Seizures and Epilepsy in Alzheimer's Disease
Open accessAbstract
SUMMARY: Many studies have shown that patients with Alzheimer's disease (AD) are at increased risk for developing seizures and epilepsy. However, reported prevalence and incidence of seizures and relationship of seizures to disease measures such as severity, outcome, and progression vary widely between studies. We performed a literature review of the available clinical and epidemiological data on the topic of seizures in patients with AD. We review seizure rates and types, risk factors for seizures, electroencephalogram (EEG) studies, and treatment responses. Finally, we consider limitations and methodological issues. There is considerable variability in the reported prevalence and incidence of seizures in patients with AD—with reported lifetime prevalence rates of 1.5–64%. More recent, prospective, and larger studies in general report lower rates. Some, but not all, studies have noted increased seizure risk with increasing dementia severity or with younger age of AD onset. Generalized convulsive seizures are the most commonly reported type, but often historical information is the only basis used to determine seizure type and the manifestation of seizures may be difficult to distinguish from other behaviors common in demented patients. EEG has infrequently been performed and reported. Data on treatment of seizures in AD are extremely limited. Similarly, the relationship between seizures and cognitive impairment in AD is unclear. We conclude that the literature on seizures and epilepsy in AD, including diagnosis, risk factors, and response to treatment suffers from methodological limitations and gaps.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Disorders accompanied by alterations in spine numbers, including neurodegenerative and neuropsychiatric disorders, are frequently associated with development of anxiety and seizures and cognitive decline.
“Disorders accompanied by alterations in spine numbers, including neurodegenerative and neuropsychiatric disorders, are frequently associated with the development of anxiety and seizures33 and cognitive decline34.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Incidence of Epilepsy and Unprovoked Seizures in Rochester, Minnesota: 1935–1984
Hauser, W. A., Annegers, J. F., & Kurland, L. T. (1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb02586.x · Cited by 2,084 · see citing works
Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653 · see citing works
Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works
How common are the "common" neurologic disorders?
Hirtz, D., Thurman, D. J., Gwinn-Hardy, K., Mohamed, M., Chaudhuri, A. R., & Zalutsky, R. (2007) · Neurology · doi:10.1212/01.wnl.0000252807.38124.a3 · Cited by 1,365 · see citing works
HOW COMMON ARE THE “COMMON” NEUROLOGIC DISORDERS?
Kaplin, A. I., & Williams, M. (2007) · Neurology · doi:10.1212/01.wnl.0000278071.91524.4d · Cited by 1,132 · see citing works
Turski, W. A., Cavalheiro, É. A., Schwarz, M., Czuczwar, S. J., Kleinrok, Z., & Turski, L. (1983) · Behavioural Brain Research · doi:10.1016/0166-4328(83)90136-5 · Cited by 1,114 · see citing works
Brain Inflammation in Epilepsy: Experimental and Clinical Evidence
Vezzani, A., & Granata, T. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00298.x · Cited by 1,038 · see citing works
Apolipoprotein E and Alzheimer disease.
Strittmatter, W. J., & Roses, A. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4725 · Cited by 699 · see citing works
Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy
Minkeviciene, R., Rheims, S., Dobszay, M. B., Zilberter, M. Y., Hartikainen, J., Fülöp, L., Penke, B., Zilberter, Y., Harkany, T., Pitkänen, A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5215-08.2009 · Cited by 648 · see citing works
Neuron Number in the Entorhinal Cortex and CA1 in Preclinical Alzheimer Disease
Price, J. L., Ko, A. I., Wade, M. J., Tsou, S. K., McKeel, D. W., & Morris, J. C. (2001) · Archives of Neurology · doi:10.1001/archneur.58.9.1395 · Cited by 596 · see citing works
Incidence and Predictors of Seizures in Patients with Alzheimer's Disease
Amatniek, J. C., Hauser, W. A., del Castillo–Castañeda, C., Jacobs, D. M., Marder, K. S., Bell, K. L., Albert, M., Brandt, J., & Stern, Y. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00554.x · Cited by 592 · see citing works
A Prospective Study of Alzheimer Disease in Down Syndrome
Lai, F., & Williams, R. S. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520440031017 · Cited by 561 · see citing works
Scharfman, H. E. (2007) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-007-0053-z · Cited by 524 · see citing works
Rowan, A. J., Ramsay, R. E., Collins, J. F., Pryor, F. M., Boardman, K. D., Uthman, B. M., Spitz, M. C., Frederick, T. E., Towne, A. R., Carter, G. S., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000167384.68207.3e · Cited by 509 · see citing works
Intracranial EEG Substrates of Scalp EEG Interictal Spikes
Tao, J. X., Ray, A. K., Hawes‐Ebersole, S., & Ebersole, J. S. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.11404.x · Cited by 425 · see citing works
Validation of clinical diagnostic criteria for Alzheimer's disease
Morris, J. C., McKeel, D. W., Fulling, K., Torack, R. M., & Berg, L. (1988) · Annals of Neurology · doi:10.1002/ana.410240105 · Cited by 362 · see citing works
Ólafsson, E., Lúðvígsson, P., Hesdorffer, D. C., Kjartansson, Ó., Hauser, W. A., & Guðmundsson, G. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70172-1 · Cited by 354 · see citing works
Effects of Psychotropic Drugs on Seizure Threshold
Pisani, F., Oteri, G., Costa, C., Raimondo, G. D., & Perri, R. D. (2002) · Drug Safety · doi:10.2165/00002018-200225020-00004 · Cited by 353 · see citing works
Phenotype associated with APP duplication in five families
Cabrejo, L., Guyant‐Maréchal, L., Laquerrière, A., Vercelletto, M., Fournière, F. D. L., Thomas-Antérion, C., Verny, C., Letournel, F., Pasquier, F., Vital, A., et al. (2006) · Brain · doi:10.1093/brain/awl237 · Cited by 342 · see citing works
Seizures and myoclonus in patients with Alzheimer's disease
Hauser, W. A., Morris, M. L., Heston, L. L., & Anderson, V. E. (1986) · Neurology · doi:10.1212/wnl.36.9.1226 · Cited by 336 · see citing works
Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG?
