The Relationship between Obstructive Sleep Apnea and Alzheimer’s Disease
Open accessAbstract
Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are highly prevalent conditions with growing impact on our aging society. While the causes of OSA are now better characterized, the mechanisms underlying AD are still largely unknown, challenging the development of effective treatments. Cognitive impairment, especially affecting attention and executive functions, is a recognized clinical consequence of OSA. A deeper contribution of OSA to AD pathogenesis is now gaining support from several lines of research. OSA is intrinsically associated with disruptions of sleep architecture, intermittent hypoxia and oxidative stress, intrathoracic and hemodynamic changes as well as cardiovascular comorbidities. All of these could increase the risk for AD, rendering OSA as a potential modifiable target for AD prevention. Evidence supporting the relevance of each of these mechanisms for AD risk, as well as a possible effect of AD in OSA expression, will be explored in this review.
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Poor sleep quality, such as that caused by obstructive sleep apnea, may raise dementia risk by disrupting blood flow to the brain and normal brain activity that supports memory and attention.
“Poor sleep quality such as that caused by obstructive sleep apnea may increase risk by interfering with blood flow to the brain and normal patterns of brain activity that promote memory and attention.198,199”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [198]
Poor sleep quality such as that caused by obstructive sleep apnea may increase dementia risk by interfering with blood flow to the brain and normal patterns of brain activity that promote memory and attention.
“In addition, poor sleep quality such as that caused by obstructive sleep apnea may increase risk by interfering with blood flow to the brain and normal patterns of brain activity that promote memory and attention.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [212]
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Decoding Causal Links Between Sleep Apnea and Alzheimer’s Disease
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BACE1 as an early biomarker and its relevance to risk factors for Alzheimer’s disease
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Exploring the combined effects of sleep apnea and APOE-e4 on biomarkers of Alzheimer’s disease
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Self-citation
- Authors
- Andrade, A. G., Bubu, O. M., Varga, A. W., & Osorio, R. S.
- Affiliations
- NYU Langone Health (US)
- University of South Florida (US)
- Icahn School of Medicine at Mount Sinai (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Andrade, Andreia G.
- Osorio, Ricardo S.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2018-06-12
- Volume
- 64
- Issue
- s1
- Pages
- S255-S270
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC6542637
- OpenAlex
- W2804158148
- Cited by
- 216
- References
- 191
- Citations by year
- 2026: 18 · 2025: 29 · 2024: 38 · 2023: 43 · 2022: 32 · 2021: 29 · 2020: 19 · 2019: 5 · 2018: 1 · 2012: 1
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- Funders
- National Institute on Aging (R01AG056682, R01AG022374, R21AG055002, R21AG049348, P30AG008051, R01AG056031, R21AG059179)
- National Heart, Lung, and Blood Institute (R01HL118624)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- obstructive sleep apnea, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Humans, Sleep Apnea, Obstructive
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