The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Blood pressure from mid- to late life and risk of incident dementia
Open accessAbstract
OBJECTIVE: To determine the association between blood pressure during midlife (40-64 years) to late life (≥65 years) and risk of incident dementia. METHODS: This study included 1,440 (758 women, mean age 69 ± 6 years) Framingham Offspring participants who were free of dementia and attended 5 consecutive examinations at 4-year intervals starting at midlife (1983-1987, mean age 55 years) until late life (1998-2001, mean 69 years) and subsequently were followed up for incident dementia (mean 8 years). We determined the effect of midlife hypertension (≥140/90 mm Hg), late life hypertension, lower late life blood pressure (<100/70 mm Hg), persistence of hypertension during mid- to late life, and steep decline in blood pressure from mid- to late life over an 18-year exposure period. RESULTS: During the follow-up period, 107 participants (71 women) developed dementia. Using multivariable Cox proportional hazards models, we found that midlife systolic hypertension (hazard ratio [HR] 1.57, 95% confidence interval [CI] 1.05-2.35) and persistence of systolic hypertension into late life (HR 1.96, 95% CI 1.25-3.09) were associated with an elevated risk of incident dementia. However, in individuals with low to normal blood pressure (≤140/90 mm Hg) at midlife, a steep decline in systolic blood pressure during mid- to late life was also associated with a >2-fold increase in dementia risk (HR 2.40, 95% CI 1.39-4.15). CONCLUSIONS: Elevated blood pressure during midlife, persistence of elevated blood pressure into late life, and, among nonhypertensives, a steep decline in blood pressure during mid- to late life were associated with an increased dementia risk in a community-based cohort. Our data highlight the potential sustained cognitive benefits of lower blood pressures in midlife but also suggest that declining blood pressure in older adults with prehypertension or normotension, but not in those with hypertension, may be a risk marker for dementia.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Life course is important when considering risk, for example, obesity and hypertension in midlife predict future dementia, but both weight and blood pressure usually fall in later life in those with or developing dementia,9 so lower weight and blood pressure in later life might signify illness, not an absence of risk.11, 12, 13, 14”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [12]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In the Framingham Offspring cohort comprising 1440 people, elevated systolic blood pressure (≥140 mm Hg in midlife; mean age 55 years) was associated with an increased risk of developing dementia (HR 1·6, 95% CI 1·1–2·4) over an 18 year follow-up period.”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [12]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Of note, blood pressure declines in later life and this decline is associated with and, potentially caused by, dementia development (HR 2·4, 95% CI 1·4–4·2).”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [12]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“In this study risk increased further if hypertension persisted into later life (mean age 69 years; HR 2·0, 95% CI 1·3–3·1).”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [12]
The cited source says what the claim attributes to it.
In the citing paper
“Persistent midlife hypertension is associated with increased risk of a late life dementia.”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Chobanian, A. V. (2003) · JAMA · doi:10.1001/jama.289.19.2560 · Cited by 25,386
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,168
