Midlife and Late-Life Blood Pressure and Dementia in Japanese Elderly: The Hisayama Study
Abstract
The associations between blood pressure and dementia have been inconclusive. We followed up a total of 668 community-dwelling Japanese individuals without dementia, aged 65 to 79 years, for 17 years and examined the associations of late-life and midlife hypertension with the risk of vascular dementia and Alzheimer disease using the Cox proportional hazards model. During the follow-up, 76 subjects experienced vascular dementia and 123 developed Alzheimer disease. The age- and sex-adjusted incidence of vascular dementia significantly increased with elevated late-life blood pressure levels (normal: 2.3, prehypertension: 8.4, stage 1 hypertension: 12.6, and stage 2 hypertension: 18.9 per 1000 person-years; P(trend)<0.001), whereas no such association was observed for Alzheimer disease (P(trend)=0.88). After adjusting for potential confounding factors, subjects with prehypertension and stage 1 or stage 2 hypertension had 3.0-fold, 4.5-fold, and 5.6-fold greater risk of vascular dementia, respectively, compared with subjects with normal blood pressure. Likewise, there was a positive association of midlife blood pressure levels with the risk of vascular dementia but not with the risk of Alzheimer disease. Compared with those without hypertension in both midlife and late life, subjects with midlife hypertension had an ≈5-fold greater risk of vascular dementia, regardless of late-life blood pressure levels. Our findings suggest that midlife hypertension and late-life hypertension are significant risk factors for the late-life onset of vascular dementia but not for that of Alzheimer disease in a general Japanese population. Midlife hypertension is especially strongly associated with a greater risk of vascular dementia, regardless of late-life blood pressure levels.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Controllable risk factors for AD include obesity, hyperlipidemia, hypertension, type 2 diabetes, and sedentary lifestyle.
“there are several controllable risk factors including obesity [156,157], hyperlipidemia [158,159], hypertension [160,161,162,163], type 2 diabetes [164,165,166,167], and sedentary lifestyle [168] that can be addressed in an effort to decrease the risk of developing AD.”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [161]
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271 · see citing works
Global burden of hypertension: analysis of worldwide data
Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K., & He, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17741-1 · Cited by 8,578 · see citing works
Revised Equations for Estimated GFR From Serum Creatinine in Japan
Matsuo, S., Imai, E., Horio, M., Yasuda, Y., Tomita, K., Nitta, K., Yamagata, K., Tomino, Y., Yokoyama, H., & Hishida, A. (2009) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2008.12.034 · Cited by 6,439 · see citing works
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
15-year longitudinal study of blood pressure and dementia
Skoog, I., Nilsson, L., Persson, G., Lernfelt, B., Landahl, S., Palmertz, B., Andreasson, L.-A., Odén, A., & Svanborg, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90608-x · Cited by 1,726 · see citing works
Hachinski, V., Iadecola, C., Petersen, R. C., Breteler, M. M., Nyenhuis, D. L., Black, S. E., Powers, W. J., DeCarli, C., Merino, J. G., Kalaria, R. N., et al. (2006) · Stroke · doi:10.1161/01.str.0000237236.88823.47 · Cited by 1,722 · see citing works
Kivipelto, M., Helkala, E.-L., Laakso, M. P., Hänninen, T., Hallikainen, M., Alhainen, K., Soininen, H., Tuomilehto, J., & Nissinen, A. (2001) · BMJ · doi:10.1136/bmj.322.7300.1447 · Cited by 1,618 · see citing works
HYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works
Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261 · see citing works
The age-dependent relation of blood pressure to cognitive function and dementia
Qiu, C., Winblad, B., & Fratiglioni, L. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70141-1 · Cited by 1,138 · see citing works
Midlife blood pressure and dementia: the Honolulu–Asia aging study☆
Launer, L. J., Ross, G. W., Petrovitch, H., Masaki, K., Foley, D., White, L. R., & Havlik, R. J. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00096-8 · Cited by 1,008 · see citing works
The neuropathology of probable Alzheimer disease and mild cognitive impairment
Schneider, J. A., Arvanitakis, Z., Leurgans, S. E., & Bennett, D. A. (2009) · Annals of Neurology · doi:10.1002/ana.21706 · Cited by 935 · see citing works
Yoshitake, T., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., Nomiyama, K., Kawano, H., Ueda, K., et al. (1995) · Neurology · doi:10.1212/wnl.45.6.1161 · Cited by 829 · see citing works
Peters, R., Beckett, N., Forette, F., Tuomilehto, J., Clarke, R., Ritchie, C., Waldman, A., Walton, I., Poulter, R., Ma, S., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70143-1 · Cited by 770 · see citing works
(2000) · PubMed · Cited by 683 · see citing works
Worldwide Prevalence and Incidence of Dementia
Fratiglioni, L., Ronchi, D. D., & Torres, H. A. (1999) · Drugs & Aging · doi:10.2165/00002512-199915050-00004 · Cited by 490 · see citing works
Longitudinal study of blood pressure and white matter hyperintensities: The EVA MRI Cohort
Dufouil, C., de Kersaint–Gilly, A., Besançon, V., Levy, C., Auffray, E., Brunnereau, L., Alpérovitch, A., & Tzourio, C. (2001) · Neurology · doi:10.1212/wnl.56.7.921 · Cited by 465 · see citing works
Kubo, M., Kiyohara, Y., Kato, I., Tanizaki, Y., Arima, H., Tanaka, K., Nakamura, H., Okubo, K., & Iida, M. (2003) · Stroke · doi:10.1161/01.str.0000090348.52943.a2 · Cited by 408 · see citing works
Association of midlife blood pressure to late-life cognitive decline and brain morphology
Swan, G. E., DeCarli, C. S., Miller, B. L., Reed, T., Wolf, P. A., Jack, L. M., & Carmelli, D. (1998) · Neurology · doi:10.1212/wnl.51.4.986 · Cited by 388 · see citing works
The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function
Posner, H. B., Tang, M. X., Luchsinger, J. A., Lantigua, R., Stern, Y., & Mayeux, R. P. (2002) · Neurology · doi:10.1212/wnl.58.8.1175 · Cited by 330 · see citing works
Low blood pressure and the risk of dementia in very old individuals
Verghese, J., Lipton, R. B., Hall, C. B., Kuslansky, G., & Katz, M. (2003) · Neurology · doi:10.1212/01.wnl.0000098934.18300.be · Cited by 311 · see citing works
Risk Factors for Dementia in the Cardiovascular Health Cognition Study
Kuller, L. H., López, O. L., Newman, A. B., Beauchamp, N. J., Burke, G. L., Dulberg, C. S., Fitzpatrick, A. L., Fried, L. P., & Haan, M. N. (2003) · Neuroepidemiology · doi:10.1159/000067109 · Cited by 294 · see citing works
Blood Pressure and Risk of Dementia: Results from the Rotterdam Study and the Gothenburg H-70 Study
Ruitenberg, A., Skoog, I. G., Ott, A., Aevarsson, Ó., Witteman, J. C. M., Lernfelt, B., van Harskamp, F., Albert Hofman, D., & Breteler, M. M. B. (2000) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051233 · Cited by 267 · see citing works
Yamada, M., Kasagi, F., Sasaki, H., Masunari, N., Mimori, Y., & Suzuki, G. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51117.x · Cited by 255 · see citing works
Imai, Y., & Hasegawa, K. (1994) · Hong Kong journal of psychiatry · Cited by 249 · see citing works
Demonstrating the case that AD is a vascular disease: epidemiologic evidence
Launer, L. J. (2002) · Ageing Research Reviews · doi:10.1016/s0047-6374(01)00364-5 · Cited by 227 · see citing works
Morris, M. C., Scherr, P. A., Hebert, L. E., Glynn, R. J., Bennett, D. A., & Evans, D. A. (2001) · Archives of Neurology · doi:10.1001/archneur.58.10.1640 · Cited by 217 · see citing works
