The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Association between diabetes and subsequent Parkinson disease: A record-linkage cohort study
Abstract
Objective To investigate the association between type 2 diabetes mellitus (T2DM) and subsequent Parkinson disease (PD). Methods Linked English national Hospital Episode Statistics and mortality data (1999–2011) were used to conduct a retrospective cohort study. A cohort of individuals admitted for hospital care with a coded diagnosis of T2DM was constructed, and compared to a reference cohort. Subsequent PD risk was estimated using Cox regression models. Individuals with a coded diagnosis of cerebrovascular disease, vascular parkinsonism, drug-induced parkinsonism, and normal pressure hydrocephalus were excluded from the analysis. Results A total of 2,017,115 individuals entered the T2DM cohort and 6,173,208 entered the reference cohort. There were significantly elevated rates of PD following T2DM (hazard ratio [HR] 1.32, 95% confidence interval [CI] 1.29–1.35; p < 0.001). The relative increase was greater in those with complicated T2DM (HR 1.49, 95% CI 1.42–1.56) and when comparing younger individuals (HR 3.81, 95% CI 2.84–5.11 in age group 25–44 years). Conclusions We report an increased rate of subsequent PD following T2DM in this large cohort study. These findings may reflect shared genetic predisposition and/or disrupted shared pathogenic pathways with potential clinical and therapeutic implications.
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“Diabetes is a well-established risk factor for PD, and has been linked to a faster disease progression”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [613]
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Cites
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“A recent doubleblind trial involving 62 patients with PD randomly assigned to placebo or exenatide 2-mg weekly injections showed positive and persistent effects on motor symptoms measured by section 3 of the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale.(9)Whether the effect is secondary to sympto…”
BackgroundSelf-citationMeta‐analysis of early nonmotor features and risk factors for Parkinson disease
Noyce, A. J., Bestwick, J. P., Silveira‐Moriyama, L., Hawkes, C. H., Giovannoni, G., Lees, A. J., & Schrag, A. E. (2012) · Annals of Neurology · doi:10.1002/ana.23687 · Cited by 834
Self-citationType 2 Diabetes and the Risk of Parkinson's Disease
Hu, G., Jousilahti, P., Bidel, S., Antikainen, R., & Tuomilehto, J. (2007) · Diabetes Care · doi:10.2337/dc06-2011 · Cited by 466
Diabetes and Risk of Parkinson’s Disease
Xu, Q., Park, Y., Huang, X., Hollenbeck, A. R., Blair, A. E., Schatzkin, A. G., & Chen, H. (2011) · Diabetes Care · doi:10.2337/dc10-1922 · Cited by 282
Diabetes and Risk of Parkinson’s Disease
Cereda, E., Barichella, M., Pedrolli, C., Klersy, C., Cassani, E., Caccialanza, R., & Pezzoli, G. (2011) · Diabetes Care · doi:10.2337/dc11-1584 · Cited by 247
Obesity, diabetes, and risk of Parkinson's disease
Palacios, N., Gao, X., McCullough, M. L., Jacobs, E. J., Patel, A. V., Mayo, T. L., Schwarzschild, M. A., & Ascherio, A. (2011) · Movement Disorders · doi:10.1002/mds.23855 · Cited by 170
Neuroendocrine abnormalities in Parkinson's disease
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Association between Parkinson's disease and diabetes: Data from NEDICES study
Pablo‐Fernández, E. D., Hidalgo, F. S., Benito‐León, J., & Bermejo‐Pareja, F. (2017) · Acta Neurologica Scandinavica · doi:10.1111/ane.12793 · Cited by 63
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Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology
Simon, D. K., Tanner, C. M., & Brundin, P. (2020) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2019.08.002 · Cited by 1,114
Update of the MDS research criteria for prodromal Parkinson's disease
Heinzel, S., Berg, D., Gasser, T., Chen, H., Yao, C. W., Postuma, R. B., & the MDS Task Force on the Definition of Parkinson's Disease (2019) · Movement Disorders · doi:10.1002/mds.27802 · Cited by 804
Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis
Johnson, M., Stecher, B., Labrie, V., Brundin, L., & Brundin, P. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.09.007 · Cited by 321
Sun, J., Li, H., Jin, Y., Yu, J., Mao, S., Su, K.-P., Ling, Z., & Liu, J. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.10.014 · Cited by 264
Metadata
- Authors
- De Pablo-Fernandez, E., Goldacre, R., Pakpoor, J., Noyce, A. J., & Warner, T. T.
- Affiliations
- From the Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neurosciences (E.D.P.-F., A.J.N., T.T.W.), and Queen Square Brain Bank for Neurological Disorders (E.D.P.-F., T.T.W.), UCL Institute of Neurology, London; Unit of Health-Care Epidemiology (R.G., J.P.), Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford; and Preventive Neurology Unit (A.J.N.), Wolfson Institute of Preventive...
- Queen Mary University of London (GB)
- Venue
- Neurology
- Published
- 2018-07-10
- Volume
- 91
- Issue
- 2
- Pages
- e139-e142
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2807806732
- Cited by
- 242
- References
- 9
- Citations by year
- 2026: 23 · 2025: 21 · 2024: 36 · 2023: 28 · 2022: 29 · 2021: 35 · 2020: 34 · 2019: 26 · 2018: 9
- FWCI
- 17.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Prothena
- Barts Charity (MGU0364)
- National Institute for Health and Care Research (RNC/035/02)
- Parkinson's UK
- Brain Research Trust
- University College London
- University of Oxford
- Britannia Pharmaceuticals
- Medical Research Council (MR/L023784/2, MR/L023784/1)
- NIHR Oxford Biomedical Research Centre
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- type 2 diabetes, Parkinson's disease, risk factors, complicated diabetes, young adults, pathogenic pathways
- MeSH terms
- Adult, Age Factors, Aged, Diabetes Mellitus, Type 2, England, Female, Humans, Male, Middle Aged, Parkinson Disease, Retrospective Studies, Risk Factors, Comorbidity, Case-Control Studies
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- De Pablo-Fernandez, E., Goldacre, R., Pakpoor, J., Noyce, A. J., & Warner, T. T. (2018). Association between diabetes and subsequent Parkinson disease: A record-linkage cohort study. Neurology. https://doi.org/10.1212/wnl.0000000000005771
