The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Association of epileptiform abnormalities and seizures in Alzheimer disease.
Open accessAbstract
Objective To examine the relationship between scalp EEG biomarkers of hyperexcitability in Alzheimer disease (AD) and to determine how these electric biomarkers relate to the clinical expression of seizures in AD. Methods In this cross-sectional study, we performed 24-hour ambulatory scalp EEGs on 43 cognitively normal elderly healthy controls (HC), 41 participants with early-stage AD with no history or risk factors for epilepsy (AD-NoEp), and 15 participants with early-stage AD with late-onset epilepsy related to AD (AD-Ep). Two epileptologists blinded to diagnosis visually reviewed all EEGs and annotated all potential epileptiform abnormalities. A panel of 9 epileptologists blinded to diagnosis was then surveyed to generate a consensus interpretation of epileptiform abnormalities in each EEG. Results Epileptiform abnormalities were seen in 53% of AD-Ep, 22% of AD-NoEp, and 4.7% of HC. Specific features of epileptiform discharges, including high frequency, robust morphology, right temporal location, and occurrence during wakefulness and REM, were associated with clinical seizures in AD. Multiple EEG biomarkers concordantly demonstrated a pattern of left temporal lobe hyperexcitability in early stages of AD, whereas clinical seizures in AD were often associated with bitemporal hyperexcitability. Frequent small sharp spikes were specifically associated with epileptiform EEGs and thus identified as a potential biomarker of hyperexcitability in AD. Conclusion Epileptiform abnorm…
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“In Alzheimer’s disease (AD), which is the most common tauopathy, an estimated 60% of patients have seizures and subclinical epileptic activity (Vossel et al., 2016, 2017; Lam et al., 2020; Horvath et al., 2021).”
From Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms (2022) · cites this paper as Lam et al., 2020
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“Participants recruited from clinics had probable AD according to the National Institute on Aging–Alzheimer’s Association diagnostic guidelines.(26,27)”
Seizures and Epilepsy in Alzheimer's Disease
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Blood-brain barrier leakage in Alzheimer’s disease: From discovery to clinical relevance
Nehra, G., Bauer, B., & Hartz, A. M. S. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108119 · Cited by 127
Epilepsy in Down Syndrome: A Highly Prevalent Comorbidity
Altuna, M., Giménez, S., & Fortea, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132776 · Cited by 99
Chang, C.-W., Evans, M. D., Yu, X., Yu, G.-Q., & Mucke, L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109855 · Cited by 81
Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms
Hwang, K., Vaknalli, R. N., Addo-Osafo, K., Vicente, M., & Vossel, K. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.903973 · Cited by 35
Metadata
- Authors
- Lam, A. D., Sarkis, R. A., Pellerin, K. R., Jing, J., Dworetzky, B. A., Hoch, D. B., Jacobs, C. S., Lee, J. W., Weisholtz, D. S., Zepeda, R., Westover, M. B., Cole, A. J., & Cash, S. S.
- Affiliations
- Brigham and Women's Hospital (US)
- ORCID
- Venue
- Neurology
- Published
- 2020-10-20
- Volume
- 95
- Issue
- 16
- Pages
- e2259-e2270
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC7713786
- OpenAlex
- W3046988908
- Cited by
- 172
- References
- 3
- Citations by year
- 2026: 22 · 2025: 36 · 2024: 32 · 2023: 37 · 2022: 22 · 2021: 21 · 2020: 1
- FWCI
- 14.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P30AG062421)
- National Institute of Neurological Disorders and Stroke (R01NS102574, R01NS062092, K23NS090900, K23NS101037, K24NS088568, R01NS102190, R01NS107291, R25NS065743)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, epileptiform abnormalities, seizures, hyperexcitability, EEG biomarkers, REM sleep, seizure risk
- MeSH terms
- Aged, Alzheimer Disease, Cross-Sectional Studies, Electroencephalography, Epilepsy, Female, Humans, Male, Risk Factors, Seizures, Biomarkers
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