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Cited by 190Multiple Sclerosis Research StudiesPolyomavirus and related diseasesClimate Change and Health Impacts

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Incidence of MS has increased markedly over six decades in Denmark particularly with late onset and in women

Koch-Henriksen, Nils, Thygesen, Lau Caspar, Stenager, Egon, Laursen, Bjarne, Magyari, Melinda·2018·Neurology
DOI 10.1212/wnl.0000000000005612
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Abstract

Objective To describe the pattern of development of incidence of multiple sclerosis (MS) over 60 years in Denmark with age-period-cohort analyses and seasonality of birth. Methods Data on virtually all patients with onset of MS have since 1950 been prospectively recorded and kept in the Danish Multiple Sclerosis Registry with multiple sources of notification. Annualized incidence rates per 100,000 were directly standardized to the European Standard Population. Results We have registered 19,536 cases with clinical onset of confirmed MS in Denmark from 1950 to 2009. From the 1950-1959 to the 2000-2009 onset period, incidence more than doubled in women, with an increase from 5.91 (95% confidence interval [CI]: 5.60-6.24) to 12.33 (95% CI: 11.91-12.75) per 100,000 per year compared with a modest 24% increase in men from 4.52 (95% CI: 4.24-4.81) to 6.08 (95% CI: 5.79-6.38). With age at onset of 50 years and older, incidence increased with a factor 4.30 in women and 2.72 in men. The female/male sex ratio increased over time and with year of birth. Age-period-cohort analysis revealed a significant birth cohort effect in addition to the age and period effect. We found no statistically significant seasonality of births. Conclusion The incidence of MS has doubled in women, most pronounced with late onset, and has only modestly increased in men. Lifestyle changes in the female population that could include fewer childbirths, increased occurrence of obesity, and increased cigarette consu…

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Crossref · 10.1212/wnl.0000000000005612

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Research works printed but not linked: 3

  1. Hyllested K. Disseminated Sclerosis in Denmark: Prevalence and Geographical Distribution [doctoral thesis]. Copenhagen: J. Jørgensen; 1956.
  2. Allison RS, Millar JDH. Prevalence and familial incidence of disseminated sclerosis. Ulster Med J 1954;23(suppl 2):1–92.
  3. 10.1111/ane.12615 · DOI

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Metadata

Authors
Koch-Henriksen, N., Thygesen, L. C., Stenager, E., Laursen, B., & Magyari, M.
Affiliations
  • From the Clinical Institute (N.K.-H.), Department of Clinical Epidemiology, University of Aarhus; Danish Multiple Sclerosis Registry (N.K.-H., E.S., M.M.) and Department of Neurology (M.M.), Rigshospitalet, University of Copenhagen; National Institute of Public Health (L.C.T., B.L.), University of Southern Denmark in Copenhagen; Institute of Regional Health Research (E.S.), University of Southern Denmark, Odense.
  • University of Copenhagen (DK)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-05-29
Volume
90
Issue
22
Pages
e1954-e1963
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000005612
OpenAlex
W2799594477
Cited by
188
References
45
Citations by year
2026: 17 · 2025: 25 · 2024: 23 · 2023: 25 · 2022: 27 · 2021: 19 · 2020: 21 · 2019: 25 · 2018: 6
FWCI
13.49
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
  • Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Climate Change and Health Impacts
Keywords
multiple sclerosis, incidence trends, sex differences, late-onset multiple sclerosis, birth cohort effects, birth seasonality, age-period-cohort analysis, lifestyle factors, Denmark
MeSH terms
Adult, Denmark, Female, Humans, Male, Middle Aged, Multiple Sclerosis, Prospective Studies, Registries, Sex Factors, Incidence, Age of Onset, Young Adult

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