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Self-citation15-year longitudinal study of blood pressure and dementia
Skoog, I., Nilsson, L., Persson, G., Lernfelt, B., Landahl, S., Palmertz, B., Andreasson, L.-A., Odén, A., & Svanborg, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90608-x · Cited by 1,726
Forette, F., Seux, M.-L., Staessen, J. A., Thijs, L., Birkenhäger, W. H., Babarskiene, M.-R., Babeanu, S., Bossini, A., Gil-Extremera, B., Girerd, X., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03086-4 · Cited by 1,441
Midlife cardiovascular risk factors and risk of dementia in late life
Whitmer, R. A., Sidney, S., Selby, J., Johnston, S. C., & Yaffe, K. (2005) · Neurology · doi:10.1212/01.wnl.0000149519.47454.f2 · Cited by 1,238
Midlife blood pressure and dementia: the Honolulu–Asia aging study☆
Launer, L. J., Ross, G. W., Petrovitch, H., Masaki, K., Foley, D., White, L. R., & Havlik, R. J. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00096-8 · Cited by 1,008
The framingham offspring study. Design and preliminary data
Feinleib, M., Kannel, W. B., Garrison, R. J., McNamara, P. M., & Castelli, W. P. (1975) · Preventive Medicine · doi:10.1016/0091-7435(75)90037-7 · Cited by 926
Cited by
Sorted by citations
Items 101–200 of 288
Yu, J. S., Lee, K., Kim, H., Han, K., & Lee, S.-H. (2023) · Scientific Reports · doi:10.1038/s41598-023-47566-y · Cited by 17
Hong, N., Kim, K. J., Yu, M. H., Jeong, S. H., Lee, S., Lim, J. S., & Rhee, Y. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01274-x · Cited by 16
Investigating the Interplay between Cardiovascular and Neurodegenerative Disease
Cousineau, J., Dawe, A. M., & Alpaugh, M. (2024) · Biology · doi:10.3390/biology13100764 · Cited by 15
Blood pressure trajectories over 35 years and dementia risk: A retrospective study: The HUNT study
Selbæk, G., Stuebs, J., Engedal, K., Hachinski, V., Hestad, K. A., Trevino, C. S., Skjellegrind, H. K., Wedatilake, Y., & Strand, B. H. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.931715 · Cited by 14
Scambray, K. A., Nguyen, H. L., & Sajjadi, S. A. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad020 · Cited by 14
Ricci, F., Martorana, A., Bonomi, C. G., Serafini, C., Mercuri, N. B., Koch, G., & Motta, C. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230792 · Cited by 14
Impact of metabolic dysfunction on cognition in humans
Rasmussen, I. J., Thomassen, J. Q., & Frikke‐Schmidt, R. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000723 · Cited by 14
Cheng, G., He, S., He, Q., Xie, X., Tang, C., Xie, Q., Wu, X. H., Jiang, N., Li, C., Min, X., et al. (2021) · Aging · doi:10.18632/aging.203228 · Cited by 14
The relationship between isolated hypertension with brain volumes in UK Biobank
Newby, D., Winchester, L. M., Sproviero, W., Fernandes, M., Ghose, U., Lyall, D. M., Launer, L. J., & Nevado‐Holgado, A. J. (2022) · Brain and Behavior · doi:10.1002/brb3.2525 · Cited by 13
Decoding information about cognitive health from the brainwaves of sleep
Adra, N., Dummer, L., Paixão, L. G. P., Tesh, R. A., Sun, H., Ganglberger, W., Westmeijer, M., Cardoso, M. D. S., Kumar, A., Ye, E. M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-37128-7 · Cited by 13
Predicting dementia in people with Parkinson’s disease
Aborageh, M., Hähnel, T., Conde, P. M., Klucken, J., & Fröhlich, H. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-00983-4 · Cited by 13
Birth Cohorts and Cognitive Reserve Influence Cognitive Performances in Older Adults
Turcotte, V., Initiative, A. D. N., Potvin, O., Dadar, M., Hudon, C., & Duchesne, S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215044 · Cited by 15
The Effect of Alzheimer’s Disease-Associated Genetic Variants on Longevity