Ohmura, T., Ueda, K., Kiyohara, Y., Kato, I., Iwamoto, H., Nakayama, K., Nomiyama, K., Ohmori, S., Yoshitake, T., Shinkawu, A., et al. (1993) · Diabetologia · doi:10.1007/bf00401066 · Cited by 184 · see citing works
Blood Pressure-Related Cognitive Decline
Elias, P. K., Elias, M. F., Robbins, M. A., & Budge, M. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000145858.07252.99 · Cited by 181 · see citing works
Sekita, A., Ninomiya, T., Tanizaki, Y., Doi, Y., Hata, J., Yonemoto, K., Arima, H., Sasaki, K., Iida, M., Iwaki, T., et al. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01587.x · Cited by 138 · see citing works
Suh, G., & Shah, A. (2001) · Acta Psychiatrica Scandinavica · doi:10.1034/j.1600-0447.2001.00210.x · Cited by 135 · see citing works
Developmental and vascular risk factors for Alzheimer's disease
Borenstein, A. R., Wu, Y., Mortimer, J. A., Schellenberg, G. D., McCormick, W. C., Bowen, J. D., McCurry, S. M., & Larson, E. B. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.04.010 · Cited by 125 · see citing works
Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama study
Matsui, Y., Tanizaki, Y., Arima, H., Yonemoto, K., Doi, Y., Ninomiya, T., Sasaki, K., Iida, M., Iwaki, T., Kanba, S., et al. (2008) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.155481 · Cited by 125 · see citing works
Blood Pressure Reduction for Vascular Risk
Birns, J., Markus, H. S., & Kalra, L. (2005) · Stroke · doi:10.1161/01.str.0000165901.38039.5f · Cited by 98 · see citing works
Experience with a Swedish version of the Geriatric Depression Scale in primary care centres
Gottfries, G. G., Noltorp, S., & N�rgaard, N. (1997) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199710)12:10 · Cited by 92 · see citing works
Relationship between blood pressure and Alzheimer's disease in Linxian County, China
Wu, C., Zhou, D., Chen, W., Zhang, L., Como, P. G., & Qiao, Y. (2003) · Life Sciences · doi:10.1016/s0024-3205(02)02367-6 · Cited by 80 · see citing works
Yamada, M., Mimori, Y., Kasagi, F., Miyachi, T., Ohshita, T., Sudoh, S., Ikeda, J., Matsui, K., Nakamura, S., Matsumoto, M., et al. (2008) · Neuroepidemiology · doi:10.1159/000122332 · Cited by 44 · see citing works
Flagged first, then by citations
1 of the 43 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286 · see citing works
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655 · see citing works
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069 · see citing works
2013 Alzheimer's disease facts and figures
Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,331 · see citing works
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001940 · Cited by 2,885 · see citing works
2019 Alzheimer’s disease facts and figures.
Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461 · see citing works
2020 Alzheimer's disease facts and figures
(2020) · Alzheimer's & Dementia · doi:10.1002/alz.12068 · Cited by 2,353 · see citing works
2022 Alzheimer's disease facts and figures
Anonymous (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12638 · Cited by 2,384 · see citing works
2021 Alzheimer's disease facts and figures
Anonymous (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12328 · Cited by 2,236 · see citing works
2018 Alzheimer's disease facts and figures
Alzheimer's Association (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.001 · Cited by 1,912 · see citing works
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Umemura, S., Arima, H., Arima, S., Asayama, K., Dohi, Y., Hirooka, Y., Horio, T., Hoshide, S., Ikeda, S., Ishimitsu, T., et al. (2019) · Hypertension Research · doi:10.1038/s41440-019-0284-9 · Cited by 1,880 · see citing works
2015 Alzheimer's disease facts and figures
