Cited by 317T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

The locus ceruleus norepinephrine system: Functional organization and potential clinical significance

Benarroch, Eduardo E.·2009·Neurology

DOI 10.1212/wnl.0b013e3181c2937c

Open this paper in CoChat — free account

Abstract

IL-9–producing Th cells, termed Th9 cells, contribute to immunity against parasites and cancers but have detrimental roles in allergic disease and colitis. Th9 cells differentiate in response to IL-4 and TGF-β, but these signals are insufficient to drive Th9 differentiation in the absence of IL-2. IL-2–induced STAT5 activation is required for chromatin accessibility within Il9 enhancer and promoter regions and directly transactivates the Il9 locus. STAT5 also suppresses gene expression during Th9 cell development, but these roles are less well defined. In this study, we demonstrate that human allergy-associated Th9 cells exhibited a signature of STAT5-mediated gene repression that is associated with the silencing of a Th17-like transcriptional signature. In murine Th9 cell differentiation, blockade of IL-2/STAT5 signaling induced the expression of IL-17 and the Th17-associated transcription factor Rorγt. However, IL-2–deprived Th9 cells did not exhibit a significant Th17- or STAT3-associated transcriptional signature. Consistent with these observations, differentiation of IL-17–producing cells under these conditions was STAT3-independent but did require Rorγt and BATF. Furthermore, ectopic expression of Rorγt and BATF partially rescued IL-17 production in STAT3-deficient Th17 cells, highlighting the importance of these factors in this process. Although STAT3 was not required for the differentiation of IL-17–producing cells under IL-2–deprived Th9 conditions, their prolonged survival was STAT3-dependent, potentially explaining why STAT3-independent IL-17 production is not commonly observed in vivo. Together, our data suggest that IL-2/STAT5 signaling plays an important role in controlling the balance of a Th9 versus a Th17-like differentiation program in vitro and in allergic disease.

Integrity signals

Registry

Crossref · 10.1212/wnl.0b013e3181c2937c

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance
Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472
The reorienting system of the human brain: from environment to theory of mind
Corbetta, M., Patel, G., & Shulman, G. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.017 · Cited by 3,889
The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes
Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
The locus coeruleus and noradrenergic modulation of cognition
Sara, S. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2573 · Cited by 1,848
Neuronal Loss Is Greater in the Locus Coeruleus Than Nucleus Basalis and Substantia Nigra in Alzheimer and Parkinson Diseases
Zarow, C., Lyness, S. A., Mortimer, J. A., & Chui, H. C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.337 · Cited by 1,003
Network reset: a simplified overarching theory of locus coeruleus noradrenaline function
Bouret, S., & Sara, S. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.09.002 · Cited by 862
Adrenergic pharmacology and cognition: Focus on the prefrontal cortex
Ramos, B. P., & Arnsten, A. F. T. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.11.006 · Cited by 641
Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback
Fuller, P. M., Gooley, J. J., & Saper, C. B. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406294627 · Cited by 636
Convergent regulation of locus coeruleus activity as an adaptive response to stress
Valentino, R. J., & Van Bockstaele, E. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.062 · Cited by 569
Disease‐specific patterns of locus coeruleus cell loss
German, D. C., Manaye, K. F., White, C. L., Woodward, D. J., McIntire, D. D., Smith, W. K., Kalaria, R. N., & Mann, D. M. A. (1992) · Annals of Neurology · doi:10.1002/ana.410320510 · Cited by 512

Show all 29 references

Research works printed but not linked: 1

McCormick DA. Neurotransmitter actions in the thalamus and cerebral cortex. J Clin Neurophysiol 1992;9:212–223.