Tesi, N., Hulsman, M., van der Lee, S. J., Jansen, I. E., Stringa, N., van Schoor, N. M., Scheltens, P., van der Flier, W. M., Huisman, M. A., Reinders, M. J. T., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.748781 · Cited by 13
Perspectives on the relation of blood pressure and cognition in the elderly
Goshgarian, C., & Gorelick, P. B. (2018) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2018.05.011 · Cited by 13
Wang, Y., Zhang, M., Chen, S.-J., Miao, W., Wang, Z., Zhou, Y., Yu, S., Sun, Z., Zhou, X., Yu, X., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1630022 · Cited by 13
Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study
Cho, M. H., Han, K., Lee, S. W., Jeong, S., Yoo, J. E., Kim, S., Lee, J., Chun, S., & Shin, D. W. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01211-y · Cited by 12
Wiese, L. K., Pratt, B. A., Heinze, K. E., Besser, L. M., Ifill, A., & Williams, C. L. (2023) · Current Geriatrics Reports · doi:10.1007/s13670-023-00400-9 · Cited by 12
Duron, E., Vidal, J., Grouselle, D., Gabelle, A., Lehmann, S., Pasquier, F., Bombois, S., Buée, L., Allinquant, B., Schraen‐Maschke, S., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00297 · Cited by 12
Chambers, L. C., Diaz‐Otero, J. M., Fisher, C. L., Jackson, W. F., & Dorrance, A. M. (2022) · Journal of Hypertension · doi:10.1097/hjh.0000000000003208 · Cited by 12
Boulares, A., Jdidi, H., & Bragazzi, N. L. (2025) · International Dental Journal · doi:10.1016/j.identj.2024.07.005 · Cited by 11
Lee, S.-S., McGrattan, A., Soh, Y. C., Alawad, M., Su, T. T., Palanisamy, U., Hussin, A. M., Kassim, Z. B., Ghazali, A. N. B. M., Stephan, B. C. M., et al. (2022) · Nutrients · doi:10.3390/nu14030430 · Cited by 12
Association of Low Systolic Blood Pressure with Postmortem Amyloid-β and Tau
Oveisgharan, S., Capuano, A. W., Kapasi, A., Buchman, A. S., Schneider, J. A., Bennett, D. A., & Arvanitakis, Z. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200412 · Cited by 11
Liu, J., Amin, N., Sproviero, W., Arnold, M., Batra, R., Bonnechère, B., Chiou, Y., Fernandes, M., Krumsiek, J., Newby, D., et al. (2022) · medRxiv · doi:10.1101/2022.02.25.22271530 · Cited by 10
The impact of Alzheimer’s disease risk factors on the pupillary light response
Sparks, S., Pinto, J., Hayes, G., Spitschan, M., & Bulte, D. P. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1248640 · Cited by 10
Cheng, Y., Lin, L., Huang, P., Zhang, J., Wang, Y., & Pan, X. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003103 · Cited by 10
Biskaduros, A., Glodzik, L., Louis, L. A. S., Rusinek, H., Pirraglia, E., Osorio, R. S., Butler, T., Li, Y., Xi, K., Tanzi, E. B., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13800 · Cited by 9
Making DEEP Sense of Lifestyle Risk and Resilience
Kempermann, G. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00171 · Cited by 10
Perna, L., Mons, U., Stocker, H. R., Beyer, L., Beyreuther, K. T., Trares, K., Holleczek, B., Schöttker, B., Perneczky, R., Gerwert, K. B., et al. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12933 · Cited by 10
Bukhbinder, A. S., Hinojosa, M., Harris, K., Li, X., Farrell, C. M., Shyer, M. N., Goodwin, N., Anjum, S., Hasan, O., Cooper, S., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220934 · Cited by 10
Topping, M., Kim, J., & Fletcher, J. M. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230086 · Cited by 10
Schiffrin, E. L., & Engert, J. C. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad187 · Cited by 10
Zhu, W., Tang, H., Zhang, H., Rajamohan, H. R., Huang, S., Ma, X., Chaudhari, A., Madaan, D., Almahmoud, E., Chopra, S., et al. (2024) · medRxiv · doi:10.1101/2024.04.26.24306180 · Cited by 11
Are Alzheimer's and coronary artery diseases genetically related to longevity?