Binnie, C. D. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00584-2 · Cited by 332 · see citing works
Interictal EEG and the Diagnosis of Epilepsy
Pillai, J., & Sperling, M. R. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00654.x · Cited by 318 · see citing works
Dementia and adult-onset unprovoked seizures
Hesdorffer, D. C., Hauser, W. A., Annegers, J. F., Kokmen, E., & Rocca, W. A. (1996) · Neurology · doi:10.1212/wnl.46.3.727 · Cited by 311 · see citing works
Scarmeas, N., Honig, L. S., Choi, H., Cantero, J., Brandt, J., Blacker, D., Albert, M., Amatniek, J. C., Marder, K. S., Bell, K. L., et al. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.130 · Cited by 293 · see citing works
Self-citationAtherosclerosis and AD: Analysis of data from the US National Alzheimer’s Coordinating Center
Honig, L. S., Kukull, W., & Mayeux, R. (2005) · Neurology · doi:10.1212/01.wnl.0000150886.50187.30 · Cited by 284 · see citing works
Self-citationLarner, A. J., & Doran, M. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0019-5 · Cited by 256 · see citing works
Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2
Jayadev, S., Leverenz, J. B., Steinbart, E. J., Stahl, J. H., Klunk, W. E., Yu, C.-E., & Bird, T. D. (2010) · Brain · doi:10.1093/brain/awq033 · Cited by 246 · see citing works
Advanced Alzheimer's Disease Is a Risk Factor for Late-Onset Seizures
Romanelli, M. F., Morris, J. C., Ashkin, K., & Coben, L. A. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530080029006 · Cited by 242 · see citing works
Early‐onset Alzheimer's disease
Heyman, A., Wilkinson, W. E., Hurwitz, B. J., Helms, M. J., Haynes, C. S., Utley, C. M., & Gwyther, L. P. (1987) · Neurology · doi:10.1212/wnl.37.6.980 · Cited by 233 · see citing works
Seizures in Elderly Patients with Dementia
Mendez, M. F., & Lim, G. T. H. (2003) · Drugs & Aging · doi:10.2165/00002512-200320110-00001 · Cited by 219 · see citing works
Etiology of Seizures in the Elderly
Lühdorf, K., Jensen, L. K., & Plesner, A. M. (1986) · Epilepsia · doi:10.1111/j.1528-1157.1986.tb03567.x · Cited by 212 · see citing works
Morbus Alzheimer and Morbus Pick: A Genetic, Clinical and Patho-anatomical Study
SJOGREN, T., Sjögren, H., & Lindgren, A. (1953) · AIBS Bulletin · doi:10.1093/aibsbulletin/3.2.16-c · Cited by 208 · see citing works
Wieser, H. G., Elger, C. E., & Stodieck, S. R. G. (1985) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(85)91098-3 · Cited by 207 · see citing works
Placebo-Controlled Study of Divalproex Sodium for Agitation in Dementia
Porsteinsson, A. P., Tariot, P. N., Erb, R., Cox, C., Smith, E., Jakimovich, L. J., Noviasky, J. A., Kowalski, N., Holt, C. J., & Irvine, C. (2001) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200102000-00009 · Cited by 206 · see citing works
Hippocampal interictal spikes disrupt cognition in rats
Kleen, J. K., Scott, R. C., Holmes, G. L., & Lenck‐Santini, P. (2009) · Annals of Neurology · doi:10.1002/ana.21896 · Cited by 189 · see citing works
Increased Risk of Late Posttraumatic Seizures Associated With Inheritance of APOE ϵ4 Allele
Diaz-Arrastia, R. R., Gong, Y., Fair, S., Scott, K. D., García, M. C., Carlile, M. C., Agostini, M. A., & Ness, P. C. V. (2003) · Archives of Neurology · doi:10.1001/archneur.60.6.818 · Cited by 186 · see citing works
Seizures in Alzheimer's Disease: Clinicopathologic Study
Mendez, M. F., Catanzaro, P., Doss, R. C., Arguello, R., & Frey, W. H. (1994) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879400700407 · Cited by 182 · see citing works
Recurrent seizures in patients with dementia: Frequency, seizure types, and treatment outcome
Rao, S. C., Dove, G., Cascino, G. D., & Petersen, R. C. (2008) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2008.08.012 · Cited by 167 · see citing works
Video‐EEG Monitoring in the Elderly: A Review of 94 Patients
McBride, A. E., Shih, T., & Hirsch, L. J. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.24401.x · Cited by 154 · see citing works
Neurologic Signs in Alzheimer's Disease
Förstl, H. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530340054018 · Cited by 147 · see citing works
Prevalence and Causes of Seizures at the Time of Diagnosis of Probable Alzheimer’s Disease
Lozsádi, D. A., & Larner, A. J. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000093664 · Cited by 131 · see citing works
Effect of Seizures on Progression of Dementia of the Alzheimer Type
Volicer, L., Smith, S. J., & Volicer, B. J. (1995) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106956 · Cited by 129 · see citing works
