CoChat
Sign Up
Cited by 221Stroke Rehabilitation and RecoveryAcute Ischemic Stroke ManagementMedical Practices and Rehabilitation

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index; none of the 17 sources its claims cite is checked for support yet.

Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT)

Open access
Bernhardt, Julie, Churilov, Leonid, Ellery, Fiona, Collier, Janice, Chamberlain, Jan, Langhorne, Peter, Lindley, Richard I., Moodie, Marj, Dewey, Helen, Thrift, Amanda G., Donnan, Geoff, AVERT Collaboration Group, Bernhardt, Julie, Churilov, Leonid, Collier, Janice, Dewey, Helen, Donnan, Geoffrey, Ellery, Fiona, Langhorne, Peter, Lindley, Richard, Moodie, Marjory, Parsons, Brooke, Thrift, Amanda, Donnan, Geoffrey, Dewey, Helen, Bernhardt, Julie, Langhorne, Peter, Moodie, Marjory, Parsons, Brooke, Investigators MIs, Main, Indredavik, Bent, Askim, Torunn, Bath, Phillip, Bladin, Christopher, Reid, Christopher, Read, Stephen, Said, Cathy, Middleton, Sandy, Frayne, Judith, Srikanth, Velandai, Bernhardt, Australia: Julie, Dewey, Helen, Bernhardt, Julie, Donnan, Geoffrey, Thrift, Amanda, Carter, Robert, Lindley, Richard, Bernhardt, Julie, Donnan, Geoff, Lindley, Richard, Thrift, Amanda, Langhorne, Peter, Moodie, Marjory, Dewey, Helen, Churilov, Leonid, Langhorne, Peter, Langhorne, Peter, Wu, Olivia, Bernhardt, Julie, Claire Ritchie, Matthew Walters, Smith, Lorraine, Langhorne, Peter, Wu, Olivia, Ashburn, Anne, Rodgers, Helen, Bernhardt, Julie, Langhorne, Peter, Ashburn, Anne, Bernhardt, Julie, Rogers, Helen, Wu, Olivia, Lennon, Sheila, Lennon, Sheila, Power, Michael, Bernhardt, Julie, Hameed, Shahul, Hameed, Shahul, Pavanni, Ratnagopal, Lim, Peter, Bernhardt, Julie, Tan, Dawn, Churilov, Leonid, Brewer, Tim, Collier, Janice, Haritos, Nick, Leong, Edwin, Li, Cecilia, NayWin, Caesar, Nicol, Marcus, Olenka, Liudmyla, Quang, Li Chun, Moodie, Marjory, Carter, Robert, Hope, Silvia, Sheppard, Lauren, Teo, Kiusiang Tay-, Wu, Olivia, Cumming, Toby, Linden, Thomas, Borschmann, Karen, Chamberlain, Jan, Collier, Janice, Cumming, Toby, Ellery, Fiona, Occhiodoro, Teresa, Palfreeman, Helen, Purvis, Tara, Sirgo, Bernadette, Tiliacos, Nick, Van Holsteyn, John, Zhao, Henry, Armstrong, Beverly, Craig, Louise, Graham, Fiona, Legg, Lynn, Morrison, Rosemary, Moorhead, Heather, O’Donohue, Lorraine, Rogers, Susan, Smith, Myra, Forshaw, Denise, Fitzgerald, Jane, Hibbert, E, Melling, R, Petrolo, S, Purvis, T, Williamson MIs, H, Adams, P, Augoustakis, L, Batcheler, S, Berney, S, Cobani, V, Cohen, B, Dewey, H, Gangi, S, Giofre, N, Gordon, C, Hegarty, L, Hindson, M, Horvath, F, Kalinowski, S, Kleine, A, Kramer, S, Lawrence, J, Lindquist, S, Logan, N, Macdonell, A, Matlioski, J, McDonough, N, McLennan, S, McNamee, M, Miller, L, Nall, C, Nelson, E, Ng, K, Nicholas, Z, Nunn, C, Owen, K, Plant, E, Proud, L, Quah, D, Rodway, K, Sertori, S, Sheldon, V, Sherry, L, Speare, S, Stansfeld, K, Studden, N, Teoh, Z, Twist, L, Velupillai, G, Walker, L, Wall, K, Warwick, A, Wharrie, R, Wilson, J, Worboys, H, Young, D, Ancliffe MI, J, Bryant, M, Doran, B, Field, M, Fogliani, P, Haber, A, Hankey, G, Hendrie, D, Jackaman, V, Jacobsen, A, Jose, S, Lim, R, Louis, R, Nanthakumar, S, Pain, S, Power, A, Rappeport, B, Reynolds, J, Smith, L, Tombe, S, Wesseldine, A, West, T, Clarke, K, Maccanti, H, Marr, L, Plumb, S, Quiney, J, Werner MIs, L, Abeykoon, E, Apirutvorrachod, W, Attard, L, Behanan, S, Brown, D, Buchanan, K, Butler, D, Camac, M, Davis, S, Diocera, D, Gan, N, Gendre, C, Germaine, J, Hand, P, Maurenbrecher, L, McCulloch, J, Mcritchie, S, Ong, M, Pachett, R, Pesavento, L, Power, H, Reilly, R, Sawers, M, Silva, G, Stevens, C, Taylor, L, Timms, T, Ugalde, M, Vardy, A, Wallace, J, Walsh, S, Whatley, E, Winter, E, Baxter, M, Davis, M, Sundararajan MIs, L, Butler, E, Caspers, K, Coulter, E, Shaw, S, Kent, F, Lack, H, Leavold, F, Lord, J, Martin-Francisco, J, Mohanraj, R, Nelson, R, O'Neill, T, Otto, R, Parker, J, Rees, V, Stevens, B, Chen MI, R, Lindley, RI, Bindra, J, Dongre, R, Downey, N, Ferris, M, Gibson, L, Gonzalez, R, Kinniburgh, M, Lazaridou, M, McCormack, D, Singh, R, Stepney, A, Tria, Y, Bainbridge, K, Killey, B, Sheedy MIs, R, Aitchison, O, Bray, L, Clatworthy, K, Coghill, S, Collins, M, Cornwall, L, Dow, J, Gates, P, Gillett, S, Johnson, N, Joseph, S, Kopelke, K, Lam, R, Levy, R, Lloyd, N, Logan, S, McPherson, G, Newth, M, Parsons, C, Powles, K, Rebis, M, Samakowidic, T, Sanders, L, Savickas, S, Shrimpton, J, Smith, H, Smith, L, Spehr, J, Summers, J, Taylor, G, Thackeray, M, Wilkinson, B, Richardson MI, K, Frayne, J, Barber, E, Bode, L, Brakey, A, Chand, K, Christin, P, Crook, G, Delrosario-Kelly, D, Descallar, R, Deutsch, A, Easo, S, Farquhar, M, Fergus, P, Ford, J, Hamson, E, Hlaing, M, Hope, E, Lacivita, J, Laurenson, J, Lock, K, Ly, N, McKay, K, Mill, C, Moloney, K, Price, L, Terry, T, Tyers, A, Willems, S, Woolstencroft, R, Crawshaw, N, Luker, J, Wood, C, Choat