Alzheimer's Association (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.02.003 · Cited by 1,641 · see citing works
2017 Alzheimer's disease facts and figures
(, T. D. B. T. A.-R. C. C. A. S. O. A. C. B. S., different, ). J. A. I. A., destroyed, S. A. T. A. S. T. M. E. T. M. C. I. S. I. A. G. W. A. T. R. N. I. T. O. B. T. F. N. T. B. D. A. D. A. U. I. B. R. I. I. F. N. M. A. N. I. O. P. O. T. B. A. D. A., difficulties, I. E. O., agitation, I. N. S. S. A., & delusions., S. A. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.02.001 · Cited by 1,322 · see citing works
2014 Alzheimer's disease facts and figures
Alzheimer's Association (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.02.001 · Cited by 1,032 · see citing works
Global Epidemiology of Dementia: Alzheimer’s and Vascular Types
Rizzi, L., Rosset, I., & Roriz‐Cruz, M. (2014) · BioMed Research International · doi:10.1155/2014/908915 · Cited by 752 · see citing works
Daskalopoulou, S. S., Rabi, D. M., Zarnke, K. B., Dasgupta, K., Nerenberg, K. A., Cloutier, L., Gelfer, M., Lamarre-Cliché, M., Milot, A., Bolli, P., et al. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.02.016 · Cited by 678 · see citing works
Deckers, K., van Boxtel, M. P. J., Schiepers, O. J. G., de Vugt, M., Muñoz Sánchez, J. L., Anstey, K. J., Brayne, C., Dartigues, J.-F., Engedal, K., Kivipelto, M., et al. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4245 · Cited by 534 · see citing works
Neurovascular and Cognitive Dysfunction in Hypertension
Iadecola, C., & Gottesman, R. F. (2019) · Circulation Research · doi:10.1161/circresaha.118.313260 · Cited by 518 · see citing works
2013 ESH/ESC Guidelines for the management of arterial hypertension
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D. D., Dominiczak, A., et al. (2007) · Blood Pressure · doi:10.3109/08037051.2013.812549 · Cited by 6,112 · see citing works
Defining the relationship between hypertension, cognitive decline, and dementia: a review
Walker, K. A., Power, M. C., & Gottesman, R. F. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0724-3 · Cited by 394 · see citing works
Stroke, Vascular Dementia, and Alzheimer’s Disease: Molecular Links
Vijayan, M., & Reddy, P. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160527 · Cited by 264 · see citing works
Insulin, cognition, and dementia
Cholerton, B., Baker, L. D., & Craft, S. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.08.008 · Cited by 229 · see citing works
Epidemiology and Etiology of Alzheimer’s disease: From Genetic to Non- Genetic Factors
Jiang, T., Yu, J., Tian, Y., & Tan, L. (2013) · Current Alzheimer Research · doi:10.2174/15672050113109990155 · Cited by 224 · see citing works
Trends in dementia prevalence, incidence, and survival rate in a Japanese community
Ohara, T., Hata, J., Yoshida, D., Mukai, N., Nagata, M., Iwaki, T., Kitazono, T., Kanba, S., Kiyohara, Y., & Ninomiya, T. (2017) · Neurology · doi:10.1212/wnl.0000000000003932 · Cited by 214 · see citing works
Diabetes Mellitus and Dementia
Ninomiya, T. (2014) · Current Diabetes Reports · doi:10.1007/s11892-014-0487-z · Cited by 211 · see citing works
Hypertension, Brain Damage and Cognitive Decline
Gąsecki, D., Kwarciany, M., Nyka, W. M., & Narkiewicz, K. (2013) · Current Hypertension Reports · doi:10.1007/s11906-013-0398-4 · Cited by 211 · see citing works
Modifiable Risk Factors for Alzheimer’s Disease
Edwards III, G. A., Gamez, N., Escobedo Jr., G., Calderon, O., & Moreno-Gonzalez, I. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00146 · Cited by 253 · see citing works
Midlife Hypertension and Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Lennon, M. J., Makkar, S. R., Crawford, J. D., & Sachdev, P. S. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190474 · Cited by 176 · see citing works
Does Education Improve Cognitive Performance Four Decades After School Completion?