Bellou, E., & Escott‐Price, V. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1102347 · Cited by 10
Machine Learning for Alzheimer’s Disease and Related Dementias
Marc Modat, A., Cash, D. M., Canas, L. S., Bocchetta, M., & Sebastien Ourselin, A. (2023) · Neuromethods · doi:10.1007/978-1-0716-3195-9_25 · Cited by 8
Pinto, R. D., Grassi, D., Bocale, R., Carubbi, F., Ferri, C., & Desideri, G. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153243 · Cited by 9
Serum amyloid beta 42 levels correlated with metabolic syndrome and its components
Li, K., Zhou, X., Liu, Y., Li, D., Li, Y., Zhang, T., Fu, C., Li, L., Hu, Y., & Jiang, L. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1278477 · Cited by 10
Sobczuk, J., Paczkowska, K., Andrusiów, S., Bolanowski, M., & Daroszewski, J. (2024) · Biomolecules · doi:10.3390/biom14080918 · Cited by 8
Correlation between cardiovascular risk factors and cognitive decline
Desideri, G., & Bocale, R. (2021) · European Heart Journal Supplements · doi:10.1093/eurheartj/suab095 · Cited by 8
Preserving Cognition, Preventing Dementia
Cleveland, M. L. (2020) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2020.06.003 · Cited by 10
Sible, I. J., Nation, D. A., & Initiative, T. A. D. N. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221103 · Cited by 8
Reddin, C., Murphy, R., Hanrahan, C., Loughlin, E. A., Ferguson, J. P., Judge, C. S., Waters, R., Canavan, M. D., Kenny, R. A., & O'Donnell, M. J. (2023) · Age and Ageing · doi:10.1093/ageing/afad044 · Cited by 7
Documentation of prodromal features and risk factors of dementia disease in primary care practice
Michalowsky, B., Teipel, S. J., Riedel-Heller, S. G., Kostev, K., & Bohlken, J. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241295407 · Cited by 7
Velescu, D. R., Marc, M. S., Pescaru, C. C., Trăilă, D., Vaștag, E., Papavă, I., Motofelea, A. C., Ciucă, I. M., Manolescu, D., & Oancea, C. I. (2023) · Medicina · doi:10.3390/medicina59050846 · Cited by 7
Educational Needs for Coaching Judo in Older Adults: The EdJCO Focus Groups
Palumbo, F., Ciaccioni, S., Guidotti, F., Forte, R., Galea, E., Sacripanti, A., Lampe, N., Lampe, Š., Jelušić, T., Bradić, S., et al. (2023) · Sports · doi:10.3390/sports11080143 · Cited by 9
Author response: Blood pressure from mid- to late life and risk of incident dementia
McGrath, E. R., & Seshadri, S. S. (2018) · Neurology · doi:10.1212/wnl.0000000000005810 · Cited by 7
Self-citationLi, J., Li, J., Zhu, H., Liu, M., Li, T., He, Y.-K., Xu, Y., Huang, F., & Qin, Q. (2024) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000539334 · Cited by 6
Li, J. M., Gauen, A., Zmora, R., Stephen, J. J., Petito, L. C., Scholtens, D., Peterson, E., Kohli-Lynch, C. N., Mansolf, M. A., Sedaghat, S., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71065 · Cited by 6
Self-citationNumber of children and risk of dementia: a cohort study
Wolfová, K., Hubbard, R. A., Kearns, P. B., Chang, V. W., Crane, P. K., LaCroix, A. Z., Larson, E. B., & Tom, S. E. (2024) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2024-222717 · Cited by 9
Time for Neurologists to Drop the Reflex Hammer on Hypertension
Betjemann, J. P., Hemphill, J. C., & Sarkar, U. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2588 · Cited by 6
Bishnoi, A., Chaparro, G. N., & Hernandez, M. E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19010047 · Cited by 6
Pearson, A. G., Miller, K. B., Corkery, A. T., Eisenmann, N. A., Howery, A. J., Cody, K. A., Chin, N. A., Johnson, S. C., & Barnes, J. N. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.888470 · Cited by 6