MIs, S, Archer, C, Benham, D, Billinger, M, Bronca, M, Curchin, S, Dickie, C, Dixon, M, Douglass, D, Enomoto, M, Ernst, K, Fries, L, George, S, Green, E, Hamilton, L, Harris, Z, Heard, T, Hunt, G, Jamieson, N, Mackenzie, M, McKearney, H, Oermann, B, O'Reilly, C, Pearson, T, Reid, N, Rodda, L, Scutcheon, D, Simons, C, Smith, R, Tait, L, Troake, J, Usher, D, Mackey, L, Wijeratne MIs, T, Abela, C, Ashoka, S, Chen, C, Cheng, T, Chong, V, Cooke, S, Fok, A, Galang, L, Grant, C, Karageorge, S, Kat, K, Keo, L, Lee, B, Luscombe, A, Mackay, J, Minett, M, Mizen, J, Nim, P, Nunlist, N, Patel, V, Pathirage, M, Paton, A, Pombuena, M, Rathnayake, N, Rhodes, L, Sequeira, M, Smart, S, Somaratne, S, Maria, N Sta, Talbot, L, Tecle, R, Shannon, M, Gerraty MIs, R, Allen, S, Boyle, R, Fatchen, N, Hendley, N, Hyde, A, Inal, M, Kalubowilage, P, Laverde, M, Lawless, K, McFadyen, A, Peters, K, Pugh, C, Qin, C, Robertson, J, Smee, S, Tomlinson, R, Wang, V, Williams, F, Woolley, D, Yawieriin, R, Austin, N, Pomfret, S, Tinsley MIs, M, Allport, L, Ang, C, Armitage, L, Blundell, E, Courtney, A, Dela Costa, M, Thapa, T Devi, Diwakar, P, Dulleh, M, Francis, J, Cic, P, Gellie, G, Gill, C, James, D, Lee, S, Mai, T, Majcher, K, Mawson, C, Newton, G, Qiu, N, Ragonton, E, Roberts, L, Saitamis, H, Stanwell, L, Ting, L, Xu, P, Yin, L, Crosby MI, V, Broadhead, K, Church, J, Collins, R, Everitt, K, Fisher, M, Hochmuth, K, Jones, N, Lieschke, A, McCarthy, E, McGlone, C, Morey, D, Neilson, D, Spry, S, Vile, M, Grimley, R, Rowley MIs, D, Rosbergen, I, Ahern, E, Anderson, L, Boreham, J, Devin, R, Doolan, R, Dyke, M, Griffiths, L, Guest, K, Hecita, D, Kendal, N, Koltermann, J, Lacy, M, Lebeter, S, Lloyd, D, Matthews, M, McAuley, C, Pollock, A, Pyke, M, Rogers, T, Street, S, Styles, G, Tampiyappa, A, Trinder, J, Verral, T, Walker, K, White, C, Beckwith, T, Cormack MIs, L, Arriagada, J, Babenschneider, C, Blacker, D, Bennett, S, Connor, S, Cowmeadow, J, Daniel, N, Edmonds, G, Faulkner, M, Garcia-Vega, M, Kruger, K, Martial, B, McGinley, P, Mountford, H, Riley, V, Smith, N, Stepan, F, Tilley, S, Whisson, S, Groot MI, P, Bailey, J, Ballinger, K, Bell, C, Camilleri, B, Charnley, C, Crabbe, D, Crossland, S, Edirimanna, N, Fitzgerald, C, Gibbins, C, Gibbs, J, Hirst, K, Kennedy, A, Klose, E, McDowall, K, Miller, S, Morgan, R, Noonan, A, North, M, Oliver, M, Richards, K, Russell, T, Scott, N, Shlanski, A, Traynor, A, Smith MI, S, Adams, R, Banks, C, Burke, K, Hewat, S, McKenna, B, McKimmie, M, Polmear, L, Traumanis, M, Whiteman, S, Bramah, V, Errey, R, Halpin, M, Molan, V, Wheelwright, D, Wilson, N, Zhang MIs, W, Bakshi, M, Bracher, S, Bryant, M, Byrnes, W, Denton, T, DeVries, N, Fay, P, Galbraith, P, Gallaher, T, Haidar, O, Holgate, K, Hozack, K, Jackson, N, Kipps, S, Lerner, S, Markus, R, Merheb, R, Naismith, C, Nolan, G, Odelli, R, Page, K, Sangvatanakul, P, Simpson, T, van Vliet, P, Walch, K, Walker, S, Yasue, T, Auld MI, G, Baker, R, Cousins, K, Fairbrother, M, Hutchinson, K, Maclean, M, Maher, E, Mills, D, Ohlback, S, Sturm, J, Tooth, M, Watkins, J, Cramb MI, J, Atkinson, P, Conrad, J, Fichera, D, Follent, S, Gilbert, C, Herzig, M, Kohler, S, McCracken, S, Nunan, L, Roberts, S, Shelley, J, Varendorff, S, Wills, A, Moore, A, Robertson MIs, A, Britton, J, Burgess, A, Coates, T, Croft, J, Greening, E, Holland, J, O'Brien, P, Strong, R, Tighe MI, L, Bilston, S, Black, J, De Rivera, K, Dwyer, I, Gissane, S, Heckenberg, K, Jackson, S, Maclagan, A, O'Hare, L, Patel, H, Pearce, J, Scanlan, C, Seymour, K, Symington, M, Tyers, A, Waite, A, Wiesner, K, Katalinic, O, Spear MIs, M, Brown, P, Difuntorum, E, Gilbert, S, Henderson, J, James, D, Janssen, H, Lane, E, Lowndes, S, Smith, D, Thompson, S, Weaver, D, Weston, S, Wright, S, Cox, S, Tse MIs, C, Adrian, J, Doughty, M, Kok, J, McGrath, R, Morris, T, Pickup, A, Ray, E, Richardson, R, Sims, M, Thompson, C, Trinh, K, Walton, N, Whittaker, F, Andersen MI, P, Burrows, J, Dawson, M, Griffiths, D, Harris, G, Kavalieros, P, O'Brien, B, Roberts, K, Watkins, J, Whyatt, C, McRae, A, Wavish MIs, G, Anos, F, Armstrong, J, Au, E, Barber, A, Bates, C, Bertulfo, M, Boggs, A, Burgess, F, Cassels-Brown, K, Chiu, M, Dass, S, Duff, N, Farrell, J, Foster, W, Fuertez, D, Gadhvi, C, George, S, Green, A, Harvey-Fitzgerald, L, Hau, L, Hayward, L, Holman, D, Huggins, K, Jacobs, M, John, A, Kaur, H, Lagerstedt, T, Lee, J, Llenes, R, Lyons, L, Magandi, S, Martin, M, Mathew, S, Mathew, T, McKellar, D, Moss, E, Nand, KL, Nicol, K, Peterson, F, Prasad, A, Quick, K, Revell, E, Roy, S, Ryan, J, Samadi, N, Scrivener, B, Slow, J, Tharakan, S, Torrens, J, van Bysterveldt, E, Villaluz, C, Yang, S, Katijjahbe, MA, Ai Sing, G, Azlina, A, Azmi, MI, Efri, MH, Fadilah, AZ, Fathuddeen, H, Haryani, H, Hussien, H, Izuani, M, Man, ZC, Man Ying, C, Mashitoh, KM, Noor Azah, A, Norlinah, MI, Norliza, I, Ravinder, KB, Rohaizah, R, Rosnita, K, Rozita, A, Safwan, J, Sahathevan, R, Shahrul, I, Sharifah, SM, Tan, HJ, Wan Nafisah, WY, Yee, YL, Zaharah, MA, Zunaidah, AS, Tan, D, Ahmad, MT, Hameed