga, A. W. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105054 · Cited by 105
Association Between Slow-Wave Sleep Loss and Incident Dementia
Himali, J. J., Baril, A., Cavuoto, M. G., Yiallourou, S. R., Wiedner, C. D., Himali, D., DeCarli, C. S., Redline, S. S., Beiser, A., Seshadri, S. S., et al. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.3889 · Cited by 102
Self-citationREM Sleep: An Unknown Indicator of Sleep Quality
Barbato, G. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182412976 · Cited by 102
Local Sleep and Alzheimer’s Disease Pathophysiology
Mander, B. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.525970 · Cited by 97
Dietary Patterns, Physical Activity, Sleep, and Risk for Dementia and Cognitive Decline
Zhao, C., Noble, J. M., Marder, K. S., Hartman, J. S., Gu, Y., & Scarmeas, N. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0247-9 · Cited by 92
Impact of sleep disturbances on neurodegeneration: Insight from studies in animal models
Owen, J. E., & Veasey, S. C. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104820 · Cited by 91
REM obstructive sleep apnea: risk for adverse health outcomes and novel treatments
Varga, A. W., & Mokhlesi, B. (2018) · Sleep And Breathing · doi:10.1007/s11325-018-1727-2 · Cited by 88
CCCDTD5 recommendations on early non cognitive markers of dementia: A Canadian consensus
Montero‐Odasso, M., Pieruccini‐Faria, F., Ismail, Z., Li, K., Lim, A. S. P., Phillips, N. A., Kamkar, N., Sarquis‐Adamson, Y., Speechley, M. R., Theou, O., et al. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12068 · Cited by 81
Alzheimer's disease and sleep disturbances: a review
Borges, C. R., Poyares, D. R., Piovezan, R. D., Nitríni, R., & Brucki, S. M. D. (2019) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20190149 · Cited by 79
Liguori, C., Placidi, F., Izzi, F., Spanetta, M., Mercuri, N. B., & Pucchio, A. D. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0571-3 · Cited by 77
André, C., Tomadesso, C., de Florès, R., Branger, P., Rehel, S., Mézenge, F., Landeau, B., Sayette, V. D. L., Eustache, F., Chételat, G., et al. (2019) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.12.009 · Cited by 71
The Sleep Side of Aging and Alzheimer’s Disease
Romanella, S. M., Roe, D., Tatti, E., Cappon, D., Paciorek, R., Testani, E., Rossi, A., Rossi, S., & Santarnecchi, E. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.05.029 · Cited by 72
Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An Update
Fifel, K., & Videnović, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.627330 · Cited by 71
Winsky‐Sommerer, R., de Oliveira, P., Loomis, S., Wafford, K. A., Dijk, D., & Gilmour, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.027 · Cited by 69
Sex differences in sleep health
Meers, J. M., Stout-Aguilar, J., & Nowakowski, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815373-4.00003-4 · Cited by 69
The role of lifestyle factors and sleep duration for late-onset dementia: a cohort study
Larsson, S. C., & Wolk, A. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180529 · Cited by 62
Dynamic Contributions of Slow Wave Sleep and REM Sleep to Cognitive Longevity
Scullin, M. K., & Gao, C. (2018) · Current Sleep Medicine Reports · doi:10.1007/s40675-018-0131-6 · Cited by 60
Slow-Wave Sleep and MRI Markers of Brain Aging in a Community-Based Sample
Baril, A., Beiser, A., Mysliwiec, V., Sanchez, E., DeCarli, C. S., Redline, S. S., Gottlieb, D. J., Maillard, P., Romero, J. R., Satizábal, C. L., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000011377 · Cited by 59
Self-citationCavaillès, C., Berr, C., Helmer, C., Gabelle, A., Jaussent, I., & Dauvilliers, Y. A. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00952-y · Cited by 58
Understanding Expert Disagreement in Medical Data Analysis through Structured Adjudication