Sorted by citations

Items 101–200 of 316

Asymmetrical characteristics of emotional responses to pictures and sounds: Evidence from pupillometry
Nakakoga, S., Higashi, H., Muramatsu, J., Nakauchi, S., & Minami, T. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230775 · Cited by 43
Heavy metals in locus ceruleus and motor neurons in motor neuron disease
Pamphlett, R., & Jew, S. K. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-81 · Cited by 36
Investigation of Behavioral Dysfunctions Induced by Monoamine Depletions in a Mouse Model of Parkinson's Disease
Li, Y. H., Jiao, Q., Du, X., Bi, M., Han, S., Jiao, L., & Jiang, H. F. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00241 · Cited by 36
Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons
Li, S., Shi, Y., Yao, X., Wang, X., Shen, L., Rao, Z., Yuan, J., Liu, Y., Zhou, Z., Zhang, Z., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.042 · Cited by 37
Impaired connectivity within neuromodulatory networks in multiple sclerosis and clinical implications
Carotenuto, A., Wilson, H., Giordano, B., Caminiti, S. P., Chappell, Z., Williams, S., Hammers, A., Silber, E., Brex, P., & Politis, M. (2020) · Journal of Neurology · doi:10.1007/s00415-020-09806-3 · Cited by 36
Visual Hallucinations and the Role of Medications in Parkinson’s Disease: Triggers, Pathophysiology, and Management
Powell, A., Ireland, C., & Lewis, S. J. G. (2020) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.19110316 · Cited by 40
Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus
Pamphlett, R., Mak, R., Lee, J., Buckland, M. E., Harding, A. J., Jew, S. K., Paterson, D. J., Jones, M. W., & Lay, P. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233300 · Cited by 36
A probabilistic atlas of locus coeruleus pathways to transentorhinal cortex for connectome imaging in Alzheimer's disease
Sun, W., Tang, Y., Qiao, Y., Ge, X., Mather, M., Ringman, J. M., & Shi, Y. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117301 · Cited by 40
The role of neurotransmitter systems in mediating deep brain stimulation effects in Parkinson’s disease
Alosaimi, F., Boonstra, J. T., Tan, S. K. H., Temel, Y., & Jahanshahi, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.998932 · Cited by 37
Neuromelanin‐Sensitive Magnetic Resonance Imaging Changes in the Locus Coeruleus/Subcoeruleus Complex in Patients with Typical and Atypical Parkinsonism
Nobileau, A., Gaurav, R., Chougar, L., Faucher, A., Valabrègue, R., Mangone, G., Leu‐Semenescu, S., Lejeune, F., Corvol, J., Arnulf, I., et al. (2023) · Movement Disorders · doi:10.1002/mds.29309 · Cited by 35
A concerted action of L- and T-type Ca2+ channels regulates locus coeruleus pacemaking
Matschke, L. A., Bertoune, M., Roeper, J., Snutch, T. P., Oertel, W. H., Rinné, S., & Decher, N. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.08.012 · Cited by 35
Consequences of tuning network function by tonic and phasic locus coeruleus output and stress: Regulating detection and discrimination of peripheral stimuli
Devilbiss, D. M. (2018) · Brain Research · doi:10.1016/j.brainres.2018.06.015 · Cited by 33
Pupillometric indices of locus-coeruleus activation are not modulated following single bouts of exercise
McGowan, A. L., Chandler, M. C., Brascamp, J. W., & Pontifex, M. B. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.04.004 · Cited by 35
The Contribution of the Locus Coeruleus–Noradrenaline System Degeneration during the Progression of Alzheimer’s Disease
Mercan, D., & Heneka, M. T. (2022) · Biology · doi:10.3390/biology11121822 · Cited by 34
Respiratory Abnormalities in Parkinson’s Disease: What Do We Know from Studies in Humans and Animal Models?
Kaczyńska, K., Orłowska, M. E., & Andrzejewski, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073499 · Cited by 38
Quantitative Analysis of Catecholamines in the Pink1 −/− Rat Model of Early-onset Parkinson’s Disease
Kelm‐Nelson, C. A., Trevino, M. A., & Ciucci, M. R. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.02.027 · Cited by 33
Attention Network Performance and Psychopathic Symptoms in Early Adolescence: An ERP Study
Racer, K. H., Gilbert, T., Luu, P., Felver, J. C., Abdullaev, Y. G., & Dishion, T. J. (2011) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-011-9522-6 · Cited by 33