Schneeweis, N. E., Skirbekk, V., & Winter‐Ebmer, R. (2014) · Demography · doi:10.1007/s13524-014-0281-1 · Cited by 173 · see citing works
Iadecola, C. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03040 · Cited by 166 · see citing works
Insulin resistance and pathological brain ageing
Cholerton, B., Baker, L. D., & Craft, S. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03464.x · Cited by 160 · see citing works
Hypertension and cognitive dysfunction in elderly: blood pressure management for this global burden
Tadic, M. V., Cuspidi, C., & Hering, D. (2016) · BMC Cardiovascular Disorders · doi:10.1186/s12872-016-0386-0 · Cited by 158 · see citing works
Tooth Loss and Risk of Dementia in the Community: the Hisayama Study
Takeuchi, K., Ohara, T., Furuta, M., Takeshita, T., Shibata, Y., Hata, J., Yoshida, D., Yamashita, Y., & Ninomiya, T. (2017) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14791 · Cited by 154 · see citing works
Oishi, E., Ohara, T., Sakata, S., Fukuhara, M., Hata, J., Yoshida, D., Shibata, M., Ohtsubo, T., Kitazono, T., Kiyohara, Y., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.025667 · Cited by 140 · see citing works
Hypertension and Cognitive Functioning
Elias, M. F., Goodell, A. L., & Dore, G. A. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.186429 · Cited by 136 · see citing works
Autophagy Dysfunction in Alzheimer’s Disease: Mechanistic Insights and New Therapeutic Opportunities
Di Meco, A., Curtis, M. E., Lauretti, E., & Praticò, D. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.008 · Cited by 133 · see citing works
Toledo, J. B., Toledo, E., Weiner, M. W., Jack, C. R., Jagust, W., Lee, V. M. ‐., Shaw, L. M. J., & Trojanowski, J. Q. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.08.008 · Cited by 130 · see citing works
Ozawa, M., Ohara, T., Ninomiya, T., Hata, J., Yoshida, D., Mukai, N., Nagata, M., Uchida, K., Shirota, T., Kitazono, T., et al. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12887 · Cited by 128 · see citing works
Japanese Legacy Cohort Studies: The Hisayama Study
Ninomiya, T. (2018) · Journal of Epidemiology · doi:10.2188/jea.je20180150 · Cited by 115 · see citing works
Blood Pressure and Risk of Vascular Dementia
Emdin, C. A., Rothwell, P. M., Salimi‐Khorshidi, G., Kiran, A., Conrad, N., Callender, T., Mehta, Z., Pendlebury, S. T., Anderson, S. G., Mohseni, H., et al. (2016) · Stroke · doi:10.1161/strokeaha.116.012658 · Cited by 113 · see citing works
Redox proteomics and amyloid β-peptide: Insights into Alzheimer disease
Butterfield, D. A., & Boyd‐Kimball, D. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14589 · Cited by 105 · see citing works
Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease
Takeuchi, K., Matsumoto, K., Furuta, M., Fukuyama, S., Takeshita, T., Ogata, H., Suma, S., Shibata, Y., Shimazaki, Y., Hata, J., et al. (2019) · Journal of Dental Research · doi:10.1177/0022034519833630 · Cited by 104 · see citing works
Higher Blood Pressure as a Risk Factor for Diseases Other Than Stroke and Ischemic Heart Disease
Kokubo, Y., & Iwashima, Y. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.03480 · Cited by 101 · see citing works
High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease
Stukas, S. K., Robert, J., & Wellington, C. L. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.003 · Cited by 96 · see citing works
Prevalence of HTN in Iran: Meta-analysis of Published Studies in 2004-2018
Jafari‐Oori, M., Shahboulaghi, F. M., Nourozi, K., Fallahi‐Khoshknab, M., Ebadi, A., & Gheshlagh, R. G. (2019) · Current Hypertension Reviews · doi:10.2174/1573402115666190118142818 · Cited by 98 · see citing works
Hypertension, Prehypertension, and Hypertension Control
de Menezes, S. T., Giatti, L., Brant, L. C. C., Griep, R. H., Schmidt, M. I., Duncan, B. B., Suemoto, C. K., Ribeiro, A. L. P., & Barreto, S. M. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16080 · Cited by 98 · see citing works
Yoshida, D., Ninomiya, T., Doi, Y., Hata, J., Fukuhara, M., Ikeda, F., Mukai, N., & Kiyohara, Y. (2012) · Journal of Epidemiology · doi:10.2188/jea.je20110083 · Cited by 97 · see citing works