Schaekermann, M., Beaton, G., Habib, M., Lim, A. S. P., Larson, K. S., & Law, E. (2019) · Proceedings of the ACM on Human-Computer Interaction · doi:10.1145/3359178 · Cited by 58
Impact of Sleep Disorder as a Risk Factor for Dementia in Men and Women
Jee, H. J., Shin, W., Jung, H. J., Kim, B., Lee, B. K., & Jung, Y.-S. (2019) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2019.192 · Cited by 58
Owen, J. E., Benediktsdóttir, B., Cook, E., Ólafsson, Í., Gíslason, Þ., & Robinson, S. R. (2020) · SLEEP · doi:10.1093/sleep/zsaa195 · Cited by 59
Masaki, M., Tsumoto, S., Tani, A., Tominaga, M., Seol, J., Chiba, S., Miyanishi, K., Nishida, K., Kawana, F., Amemiya, T., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412895121 · Cited by 57
Anderson, E. L., Richmond, R. C., Jones, S. E., Hemani, G., Wade, K. H., Dashti, H. S., Lane, J. M., Wang, H., Saxena, R., Brumpton, B. M., et al. (2020) · International Journal of Epidemiology · doi:10.1093/ije/dyaa183 · Cited by 57
Risk Factors, Lifestyle Behaviors, and Vascular Brain Health
Gottesman, R. F., & Seshadri, S. S. (2022) · Stroke · doi:10.1161/strokeaha.121.032610 · Cited by 53
Self-citationSex differences in the effects of sleep disorders on cognitive dysfunction
Zhou, L., Kong, J., Li, X., & Ren, Q. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105067 · Cited by 51
Insomnia: Risk Factor for Neurodegenerative Diseases
Shamim, S. A., Warriach, Z. I., Tariq, M. A., Rana, K. F., & Malik, B. H. (2019) · Cureus · doi:10.7759/cureus.6004 · Cited by 51
Wang, S., Zheng, X., Huang, J., Liu, J., Li, C., & Shang, H. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12380-7 · Cited by 49
Cerebral capillary blood flow upsurge during REM sleep is mediated by A2a receptors
Tsai, C.-J., Nagata, T., Liu, C.-Y., Suganuma, T., Kanda, T., Miyazaki, T., Liu, K., Saitoh, T., Nagase, H., Lazarus, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109558 · Cited by 48
Mayer, G., Frohnhofen, H., Jokisch, M., Hermann, D. M., & Gronewold, J. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1372326 · Cited by 47
Carnicelli, L., Maestri, M., Coscio, E. D., Tognoni, G., Fabbrini, M., Schirru, A., Giorgi, F. S., Siciliano, G., Bonuccelli, U., & Bonanni, E. (2019) · Journal of Sleep Research · doi:10.1111/jsr.12821 · Cited by 47
Smith, M. G., Ögren, M., Thorsson, P. J., Hussain‐Alkhateeb, L., Pedersen, E., Forssén, J., Morsing, J. A., & Waye, K. P. (2020) · SLEEP · doi:10.1093/sleep/zsaa046 · Cited by 47
Zhang, J., Ou, J., Lu, X., Wang, T., Dang, W., Ding, L., Liu, Y., Xu, J., Yan, B., & Yu, H. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13372-x · Cited by 46
Neuroendocrine Control of Sleep
Smith, P. C., & Mong, J. A. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_107 · Cited by 45
Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease
Jin, J., Chen, J., Cavaillès, C., Yaffe, K. S., Winer, J. R., Stankeviciute, L. S., Lucey, B. P., Zhou, X., Gao, S., Peng, D., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14495 · Cited by 44
Carpi, M., Fernandes, M., Mercuri, N. B., & Liguori, C. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230933 · Cited by 41
Therapy for Insomnia and Circadian Rhythm Disorder in Alzheimer Disease
Ferini‐Strambi, L., Galbiati, A., Casoni, F. M., & Salsone, M. (2020) · Current Treatment Options in Neurology · doi:10.1007/s11940-020-0612-z · Cited by 39
Longitudinal association of apolipoprotein E and sleep with incident dementia
Palpatzis, E., Bass, N. J., Jones, R., & Mukadam, N. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12439 · Cited by 39
Association of sleep with cognition and beta amyloid accumulation in adults with Down syndrome
Cody, K. A., Piro‐Gambetti, B., Zammit, M. D., Christian, B. T., Handen, B. L., Klunk, W. E., Zaman, S. H., Johnson, S. C., Plante, D. T., & Hartley, S. L. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.04.018 · Cited by 38
