The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Very Early Constraint-Induced Movement during Stroke Rehabilitation (VECTORS): A single-center RCT
Open accessAbstract
BACKGROUND: Constraint-induced movement therapy (CIMT) is among the most developed training approaches for motor restoration of the upper extremity (UE). METHODS: Very Early Constraint-Induced Movement during Stroke Rehabilitation (VECTORS) was a single-blind phase II trial of CIMT during acute inpatient rehabilitation comparing traditional UE therapy with dose-matched and high-intensity CIMT protocols. Participants were adaptively randomized on rehabilitation admission, and received 2 weeks of study-related treatments. The primary endpoint was the total Action Research Arm Test (ARAT) score on the more affected side at 90 days after stroke onset. A mixed model analysis was performed. RESULTS: A total of 52 participants (mean age 63.9 +/- 14 years) were randomized 9.65 +/- 4.5 days after onset. Mean NIHSS was 5.3 +/- 1.8; mean total ARAT score was 22.5 +/- 15.6; 77% had ischemic stroke. Groups were equivalent at baseline on all randomization variables. As expected, all groups improved with time on the total ARAT score. There was a significant time x group interaction (F = 3.1, p < 0.01), such that the high intensity CIT group had significantly less improvement at day 90. No significant differences were found between the dose-matched CIMT and control groups at day 90. MRI of a subsample showed no evidence of activity-dependent lesion enlargement. CONCLUSION: Constraint-induced movement therapy (CIMT) was equally as effective but not superior to an equal dose of traditional therapy during inpatient stroke rehabilitation. Higher intensity CIMT resulted in less motor improvement at 90 days, indicating an inverse dose-response relationship. Motor intervention trials should control for dose, and higher doses of motor training cannot be assumed to be more beneficial, particularly early after stroke.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, a 3-arm early rehabilitation trial testing upper limb constraint regimens, although small (n = 52), also found that a higher amount of training was inferior to lower-dose usual care.18”
From Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT) (2016) · cites this paper as [18]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1965) · PubMed · Cited by 14,925
Functional evaluation : Barthel index
Mahonery, F. I. (1965) · Medical Entomology and Zoology · Cited by 12,762
Measurements of acute cerebral infarction: a clinical examination scale.
Brott, T. G., Adams, H. P., Olinger, C. P., Marler, J. R., Barsan, W. G., Biller, J., Spilker, J. A., Holleran, R. S., EBERLE, R. W., & Hertzberg, V. (1989) · Stroke · doi:10.1161/01.str.20.7.864 · Cited by 6,034
Cerebral Vascular Accidents in Patients over the Age of 60: II. Prognosis
Rankin, J. O. (1957) · Scottish Medical Journal · doi:10.1177/003693305700200504 · Cited by 2,534
Validation of a short Orientation-Memory-Concentration Test of cognitive impairment
Katzman, R., Brown, T., Fuld, P. A., Peck, A., Schechter, R., & Schimmel, H. (1983) · American Journal of Psychiatry · doi:10.1176/ajp.140.6.734 · Cited by 2,119
Fundamentals of Resistance Training: Progression and Exercise Prescription
KRAEMER, W. J., & RATAMESS, N. A. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000121945.36635.61 · Cited by 1,992
Effect of Constraint-Induced Movement Therapy on Upper Extremity Function 3 to 9 Months After Stroke
Wolf, S. L., Winstein, C. J., Miller, J. P., Taub, E., Uswatte, G., Morris, D. M., Giuliani, C., Light, K. E., Nichols‐Larsen, D. S., & for the EXCITE Investigators (2006) · JAMA · doi:10.1001/jama.296.17.2095 · Cited by 1,891
Self-citationTechnique to improve chronic motor deficit after stroke.
Taub, E., Miller, N. E., Novack, T. A., Cook, E. W., Fleming, W. C., Nepomuceno, C., Connell, J., & Crago, J. E. (1993) · PubMed · Cited by 1,557
Appendix G: Geriatric Depression Scale
Marks, W. J. (2015) · doi:10.1017/cbo9781316026625.021 · Cited by 1,536
Lyle, R. C. (1981) · International Journal of Rehabilitation Research · doi:10.1097/00004356-198112000-00001 · Cited by 1,335
Research works printed but not linked: 3
- Wong DL Hockenberg-Eaton M Wilson D Winklestein ML Schwarz P. Wong’s Essentials of Pediatric Nursing. St. Louis: Mosby;
- Yesavage JA. Geriatric Depression Scale. Psychopharmacol Bull 1988;24:709–711.
- Meinert CL. Clinical Trials: Design Conduct and Analysis. New York: Oxford Press;
Cited by
Sorted by citations
Winstein, C. J., Stein, J., Arena, R., Bates, B., Cherney, L. R., Cramer, S. C., Deruyter, F., Eng, J. J., Fisher, B., Harvey, R. L., et al. (2016) · Stroke · doi:10.1161/str.0000000000000098 · Cited by 3,293
Self-citationPlasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938
Robot-Assisted Therapy for Long-Term Upper-Limb Impairment after Stroke
Lo, A. C., Guarino, P. D., Richards, L. G., Haselkorn, J. K., Wittenberg, G. F., Federman, D. G., Ringer, R. J., Wagner, T. H., Krebs, H. I., Volpe, B. T., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0911341 · Cited by 1,397
Bernhardt, J. A., Hayward, K. S., Kwakkel, G., Ward, N., Wolf, S. L., Borschmann, K., Krakauer, J. W., Boyd, L. A., Carmichael, S. T., Corbett, D., et al. (2017) · International Journal of Stroke · doi:10.1177/1747493017711816 · Cited by 1,242
Self-citationWhat Is the Evidence for Physical Therapy Poststroke? A Systematic Review and Meta-Analysis
Veerbeek, J. M., van Wegen, E., van Peppen, R., van der Wees, P. J., Hendriks, E., Rietberg, M., & Kwakkel, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087987 · Cited by 1,203
Metadata
- Authors
- Dromerick, A. W., Lang, C. E., Birkenmeier, R. L., Wagner, J. M., Miller, J. P., Videen, T. O., Powers, W. J., Wolf, S. L., & Edwards, D. F.
- Affiliations
- MedStar National Rehabilitation Hospital (US)
- University of North Carolina at Chapel Hill (US)
- Venue
- Neurology
- Published
- 2009-07-21
- Volume
- 73
- Issue
- 3
- Pages
- 195-201
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC2715572
- OpenAlex
- W1967063999
- Cited by
- 399
- References
- 36
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 7 · 2023: 20 · 2022: 18 · 2021: 20 · 2020: 20 · 2019: 25 · 2018: 29 · 2017: 29 · 2016: 25 · 2015: 25 · 2014: 41 · 2013: 29 · 2012: 42
- FWCI
- 30.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation (21002032)
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS041261, 1 RO1 NS41261-01A1)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Rehabilitation › Cerebral Palsy and Movement Disorders
- Keywords
- constraint-induced movement therapy, stroke rehabilitation, upper limb motor recovery, dose-response relationship, acute inpatient rehabilitation, ischemic stroke, Action Research Arm Test, lesion expansion
- MeSH terms
- Stroke Rehabilitation, Activities of Daily Living, Aged, Arm, Brain Ischemia, Exercise Therapy, Female, Hand, Humans, Functional Laterality, Male, Middle Aged, Paresis, Restraint, Physical, Time, Time Factors, Single-Blind Method, Treatment Outcome, Muscle, Skeletal, Recovery of Function, Stroke, Physical Therapy Modalities
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