Min, L., Kobayashi, Y., Mogi, M., Tsukuda, K., Yamada, A., Yamauchi, K., Abe, F., Iwanami, J., Xiao, J., & Horiuchi, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171515 · Cited by 92 · see citing works
Li, X.-Y., Zhang, M., Xu, W., Li, J., Cao, X., Yu, J., & Tan, L. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200103111253 · Cited by 90 · see citing works
Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease
Butterfield, D. A., & Boyd-Kimball, D. (2020) · Antioxidants · doi:10.3390/antiox9090818 · Cited by 85 · see citing works
Kishimoto, H., Ohara, T., Hata, J., Ninomiya, T., Yoshida, D., Mukai, N., Nagata, M., Ikeda, F., Fukuhara, M., Kumagai, S., et al. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0125-y · Cited by 87 · see citing works
Roles of vascular risk factors in the pathogenesis of dementia
Takeda, S., Rakugi, H., & Morishita, R. (2019) · Hypertension Research · doi:10.1038/s41440-019-0357-9 · Cited by 65 · see citing works
Vascular dementia: From pathobiology to emerging perspectives
Morgan, A. E., & Auley, M. T. M. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102278 · Cited by 91 · see citing works
Blood Pressure Variability and Dementia: A State-of-the-Art Review
Ma, Y., Tully, P. J., Albert Hofman, D., & Tzourio, C. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa119 · Cited by 83 · see citing works
Blood Pressure Levels and Risks of Dementia: a Nationwide Study of 4.5 Million People
Lee, C. J., Lee, J.-Y., Han, K., Kim, D. H., Cho, H., Kim, K. J., Kang, E. S., Cha, B.-S., Lee, Y., & Park, S. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.17283 · Cited by 81 · see citing works
Robert, J., Stukas, S. K., Button, E. B., Cheng, W. H., Lee, M., Fan, J., Wilkinson, A., Kulić, I., Wright, S. D., & Wellington, C. L. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.10.005 · Cited by 77 · see citing works
Public Knowledge about Dementia in China: A National WeChat-Based Survey
Liu, D., Cheng, G., An, L., Gan, X.-G., Wu, Y., Zhang, B., Hu, S. H., Zeng, Y., & Wu, L. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16214231 · Cited by 77 · see citing works
Ohya, Y., Arakawa, K., Arata, N., Arima, S., Arima, H., Asayama, K., Dohi, Y., Fukami, A., Furuhashi, M., Goto, K., et al. (2026) · Hypertension Research · doi:10.1038/s41440-025-02462-y · Cited by 81 · see citing works
Kidney and epigenetic mechanisms of salt-sensitive hypertension
Kawarazaki, W., & Fujita, T. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00399-2 · Cited by 73 · see citing works
Midlife and Late‐Life Smoking and Risk of Dementia in the Community: The Hisayama Study
Ohara, T., Ninomiya, T., Hata, J., Ozawa, M., Yoshida, D., Mukai, N., Nagata, M., Iwaki, T., Kitazono, T., Kanba, S., et al. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13794 · Cited by 71 · see citing works
Schliep, K. C., Mclean, H., Yan, B., Qeadan, F., Theilen, L. H., de Havenon, A., Majersik, J. J., Østbye, T., Sharma, S., & Varner, M. W. (2023) · Hypertension · doi:10.1161/hypertensionaha.122.19399 · Cited by 69 · see citing works
Kim, Y. J., Kim, S. M., Jeong, D. H., Lee, S., Ahn, M., & Ryu, O. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-00620-5 · Cited by 67 · see citing works
Cognitive and physical function in chronic kidney disease
Weiner, D. E., & Seliger, S. L. (2014) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000444821.87873.7b · Cited by 67 · see citing works
Bell, S. P., Liu, D., Samuels, L. R., Shah, A. S., Gifford, K. A., Hohman, T. J., & Jefferson, A. L. (2017) · The journal of nutrition health & aging · doi:10.1007/s12603-017-0906-3 · Cited by 63 · see citing works
Montgomery, W. S., Ueda, K., Jorgensen, M., Stathis, S., Cheng, Y., & Nakamura, T. (2017) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s146788 · Cited by 63 · see citing works
Takae, K., Hata, J., Ohara, T., Yoshida, D., Shibata, M., Mukai, N., Hirakawa, Y., Kishimoto, H., Tsuruya, K., Kitazono, T., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.006693 · Cited by 61 · see citing works
