The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Psychiatric Disorders in Children and Adolescents With Psychogenic Nonepileptic Seizures
Abstract
Objective Knowledge regarding psychiatric disorders in children and adolescents with psychogenic nonepileptic seizures (PNES) is limited. This study outlines the spectrum and risk of psychiatric disorders in childhood-onset PNES. Methods We performed a nationwide matched cohort study of children and adolescents with PNES 5 to 17 years of age at the time of diagnosis between January 1, 1996, and December 31, 2014. Two matched comparison groups were included: children and adolescents with epilepsy (ES) and children and adolescents without PNES or epilepsy, called healthy controls (HC). Outcomes were prevalent psychiatric disorders before index (i.e., date of diagnosis or corresponding date for HC) and incident psychiatric disorders 2 years after index. Relative risks (RRs) were calculated and adjusted for potential confounders. Results We included 384 children and adolescents with validated PNES, 1,152 with ES, and 1,920 HC. Among the cases of PNES, 153 (39.8%) had prevalent psychiatric disorders and 150 (39.1%) had incident psychiatric disorders. Compared to the ES and HC groups, children and adolescents with PNES had elevated risks of both prevalent psychiatric disorders (adjusted RRPNES/ES 1.87, 95% confidence interval [CI] 1.59–2.21, adjusted RRPNES/HC 5.54, 95% CI 4.50–6.81) and incident psychiatric disorders (adjusted RRPNES/ES 2.33, 95% CI 1.92–2.83, adjusted RRPNES/HC 8.37, 95% CI 6.31–11.11). A wide spectrum of specific psychiatric disorders displayed elevated RRs. Conclusions Children and adolescents with PNES are at higher risk of a wide range of psychiatric disorders compared to children and adolescents with ES and HC. A careful psychiatric evaluation is warranted to optimize and individualize treatment.
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“The implication is that the diagnosis of comorbid mental health concerns in children with FND is much more likely to be accurate when it is based on clinical interview rather than self-report measures using psychological constructs [32,65].”
From Illness-Promoting Psychological Processes in Children and Adolescents with Functional Neurological Disorder (2023) · cites this paper as [32]
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A Modified Poisson Regression Approach to Prospective Studies with Binary Data
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The Danish Psychiatric Central Research Register
Mors, O., Perto, G. P., & Mortensen, P. B. (2011) · Scandinavian Journal of Public Health · doi:10.1177/1403494810395825 · Cited by 1,589
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Emotion regulation and mental health: recent findings, current challenges, and future directions
Berking, M., & Wupperman, P. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283503669 · Cited by 836
Goldstein, L. H., Robinson, E. J., Mellers, J. D. C., Stone, J., Carson, A., Reuber, M., Medford, N., McCrone, P., Murray, J., Richardson, M. P., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30128-0 · Cited by 287
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Validation of epilepsy diagnoses in the Danish National Hospital Register
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Self-citationThe aetiology of psychogenic non-epileptic seizures: risk factors and comorbidities.
Popkirov, S., Asadi-Pooya, A., Duncan, R., Gigineishvili, D., Hingray, C., Kanner, A. M., LaFrance, W., Pretorius, C., & Reuber, M. (2019) · Epileptic disorders · doi:10.1684/epd.2019.1107 · Cited by 180
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Treatment approaches for functional neurological disorders in children
Vassilopoulos, A., Mohammad, S., Dure, L., Kozlowska, K., & Fobian, A. D. (2022) · Current Treatment Options in Neurology · doi:10.1007/s11940-022-00708-5 · Cited by 70
Stager, L., Morriss, S., McKibben, L., Grant, M., Szaflarski, J. P., & Fobian, A. D. (2022) · Seizure · doi:10.1016/j.seizure.2022.03.021 · Cited by 21
Stager, L., Morriss, S., Szaflarski, J. P., & Fobian, A. D. (2022) · Seizure · doi:10.1016/j.seizure.2022.04.006 · Cited by 22
Stager, L., Szaflarski, J. P., & Fobian, A. D. (2021) · Epilepsy & Behavior Reports · doi:10.1016/j.ebr.2021.100503 · Cited by 16
Kozlowska, K., Schollar-Root, O., Savage, B., Hawkes, C., Chudleigh, C., Raghunandan, J., Scher, S., & Helgeland, H. (2023) · Children · doi:10.3390/children10111724 · Cited by 14
Metadata
- Authors
- Hansen, A. S., Rask, C. U., Christensen, A.-E., Rodrigo-Domingo, M., Christensen, J., & Nielsen, R. E.
- Affiliations
- Aarhus University (DK)
- From Psychiatry (A.S.H., A.-E.C., M.R.-D., R.E.N.), Aalborg University Hospital; Department of Clinical Medicine (A.S.H., R.E.N.), Aalborg University; Department of Child and Adolescent Psychiatry (C.U.R.), Research Unit, and Department of Neurology (J.C.), Aarhus University Hospital; and Department of Clinical Medicine (C.U.R., J.C.), Aarhus University, Denmark.
- ORCID
- Venue
- Neurology
- Published
- 2021-08-03
- Volume
- 97
- Issue
- 5
- Pages
- e464-e475
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W3164089143
- Cited by
- 35
- References
- 41
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 3
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Funders
- Novo Nordisk Fonden (NNF16OC0 019126)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- psychogenic non-epileptic seizures, mental illness, adolescents, epilepsy, prevalence, incidence, psychiatric comorbidity, psychiatric risk
- MeSH terms
- Adolescent, Affective Symptoms, Mental Disorders, Child, Child, Preschool, Denmark, Dissociative Disorders, Electroencephalography, Female, Humans, Male, Parents, Registries, Seizures, Cohort Studies, Incidence, Prevalence, Risk Assessment, International Classification of Diseases
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