Understanding Cognitive Deficits in People with High Blood Pressure
Kang, W., & Hernández, S. P. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13111592 · Cited by 6
Protective and risk factors in daily life associated with cognitive decline of older adults
Tong, F., Yang, H., Yu, H., Sui, L.-W., Yao, J.-Y., Shi, C., Yao, Q.-Y., Shi, M., Qian, C.-L., Li, G., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1496677 · Cited by 6
Dementia risk across blood pressure categories: a South Korean nationwide study
Jung, Y. H., Kim, J., Han, K., Lee, J., Cheon, D. Y., Lim, J., & Lee, M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf840 · Cited by 5
Gao, Y., Zhang, P., Yang, H., Li, S., Su, H., & Zhang, Q. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-06465-9 · Cited by 5
Davidescu, D., Goman, A., Voiţă-Mekereş, F., Bradacs, A. I., Florina, S. F. S., Csep, A. N., Szilagyi, G., Motofelea, A. C., & Davidescu, L. (2024) · Cureus · doi:10.7759/cureus.70085 · Cited by 5
Alam, A. B., Kulshreshtha, A., Li, L., Subramanya, V., & Alonso, Á. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11195800 · Cited by 5
Jacqmin‐Gadda, H., Philipps, V., Guillet, F., Tzourio, C., Helmer, C., & Joly, P. (2023) · European Journal of Epidemiology · doi:10.1007/s10654-023-00974-w · Cited by 5
The Relation Between Arterial Hypertension and Cognitive Impairment: A Literature Review
Salazar, G. Z., Zúñiga, D., Balasubramanian, S., Mehmood, K. T., & AL-Baldawi, S. A. A. (2024) · Cureus · doi:10.7759/cureus.52782 · Cited by 8
Rodrigues, J., Costa, M., de Sousa, D., Costa, A. R., Lunet, N., Cruz, V. T., & Padrão, P. (2024) · Nutrients · doi:10.3390/nu16101419 · Cited by 5
Wang, H., Xu, Y., Ren, R., Feng, Y., Chen, M., Sheng, Z., Guo, X., Li, Y., Chen, S., & Wang, G. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210679 · Cited by 5
Blood pressure screening in midlife aids in prediction of dementia later in life
Moberg, L., Leppert, J., Liljeström, S., Rehn, M., Kilander, L., & Chabok, A. (2022) · Upsala Journal of Medical Sciences · doi:10.48101/ujms.v127.7860 · Cited by 5
Cooper, L. L., & Mitchell, G. F. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0919-x · Cited by 5
Ide, K., Mizushima, S., Saito, K., Suzuki, H., Chiba, Y., Abe, K., Yoshimi, A., Hishimoto, A., Yamanaka, T., Sakurai, T., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251344222 · Cited by 5
Ariyath, A., Mputhia, Z., Dougherty, C., Rahuman, B. K., Fernando, W. M. A. D. B., Brown, B. M., Gardener, S. L., Rainey‐Smith, S. R., Martins, R. N., & Bharadwaj, P. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71191 · Cited by 4
Kang, M.-I., Ang, T. F. A., Devine, S., Sherva, R., Mukherjee, S., Trittschuh, E. H., Gibbons, L. E., Scollard, P., Lee, M., Choi, S.-E., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70681 · Cited by 5
Na, S., Lee, C., Ho, S. H., Hong, Y. J., Jeong, J. H., Park, K. H., Kim, S., Wang, M. J., Choi, S. H., Han, S., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230667 · Cited by 4
Taniguchi, R., Ukawa, S., Zhao, W., Okabayashi, S., Kimura, T., Shan, Y., Ando, M., Wakai, K., Tsushita, K., Kawamura, T., et al. (2024) · Archives of Gerontology and Geriatrics Plus · doi:10.1016/j.aggp.2024.100023 · Cited by 4
Wang, L., Cheng, L., Lv, C., Kou, J., Feng, W., Xie, H., Yan, R., Wang, X., Chen, S., Song, X., et al. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s474907 · Cited by 4
Gyanwali, B., Cai, C. G. X., Chen, C., Vrooman, H. A., Tan, C. S., & Hilal, S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210188 · Cited by 4