Alzheimer's disease and senile dementia of Alzheimer type
Sulkava, R. O. (1982) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1982.tb03117.x · Cited by 125 · see citing works
Myoclonus, Seizures, and Paratonia in Alzheimer Disease
Risse, S. C., Lampe, T. H., Bird, T. D., Nochlin, D., Sumi, S. M., Keenan, T., Cubberley, L., Peskind, E. R., & Raskind, M. A. (1990) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199040400-00003 · Cited by 117 · see citing works
Adverse effects associated with the use of donepezil in general practice in England
Dunn, N. R., Pearce, G. L., & Shakir, S. (2000) · Journal of Psychopharmacology · doi:10.1177/026988110001400410 · Cited by 117 · see citing works
Vogt, D. L., Thomas, D., Galván, V., Bredesen, D. E., Lamb, B. T., & Pimplikar, S. W. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.09.002 · Cited by 113 · see citing works
Morbus Alzheimer and Morbus Pick.
KALMUS, H., Sjogren, T., Sjögren, H., & Lindgren, Å. G. H. (1953) · Population Studies · doi:10.2307/2172384 · Cited by 109 · see citing works
A Placebo-Controlled Trial of Valproate for Agitation and Aggression in Alzheimer’s Disease
Herrmann, N., Lanctôt, K. L., Rothenburg, L. S., & Eryavec, G. M. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000097757 · Cited by 106 · see citing works
Zarow, C., Sitzer, T. E., & Chui, H. C. (2008) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-008-0057-3 · Cited by 104 · see citing works
Increased seizure threshold and severity in young transgenic CRND8 mice
Vecchio, R. A. D., Gold, L. H., Novick, S. J., Wong, G., & Hyde, L. A. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.05.107 · Cited by 103 · see citing works
Epileptic Seizures in Elderly Patients with Dementia
McAreavey, M. J., Ballinger, B. R., & Fenton, G. W. (1992) · Epilepsia · doi:10.1111/j.1528-1157.1992.tb02343.x · Cited by 100 · see citing works
CLINICAL AND ELECTROENCEPHALOGRAPHIC OBSERVATIONS IN ALZHEIMER'S DISEASE
Letemendia, F. J. J., & Pampiglione, G. (1958) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.21.3.167 · Cited by 99 · see citing works
Morbus Alzheimer and Morbus Pick: A Genetic, Clinical and Patho-Anatomical Study.
(1953) · Archives of Internal Medicine · doi:10.1001/archinte.1953.00240180127021 · Cited by 96 · see citing works
Пономарева, Н. В., Коровайцева, Г. И., & Rogaev, E. I. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.019 · Cited by 93 · see citing works
Prevalence and Associated Features of Epilepsy in Adults with Down's Syndrome
McVicker, R. W., Shanks, O. E. P., & McClelland, R. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.164.4.528 · Cited by 90 · see citing works
Fernández-Torre, J. L., Alarcón, G., Binnie, C. D., & Polkey, C. E. (1999) · Clinical Neurophysiology · doi:10.1016/s1388-2457(99)00039-5 · Cited by 88 · see citing works
Belcastro, V., Costa, C., Galletti, F., Pisani, F., Calabresi, P., & Parnetti, L. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01907.x · Cited by 87 · see citing works
Nayak, D. S., Valentı́n, A., Alarcón, G., Seoane, J. J. G., Brunnhuber, F., Juler, J., Polkey, C. E., & Binnie, C. D. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.01.009 · Cited by 86 · see citing works
Prevalence and Clinical Significance of Epileptiform EEG Discharges in a Large Memory Clinic Cohort
Liedorp, M., Stam, C. J., van der Flier, W. M., Pijnenburg, Y. A. L., & Scheltens, P. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000278620 · Cited by 68 · see citing works
Mareš, P., & Mikulecká, A. (2008) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2008.08.013 · Cited by 64 · see citing works
Seizures in Alzheimer's disease: a retrospective study of a cohort of outpatients
Bernardi, S., Scaldaferri, N., Vanacore, N., Trebbastoni, A., Francia, A., D'Amico, A., & Prencipe, M. (2010) · Epileptic Disorders · doi:10.1684/epd.2010.0290 · Cited by 64 · see citing works
Ramsay, R. E., & Pryor, F. M. (2000) · PubMed · Cited by 62 · see citing works
Clinical Features and Mortality in Patients with Early-Onset Alzheimer’s Disease
Samson, W. N., van Duijn, C. M., Hop, W. C. J., & Albert Hofman, D. (2008) · European Neurology · doi:10.1159/000117218 · Cited by 58 · see citing works
Profenno, L. A., Jakimovich, L. J., Holt, C. J., Porsteinsson, A. P., & Tariot, P. N. (2005) · Current Alzheimer Research · doi:10.2174/156720505774932205 · Cited by 50 · see citing works
A Randomized, Double‐Blind, Placebo‐Controlled Trial of Donepezil to Improve Memory in Epilepsy