Rapid Eye Movement Sleep, Neurodegeneration, and Amyloid Deposition in Aging
André, C., Champetier, P., Rehel, S., Kuhn, E., Touron, E., Ourry, V., Landeau, B., Du, G. L., Mézenge, F., Segobin, S. H., et al. (2023) · Annals of Neurology · doi:10.1002/ana.26604 · Cited by 37
Giri, S., Ranjan, A., Kumar, A., Amar, M., & Mallick, B. N. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24838 · Cited by 36
Relationship of Sleep Disorder with Neurodegenerative and Psychiatric Diseases: An Updated Review
Xiao, X., Rui, Y., Jin, Y., & Chen, M. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04086-5 · Cited by 35
Maezono, S. E. B., Kanuka, M., Tatsuzawa, C., Morita, M., Kawano, T., Kashiwagi, M., Nondhalee, P., Sakaguchi, M., Saito, T., Saido, T. C., et al. (2020) · eNeuro · doi:10.1523/eneuro.0093-20.2020 · Cited by 30
Systemic inflammation as a moderator between sleep and incident dementia
Baril, A., Beiser, A., Redline, S. S., McGrath, E. R., Aparicio, H. J., Gottlieb, D. J., Seshadri, S. S., Pase, M. P., & Himali, J. J. (2020) · SLEEP · doi:10.1093/sleep/zsaa164 · Cited by 31
Self-citationLinking brain structure, cognition, and sleep: insights from clinical data
Wei, R., Ganglberger, W., Sun, H., Hadar, P., Gollub, R. L., Pieper, S., Billot, B., Au, R., Iglesias, J. E., Cash, S. S., et al. (2023) · SLEEP · doi:10.1093/sleep/zsad294 · Cited by 30
Self-citationSleep features and long-term incident neurodegeneration: a polysomnographic study
Ibrahim, A., Cesari, M., Heidbreder, A., Defrancesco, M., Brandauer, E., Seppi, K., Kiechl, S. J., Högl, B., & Stefani, A. (2023) · SLEEP · doi:10.1093/sleep/zsad304 · Cited by 30
Influence of rapid eye movement sleep on all-cause mortality: a community-based cohort study
Zhang, J., Jin, X., Li, R., Gao, Y., Li, J., & Wang, G. (2019) · Aging · doi:10.18632/aging.101858 · Cited by 30
André, C., Lanièpce, A., Chételat, G., & Rauchs, G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101252 · Cited by 30
Lo, C.-C., Liu, W., Lu, Y., Wu, D., Wu, C., Chen, T., Fang, Y.-T., Lo, Y., Chen, Y., Kang, L., et al. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-19482-7 · Cited by 29
Pham, L. V., Jun, J. C., & Polotsky, V. Y. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-323-91532-8.00017-3 · Cited by 28
Howard, C., Mukadam, N., Hui, E. K., & Livingston, G. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.10.022 · Cited by 26
Muto, V., Koshmanova, E., Ghaemmaghami, P., Jaspar, M., Meyer, C., Elansary, M., Egroo, M. V., Chylinski, D., Berthomier, C., Brandewinder, M., et al. (2020) · SLEEP · doi:10.1093/sleep/zsaa137 · Cited by 26
The role of orexin in Alzheimer disease: From sleep-wake disturbance to therapeutic target
Gao, F., Liu, T., Tuo, M., & Chi, S. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136247 · Cited by 26
Dementia Prevention in Clinical Practice
Niotis, K., Akiyoshi, K., Carlton, C., & Isaacson, R. (2022) · Seminars in Neurology · doi:10.1055/s-0042-1759580 · Cited by 26
Loughman, A., Adler, C. J., & Macpherson, H. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220760 · Cited by 26
REM sleep is associated with the volume of the cholinergic basal forebrain in aMCI individuals
André, C., Martineau‐Dussault, M., Daneault, V., Blais, H., Frenette, S., Lorrain, D., Hudon, C., Bastien, C., Petit, D., Lafrenière, A., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01265-y · Cited by 25
Jayakody, O. M., Blumen, H. M., Breslin, M. C., Wang, C., & Verghese, J. (2024) · Journal of the American Geriatrics Society · doi:10.1111/jgs.19032 · Cited by 25
Reduced rapid eye movement sleep in late middle-aged and older apolipoprotein E ɛ 4 allele carriers
André, C., Martineau‐Dussault, M., Baril, A., Marchi, N. A., Daneault, V., Lorrain, D., Hudon, C., Bastien, C., Petit, D., Thompson, C., et al. (2024) · SLEEP · doi:10.1093/sleep/zsae094 · Cited by 24
Lewy Body Dementias: A Coin with Two Sides?