Zhu, M., Tian, X., Han, X., Ma, Y., Fa, W., Wang, N., Liu, R., Dong, Y., Ren, Y., Liu, C., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14209 · Cited by 3
Hosokawa, M., Kabayama, M., Godai, K., Akagi, Y., Tachibana, Y., Gondo, Y., Yasumoto, S., Masui, Y., Hirata, T., Ishizaki, T., et al. (2024) · BMC Geriatrics · doi:10.1186/s12877-024-05354-x · Cited by 5
Exploring the association of early life physical activity and risk of dementia: a systematic review
Gatta, F. D., Lacorte, E., Fabrizi, E., Remoli, G., Cipollini, V., Troili, F., Vanacore, N., & Giubilei, F. (2021) · Minerva Medica · doi:10.23736/s0026-4806.21.07542-x · Cited by 6
The enigma of vascular dementia: current state and emerging perspectives
Jellinger, K. A. (2026) · Journal of Neural Transmission · doi:10.1007/s00702-026-03104-4 · Cited by 3
Liu, C., Tsai, M., Yang, N., Chang, T.-Y., Chen, T., & Wei, Y. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71153 · Cited by 4
Baumann, B., Lipka, T., Jänner, M., & Kujovic, M. (2022) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-022-01516-3 · Cited by 3
Zhou, R., Wang, Y., Gao, L., Dang, L., Shang, S., Hu, N., Peng, W., Zhao, Y. C., Wei, S., Yuan, Y., et al. (2023) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2023.120613 · Cited by 3
Parandiyal, N., Chutia, P., Sinha, S. S., Pandit, P., Majrashi, N. A. A., Qureshi, N. A., & Tripathi, S. M. (2024) · Frontiers in Dementia · doi:10.3389/frdem.2024.1486147 · Cited by 3
Salazar‐Londoño, S., Silva‐Buriticá, C., Herrera‐Velez, L., & Rosselli, D. (2024) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.70029 · Cited by 3
The role of angiotensin peptides in the brain during health and disease
Zhang, D. E. W., Sobey, C. G., & Silva, T. M. D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99618-1.00026-x · Cited by 3
Prävention demenzieller Erkrankungen
Schippinger, W., & Pichler, G. (2023) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s00391-023-02175-2 · Cited by 3
Hassani, S., & Gorelick, P. B. (2024) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2024.100367 · Cited by 3
Phytotherapeutic targeting of the mitochondria in neurodegenerative disorders
Sarkar, P., Kumar, A. A., Behera, P. S., & Thirumurugan, K. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2023.02.013 · Cited by 2
Zhao, X., Xu, X., Wang, S., Zhang, X., Zheng, R., Wang, K., Xiang, Y., Wang, T., Zhao, Z., Li, M., et al. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16145 · Cited by 2
A life course approach to neurodegeneration
James, S., Schott, J. M., & Ben‐Shlomo, Y. (2025) · Oxford University Press eBooks · doi:10.1093/oso/9780198895961.003.0011 · Cited by 2
Trajectories of Cognitive Decline Before and After New‐Onset Hypertension
Chen, Q., Dong, J., Chen, G., Li, H., Shen, Y., & Hua, J. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039849 · Cited by 2
Kučera, M., Šeblová, D., Bosmans, J. E., Broulíková, H. M., & Kearns, P. B. (2025) · European Journal of Public Health · doi:10.1093/eurpub/ckaf112 · Cited by 2
Palmer, J. C., Hart, E. C., Anderson, E. L., Love, S., & Lawlor, D. A. (2025) · BMC Medicine · doi:10.1186/s12916-025-04295-5 · Cited by 3
Mulligan, M., Beiser, A., O’Donnell, A., Banerjee, A., Ghosh, S., Thibault, E. G., Fakhri, G. E., Johnson, K. A., Seshadri, S. S., & McGrath, E. R. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251372561 · Cited by 2
Self-citationWang, R., Gao, Y., Ee, N., Akinyede, F., Xu, X., Chen, L., Xiong, S., Chen, X., Anderson, C. S., Harris, K., et al. (2026) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2026.100500 · Cited by 2