Hamberger, M. J., Palmese, C. A., Scarmeas, N., Weintraub, D. B., Choi, H., & Hirsch, L. J. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01114.x · Cited by 47 · see citing works
Self-citationMatsuda, T., Wu, J. ‐., & Roberts, E. (1973) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1973.tb04236.x · Cited by 40 · see citing works
Leppik, I. E., & Birnbaum, A. K. (2002) · Seminars in Neurology · doi:10.1055/s-2002-36650 · Cited by 39 · see citing works
Morbidity associated with the use of foramen ovale electrodes
Pastor, J., de Sola, R. G., Hernando‐Requejo, V., Navarrete, E. G., & Pulido, P. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01314.x · Cited by 38 · see citing works
Clinical Analysis of Morbus Alzheimer and Morbus Pick
Sjögren, H. (1953) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1952.tb10980.x · Cited by 34 · see citing works
The accuracy of self-reported history of seizures in Danish, Norwegian and U.S. twins
Corey, L. A., Kjeldsen, M. J., Solaas, M. H., Nakken, K. O., Friis, M. L., & Pellock, J. M. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2008.11.014 · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [67]Torre JLF Alarcon G Binnie CD Polkey CE Comparison of sphenoidal, foramen ovale and anterior temporal placements for detecting interictal epileptiform discharges in presurgical assessment for temporal lobe epilepsy Clin Neurophysiol 1999 110 895 904 10400203
Cited by
Sorted by citations
On the nature of seizure dynamics
Jirsa, V., Stacey, W. C., Quilichini, P., Ivanov, A., & Bernard, C. (2014) · Brain · doi:10.1093/brain/awu133 · Cited by 760 · see citing works
Epileptic activity in Alzheimer’s disease: Causes and clinical relevance
Vossel, K. A., Tartaglia, M. C., Nygaard, H. B., Zeman, A. Z., & Miller, B. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30044-3 · Cited by 590 · see citing works
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
Wiseman, F. K., Al-Janabi, T., Hardy, J., Karmiloff-Smith, A., Nizetic, D., Tybulewicz, V. L. J., Fisher, E. M. C., & Strydom, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3983 · Cited by 562 · see citing works
Epigenetic regulation of brain region-specific microglia clearance activity
Ayata, P., Badimon, A., Strasburger, H. J., Duff, M. K., Montgomery, S. E., Loh, Y.-H. E., Ebert, A., Pimenova, A. A., Ramirez, B. R., Chan, A. T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0192-3 · Cited by 460 · see citing works
Modifiable Risk Factors for Alzheimer’s Disease
Edwards III, G. A., Gamez, N., Escobedo Jr., G., Calderon, O., & Moreno-Gonzalez, I. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00146 · Cited by 253 · see citing works
Aging and the Epidemiology of Epilepsy
Beghi, E., & Giussani, G. (2018) · Neuroepidemiology · doi:10.1159/000493484 · Cited by 216 · see citing works
The somatic comorbidity of epilepsy: A weighty but often unrecognized burden
Gaitatzis, A., Sisodiya, S. M., & Sander, J. W. A. S. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03528.x · Cited by 210 · see citing works
Jiménez-Baladó, J., & Eich, T. S. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.01.005 · Cited by 185 · see citing works
Association of epileptiform abnormalities and seizures in Alzheimer disease.
Lam, A. D., Sarkis, R. A., Pellerin, K. R., Jing, J., Dworetzky, B. A., Hoch, D. B., Jacobs, C. S., Lee, J. W., Weisholtz, D. S., Zepeda, R., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000010612 · Cited by 172 · see citing works
Epidemiology of neurological diseases in older adults
Dumurgier, J., & Tzourio, C. (2020) · Revue Neurologique · doi:10.1016/j.neurol.2020.01.356 · Cited by 178 · see citing works
EEG microstate complexity for aiding early diagnosis of Alzheimer’s disease
Tait, L., Tamagnini, F., Stothart, G., Barvas, E., Monaldini, C., Frusciante, R., Volpini, M., Guttmann, S., Coulthard, E. J., Brown, J. T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74790-7 · Cited by 167 · see citing works
Takahashi, K., Kong, Q., Lin, Y., Stouffer, N., Schulte, D. A., Lai, L., Liu, Q., Chang, L., Dominguez, S., Xing, X., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20140413 · Cited by 157 · see citing works
Imfeld, P., Bodmer, M., Schuerch, M., Jick, S. S., & Meier, C. R. (2012) · Epilepsia · doi:10.1111/epi.12045 · Cited by 153 · see citing works
Kam, K., Duffy, Á., Moretto, J. N., LaFrancois, J. J., & Scharfman, H. E. (2016) · Scientific Reports · doi:10.1038/srep20119 · Cited by 136 · see citing works