Characterization of the amplificatory effect of norepinephrine in the acquisition of Pavlovian threat associationsPreprint
Díaz-Mataix, L., Piper, W. T., Schiff, H. C., Roberts, C. H., Campese, V. D., Sears, R. M., & LeDoux, J. E. (2017) · Learning & Memory · doi:10.1101/lm.044412.116 · Cited by 35
Development of amyloid burden in African Green monkeys
Kalinin, S., Willard, S. L., Shively, C. A., Kaplan, J. R., Register, T. C., Jorgensen, M. J., Polak, P. E., Rubinstein, I., & Feinstein, D. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.023 · Cited by 32
From Fundamentals to Innovation in Alzheimer’s Disease: Molecular Findings and Revolutionary Therapies
Sighencea, M. G., Popescu, R. Ș., & Trifu, S. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212311 · Cited by 33
Salmeterol, a β2 Adrenergic Agonist, Promotes Adult Hippocampal Neurogenesis in a Region-Specific Manner
Bortolotto, V., Bondi, H., Cuccurazzu, B., Rinaldi, M., Canonico, P. L., & Grilli, M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01000 · Cited by 32
Astrocytic face of Alzheimer's disease
Zorec, R., Parpura, V., Vardjan, N., & Verkhratsky, A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.021 · Cited by 30
Neural correlates of sleep, stress, and selective memory consolidation
Kim, S. Y., & Payne, J. D. (2020) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.12.009 · Cited by 33
Astrocytic Pathological Calcium Homeostasis and Impaired Vesicle Trafficking in Neurodegeneration
Vardjan, N., Verkhratsky, A., & Zorec, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020358 · Cited by 34
A Neural Model of Empathic States in Attachment-Based Psychotherapy
Cittern, D., & Edalat, A. (2017) · Computational Psychiatry · doi:10.1162/cpsy_a_00006 · Cited by 30
Pupillary response is associated with the reset and switching of functional brain networks during salience processing
He, H., Hong, L., & Sajda, P. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011081 · Cited by 30
Psychoneuroendocrinology of Stress
Gunnar, M. R., Doom, J. R., & Esposito, E. A. (2015) · Wiley eBooks · doi:10.1002/9781118963418.childpsy304 · Cited by 29
The Locus Coeruleus—Noradrenergic System in the Healthy and Diseased Brain: A Narrative Review
Caestecker, S., Lescrauwaet, E., Boon, P., Carrette, E., Raedt, R., & Vonck, K. E. J. (2025) · European Journal of Neurology · doi:10.1111/ene.70337 · Cited by 34
Differentiating global luminance, arousal and cognitive signals on pupil size and microsaccades
Wang, C., & Munoz, D. P. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15508 · Cited by 31
Axonal projection‐specific differences in somatodendritic α2 autoreceptor function in locus coeruleus neurons
Wagner‐Altendorf, T. A., Fischer, B., & Roeper, J. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14553 · Cited by 27
Adrenergic regulation of astroglial aerobic glycolysis and lipid metabolism: Towards a noradrenergic hypothesis of neurodegeneration
Zorec, R., & Vardjan, N. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106132 · Cited by 28
Degeneration of the locus coeruleus is a common feature of tauopathies and distinct from TDP-43 proteinopathies in the frontotemporal lobar degeneration spectrum
Ohm, D. T., Peterson, C. S., Lobrovich, R., Cousins, K. A. Q., Gibbons, G. S., McMillan, C. T., Wolk, D. A., Deerlin, V. M. V., Elman, L. B., Spindler, M., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02210-1 · Cited by 26
Weight variation before and after surgery in Parkinson's disease: A noradrenergic modulation?
Guimarães, J., Moura, E., Vieira‐Coelho, M. A., & Garrett, C. (2012) · Movement Disorders · doi:10.1002/mds.25063 · Cited by 26
Levodopa responsive freezing of gait is associated with reduced norepinephrine transporter binding in Parkinson's disease
McKay, J. L., Nye, J. A., Goldstein, F. C., Sommerfeld, B., Smith, Y., Weinshenker, D., & Factor, S. A. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106048 · Cited by 25
Respiratory Dysfunction in Alzheimer’s Disease—Consequence or Underlying Cause? Applying Animal Models to the Study of Respiratory Malfunctions
Wrzesień, A., Andrzejewski, K., Jampolska, M., & Kaczyńska, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042327 · Cited by 25
