The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Intracortical somatosensory stimulation to elicit fingertip sensations in an individual with spinal cord injury.
Open accessPublished version of a preprint
Abstract
BACKGROUND AND OBJECTIVES: The restoration of touch to fingers and fingertips is critical to achieving dexterous neuroprosthetic control for individuals with sensorimotor dysfunction. However, localized fingertip sensations have not been evoked via intracortical microstimulation (ICMS). METHODS: Using a novel intraoperative mapping approach, we implanted electrode arrays in the finger areas of left and right somatosensory cortex and delivered ICMS over a 2-year period in a human participant with spinal cord injury. RESULTS: Stimulation evoked tactile sensations in 8 fingers, including fingertips, spanning both hands. Evoked percepts followed expected somatotopic arrangements. The subject was able to reliably identify up to 7 finger-specific sites spanning both hands in a finger discrimination task. The size of the evoked percepts was on average 33% larger than a finger pad, as assessed via manual markings of a hand image. The size of the evoked percepts increased modestly with increased stimulation intensity, growing 21% as pulse amplitude increased from 20 to 80 µA. Detection thresholds were estimated on a subset of electrodes, with estimates of 9.2 to 35 µA observed, roughly consistent with prior studies. DISCUSSION: These results suggest that ICMS can enable the delivery of consistent and localized fingertip sensations during object manipulation by neuroprostheses for individuals with somatosensory deficits. CLINICALTRIALSGOV IDENTIFIER: NCT03161067.
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“Additionally, it is now possible to create artificial sensations, with unprecedented resolution, via delivery of intracortical microstimulation (Fernandez et al., 2021; Fernandez, 2022; Fifer et al., 2022).”
From Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges (2022) · cites this paper as Fifer et al., 2022
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Toward a personalized closed-loop stimulation of the visual cortex: Advances and challenges
Grani, F., Soto-Sánchez, C., Fimia, A., & Fernández, E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1034270 · Cited by 16
Selective induction of fingertip sensations for better neuroprosthetic control.
Fernandez, E. (2022) · Neurology · doi:10.1212/wnl.0000000000013177 · Cited by 2
Metadata
- Authors
- Fifer, M. S., McMullen, D. P., Osborn, L. E., Thomas, T. M., Christie, B., Nickl, R. W., Candrea, D. N., Pohlmeyer, E. A., Thompson, M. C., Anaya, M. A., Schellekens, W., Ramsey, N. F., Bensmaia, S. J., Anderson, W. S., Wester, B. A., Crone, N. E., Celnik, P. A., Cantarero, G. L., & Tenore, F. V.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Venue
- Neurology
- Published
- 2022-02-15
- Volume
- 98
- Issue
- 7
- Pages
- e679-e687
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC8865889
- OpenAlex
- W4200193730
- Cited by
- 103
- References
- 38
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 21 · 2023: 16 · 2022: 17
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Neurology (publishedVersion)
- medRxiv (acceptedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (T32EB003383)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Keywords
- intracortical microstimulation, fingertip sensation, spinal cord injury, somatosensory cortex, neural prostheses, tactile perception, somatotopic mapping, detection threshold, stimulation intensity
- MeSH terms
- Electric Stimulation, Hand, Humans, Somatosensory Cortex, Spinal Cord Injuries, Touch
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- Fifer, M. S., McMullen, D. P., Osborn, L. E., Thomas, T. M., Christie, B., Nickl, R. W., Candrea, D. N., Pohlmeyer, E. A., Thompson, M. C., Anaya, M. A., Schellekens, W., Ramsey, N. F., Bensmaia, S. J., Anderson, W. S., Wester, B. A., Crone, N. E., Celnik, P. A., Cantarero, G. L., & Tenore, F. V. (2022). Intracortical somatosensory stimulation to elicit fingertip sensations in an individual with spinal cord injury. Neurology. https://doi.org/10.1212/wnl.0000000000013173