Balestrini, S., Arzimanoglou, A. A., Blümcke, I., Scheffer, I. E., Wiebe, S., Zelano, J., & Walker, M. C. (2021) · Epileptic Disorders · doi:10.1684/epd.2021.1255 · Cited by 131 · see citing works
Behr, C., Goltzène, M.-A., Kosmalski, G., Hirsch, É., & Ryvlin, P. (2016) · Revue Neurologique · doi:10.1016/j.neurol.2015.11.003 · Cited by 129 · see citing works
Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly
Chen, L., Li, X., Tjia, M., & Thapliyal, S. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102553 · Cited by 128 · see citing works
The association between dementia and epilepsy: A systematic review and meta‐analysis
Subota, A., Pham, T., Jetté, N., Sauro, K. M., Lorenzetti, D., & Holroyd-Leduc, J. M. (2017) · Epilepsia · doi:10.1111/epi.13744 · Cited by 127 · see citing works
Tang, M., Ryman, D. C., McDade, E., Jasielec, M. S., Buckles, V. D., Cairns, N. J., Fagan, A. M., Goate, A., Marcus, D. S., Xiong, C., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30229-0 · Cited by 121 · see citing works
Kazim, S. F., Seo, J. H., Bianchi, R., Larson, C. S., Sharma, A., Wong, R. K. S., Gorbachev, K., & Pereira, A. C. (2021) · eNeuro · doi:10.1523/eneuro.0418-20.2020 · Cited by 113 · see citing works
Excitatory-inhibitory imbalance in Alzheimer's disease and therapeutic significance
Varela, E. V., Etter, G., & Williams, S. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.04.010 · Cited by 116 · see citing works
Kazim, S. F., Chuang, S.-C., Zhao, W., Wong, R. K. S., Bianchi, R., & Iqbal, K. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00071 · Cited by 109 · see citing works
Seizures in dominantly inherited Alzheimer disease
Zaréa, A., Charbonnier, C., Rovelet‐Lecrux, A., Nicolas, G., Rousseau, S., Borden, A., Pariente, J., Ber, I. L., Pasquier, F., Formaglio, M., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000003048 · Cited by 109 · see citing works
Epileptic Seizures in Alzheimer Disease
Horvath, A. A., Szűcs, A., Barcs, G., Noebels, J. L., & Kamondi, A. (2016) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000134 · Cited by 107 · see citing works
Kwakowsky, A., Guzmán, B. C., Pandya, M., Turner, C. P., Waldvogel, H. J., & Faull, R. L. M. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14325 · Cited by 96 · see citing works
Bi-directional association between epilepsy and dementia
Stefanidou, M., Beiser, A., Himali, J. J., Peng, T. J., Devinsky, O., Seshadri, S. S., & Friedman, D. J. (2020) · Neurology · doi:10.1212/wnl.0000000000011077 · Cited by 94 · see citing works
Self-citationKamondi, A., Grigg-Damberger, M. M., Löscher, W., Tanila, H., & Horvath, A. A. (2024) · Nature Reviews Neurology · doi:10.1038/s41582-024-00932-4 · Cited by 102 · see citing works
Link between hippocampus' raised local and eased global intrinsic connectivity in AD
Pasquini, L., Scherr, M., Tahmasian, M., Meng, C., Myers, N. E., Ortner, M., Mühlau, M., Kurz, A., Förstl, H., Zimmer, C., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.02.007 · Cited by 90 · see citing works
Hyperactivity Induced by Soluble Amyloid-β Oligomers in the Early Stages of Alzheimer's Disease
Hector, A., & Brouillette, J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.600084 · Cited by 90 · see citing works
Szot, P. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03476.x · Cited by 86 · see citing works
van Nifterick, A. M., Mulder, D., Duineveld, D. J., Diachenko, M., Scheltens, P., Stam, C. J., van Kesteren, R. E., Linkenkaer‐Hansen, K., Hillebrand, A., & Gouw, A. A. (2023) · Scientific Reports · doi:10.1038/s41598-023-33973-8 · Cited by 84 · see citing works
Epilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways
Cano, A. C., Fonseca, E., Ettcheto, M., Sánchez‐López, E., de Rojas, I., Alonso-Lana, S., Morató, X., Souto, E. B., Toledo, M., Boada, M., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14101057 · Cited by 83 · see citing works
Seizures in Alzheimer’s disease are highly recurrent and associated with a poor disease course
Vöglein, J., Ricard, I., Noachtar, S., Kukull, W. A., Dieterich, M., Levin, J., & Danek, A. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09937-7 · Cited by 78 · see citing works
Epilepsy and Alzheimer’s Disease: Potential mechanisms for an association
Giorgi, F. S., Saccaro, L. F., Busceti, C. L., Biagioni, F., & Fornai, F. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.04.009 · Cited by 76 · see citing works
Cognitive deterioration in adult epilepsy: Does accelerated cognitive ageing exist?