Locus Coeruleus-Norepinephrine System: Spheres of Influence and Contribution to the Development of Neurodegenerative Diseases
Nikolenko, V. N., Borminskaya, I. D., Nikitina, A. T., Golyshkina, M. S., Rizaeva, N. A., & Oganesyan, M. V. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2903118 · Cited by 28
Orienting Hypnosis
Hope, A. E., & Sugarman, L. I. (2015) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2014.976787 · Cited by 24
Manipulation of vocal communication and anxiety through pharmacologic modulation of norepinephrine in the Pink1-/- rat model of Parkinson disease
Hoffmeister, J. D., Kelm‐Nelson, C. A., & Ciucci, M. R. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113642 · Cited by 23
Sleep disorders in Lewy body dementia: Mechanisms, clinical relevance, and unanswered questions
Townsend, L., Anderson, K. N., Boeve, B. F., McKeith, I. G., & Taylor, J. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13350 · Cited by 24
Norepinephrine mediates contextual fear learning and hippocampal pCREB in juvenile rats exposed to predator odor
Kabitzke, P., Silva, L., & Wiedenmayer, C. P. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.04.003 · Cited by 25
Melatonin inhibits attention-deficit/hyperactivity disorder caused by atopic dermatitis-induced psychological stress in an NC/Nga atopic-like mouse model
Park, G., Jung, Y., Park, M.-K., Yang, C. H., & Kim, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-33317-x · Cited by 22
Emotion–Cognition Interactions in Attention-Deficit/Hyperactivity Disorder: Increased Early Attention Capture and Weakened Attentional Control in Emotional Contexts
Karalunas, S. L., Weigard, A. S., & Alperin, B. R. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.12.021 · Cited by 24
Coupling and dynamics of cortical and autonomic signals are linked to central inhibition during the wake-sleep transition
Ulke, C., Huang, J., Schwabedal, J. T. C., Surova, G., Mergl, R., & Hensch, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-09513-6 · Cited by 23
Retracted: Exendin‐4 reverts behavioural and neurochemical dysfunction in a pre‐motor rodent model of Parkinson's disease with noradrenergic deficit
Rampersaud, N., Harkavyi, A., Giordano, G., Lever, R., Whitton, J., & Whitton, P. S. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02100.x · Cited by 22
Retracted
Effects of aging and involuntary capture of attention on event-related potentials associated with the processing of and the response to a target stimulus
Cid‐Fernández, S., LindÃn, M. N., & DÃaz, F. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00745 · Cited by 22
A framework for quantifying the coupling between brain connectivity and heartbeat dynamics: Insights into the disrupted network physiology in Parkinson's disease
Candia‐Rivera, D., Vidailhet, M., Chávez, M., & Fallani, F. D. V. (2024) · Human Brain Mapping · doi:10.1002/hbm.26668 · Cited by 21
Imaging Parkinsonian Pathology in Substantia Nigra with MRI
Huddleston, D. E., Langley, J. A., Dušek, P., He, N., Faraco, C. C., Crosson, B., Factor, S. A., & Hu, X. P. (2018) · Current Radiology Reports · doi:10.1007/s40134-018-0272-x · Cited by 21
Link between temperament traits, brain neurochemistry and response to SSRI: insights from animal model of social behavior
Murlanova, K., Michaelevski, I., Kreinin, A., Terrillion, C. E., Pletnikov, M. V., & Pinhasov, A. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.11.005 · Cited by 21
Epigenetic dysregulation of brainstem nuclei in the pathogenesis of Alzheimer’s disease: looking in the correct place at the right time?
Iatrou, A., Kenis, G., Rutten, B. P. F., Lunnon, K., & van den Hove, D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2361-4 · Cited by 22
ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines
Cao, S.-X., Zhang, Y., Hu, X., Hong, B., Sun, P., He, H.-Y., Geng, H.-Y., Bao, A., Duan, S., Yang, J., et al. (2018) · eLife · doi:10.7554/elife.39907 · Cited by 22
Investigation of Resting-State BOLD Networks in the Human Brainstem and Spinal Cord
Harita, S., Ioachim, G., Powers, J. M., & Stroman, P. W. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.02.009 · Cited by 21