MIs, S, Bakari, MFB, Britto, J, Chen, JJ, Choo, S, Faizal, M, Fong, FK, Hong, S, Ja'afar, J, Ke, Z, Koh, G, Lee, CK, Lee, YF, Lim, P, Lim, GM, Ninhadi, SH, Ong, G, Pei, T Pei, Penero, V, Rahim, N, Ratnagopal, P, Saleh, K, Seow, HC, Sim, E, Tan, CK, Tay, PY, Teo, I, Thilarajah, S, Wong, PHJ, Wong, WP, Yeap, S, Macleod MI, M, Anderson, A, Armstrong, K, Baird, K, Balfour, D, Boyd, M, Cameron, J, Carswell, C, Clanachan, C, Cuthill, L, Devoy, I, Forsyth, S, Gavin, J, Hughes, M, Marr, E, McAuley, S, McCagherty, E, McCallum, K, McDonald, N, McGhee, C, McIntyre, TA, Noonan, L, Smart, A, Walshe, R, Neal MI, D, Allison, J, Ball, G, Board, S, Brunt, H, Buckley, C, Carroll, C, Hayward, D, Hutchinson, T, Jones, E, Keeling, E, Marsh, E, Mead, N, Smith, H, Vickers, C, Williams-Yesson, B, Wood, D, Coyle, J, Keeling MIs, M, Ackroyd, L, Brown, C, Donnan, K, Dyer, N, Green, H, Kilbride, G, Nicholson, C, Porteous, M, Louw MI, S, Annamalai, A, Barkat, A, Crawford, S, Fawcett, M, Harvey, D, Hogg, V, Hughes, A, Kemp, J, Morrison, J, Storey, K, Thompson, T, Furnace, J, Macleod MIs, MJ, Bell, J, Bennett, K, Bruce, M, Clarke, R, Cowie, H, Gow, H, Irvine, J, Joyson, A, MacDonald, S, Macvicar, A, Murphy, N, Robertson, J, Gordon, C, Kwan, J, Redpath, L, Saunders MIs, K, Bell, J, Burrow, R, Clarke, C, Dickson, C, Hann, G, Heath, M, Heath, S, Hewett, A, Humphrey, R, Longland, B, Orpen, A, Ovington, C, Page, J, Rogers, E, Toombs, K, Howes, R, Lacey, A, Meakin MIs, P, Ames, D, Banerjee, S, Beranova, E, Berry, S, Burke, MJ, Cassama, V, Collins, K, Crow, J, Dunne, A, Gomez, C, Hawkins, A, Hellier, K, Howard, SA, Kar, A, Lambert, E, Lee, H, Mandri, C, Moye, J, Murtagh, E, Pushpa-Rajah, J, Richardson, J, TSachs, Stilwell, J, Tilley, V, Wilding, P, Wilson, N, Feely, E, Kirk MIs, S, Cassidy, P, Chalmers, A, Duguid, C, Hughes, N, Hutton, J, Lapsley, K, Lee, J, Murray, A, Weir, L, Whitelaw, M, Barber, M, Esson MIs, D, Armit, H, Devlin, C, Duncan, R, Forman, C, Frame, K, Hogg, L, McLeod, P, McWhinney, R, Porter, J, Purves, M, Snowball, L, Wroath MI, B, Ferson, L, Gibson, M, Gillespie, S, Ignatius, N, Kane, T, Kwant, J, Matthews, M, McCallion, C, McConville, C, McDowell, M, McNally, C, Moore, L, Murphy, P, Nesbitt, A, Newell, J, Power, M, Reid, E, Robinson, K, Charnley, C, James MIs, M, Bacon, S, Booth, N, Bowring, A, Boxall, L, Burt, J, Cageao, J, Green, N, Gupwell, K, Keenan, S, Kingwell, H, Kryszkowska, M, Mortimore, J, Peace, B, Roughan, C, Gunathilagan, G, Sampson, J, Thomas MIs, G, Allen, T, Dane, G, Harris, K, Hart, S, Jones, SA, Reader, M, Browne, P, McGoldrick, C, Mullan MIs, D, Adair, P, Armstrong, J, Beggs, E, Bell, I, Edwards, C, Gilligan, L, Kelly, C, Kennedy, M, Kurian, J, Leal, L, McAtamney, A, McKay, E, Rogan, E, Smyth, M, Wiseman, E, Vahidassr, J, Price, C, Riddell MIs, V, Bendix, E, Craig, K, Davison, R, Harrison, A, Smith, A, Green MI, V, Ashton, K, Barkhuizen, W, Daniel, A, Dickinson, C, Durdu, H, Eastwood, D, Goddard, H, Hodkin, R, Howard, J, Jeffs, C, Joyce, S, Kelly, C, Kerr, G, Lanes, J, Magnall, B, McMahon, M, Moody, M, Patton, S, Taylor, R, Watson, A, Mitchelson, K, Mokoena MIs, L, Aird, L, Lakey, R, Murdy, J, Nelson, K, Storey, G, McGeown, R, Tauro MIs, S, Brady, R, Holland, D, Kinnaird, M, Maltman, L, Martin, D, McCord, K, McKenna, S, Morgan, C, Shannon, C, Steele, A, Wiggam, I, Appleby, S, Brotheridge, S, Prescott MIs, M, Bagot, P, Baston, D, Bennett, C, Featherstone, J, Hare, C, McCluskey, A, Wade, S, Worton, R, Hakim, E, Herman, J, Norman MIs, T, Beale, L, Buckley, E, Byrne, K, Gasior, M, Robles, B, Smallwood, C, Stevens, S, Thomas, M, Williams, V, Buck MI, K, Armstrong, S, Brice, V, Edwards, A, Gething, S, Griffiths, A, Hills, T, Howells, D, Langdon, S, Moseley, S, Powell, G, Reynolds, G, Richard, B, Scott, E, White, R, Zebedee, J, Walters MI, M, Alexander, J, Brand, L, Colquhoun, E, Hill, A, Macartney, D, MacDonald, H, Manak, B, Morgan, H, Ritchie, C, Hunter MI, H, Blair, T, Duffy, M, Graham, J, Scott, J, Vu, T, Yorston, P, Nair MI, A, Shakir, I, Button, C, Friend, M, Greig, J, Hairsine, B, Wade, S, Williamson, S, Cloud MI, G, Adedoyin, T, Dayal, N, Gawned, S, Ghatala, R, Jeyaraj, N, Kerin, L, Montague, L, Orefo, C, O'Reilly, J, Styles, J, Trippier, S, Watchurst, C, Watson, F, Hunt, J, Latif MIs, R, Barrett, C, Cox, J, Hammonds, F, Quick, K, Robinson, K, Skinner, A, Vernon, C, Burgess, S, Elder-Gracie MIs, T, Browne, C, Cameron, W, Coleman, V, Fulgencio, C, Gibson, L, Halliday, P, Heaney, D, Main, L, McGavin, K, Mead, G, Proudfoot, F, Redpath, A, Rodger, C, Scott, S, Robinson, K., Mason MI, K, Baxter, L, Bryce, A, Halkett, M, Halliday, J, McAllister, A, McGuiness, M, Munro, M, Robb, A, Thompson, A, Tougher, B, Weadon, J, Young, J, Douglas MI, C, McParland, M, Boyle, S, Byrne, B, Comiskey, L, Gilpin, J, Gilpin, S, Harris, A, Harshaw, S, Haughey, J, McArdle, F, McConnell, L, McEneaney, E, Millar, M, Murphy, M, Tilley, J·2016·Neurology
DOI 10.1212/wnl.0000000000002459PMC PMC4898313
Open this paper in CoChat — free accountOpen PDF