Hayes, C. A., Agwu, C., Dharmapuri, A., Contreras, J. A., & The Health and Aging Brain Study (HABS‐HD) Study Team (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261427706 · Cited by 2
Ishida, S., Kawazoe, M., Fujii, T., Inoue, Y., Yamamoto, K., Sakima, A., Inoue, T., Komori, T., Ninomiya, T., Nozato, Y., et al. (2026) · Hypertension Research · doi:10.1038/s41440-026-02619-3 · Cited by 2
The Association Between 24-Hour Blood Pressure Profiles and Dementia
Gibson, M., Yiallourou, S. R., & Pase, M. P. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230400 · Cited by 3
Aguilar-Navarro, S. G., Yeverino-Castro, S. G., Mejía-Arango, S., Moctezuma‐Gallegos, R., Juárez‐Cedillo, T., & Mimenza-Alvarado, A. J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304234 · Cited by 2
Floud, S., Hermon, C., Whiteley, W. N., Fitzpatrick, K. E., & REEVES, G. K. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70595 · Cited by 1
Cardiovascular Risk Trajectories and Risk of Developing Stroke and Dementia
Chen, P., Su, T., Chen, Y.-Y., Lee, Y., & Chien, K. (2025) · Neurology · doi:10.1212/wnl.0000000000214179 · Cited by 2
Pan, X., Zhang, D. “., Heo, J. H., Park, C., Li, G., Crish, S. D., Li, Y., Gu, Y., Young, H. N., Lavender, D. L., et al. (2022) · Drugs & Aging · doi:10.1007/s40266-022-00981-8 · Cited by 2
Risk factors for vascular dementia
Ivanova, L. A. (2023) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2023-8.3.13 · Cited by 2
Dementia in elderly patients as a consequence of arterial hypertension (literature review)
Mikhailov, S. S., Kozlov, K. L., Шишкевич, А. Н., Bessonov, E. Y., Lukjanov, N. G., & Puhal'skaja, A. E. (2021) · Pharmacy Formulas · doi:10.17816/phf49978 · Cited by 2
Blood pressure variability compromises vascular function in middle-aged micePreprint
Mendiola, P. J., O’Herron, P. J., Xie, K., Brands, M. W., Bush, W., Patterson, R., Stefano, V. D., & Filosa, J. A. (2025) · eLife · doi:10.7554/elife.104082 · Cited by 2
Metadata
- Authors
- McGrath, E. R., Beiser, A. S., DeCarli, C., Plourde, K. L., Vasan, R. S., Greenberg, S. M., & Seshadri, S.
- Affiliations
- Boston University (US)
- From the Department of Neurology (E.R.M.), Brigham & Women's Hospital; Department of Neurology (E.R.M., S.M.G.), Massachusetts General Hospital; Harvard Medical School (E.R.M., S.M.G.); Boston University School of Medicine (A.S.B., R.S.V., S.S.); Boston University School of Public Health (A.S.B., K.L.P., R.S.V.); Framingham Heart Study (A.S.B., R.S.V., S.S.), MA; and 7Department of Neurology (C.D.), University of California, Davis.
- ORCID
- Venue
- Neurology
- Published
- 2017-12-12
- Volume
- 89
- Issue
- 24
- Pages
- 2447-2454
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC5729797
- OpenAlex
- W2767297946
- Cited by
- 289
- References
- 37
- Citations by year
- 2026: 31 · 2025: 40 · 2024: 42 · 2023: 42 · 2022: 44 · 2021: 37 · 2020: 19 · 2019: 22 · 2018: 12
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (P30AG010129, U01AG049505, U01AG052409, R01AG054076, R01AG049607, R01AG033193)
- National Institute of Neurological Disorders and Stroke (UH2NS100605, R01NS017950)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- blood pressure, dementia, hypertension, midlife, old age, systolic blood pressure, blood pressure reduction, prehypertension, normotension, dementia risk, Framingham Offspring cohort
- MeSH terms
- Adult, Aged, Blood Pressure, Dementia, Female, Humans, Hypertension, Male, Middle Aged, United States, Cohort Studies, Incidence, Multivariate Analysis, Proportional Hazards Models, Prehypertension
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