Visit-to-Visit Blood Pressure Variability in Alzheimer Disease
Lattanzi, S., Viticchi, G., Falsetti, L., Buratti, L., Luzzi, S., Provinciali, L., & Silvestrini, M. (2014) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000040 · Cited by 58 · see citing works
Epidemiological Evidence of the Relationship Between Diabetes and Dementia
Ninomiya, T. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_2 · Cited by 57 · see citing works
Guo, J., Brickman, A. M., Manly, J. J., Reitz, C., Schupf, N., Mayeux, R. P., & Gu, Y. (2021) · Alzheimer's & Dementia · doi:10.1002/alz.12359 · Cited by 56 · see citing works
Otobe, Y., Hiraki, K., Hotta, C., Nishizawa, H., Izawa, K. P., Taki, Y., Imai, N., Sakurada, T., & Shibagaki, Y. (2017) · Nephrology · doi:10.1111/nep.13173 · Cited by 55 · see citing works
Clinical observation on effect of scalp electroacupuncture for mild cognitive impairment
Zhang, H., Zhao, L., Yang, S., Chen, Z., Li, Y., Peng, X., Yang, Y., & Zhu, M. (2013) · 中医杂志：英文版 · doi:10.1016/s0254-6272(13)60099-0 · Cited by 53 · see citing works
Aortic Stiffness is Associated with Increased Risk of Incident Dementia in Older Adults
Cui, C., Sekikawa, A. M., Kuller, L. H., López, O. L., Newman, A. B., Kuipers, A. L., & Mackey, R. H. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180449 · Cited by 52 · see citing works
Hypertension and Dementia: A comprehensive review from the HOPE Asia Network
Turana, Y., Tengkawan, J., Chia, Y. C., Hoshide, S., Shin, J., Chen, C., Buranakitjaroen, P., Nailes, J. M., Park, S., Siddique, S., et al. (2019) · Journal of Clinical Hypertension · doi:10.1111/jch.13558 · Cited by 51 · see citing works
The Association between Hypertension and Dementia in the Elderly
Igase, M., Kohara, K., & Miki, T. (2011) · International Journal of Hypertension · doi:10.1155/2012/320648 · Cited by 50 · see citing works
Nasoohi, S., Parveen, K., & Ishrat, T. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180735 · Cited by 51 · see citing works
Hatabe, Y., Shibata, M., Ohara, T., Oishi, E., Yoshida, D., Honda, T., Hata, J., Kanba, S., Kitazono, T., & Ninomiya, T. (2018) · Journal of Epidemiology · doi:10.2188/jea.je20180137 · Cited by 48 · see citing works
Prevalence, awareness, and control of hypertension in elderly and very elderly in Poland
Zdrojewski, T. R., Wizner, B., Więcek, A., Ślusarczyk, P., Chudek, J. T., Mossakowska, M., Bandosz, P., Bobák, M., Kozakiewicz, K., Broda, G., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000823 · Cited by 47 · see citing works
Shang, S., Li, P., Deng, M., Jiang, Y., Chen, C., & Qu, Q. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159485 · Cited by 47 · see citing works
Framingham Risk Score and the Risk of Progression from Mild Cognitive Impairment to Dementia
Viticchi, G., Falsetti, L., Buratti, L., Sajeva, G., Luzzi, S., Bartolini, M., Provinciali, L., & Silvestrini, M. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170160 · Cited by 45 · see citing works
Blood pressure, smoking and alcohol use, association with vascular dementia
Peters, R. K. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.05.018 · Cited by 42 · see citing works
Annear, M. J., Otani, J., & Li, J. (2016) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12911 · Cited by 41 · see citing works
Ding, L., Zhu, X., Xiong, Z., Yang, F., & Zhang, X. (2022) · Journal of General Internal Medicine · doi:10.1007/s11606-022-07951-1 · Cited by 39 · see citing works
Treating Hypertension to Prevent Cognitive Decline and Dementia: Re-Opening the Debate
Iulita, M. F., & Girouard, H. (2016) · Advances in experimental medicine and biology · doi:10.1007/5584_2016_98 · Cited by 36 · see citing works
Mukai, N., Ohara, T., Hata, J., Hirakawa, Y., Yoshida, D., Kishimoto, H., Koga, M., Nakamura, U., Kitazono, T., Kiyohara, Y., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00439 · Cited by 34 · see citing works
Increasing complexity: which drug class to choose for treatment of hypertension in the elderly?