Breuer, L. E. M., Boon, P., Bergmans, J. W. M., Mess, W. H., Besseling, R. M. H., de Louw, A. J. A., Tijhuis, A. G., Zinger, S., Bernas, A., Klooster, D., et al. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.004 · Cited by 75 · see citing works
van Nifterick, A. M., Gouw, A. A., van Kesteren, R. E., Scheltens, P., Stam, C. J., & de Haan, W. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01041-4 · Cited by 70 · see citing works
Sarkis, R. A., Dickerson, B. C., Cole, A. J., & Chemali, Z. N. (2015) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.15060143 · Cited by 75 · see citing works
In search of antiepileptogenic treatments for post-traumatic epilepsy
Saletti, P. G., Ali, I. Y., Casillas-Espinosa, P. M., Semple, B. D., Lisgaras, C. P., Moshé, S. L., & Galanopoulou, A. S. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.06.017 · Cited by 75 · see citing works
Oral, Ö., Akkoç, Y., Bayraktar, O., & Gözüaçık, D. (2016) · PubMed · doi:10.14670/hh-11-714 · Cited by 75 · see citing works
Seizures and dementia in the elderly: Nationwide Inpatient Sample 1999–2008
Sherzai, D., Losey, T. E., Vega, S., & Sherzai, A. Z. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2014.04.015 · Cited by 68 · see citing works
Hagihara, H., Murano, T., Ohira, K., Miwa, M., Nakamura, K., & Miyakawa, T. (2019) · Molecular Brain · doi:10.1186/s13041-019-0522-8 · Cited by 70 · see citing works
Tau-induced pathology in epilepsy and dementia: notions from patients and animal models.
Sánchez, M., García-Cabrero, A., Sánchez-Elexpuru, G., Burgos, D., & Serratosa, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041092 · Cited by 68 · see citing works
Ribarič, S. (2023) · Biomedicines · doi:10.3390/biomedicines11020355 · Cited by 66 · see citing works
Isopi, E., Granzotto, A., Corona, C., Bomba, M., Ciavardelli, D., Curcio, M., Canzoniero, L. M. T., Navarra, R., Lattanzio, R., Piantelli, M., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.11.013 · Cited by 67 · see citing works
Sleep and hippocampal neurogenesis: Implications for Alzheimer’s disease
Kent, B. A., & Mistlberger, R. E. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.02.004 · Cited by 64 · see citing works
A review of the mechanisms underlying selected comorbidities in Alzheimer’s disease
Maciejewska, K., Czarnecka, K., & Szymański, P. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00293-5 · Cited by 64 · see citing works
Zhu, W., Howard, V. J., Wadley, V. G., Hutto, B., Blair, S. N., Vena, J. E., Colabianchi, N., Rhodes, D., & Hooker, S. P. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13829 · Cited by 62 · see citing works
Ahmad, G., Rasool, N., Rızwan, K., Imran, I., Zahoor, A. F., Zubair, M., Sadiq, A., & Rashid, U. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103216 · Cited by 62 · see citing works
Alzheimer‘s Disease and Epilepsy: Insight From Animal Models
Scharfman, H. E. (2012) · Future Neurology · doi:10.2217/fnl.12.8 · Cited by 60 · see citing works
Neurodegenerative pathways as targets for acquired epilepsy therapy development
Casillas-Espinosa, P. M., Ali, I. Y., & O'Brien, T. J. (2020) · Epilepsia Open · doi:10.1002/epi4.12386 · Cited by 58 · see citing works
Karve, S. J., Ringman, J. M., Lee, A. S., Juarez, K. O., & Mendez, M. F. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6481-y · Cited by 58 · see citing works
Incidence and risk of seizures in Alzheimer's disease: A nationwide population-based cohort study
Cheng, C., Liu, C., Ou, S., Yeh, C., Chen, T., Lin, Y., & Wang, S. (2015) · Epilepsy Research · doi:10.1016/j.eplepsyres.2015.05.009 · Cited by 55 · see citing works
Tombini, M., Assenza, G., Ricci, L., Lanzone, J., Boscarino, M., Vico, C., Magliozzi, A., & Lazzaro, V. D. (2021) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-200286 · Cited by 54 · see citing works
Warner, T. A., Kang, J., Kennard, J. A., & Harrison, F. E. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.11.017 · Cited by 53 · see citing works
Khan, M. Z. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.02.026 · Cited by 50 · see citing works
The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease
Gourmaud, S., Stewart, D. A., Irwin, D. J., Roberts, N., Barbour, A. J., Eberwine, G., O’Brien, W. T., Vassar, R. J., Talos, D. M., & Jensen, F. E. (2021) · Brain · doi:10.1093/brain/awab268 · Cited by 48 · see citing works
Does Alzheimer's disease with mesial temporal lobe epilepsy represent a distinct disease subtype?