Targeting of Locus Ceruleus Noradrenergic Neurons Expressing Human Interleukin-2 Receptor α-Subunit in Transgenic Mice by a Recombinant Immunotoxin anti-Tac(Fv)-PE38: A Study for Exploring Noradrenergic Influence upon Anxiety-Like and Depression-Like Behaviors
Itoi, K., Sugimoto, N., Suzuki, S., Sawada, K., Das, G., Uchida, K., Fuse, T., Ohara, S., & Kobayashi, K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5188-10.2011 · Cited by 21
The Impact of Acute Psychosocial Stress on Magnetoencephalographic Correlates of Emotional Attention and Exogenous Visual Attention
Elling, L., Schupp, H. T., Bayer, J., Bröckelmann, A., Steinberg, C., Dobel, C., & Junghöfer, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035767 · Cited by 23
Activation of subthalamic alpha 2 noradrenergic receptors induces motor deficits as a consequence of neuronal burst firing
Delaville, C., Zapata, J., Cardoit, L., & Benazzouz, A. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.019 · Cited by 20
Impact of Combined Subthalamic Nucleus and Substantia Nigra Stimulation on Neuropsychiatric Symptoms in Parkinson’s Disease Patients
Hidding, U., Gulberti, A., Horn, A., Buhmann, C., Hamel, W., Koeppen, J. A., Westphal, M., Engel, A. K., Gerloff, C. P., Weiss, D., et al. (2017) · Parkinson s Disease · doi:10.1155/2017/7306192 · Cited by 20
Astroglial signalling in health and disease
Verkhratsky, A., & Zorec, R. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.07.026 · Cited by 22
Neuronal Activation in the Central Nervous System of Rats in the Initial Stage of Chronic Kidney Disease-Modulatory Effects of Losartan and Moxonidine
Palkovits, M., Šebeková, K., Klenovics, K. S., Kebis, A., Fazeli, G., Bahner, U., & Heidland, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066543 · Cited by 21
Pathophysiology of the human locus coeruleus complex in fetal/neonatal sudden unexplained death
Lavezzi, A. M., Alfonsi, G., & Matturri, L. (2013) · Neurological Research · doi:10.1179/1743132812y.0000000108 · Cited by 20
Near‐death experience: arising from the borderlands of consciousness in crisis
Nelson, K. R. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12576 · Cited by 23
Clonidine modulates the activity of the subthalamic‐supplementary motor loop: evidence from a pharmacological study combining deep brain stimulation and electroencephalography recordings in Parkinsonian patients
Spay, C., Albares, M., Lio, G., Thobois, S., Broussolle, E., Lau, B., Ballanger, B., & Boulinguez, P. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14447 · Cited by 22
Locus Coeruleus Pathology Indicates a Continuum of Lewy Body Dementia
Tilley, B. S., Patel, S. R., Goldfinger, M., Pearce, R. K. B., & Gentleman, S. (2021) · Journal of Parkinson s Disease · doi:10.3233/jpd-212748 · Cited by 18
The P300 Auditory Evoked Potential: A Physiological Measure of the Engagement of Cognitive Systems Contributing to Listening Effort?
Kestens, K., Yper, L. N. V., Degeest, S., & Keppler, H. (2023) · Ear and Hearing · doi:10.1097/aud.0000000000001381 · Cited by 17
Neurotransmitter receptor density changes in Pitx3ak mice – A model relevant to Parkinson’s disease
Cremer, J. N., Amunts, K., Graw, J., Piel, M., Rösch, F., & Zilles, K. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.050 · Cited by 18
Depressive symptoms are associated with daytime sleepiness and subjective sleep quality in dementia with Lewy bodies
Elder, G. J., Colloby, S. J., Lett, D. J., O'Brien, J. T., Anderson, K. N., Burn, D. J., McKeith, I. G., & Taylor, J. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4389 · Cited by 18
Molecular Imaging of the Noradrenergic System in Idiopathic Parkinson's Disease
Nahimi, A., Kinnerup, M. B., Sommerauer, M., GJEDDE, A. H., & Borghammer, P. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.028 · Cited by 17
Nx4 Reduced Susceptibility to Distraction in an Attention Modulation Task
Mayer, K., Krylova, M., Alizadeh, S., Jamalabadi, H., van der Meer, J. N., Vester, J., Naschold, B., Schultz, M., & Walter, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.746215 · Cited by 17
Effects of mild to moderate sedation on saccadic eye movements
Busettini, C., & Frölich, M. A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.012 · Cited by 17
Tauopathy in transgenic (SHR72) rats impairs function of central noradrenergic system and promotes neuroinflammation