Schäfer, H., Kaiser, E. A., & Lotze, U. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s40154 · Cited by 36 · see citing works
Nishihira, J., Tokashiki, T., Higashiuesato, Y., Willcox, D. C., Mattek, N., Shinto, L. H., Ohya, Y., & Dodge, H. H. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150910 · Cited by 34 · see citing works
Lourenço, J. S., Serrano, A., Santos‐Silva, A., Gomes, M., Afonso, C., Freitas, P., Paúl, C., & Costa, E. M. (2018) · Aging and Disease · doi:10.14336/ad.2017.0128 · Cited by 35 · see citing works
Association Between Serum β-Alanine and Risk of Dementia
Hata, J., Ohara, T., Katakura, Y., Shimizu, K., Yamashita, S., Yoshida, D., Honda, T., Hirakawa, Y., Shibata, M., Sakata, S., et al. (2019) · American Journal of Epidemiology · doi:10.1093/aje/kwz116 · Cited by 33 · see citing works
Blood pressure and Alzheimer's disease: A review of meta-analysis
Saiz-Vázquez, O., Puente-Martínez, A., Pacheco, J., & Ubillos-Landa, S. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2022.1065335 · Cited by 30 · see citing works
Cho, Y., Han, K., Kim, D. H., Park, Y., Yoon, K., Kim, M. K., & Lee, S. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2020.935 · Cited by 32 · see citing works
Hu, H., Wu, B., Ou, Y., Ma, Y., Huang, Y., Cheng, W., Tan, L., & Yu, J. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01923-z · Cited by 31 · see citing works
Vascular Aging and Cognitive Dysfunction: Silent Midlife Crisis in the Brain
Lin, C.-H., Cheng, H., Chuang, S., & Chen, C. (2017) · Pulse · doi:10.1159/000481734 · Cited by 30 · see citing works
Seraj, Z., Al-Najjar, D., Akl, M. A., Aladle, N., Altijani, Y., Zaki, A. F., & Kawas, S. A. (2017) · International Journal of Dentistry · doi:10.1155/2017/5732748 · Cited by 31 · see citing works
Valenzuela, M., Esler, M., Ritchie, K. A., & Brodaty, H. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.28 · Cited by 26 · see citing works
Ryuno, H., Kamide, K., Gondo, Y., Kabayama, M., Oguro, R., Nakama, C., Yokoyama, S., Nagasawa, M., Maeda, S., Imaizumi, Y., et al. (2017) · Hypertension Research · doi:10.1038/hr.2017.15 · Cited by 27 · see citing works
Genetic and environmental factors in vascular dementia: an update of blood brain barrier dysfunction
Srinivasan, V., Braidy, N., Chan, E. K. W., Xu, Y., & Chan, D. K. Y. (2016) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12558 · Cited by 28 · see citing works
Alzheimer's disease knowledge among American Indians and Alaska Natives
Jernigan, M., Boyd, A. D., Noonan, C., & Buchwald, D. (2020) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12101 · Cited by 25 · see citing works
Ryuno, H., Kamide, K., Gondo, Y., Nakama, C., Oguro, R., Kabayama, M., Kawai, T., Kusunoki, H., Yokoyama, S., Imaizumi, Y., et al. (2016) · Hypertension Research · doi:10.1038/hr.2016.25 · Cited by 25 · see citing works
Chen, J. X. Y., Vipin, A., Sandhu, G. K., Leow, Y. J., Zailan, F. Z., Tanoto, P., Lee, E. S., Lee, K. L., Cheung, C., & Kandiah, N. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2024.100029 · Cited by 22 · see citing works
- Authors
- Ninomiya, T., Ohara, T., Hirakawa, Y., Yoshida, D., Doi, Y., Hata, J., Kanba, S., Iwaki, T., & Kiyohara, Y.
- Affiliations
- Kyushu University (JP)
- Venue
- Hypertension
- Published
- 2011-07
- Volume
- 58
- Issue
- 1
- Pages
- 22-28
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2129684069
- Cited by
- 230
- References
- 43
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 10 · 2023: 14 · 2022: 16 · 2021: 20 · 2020: 16 · 2019: 21 · 2018: 19 · 2017: 22 · 2016: 17 · 2015: 13 · 2014: 18 · 2013: 12 · 2012: 14
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (23590798, 22300116, 22240073)
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- blood pressure, midlife hypertension, vascular dementia, Alzheimer's disease, dementia risk factors, prehypertension, Japanese older adults, community-dwelling older adults
- MeSH terms
- Aged, Aging, Blood Pressure, Female, Humans, Hypertension, Japan, Male, Prospective Studies, Risk Factors, Urban Population, Dementia, Vascular, Incidence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