Abstract

OBJECTIVE: Our prespecified dose-response analyses of A Very Early Rehabilitation Trial (AVERT) aim to provide practical guidance for clinicians on the timing, frequency, and amount of mobilization following acute stroke. METHODS: Eligible patients were aged ≥18 years, had confirmed first (or recurrent) stroke, and were admitted to a stroke unit within 24 hours of stroke onset. Patients were randomized to receive very early and frequent mobilization, commencing within 24 hours, or usual care. We used regression analyses and Classification and Regression Trees (CART) to investigate the effect of timing and dose of mobilization on efficacy and safety outcomes, irrespective of assigned treatment group. RESULTS: A total of 2,104 patients were enrolled, of whom 2,083 (99.0%) were followed up at 3 months. We found a consistent pattern of improved odds of favorable outcome in efficacy and safety outcomes with increased daily frequency of out-of-bed sessions (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.09 to 1.18, p < 0.001), keeping time to first mobilization and mobilization amount constant. Increased amount (minutes per day) of mobilization reduced the odds of a good outcome (OR 0.94, 95% CI 0.91 to 0.97, p < 0.001). Session frequency was the most important variable in the CART analysis, after prognostic variables age and baseline stroke severity. CONCLUSION: These data suggest that shorter, more frequent mobilization early after acute stroke is associated with greater odds of favorable outcome at 3 months when controlling for age and stroke severity. CLASSIFICATION OF EVIDENCE: This study provides Class III evidence that shorter, more frequent early mobilization improves the chance of regaining independence after stroke.

Overview

AI snapshot

Written from the paper’s full text.

TL;DR

In prespecified dose-response analyses of AVERT (2,104 randomized; 2,083 followed at 3 months), shorter, more frequent out-of-bed mobilization after acute stroke was associated with greater odds of favorable outcome at 3 months, while greater daily minutes of mobilization was associated with lower odds. These exploratory analyses suggest session frequency may be a key driver of outcome, but require confirmation in RCTs.

Key findings

  • Increased daily frequency of out-of-bed sessions was associated with improved odds of favorable outcome (mRS 0–2): OR 1.13, 95% CI 1.09–1.18, p < 0.001, holding time to first mobilization and mobilization amount constant; it also improved the odds of walking 50 meters unassisted by 66% (95% CI 53–80, p < 0.001).
  • Increased daily amount (minutes/day) of mobilization reduced the odds of a good outcome: OR 0.94, 95% CI 0.91–0.97, p < 0.001. Greater time to first mobilization was associated with reduced odds of favorable outcome: OR 0.99, 95% CI 0.98–1.00, p = 0.036.
  • Increasing session frequency was the only dose characteristic that reduced the odds of death by approximately 20%; nonfatal SAE associations were less consistent, and the relatively few immobility and neurologic SAEs should be viewed with caution.
  • In CART, after baseline stroke severity (NIHSS, relative importance 100%), session frequency was next most important (39.2%), then age (32.4%), TTFM (10.5%), and daily amount (2.7%); treatment group was not an important discriminator. In the usual care group alone, more frequent sessions improved the odds of a good outcome by 12% (OR 1.12, 95% CI 1.04–1.21, p < 0.004).

Methods

  • Prespecified dose-response analysis of AVERT, a pragmatic, parallel-group RCT conducted in 56 stroke units in 5 countries; 2,104 patients were randomized to very early mobilization or usual care, and 2,083 (99.0%) were followed at 3 months. Eligible patients were aged ≥18 years, had confirmed first or recurrent stroke, and were admitted to a stroke unit within 24 hours of stroke onset.
  • Dose measures were time from stroke onset to first mobilization out of bed (TTFM, hours), median number of out-of-bed sessions per patient per day (frequency), median minutes of out-of-bed activity per patient per day (daily amount), and total minutes over the intervention period. Frequency and TTFM were derived from nurse and physiotherapist data; daily and total amount reflected physiotherapy data alone.
  • Analyses used binary logistic regression for favorable outcome (mRS 0–2) and walking, Cox regression for time to unassisted walking, logistic regression for death, and negative binomial regression for SAEs, adjusted for age and baseline NIHSS. Two models were tested to avoid collinearity between daily and total amount; CART with 10-fold internal cross-validation explored interactions.