Zawar, I., & Kapur, J. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.12943 · Cited by 49 · see citing works
Medical management of epileptic seizures: challenges and solutions
Brophy, G. M., Sarma, A. K., Khandker, N., & Kurczewski, L. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s80586 · Cited by 47 · see citing works
Subclinical epileptiform activity during sleep in Alzheimer's disease and mild cognitive impairment
Brunetti, V., D’Atri, A., Marca, G. D., Vollono, C., Marra, C., Vita, M. G., Scarpelli, S., Gennaro, L. D., & Rossini, P. M. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.02.015 · Cited by 47 · see citing works
The clinical correlation between Alzheimer's disease and epilepsy
Zhang, D., Chen, S., Xu, S., Wu, J., Zhuang, Y., Cao, W., Chen, X., & Li, X. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.922535 · Cited by 46 · see citing works
Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission
Doshina, A., Gourgue, F., Onizuka, M., Opsomer, R., Wang, P., Ando, K., Tasiaux, B., Dewachter, I., Kienlen-Campard, P., Brion, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00325-2 · Cited by 33 · see citing works
Epilepsy, antiepileptic drugs and dementia
Beghi, E., & Beghi, M. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000802 · Cited by 44 · see citing works
Luo, Y., Wu, P., Zhou, J., Xiao, W., He, J., Guan, X., Zhang, J., Hu, Z., Wang, F., & Chen, J. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12228 · Cited by 43 · see citing works
Linsley, J. W., Tripathi, A., Epstein, I., Schmunk, G., Mount, E., Campioni, M. R., Oza, V. D., Barch, M., Javaherian, A., Nowakowski, T. J., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0411-9 · Cited by 38 · see citing works
Neuronal Activity and Amyloid Plaque Pathology: An Update
Ovsepian, S. V., & O’Leary, V. B. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150544 · Cited by 42 · see citing works
Tau Related Pathways as a Connecting Link between Epilepsy and Alzheimer’s Disease
Paudel, Y. N., Angelopoulou, E., Jones, N. C., O'Brien, T. J., Kwan, P., Piperi, C., Othman, I., & Shaikh, M. F. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00460 · Cited by 42 · see citing works
Kim, D. W., Lee, S., Chung, S. E., Cheong, H., Jung, K., & the Korean Epilepsy Society (2013) · Epilepsia · doi:10.1111/epi.12469 · Cited by 40 · see citing works
Paudel, Y. N., Angelopoulou, E., Piperi, C., Othman, I., & Shaikh, M. F. (2020) · Biology · doi:10.3390/biology9060122 · Cited by 42 · see citing works
Deep Brain Stimulation for Alzheimer’s Disease: Tackling Circuit Dysfunction
Lam, J., Lee, J., Liu, C. Y., Lozano, A. M., & Lee, D. J. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13305 · Cited by 42 · see citing works
Badawi, G. A., Shokr, M. M., Elshazly, S. M., Zaki, H. F., & Mohamed, A. F. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176851 · Cited by 39 · see citing works
Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice
Liu, S., Shen, Y., Shultz, S. R., Nguyen, A., Hovens, C. M., Adlard, P. A., Bush, A. I., Chan, J., Kwan, P., O'Brien, T. J., et al. (2017) · Epilepsia · doi:10.1111/epi.13847 · Cited by 39 · see citing works
Mechanisms Involved in Epileptogenesis in Alzheimer’s Disease and Their Therapeutic Implications
Altuna, M., Olmedo‐Saura, G., Carmona‐Iragui, M., & Fortea, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084307 · Cited by 39 · see citing works
Targeting neurodegeneration to prevent post-traumatic epilepsy.
Ali, I., Silva, J. C., Liu, S., Shultz, S. R., Kwan, P., Jones, N. C., & O'Brien, T. J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.08.006 · Cited by 38 · see citing works
Wirt, R. A., Crew, L. A., Ortiz, A. A., McNeela, A. M., Flores, E., Kinney, J. W., & Hyman, J. M. (2021) · Communications Biology · doi:10.1038/s42003-021-02558-4 · Cited by 38 · see citing works
Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice
Sos, K. E., Mayer, M. I., Takács, V. T., Major, A., Bardóczi, Z., Beres, B. M., Szeles, T., Saito, T., Saido, T. C., Mody, I., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0233700 · Cited by 37 · see citing works
Hickman, L. B., Stern, J. M., Silverman, D. H. S., Salamon, N., & Vossel, K. A. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1241638 · Cited by 36 · see citing works
Do we know how to diagnose epilepsy early in Alzheimer's disease?
Cretin, B., Philippi, N., Bousiges, O., Bitonto, L. D., Sellal, F., Martin‐Hunyadi, C., & Blanc, F. (2017) · Revue Neurologique · doi:10.1016/j.neurol.2017.03.028 · Cited by 36 · see citing works
Late-onset epilepsy and subsequent increased risk of dementia
Tsai, Z.-R., Zhang, H., Tseng, C., Peng, H.-C., Kok, V. C., Li, G. P., Hsiung, C. A., & Hsu, C. (2021) · Aging · doi:10.18632/aging.202299 · Cited by 36 · see citing works
“Untangling” Alzheimer's Disease and Epilepsy
Scharfman, H. E. (2012) · Epiliepsy currents/Epilepsy currents · doi:10.5698/1535-7511-12.5.178 · Cited by 36 · see citing works
Lyou, H. J., Seo, K., Lee, J. E., Pak, H. Y., & Lee, J. H. (2018) · Dementia and Neurocognitive Disorders · doi:10.12779/dnd.2018.17.4.156 · Cited by 35 · see citing works