Milán-Tomás, Á., Fernández‐Matarrubia, M., & Rodríguez-Oroz, M. C. (2021) · Behavioral Sciences · doi:10.3390/bs11070094 · Cited by 24
de Oliveira, P., Cella, C. V., Locker, N., Ravindran, K. K. G., Mendis, A., Wafford, K. A., Gilmour, G., Dijk, D., & Winsky‐Sommerer, R. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.2162-21.2022 · Cited by 24
Sleep as the Foundation of Brain Health
Ibrahim, A., Högl, B., & Stefani, A. (2025) · Seminars in Neurology · doi:10.1055/a-2566-4073 · Cited by 23
Akkol, E. K., Bardakçı, H., Yücel, Ç., Karatoprak, G. Ş., Karpuz, B., & Khan, H. Z. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6168199 · Cited by 22
Efficacy and safety of hydroxyzine for sleep in adults: Systematic review
Burgazli, C. R., Rana, K. B., Brown, J. N., & Tillman, F. (2023) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2864 · Cited by 22
Köhler, S., Soons, L. M., Tange, H. J., Deckers, K., & van Boxtel, M. P. J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230213 · Cited by 22
Vaou, O., Lin, S. H., Branson, C. O., & Auerbach, S. H. (2018) · Current Sleep Medicine Reports · doi:10.1007/s40675-018-0112-9 · Cited by 22
Self-citationVital Exhaustion and Incidence of Dementia: Results from the Copenhagen City Heart Study
Islamoska, S., Ishtiak‐Ahmed, K., Hansen, Å. M., Grynderup, M. B., Mortensen, E. L., Garde, A. H., Gyntelberg, F., Prescott, E., Török, E., Waldemar, G., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180478 · Cited by 22
Wei, J., Wang, M., Guo, Y., Liu, Y., & Dong, X. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.12.010 · Cited by 21
Sleep-Related Changes Prior to Cognitive Dysfunction
Pérez‐Carbonell, L., & Iranzo, Á. (2023) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-023-01258-2 · Cited by 20
Locus coeruleus activity while awake is associated with REM sleep quality in older individuals
Koshmanova, E., Berger, A., Beckers, E., Campbell, I., Mortazavi, N., Sharifpour, R., Paparella, I., Balda, F., Berthomier, C., Degueldre, C., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.172008 · Cited by 20
Niotis, K., Saperia, C., Saif, N., Carlton, C., & Isaacson, R. (2024) · Nature Mental Health · doi:10.1038/s44220-023-00191-0 · Cited by 20
Healthy Sleep Every Day Keeps the Doctor Away
Feingold, C. L., & Smiley, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191710740 · Cited by 19
The gut microbiota and nervous system: Age-defined and age-defying
Madison, A. A., & Kiecolt‐Glaser, J. K. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.12.009 · Cited by 19
BaHammam, A. S., Pirzada, A. R., & Pandi-Perumal, S. R. (2022) · Sleep And Breathing · doi:10.1007/s11325-022-02602-5 · Cited by 20
Green, S. F., Frame, T. V. H., Banerjee, L. V., Gimson, A., Blackman, J., Morrison, H. D., Lloyd, K., Rudd, S., Fotherby, W. F., Bartsch, U., et al. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101665 · Cited by 19
Suh, S. W., Han, J. W., Lee, J. R., Byun, S., Kwak, K. P., Kim, B., Kim, S. G., Kim, J. L., Kim, T. H., Ryu, S., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190399 · Cited by 19
Cross talk mechanism of disturbed sleep patterns in neurological and psychological disorders
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Metadata
- Authors
- Pase, M. P., Himali, J. J., Grima, N. A., Beiser, A. S., Satizabal, C. L., Aparicio, H. J., Thomas, R. J., Gottlieb, D. J., Auerbach, S. H., & Seshadri, S.
- Affiliations
- Boston University (US)
- From the Department of Neurology (M.P.P., J.J.H., A.S.B., C.L.S., H.J.A., S.H.A., S.S.), Boston University School of Medicine; Framingham Heart Study (M.P.P., J.J.H., A.S.B., C.L.S., H.J.A., S.H.A., S.S.), MA; Centre for Human Psychopharmacology (M.P.P.), Swinburne University of Technology, Australia; Department of Biostatistics (J.J.H., A.S.B.), Boston University School of Public Health; Cognitive Neurology Unit (N.A.G.) and Division of Pulmonary, Critical Care, and Sleep Medicine, Department of...
- ORCID
- Venue
- Neurology
- Published
- 2017-09-19
- Volume
- 89
- Issue
- 12
- Pages
- 1244-1250
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC5606917
- OpenAlex
- W2747891109
- Cited by
- 241
- References
- 39
- Citations by year
- 2026: 33 · 2025: 32 · 2024: 25 · 2023: 31 · 2022: 21 · 2021: 27 · 2020: 26 · 2019: 23 · 2018: 17 · 2017: 5
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Funders
- National Institute on Aging (P30AG010129, U01AG049505, U01AG052409, R01AG054076, R01AG049607, R01AG033193, T32AG036697)
- National Institute of Neurological Disorders and Stroke (UH2NS100605, L30 NS093634, R01NS017950)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep architecture, incident dementia, REM sleep, REM latency, Alzheimer's disease, dementia risk, NREM sleep, slow-wave sleep, sleep disorders, Sleep Heart Health Study
- MeSH terms
- Aged, Dementia, Female, Follow-Up Studies, Humans, Male, Massachusetts, Middle Aged, Risk, Sleep Wake Disorders, Sleep, REM, Polysomnography
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-11-07, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-11-07 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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