Limitations

  • Stated: this exploratory analysis is not an RCT testing each intervention component separately (time, amount, frequency), and results need confirmation in further RCTs.
  • Stated: only physiotherapist-assisted out-of-bed therapy time was recorded, not nursing time, so the data underestimate actual minutes per day spent in out-of-bed activity.
  • Stated/evident: the optimal time to commence out-of-bed activity remains unknown, partly because TTFM had a compact distribution (median 20.2 hours, IQR 14.7–23.8); SAE analyses had relatively few immobility and neurologic events. Also evident: dose-response associations are observational irrespective of assigned treatment group, so residual confounding is possible, although the authors report a similar frequency association in the usual care group alone.

Model-written summary. Check it against the paper before relying on it.

Integrity signals

Registry

Crossref · 10.1212/wnl.0000000000002459

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Nothing to recompute.

Verification

Claims the paper makes

0 of 17 cited sources checked · 0 supported · 0 flagged

Show all 25 claims

  • It may state two separate claims as one. 15
  • Probably not a substantial claim. 8
20 of 20

  • The paper relies on this without support.

    In AVERT, usual care was not standardized and mobilization often commenced within 24 hours of stroke.

    “However, a recommendation of “usual care” is of limited value to clinicians seeking guidance, as usual care was not standardized and mobilization often commenced within 24 hours of stroke.”

  • The paper relies on this without support.

    The dose characteristics (TTFM, frequency, daily amount) measured from nurse and physiotherapist records accurately represent the actual mobilization dose received by patients.

    “Nurses recorded type of activity and time of the day each activity began, but not minutes, as this was not routine practice. Physiotherapists recorded activity type, time the activity began, and total out-of-bed activity time (minutes), consistent with their routine practice.”

  • The paper relies on this without support.

    The relationship between dose characteristics and outcome is not confounded by unmeasured factors beyond age and baseline stroke severity.

    “To avoid excessive collinearity between daily amount and total amount, we tested 2 separate models, adjusted for age and baseline stroke severity (NIH Stroke Scale [NIHSS]), for all analyses, as follows:”
3 of 3

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

  • CART importance ranking places frequency ahead of age

    Minor

    The abstract says session frequency ranked after both age and baseline stroke severity. The reported CART rankings instead place frequency (39.2%) ahead of age (32.4%).