Sun, J. L., Stokoe, S. A., Roberts, J. P., Sathler, M. F., Nip, K., Shou, J., Ko, K. H., Tsunoda, S., & Kim, S. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.09.005 · Cited by 35 · see citing works
Opsomer, R., Contino, S., Perrin, F., Gualdani, R., Tasiaux, B., Doyen, P. J., Vergouts, M., Vrancx, C., Doshina, A., Pierrot, N., et al. (2020) · eNeuro · doi:10.1523/eneuro.0322-19.2020 · Cited by 35 · see citing works
Mi, D. J., Dixit, S., Warner, T. A., Kennard, J. A., Scharf, D. A., Kessler, E. S., Moore, L. M., Consoli, D. C., Bown, C. W., Dukes, A. J., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.08.002 · Cited by 33 · see citing works
Nandini, H. S., Paudel, Y. N., & Krishna, K. L. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116686 · Cited by 32 · see citing works
Parkinson's disease: Less epileptic seizures more status epilepticus
Feddersen, B., Rémi, J., Einhellig, M., Stoyke, C., Krauß, P., & Noachtar, S. (2013) · Epilepsy Research · doi:10.1016/j.eplepsyres.2013.11.013 · Cited by 31 · see citing works
Association of Seizure Control with Mortality, Cognition, and Function in People With Dementia
Zawar, I., Quigg, M., Ghosal, S., Punia, V., Calle‐López, Y., Manning, C. A., & Kapur, J. (2024) · Annals of Neurology · doi:10.1002/ana.27125 · Cited by 30 · see citing works
Li, P. S., Liu, S., Liu, Q., Shen, J., Yang, R., Jiang, B., He, C., & Xiao, P. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112185 · Cited by 30 · see citing works
Singh, R., Sarangi, S. C., Singh, S., & Tripathi, M. (2022) · Seizure · doi:10.1016/j.seizure.2022.09.003 · Cited by 29 · see citing works
UPLC–TOF-MS analysis of Galium spurium towards its neuroprotective and anticonvulsant activities
Orhan, N., Orhan, D. D., Aslan, M., Sukuroglu, M. K., & Orhan, İ. E. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.01.056 · Cited by 28 · see citing works
Epilepsy in patients with Alzheimer's disease: A systematic review
Miranda, D. D. C., & Brucki, S. M. D. (2014) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642014dn81000010 · Cited by 28 · see citing works
Lisgaras, C. P., de la Prida, L. M., Bertram, E. H., Cunningham, M. O., Henshall, D. C., Liu, A. A., Gnatkovsky, V., Balestrini, S., de Curtis, M., Galanopoulou, A. S., et al. (2025) · Epilepsia · doi:10.1111/epi.18282 · Cited by 29 · see citing works
Alcantara‐Gonzalez, D., Chartampila, E., Criscuolo, C., & Scharfman, H. E. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105274 · Cited by 24 · see citing works
Lisgaras, C. P., & Scharfman, H. E. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106294 · Cited by 26 · see citing works
Risk Factors Associated With Late-Onset Epilepsy in Dementia and Mild Cognitive Impairment
Zawar, I., Quigg, M., Johnson, E. L., Ghosal, S., Manning, C. A., & Kapur, J. (2025) · JAMA Neurology · doi:10.1001/jamaneurol.2025.0552 · Cited by 26 · see citing works
Pharmacotherapeutic strategies for treating epilepsy in patients with Alzheimer’s disease
Cretin, B. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1496237 · Cited by 25 · see citing works
Incidence of epilepsy and associated factors in elderly patients in Germany
Jacob, L., Bohlken, J., Schmitz, B., & Kostev, K. (2018) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2018.10.035 · Cited by 25 · see citing works
Electrophysiological Biomarkers of Epileptogenicity in Alzheimer’s Disease
Yu, T., Liu, X., Wu, J., & Wang, Q. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.747077 · Cited by 23 · see citing works
Vicente, M. C., Addo-Osafo, K., & Vossel, K. A. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1277613 · Cited by 25 · see citing works
Ziyatdinova, S., Viswanathan, J., Hiltunen, M. O., Tanila, H., & Pitkänen, A. (2015) · Epilepsy Research · doi:10.1016/j.eplepsyres.2015.02.005 · Cited by 23 · see citing works
Treatment of epilepsy in patients with Alzheimer’s disease
Giorgi, F. S., Guida, M., Vergallo, A., Bonuccelli, U., & Zaccara, G. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1243469 · Cited by 24 · see citing works
- Authors
- Friedman, D., Honig, L. S., & Scarmeas, N.
- Affiliations
- NYU Langone Health (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Friedman, Daniel
- Venue
- CNS Neuroscience & Therapeutics
- Publisher
- Wiley
- Published
- 2011-06-07
- Volume
- 18
- Issue
- 4
- Pages
- 285-294
- ISSN
- 1755-5930 (ISSN-L)
- 1755-5949
- PMC
- PMC3630499
- OpenAlex
- W1570043013
- Cited by
- 229
- References
- 72
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 18 · 2023: 16 · 2022: 15 · 2021: 33 · 2020: 21 · 2019: 17 · 2018: 18 · 2017: 9 · 2016: 14 · 2015: 13 · 2014: 12 · 2013: 5 · 2012: 9
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- CNS Neuroscience & Therapeutics (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P50AG008702)
- National Center for Research Resources (M01RR000645)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, seizures, epilepsy, seizure prevalence, seizure incidence, risk factors, generalized convulsions, EEG, anticonvulsant therapy, dementia severity, cognitive impairment, methodological limitations
- MeSH terms
- Alzheimer Disease, Animals, Cognition Disorders, Electroencephalography, Epilepsy, Humans, Prospective Studies, Retrospective Studies, Risk Factors, Seizures
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
