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Prevalence of sleep-disordered breathing after stroke and TIA: A meta-analysis
Open accessAbstract
Objective To perform a systematic review and meta-analysis on the prevalence of sleep-disordered breathing (SDB) after stroke. Methods We searched PubMed, Embase (Ovid), the Cochrane Library, and CINAHL (from their commencements to April 7, 2017) for clinical studies reporting prevalence and/or severity of SDB after stroke or TIA. Only sleep apnea tests performed with full polysomnography and diagnostic devices of the American Academy of Sleep Medicine categories I–IV were included. We conducted random-effects meta-analysis. PROSPERO registration number: CRD42017072339. Results The initial search identified 5,211 publications. Eighty-nine studies (including 7,096 patients) met inclusion criteria. Fifty-four studies were performed in the acute phase after stroke (after less than 1 month), 23 studies in the subacute phase (after 1–3 months), and 12 studies in the chronic phase (after more than 3 months). Mean apnea-hypopnea index was 26.0/h (SD 21.7–31.2). Prevalence of SDB with apnea-hypopnea index greater than 5/h and greater than 30/h was found in 71% (95% confidence interval 66.6%–74.8%) and 30% (95% confidence interval 24.4%–35.5%) of patients, respectively. Severity and prevalence of SDB were similar in all examined phases after stroke, irrespective of the type of sleep apnea test performed. Heterogeneity between studies (I2) was mostly high. Conclusion The high prevalence of SDB after stroke and TIA, which persists over time, is important in light of recent studies reporting the (1) feasibility and (2) efficacy of SDB treatment in this clinical setting.
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“A recent meta-analysis found a prevalence of poststroke OSA of 71%, with similar findings across acute, subacute, and chronic time points.36”
From Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2021) · cites this paper as [36]
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Metadata
- Authors
- Seiler, A., Camilo, M., Korostovtseva, L., Haynes, A. G., Brill, A.-K., Horvath, T., Egger, M., & Bassetti, C. L.
- Affiliations
- University of Bern (CH)
- From the Sleep Wake Epilepsy Center (A.S., M.C., L.K., A.-K.B., T.H., C.L.B.), and Departments of Neurology (A.S., M.C., L.K., T.H., C.L.B.) and Pulmonary Medicine (A.-K.B.), Bern University Hospital, University of Bern, Switzerland; Neurology Division (M.C.), Department of Neuroscience and Behavioral Sciences, Ribeirão Preto School of Medicine, University of São Paulo, Brazil; Hypertension Department (L.K.), Somnology Group, Almazov National Medical Research Center, St. Petersburg, Russia; and CTU...
- ORCID
- Venue
- Neurology
- Published
- 2019-02-12
- Volume
- 92
- Issue
- 7
- Pages
- e648-e654
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2909717799
- Cited by
- 234
- References
- 49
- Citations by year
- 2026: 32 · 2025: 36 · 2024: 33 · 2023: 43 · 2022: 26 · 2021: 29 · 2020: 24 · 2019: 10
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Bern Open Repository and Information System (University of Bern) (submittedVersion, other-oa)
- Open Access CRIS of the University of Bern
- Funders
- University of Bern
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- sleep-disordered breathing, stroke, transient ischemic attack, sleep apnea, prevalence, apnea-hypopnea index, polysomnography, post-stroke sleep disorders, disease severity
- MeSH terms
- Ischemic Attack, Transient, Humans, Severity of Illness Index, Sleep Apnea Syndromes, Prevalence, Polysomnography, Sleep Apnea, Obstructive, Sleep Apnea, Central, Stroke
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