1 of 1

Citations

Cites

Flagged first, then by citations

Show all 25 references

Cited by

Sorted by citations

See all 221

Related

See all

Metadata

Authors
Bernhardt, J., Churilov, L., Ellery, F., Collier, J., Chamberlain, J., Langhorne, P., Lindley, R. I., Moodie, M., Dewey, H., Thrift, A. G., Donnan, G., AVERT Collaboration Group, Bernhardt, J., Churilov, L., Collier, J., Dewey, H., Donnan, G., Ellery, F., Langhorne, P., Lindley, R., Moodie, M., Parsons, B., Thrift, A., Donnan, G., Dewey, H., Bernhardt, J., Langhorne, P., Moodie, M., Parsons, B., Investigators MIs, M., Indredavik, B., Askim, T., Bath, P., Bladin, C., Reid, C., Read, S., Said, C., Middleton, S., Frayne, J., Srikanth, V., Bernhardt, A. J., Dewey, H., Bernhardt, J., Donnan, G., Thrift, A., Carter, R., Lindley, R., Bernhardt, J., Donnan, G., Lindley, R., Thrift, A., Langhorne, P., Moodie, M., Dewey, H., Churilov, L., Langhorne, P., Langhorne, P., Wu, O., Bernhardt, J., Claire Ritchie, M. W., Smith, L., Langhorne, P., Wu, O., Ashburn, A., Rodgers, H., Bernhardt, J., Langhorne, P., Ashburn, A., Bernhardt, J., Rogers, H., Wu, O., Lennon, S., Lennon, S., Power, M., Bernhardt, J., Hameed, S., Hameed, S., Pavanni, R., Lim, P., Bernhardt, J., Tan, D., Churilov, L., Brewer, T., Collier, J., Haritos, N., Leong, E., Li, C., NayWin, C., Nicol, M., Olenka, L., Quang, L. C., Moodie, M., Carter, R., Hope, S., Sheppard, L., Teo, K. T., Wu, O., Cumming, T., Linden, T., Borschmann, K., Chamberlain, J., Collier, J., Cumming, T., Ellery, F., Occhiodoro, T., Palfreeman, H., Purvis, T., Sirgo, B., Tiliacos, N., Van Holsteyn, J., Zhao, H., Armstrong, B., Craig, L., Graham, F., Legg, L., Morrison, R., Moorhead, H., O’Donohue, L., Rogers, S., Smith, M., Forshaw, D., Fitzgerald, J., Hibbert, E., Melling, R., Petrolo, S., Purvis, T., Williamson MIs, H., Adams, P., Augoustakis, L., Batcheler, S., Berney, S., Cobani, V, Cohen, B., Dewey, H., Gangi, S., Giofre, N., Gordon, C., Hegarty, L., Hindson, M., Horvath, F., Kalinowski, S., Kleine, A., Kramer, S., Lawrence, J., Lindquist, S., Logan, N., Macdonell, A., Matlioski, J., McDonough, N., McLennan, S., McNamee, M., Miller, L., Nall, C., Nelson, E., Ng, K., Nicholas, Z., Nunn, C., Owen, K., Plant, E., Proud, L., Quah, D., Rodway, K., Sertori, S., Sheldon, V, Sherry, L., Speare, S., Stansfeld, K., Studden, N., Teoh, Z., Twist, L., Velupillai, G., Walker, L., Wall, K., Warwick, A., Wharrie, R., Wilson, J., Worboys, H., Young, D., Ancliffe MI, J., Bryant, M., Doran, B., Field, M., Fogliani, P., Haber, A., Hankey, G., Hendrie, D., Jackaman, V, Jacobsen, A., Jose, S., Lim, R., Louis, R., Nanthakumar, S., Pain, S., Power, A., Rappeport, B., Reynolds, J., Smith, L., Tombe, S., Wesseldine, A., West, T., Clarke, K., Maccanti, H., Marr, L., Plumb, S., Quiney, J., Werner MIs, L., Abeykoon, E., Apirutvorrachod, W., Attard, L., Behanan, S., Brown, D., Buchanan, K., Butler, D., Camac, M., Davis, S., Diocera, D., Gan, N., Gendre, C., Germaine, J., Hand, P., Maurenbrecher, L., McCulloch, J., Mcritchie, S., Ong, M., Pachett, R., Pesavento, L., Power, H., Reilly, R., Sawers, M., Silva, G., Stevens, C., Taylor, L., Timms, T., Ugalde, M., Vardy, A., Wallace, J., Walsh, S., Whatley, E., Winter, E., Baxter, M., Davis, M., Sundararajan MIs, L., Butler, E., Caspers, K., Coulter, E., Shaw, S., Kent, F., Lack, H., Leavold, F., Lord, J., Martin-Francisco, J., Mohanraj, R., Nelson, R., O'Neill, T., Otto, R., Parker, J., Rees, V, Stevens, B., Chen MI, R., Lindley, R., Bindra, J., Dongre, R., Downey, N., Ferris, M., Gibson, L., Gonzalez, R., Kinniburgh, M., Lazaridou, M., McCormack, D., Singh, R., Stepney, A., Tria, Y., Bainbridge, K., Killey, B., Sheedy MIs, R., Aitchison, O., Bray, L., Clatworthy, K., Coghill, S., Collins, M., Cornwall, L., Dow, J., Gates, P., Gillett, S., Johnson, N., Joseph, S., Kopelke, K., Lam, R., Levy, R., Lloyd, N., Logan, S., McPherson, G., Newth, M., Parsons, C., Powles, K., Rebis, M., Samakowidic, T., Sanders, L., Savickas, S., Shrimpton, J., Smith, H., Smith, L., Spehr, J., Summers, J., Taylor, G., Thackeray, M., Wilkinson, B., Richardson MI, K., Frayne, J., Barber, E., Bode, L., Brakey, A., Chand, K., Christin, P., Crook, G., Delrosario-Kelly, D., Descallar, R., Deutsch, A., Easo, S., Farquhar, M., Fergus, P., Ford, J., Hamson, E., Hlaing, M., Hope, E., Lacivita, J., Laurenson, J., Lock, K., Ly, N., McKay, K., Mill, C., Moloney, K., Price, L., Terry, T., Tyers, A., Willems, S., Woolstencroft, R., Crawshaw, N., Luker, J., Wood, C., Choat MIs, S., Archer, C., Benham, D., Billinger, M., Bronca, M., Curchin, S., Dickie, C., Dixon, M., Douglass, D., Enomoto, M., Ernst, K., Fries, L., George, S., Green, E., Hamilton, L., Harris, Z., Heard, T., Hunt, G., Jamieson, N., Mackenzie, M., McKearney, H., Oermann, B., O'Reilly, C., Pearson, T., Reid, N., Rodda, L., Scutcheon, D., Simons, C., Smith, R., Tait, L., Troake, J., Usher, D., Mackey, L., Wijeratne MIs, T., Abela, C., Ashoka, S., Chen, C., Cheng, T., Chong, V, Cooke, S., Fok, A., Galang, L., Grant, C., Karageorge, S., Kat, K., Keo, L., Lee, B., Luscombe, A., Mackay, J., Minett, M., Mizen, J., Nim, P., Nunlist, N., Patel, V, Pathirage, M., Paton, A., Pombuena, M., Rathnayake, N., Rhodes, L., Sequeira, M., Smart, S., Somaratne, S., Maria, N. S., Talbot, L., Tecle, R., Shannon, M., Gerraty MIs, R., Allen, S., Boyle, R., Fatchen, N., Hendley, N., Hyde, A., Inal, M., Kalubowilage, P., Laverde, M., Lawless, K., McFadyen, A., Peters, K., Pugh, C., Qin, C., Robertson, J., Smee, S., Tomlinson, R., Wang, V, Williams, F., Woolley, D., Yawieriin, R., Austin, N., Pomfret, S., Tinsley MIs, M., Allport, L., Ang, C., Armitage, L., Blundell, E., Courtney, A., Dela Costa, M., Thapa, T. D., Diwakar, P., Dulleh, M., Francis, J., Cic, P., Gellie, G., Gill, C., James, D., Lee, S., Mai, T., Majcher, K., Mawson, C., Newton, G., Qiu, N., Ragonton, E., Roberts, L., Saitamis, H., Stanwell, L., Ting, L., Xu, P., Yin, L., Crosby