The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Effect of Changes in MS Diagnostic Criteria Over 25 Years on Time to Treatment and Prognosis in Patients With Clinically Isolated Syndrome
Open accessAbstract
Background and objectives To explore whether time to diagnosis, time to treatment initiation, and age to reach disability milestones have changed in patients with clinically isolated syndrome (CIS) according to different multiple sclerosis (MS) diagnostic criteria periods. Methods This retrospective study was based on data collected prospectively from the Barcelona-CIS cohort between 1994 and 2020. Patients were classified into 5 periods according to different MS criteria, and the times to MS diagnosis and treatment initiation were evaluated. The age at which patients with MS reached an Expanded Disability Status Scale (EDSS) score ≥3.0 was assessed by Cox regression analysis according to diagnostic criteria periods. Last, to remove the classic Will Rogers phenomenon by which the use of different MS criteria over time might result in a changes of prognosis, the 2017 McDonald criteria were applied, and age at EDSS score ≥3.0 was assessed by Cox regression. Results In total, 1,174 patients were included. The median time from CIS to MS diagnosis and from CIS to treatment initiation showed a 77% and 82% reduction from the Poser to the McDonald 2017 diagnostic criteria periods, respectively. Patients of a given age diagnosed in more recent diagnostic criteria periods had a lower risk of reaching an EDSS score ≥3.0 than patients of the same age diagnosed in earlier diagnostic periods (reference category Poser period): adjusted hazard ratio (aHR) 0.47 (95% confidence interval 0.24-0…
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“earlier diagnosis enables earlier initiation of DMT, which has been consistently associated with improved long-term outcomes like reduced relapse rates or lower disability accrual.”
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Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria
Polman, C. H., Reingold, S. C., Banwell, B., Clanet, M., Cohen, J. A., Filippi, M., Fujihara, K., Havrdova, E., Hutchinson, M., Kappos, L., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22366 · Cited by 9,802
A longitudinal study of abnormalities on MRI and disability from multiple sclerosis
Brex, P. A., Ciccarelli, O., O'Riordan, J. I., Sailer, M., Thompson, A. J., & Miller, D. H. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011341 · Cited by 861
Koch-Henriksen, N., Thygesen, L. C., Stenager, E., Laursen, B., & Magyari, M. (2018) · Neurology · doi:10.1212/wnl.0000000000005612 · Cited by 188
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Vidal-Jordana, A., Rovira, A., Calderon, W., Arrambide, G., Castilló, J., Moncho, D., Rahnama, K., Collorone, S., Toosy, A. T., Ciccarelli, O., et al. (2024) · Neurology · doi:10.1212/wnl.0000000000207805 · Cited by 88
Self-citationOligoclonal bands and kappa free light chains: Competing parameters or complementary biomarkers?
Konen, F. F., Wurster, U., Schwenkenbecher, P., Gerritzen, A., Groß, C. C., Eichhorn, P., Harrer, A., Isenmann, S., Lewczuk, P., Lewerenz, J., et al. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103765 · Cited by 31
Konen, F. F., Mahmoudi, N., Albers, L. M., Arrambide, G., Streichert, A. L., Haar, M., Soldatov, A., Bucak, E., Jendretzky, K. F., Nay, S., et al. (2026) · eClinicalMedicine · doi:10.1016/j.eclinm.2026.104098
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Metadata
- Authors
- Tintore, M., Cobo-Calvo, A., Carbonell, P., Arrambide, G., Otero-Romero, S., Río, J., Tur, C., Comabella, M., Nos, C., Arévalo, M. J., Midaglia, L., Galán, I., Vidal-Jordana, A., Castilló, J., Rodríguez-Acevedo, B., Zabalza de Torres, A., Salerno, A., Auger, C., Sastre-Garriga, J., Rovira, À., & Montalban, X.
- Affiliations
- From the Department of Neurology/Neuroimmunology (M.T., A.C.-C., P.C., G.A., S.O.-R., J.R., C.T., M.C., C.N., M.J.A., L.M., I.G., A.V.-J., J.C., B.R.-A., A.Z., J.S.-G., X.M.) Centre d’Esclerosi Múltiple de Catalunya (Cemcat), and Department of Radiology (IDI) (A.S., C.A., À.R.), Section of Neuroradiology and Magnetic Resonance Unit, Vall d’Hebron Institut de Recerca, Hospital Universitari Vall d´Hebron, Universitat Autònoma de Barcelona, Spain.
- Universitat Autònoma de Barcelona (ES)
- ORCID
- Venue
- Neurology
- Published
- 2021-10-26
- Volume
- 97
- Issue
- 17
- Pages
- e1641-e1652
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W3201411969
- Cited by
- 90
- References
- 3
- Citations by year
- 2026: 20 · 2025: 21 · 2024: 12 · 2023: 16 · 2022: 17 · 2021: 3
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- public-domain
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- DRYAD (public-domain)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Family Practice › Clinical Reasoning and Diagnostic Skills
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Keywords
- multiple sclerosis, clinically isolated syndrome, McDonald criteria, Poser criteria, time to diagnosis, time to treatment, Expanded Disability Status Scale, disability progression, prognosis, Will Rogers phenomenon, disease-modifying therapy, early treatment effects
- MeSH terms
- Adult, Demyelinating Diseases, Humans, Multiple Sclerosis, Retrospective Studies, Spain, Disease Progression, Time-to-Treatment
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