MI, V, Broadhead, K., Church, J., Collins, R., Everitt, K., Fisher, M., Hochmuth, K., Jones, N., Lieschke, A., McCarthy, E., McGlone, C., Morey, D., Neilson, D., Spry, S., Vile, M., Grimley, R., Rowley MIs, D., Rosbergen, I., Ahern, E., Anderson, L., Boreham, J., Devin, R., Doolan, R., Dyke, M., Griffiths, L., Guest, K., Hecita, D., Kendal, N., Koltermann, J., Lacy, M., Lebeter, S., Lloyd, D., Matthews, M., McAuley, C., Pollock, A., Pyke, M., Rogers, T., Street, S., Styles, G., Tampiyappa, A., Trinder, J., Verral, T., Walker, K., White, C., Beckwith, T., Cormack MIs, L., Arriagada, J., Babenschneider, C., Blacker, D., Bennett, S., Connor, S., Cowmeadow, J., Daniel, N., Edmonds, G., Faulkner, M., Garcia-Vega, M., Kruger, K., Martial, B., McGinley, P., Mountford, H., Riley, V, Smith, N., Stepan, F., Tilley, S., Whisson, S., Groot MI, P., Bailey, J., Ballinger, K., Bell, C., Camilleri, B., Charnley, C., Crabbe, D., Crossland, S., Edirimanna, N., Fitzgerald, C., Gibbins, C., Gibbs, J., Hirst, K., Kennedy, A., Klose, E., McDowall, K., Miller, S., Morgan, R., Noonan, A., North, M., Oliver, M., Richards, K., Russell, T., Scott, N., Shlanski, A., Traynor, A., Smith MI, S., Adams, R., Banks, C., Burke, K., Hewat, S., McKenna, B., McKimmie, M., Polmear, L., Traumanis, M., Whiteman, S., Bramah, V, Errey, R., Halpin, M., Molan, V, Wheelwright, D., Wilson, N., Zhang MIs, W., Bakshi, M., Bracher, S., Bryant, M., Byrnes, W., Denton, T., DeVries, N., Fay, P., Galbraith, P., Gallaher, T., Haidar, O., Holgate, K., Hozack, K., Jackson, N., Kipps, S., Lerner, S., Markus, R., Merheb, R., Naismith, C., Nolan, G., Odelli, R., Page, K., Sangvatanakul, P., Simpson, T., van Vliet, P., Walch, K., Walker, S., Yasue, T., Auld MI, G., Baker, R., Cousins, K., Fairbrother, M., Hutchinson, K., Maclean, M., Maher, E., Mills, D., Ohlback, S., Sturm, J., Tooth, M., Watkins, J., Cramb MI, J., Atkinson, P., Conrad, J., Fichera, D., Follent, S., Gilbert, C., Herzig, M., Kohler, S., McCracken, S., Nunan, L., Roberts, S., Shelley, J., Varendorff, S., Wills, A., Moore, A., Robertson MIs, A., Britton, J., Burgess, A., Coates, T., Croft, J., Greening, E., Holland, J., O'Brien, P., Strong, R., Tighe MI, L., Bilston, S., Black, J., De Rivera, K., Dwyer, I., Gissane, S., Heckenberg, K., Jackson, S., Maclagan, A., O'Hare, L., Patel, H., Pearce, J., Scanlan, C., Seymour, K., Symington, M., Tyers, A., Waite, A., Wiesner, K., Katalinic, O., Spear MIs, M., Brown, P., Difuntorum, E., Gilbert, S., Henderson, J., James, D., Janssen, H., Lane, E., Lowndes, S., Smith, D., Thompson, S., Weaver, D., Weston, S., Wright, S., Cox, S., Tse MIs, C., Adrian, J., Doughty, M., Kok, J., McGrath, R., Morris, T., Pickup, A., Ray, E., Richardson, R., Sims, M., Thompson, C., Trinh, K., Walton, N., Whittaker, F., Andersen MI, P., Burrows, J., Dawson, M., Griffiths, D., Harris, G., Kavalieros, P., O'Brien, B., Roberts, K., Watkins, J., Whyatt, C., McRae, A., Wavish MIs, G., Anos, F., Armstrong, J., Au, E., Barber, A., Bates, C., Bertulfo, M., Boggs, A., Burgess, F., Cassels-Brown, K., Chiu, M., Dass, S., Duff, N., Farrell, J., Foster, W., Fuertez, D., Gadhvi, C., George, S., Green, A., Harvey-Fitzgerald, L., Hau, L., Hayward, L., Holman, D., Huggins, K., Jacobs, M., John, A., Kaur, H., Lagerstedt, T., Lee, J., Llenes, R., Lyons, L., Magandi, S., Martin, M., Mathew, S., Mathew, T., McKellar, D., Moss, E., Nand, K., Nicol, K., Peterson, F., Prasad, A., Quick, K., Revell, E., Roy, S., Ryan, J., Samadi, N., Scrivener, B., Slow, J., Tharakan, S., Torrens, J., van Bysterveldt, E., Villaluz, C., Yang, S., Katijjahbe, M., Ai Sing, G., Azlina, A., Azmi, M., Efri, M., Fadilah, A., Fathuddeen, H., Haryani, H., Hussien, H., Izuani, M., Man, Z., Man Ying, C., Mashitoh, K., Noor Azah, A., Norlinah, M., Norliza, I., Ravinder, K., Rohaizah, R., Rosnita, K., Rozita, A., Safwan, J., Sahathevan, R., Shahrul, I., Sharifah, S., Tan, H., Wan Nafisah, W., Yee, Y., Zaharah, M., Zunaidah, A., Tan, D., Ahmad, M., Hameed MIs, S., Bakari, M., Britto, J., Chen, J., Choo, S., Faizal, M., Fong, F., Hong, S., Ja'afar, J., Ke, Z., Koh, G., Lee, C., Lee, Y., Lim, P., Lim, G., Ninhadi, S., Ong, G., Pei, T. P., Penero, V, Rahim, N., Ratnagopal, P., Saleh, K., Seow, H., Sim, E., Tan, C., Tay, P., Teo, I., Thilarajah, S., Wong, P., Wong, W., Yeap, S., Macleod MI, M., Anderson, A., Armstrong, K., Baird, K., Balfour, D., Boyd, M., Cameron, J., Carswell, C., Clanachan, C., Cuthill, L., Devoy, I., Forsyth, S., Gavin, J., Hughes, M., Marr, E., McAuley, S., McCagherty, E., McCallum, K., McDonald, N., McGhee, C., McIntyre, T., Noonan, L., Smart, A., Walshe, R., Neal MI, D., Allison, J., Ball, G., Board, S., Brunt, H., Buckley, C., Carroll, C., Hayward, D., Hutchinson, T., Jones, E., Keeling, E., Marsh, E., Mead, N., Smith, H., Vickers, C., Williams-Yesson, B., Wood, D., Coyle, J., Keeling MIs, M., Ackroyd, L., Brown, C., Donnan, K., Dyer, N., Green, H., Kilbride, G., Nicholson, C., Porteous, M., Louw MI, S., Annamalai, A., Barkat, A., Crawford, S., Fawcett, M., Harvey, D., Hogg, V, Hughes, A., Kemp, J., Morrison, J., Storey, K., Thompson, T., Furnace, J., Macleod MIs, M., Bell, J., Bennett, K., Bruce, M., Clarke, R., Cowie, H., Gow, H., Irvine, J., Joyson, A., MacDonald, S., Macvicar, A., Murphy, N., Robertson, J., Gordon, C., Kwan, J., Redpath, L., Saunders MIs, K., Bell, J., Burrow, R., Clarke, C., Dickson, C., Hann, G., Heath, M., Heath, S., Hewett, A., Humphrey, R., Longland, B., Orpen, A., Ovington, C., Page, J., Rogers, E., Toombs, K., Howes, R., Lacey, A., Meakin MIs, P., Ames, D., Banerjee, S., Beranova, E., Berry, S., Burke, M., Cassama, V, Collins, K., Crow, J., Dunne, A., Gomez, C., Hawkins, A., Hellier, K., Howard, S., Kar, A., Lambert, E., Lee, H., Mandri, C., Moye, J., Murtagh, E., Pushpa-Rajah, J., Richardson, J., TSachs, Stilwell, J., Tilley, V, Wilding, P., Wilson, N., Feely, E., Kirk MIs, S., Cassidy, P., Chalmers, A., Duguid, C., Hughes, N., Hutton, J., Lapsley, K., Lee, J., Murray, A., Weir, L., Whitelaw, M., Barber, M., Esson MIs, D., Armit, H., Devlin, C., Duncan, R., Forman, C., Frame, K., Hogg, L., McLeod, P., McWhinney, R., Porter, J., Purves, M., Snowball, L., Wroath MI, B., Ferson, L., Gibson, M., Gillespie, S., Ignatius, N., Kane, T., Kwant, J., Matthews, M., McCallion, C., McConville, C., McDowell, M., McNally, C., Moore, L., Murphy, P., Nesbitt, A., Newell, J., Power, M., Reid, E., Robinson, K., Charnley, C., James MIs, M., Bacon, S., Booth, N., Bowring, A., Boxall, L., Burt, J., Cageao, J., Green, N., Gupwell, K., Keenan, S., Kingwell, H., Kryszkowska, M., Mortimore, J., Peace, B., Roughan, C., Gunathilagan, G., Sampson, J., Thomas MIs, G., Allen, T., Dane, G., Harris, K., Hart, S., Jones, S., Reader, M., Browne, P., McGoldrick, C., Mullan MIs, D., Adair, P., Armstrong, J., Beggs, E., Bell, I., Edwards, C., Gilligan, L., Kelly, C., Kennedy, M., Kurian, J., Leal, L., McAtamney, A., McKay, E., Rogan, E., Smyth, M., Wiseman, E., Vahidassr, J., Price, C., Riddell MIs, V, Bendix, E., Craig, K., Davison, R., Harrison, A., Smith, A., Green MI, V, Ashton, K., Barkhuizen, W., Daniel, A., Dickinson, C., Durdu, H., Eastwood, D., Goddard, H., Hodkin, R., Howard, J., Jeffs, C., Joyce, S., Kelly, C., Kerr, G., Lanes, J., Magnall, B., McMahon, M., Moody, M., Patton, S., Taylor, R., Watson, A., Mitchelson, K., Mokoena MIs, L., Aird, L., Lakey, R., Murdy, J., Nelson, K., Storey, G., McGeown, R., Tauro MIs, S., Brady, R., Holland, D., Kinnaird, M., Maltman, L., Martin, D., McCord, K., McKenna, S., Morgan, C., Shannon, C., Steele, A., Wiggam, I., Appleby, S., Brotheridge, S., Prescott MIs, M., Bagot, P., Baston, D., Bennett, C., Featherstone, J., Hare, C., McCluskey, A., Wade, S., Worton, R., Hakim, E., Herman, J., Norman MIs, T., Beale, L., Buckley, E., Byrne, K., Gasior, M., Robles, B., Smallwood, C., Stevens, S., Thomas, M., Williams, V, Buck MI, K., Armstrong, S., Brice, V, Edwards, A., Gething, S., Griffiths, A., Hills, T., Howells, D., Langdon, S., Moseley, S., Powell, G., Reynolds, G., Richard, B., Scott, E., White, R., Zebedee, J., Walters MI, M., Alexander, J., Brand, L., Colquhoun, E., Hill, A., Macartney, D., MacDonald, H., Manak, B., Morgan, H., Ritchie, C., Hunter MI, H., Blair, T., Duffy, M., Graham, J., Scott, J., Vu, T., Yorston, P., Nair MI, A., Shakir, I., Button, C., Friend, M., Greig, J., Hairsine, B., Wade, S., Williamson, S., Cloud MI, G., Adedoyin, T., Dayal, N., Gawned, S., Ghatala, R., Jeyaraj, N., Kerin, L., Montague, L., Orefo, C., O'Reilly, J., Styles, J., Trippier, S., Watchurst, C., Watson, F., Hunt, J., Latif MIs, R., Barrett, C., Cox, J., Hammonds, F., Quick, K., Robinson, K., Skinner, A., Vernon, C., Burgess, S., Elder-Gracie MIs, T., Browne, C., Cameron, W., Coleman, V, Fulgencio, C., Gibson, L., Halliday, P., Heaney, D., Main, L., McGavin, K., Mead, G., Proudfoot, F., Redpath, A., Rodger, C., Scott, S., Robinson, K., Mason MI, K., Baxter, L., Bryce, A., Halkett, M., Halliday, J., McAllister, A., McGuiness, M., Munro, M., Robb, A., Thompson, A., Tougher, B., Weadon, J., Young, J., Douglas MI, C., McParland, M., Boyle, S., Byrne, B., Comiskey, L., Gilpin, J., Gilpin, S., Harris, A., Harshaw, S., Haughey, J., McArdle, F., McConnell, L., McEneaney, E., Millar, M., Murphy, M., & Tilley, J.
Affiliations
  • From The Florey Institute of Neuroscience and Mental Health (J.B., L.C., F.E., J. Collier, J. Chamberlain, H.D., G.D.), La Trobe University (J.B.), Melbourne, Australia; Institute of Cardiovascular and Medical Sciences (P.L.), University of Glasgow, UK; George Institute for Global Health and Westmead Hospital Clinical School (R.I.L.), University of Sydney; Deakin Health Economics (M.M.), Faculty of Health, Deakin University, Burwood; and Eastern Health Clinical School, Faculty of Medicine, Nursing...
  • The University of Sydney (AU)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-06-07
Volume
86
Issue
23
Pages
2138-2145
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000002459
PMC
PMC4898313
OpenAlex
W2317679986
Semantic Scholar
b4407b66c71a170f617687c13012a525f3d17d11
Cited by
221
References
25
Citations by year
2026: 15 · 2025: 17 · 2024: 14 · 2023: 19 · 2022: 24 · 2021: 31 · 2020: 13 · 2019: 25 · 2018: 24 · 2017: 25 · 2016: 14
FWCI
31.40
Type
journal article
Language
en
Update notices
correction (2017-07-03)
Open access
Licence
cc-by
Locations
  • Neurology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
  • Monash University Research Portal (Monash University) (submittedVersion, other-oa)
  • Figshare (submittedVersion, cc-by-nc-nd)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-nd)
Funders
  • Pfizer
  • Sanofi
  • National Institute for Health and Care Research (12/01/16)
  • Stroke Association
  • Chest Heart and Stroke Scotland (Res08/A114)
  • EVER Neuro Pharma
  • National Health and Medical Research Council (386201, 1042600, 1041401)
Topics
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Medical Practices and Rehabilitation
Keywords
acute stroke, early mobilization, dose-response relationship, stroke unit, functional outcome, stroke severity
MeSH terms
Stroke Rehabilitation, Age Factors, Aged, Aged, 80 and over, Cerebral Hemorrhage, Brain Ischemia, Disability Evaluation, Early Ambulation, Female, Humans, Male, Middle Aged, Severity of Illness Index, Time Factors, Odds Ratio, Treatment Outcome, Recovery of Function, Stroke

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

A language model drew the claims from the paper on 2026-10-08, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).

A second model labelled each claim on 2026-10-08 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review