Mravec, B., Lejavová, K., Vargovič, P., Ondičová, K., Horváthová, Ľ., Novák, P., Manz, G., Filipčík, P., Novák, M., & Květňanský, R. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0482-1 · Cited by 18
Fears, phobias, and anxiety disorders
Siracusa, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-7020-8214-6.00023-1 · Cited by 17
Effects of Social Isolation on 50-kHz Ultrasonic Vocalizations, Affective State, Cognition, and Catecholamine Concentrations in the Ventral Tegmental and Locus Coeruleus of Adult RatsPreprint
Broadfoot, C. K., Lenell, C., Kelm‐Nelson, C. A., & Ciucci, M. R. (2022) · SSRN Electronic Journal · doi:10.1016/j.bbr.2022.114157 · Cited by 15
Comparison of fluorescence biosensors and whole-cell patch clamp recording in detecting ACh, NE, and 5-HT
Zhang, K., Han, Y., Zhang, P., Zheng, Y., & Cheng, A. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1166480 · Cited by 16
Hippocampal Network Alterations in Alzheimer's Disease and Down Syndrome: From Structure to Therapy
Sanchez, M. M., Moghadam, S., Naik, P. K., Martin, K. J., & Salehi, A. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0050 · Cited by 17
Role of catalpol in ameliorating the pathogenesis of experimental autoimmune encephalomyelitis by increasing the level of noradrenaline in the locus coeruleus
Li, Q., Yang, T., Guo, A., & Fan, Y. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8378 · Cited by 16
The Task-Evoked Pupil Response in Divided Auditory Attention Tasks
Baldock, J., Kapadia, S., & van Steenbrugge, W. (2018) · Journal of the American Academy of Audiology · doi:10.3766/jaaa.17060 · Cited by 15
Cholinergic‐related pupil activity reflects level of emotionality during motor performance
Vidal, M., Onderdijk, K. E., Aguilera, A. M., Six, J., Maes, P., Fritz, T. H., & Leman, M. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15998 · Cited by 14
Modafinil, an atypical CNS stimulant?
Hersey, M., & Tanda, G. (2023) · Advances in pharmacology · doi:10.1016/bs.apha.2023.10.006 · Cited by 20
Methylphenidate’s effects on thalamic metabolism and functional connectivity in cannabis abusers and healthy controls
Demiral, Ş. B., Tomasi, D. G., Wiers, C. E., Manza, P., Kojori, E. S., Studentsova, Y., Wang, G., & Volkow, N. D. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0287-2 · Cited by 14
Alpha2-Adrenergic Receptors as a Pharmacological Target for Spike-Wave Epilepsy
Sitnikova, E., Rutskova, E. M., & Smirnov, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021477 · Cited by 16
Temporal development of behavioral impairments in rats following locus coeruleus lesion induced by 6-hydroxydopamine: Involvement of β3-adrenergic receptors
Sampaio, T. B., de Souza, B. S., Roversi, K., Schuh, T., Poli, A., Takahashi, R. N., & Prediger, R. D. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.04.006 · Cited by 15
A Concise Review of Common Plant-derived Compounds as a Potential Therapy for Alzheimer's Disease and Parkinson's Disease: Insight into Structure-Activity-Relationship
Nishal, S., Phaugat, P., Bazaad, J., Dhaka, R., Khatkar, S., Khatkar, A., Khayatkashani, M., Alizadeh, P., Haghighi, S. M., Mehri, M., et al. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220614110616 · Cited by 16
Presence but not the timing of onset of REM sleep behavior disorder distinguishes evolution patterns in Parkinson's disease
Tan, S., Zhou, C., Wen, J., Duanmu, X., Guo, T., Wu, H., Wu, J., Cao, Z., Liu, X., Chen, J., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106084 · Cited by 14
Alpha2 Adrenergic Modulation of Spike-Wave Epilepsy: Experimental Study of Pro-Epileptic and Sedative Effects of Dexmedetomidine
Sitnikova, E., Pupikina, M., & Rutskova, E. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119445 · Cited by 14
Disruption of Brain–Heart Coupling in Sepsis
Admiraal, M. M., Gilmore, E. J., van Putten, M. J. A. M., Zaveri, H. P., Hirsch, L. J., & Gaspard, N. (2017) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000381 · Cited by 14
Physiological/Neurophysiological Mechanisms Involved in the Formation of Stress Responses
Yaribeygi, H., & Sahraei, H. (2018) · Neurophysiology · doi:10.1007/s11062-018-9727-1 · Cited by 15
Astrocyte β-Adrenergic Receptor Activity Regulates NMDA Receptor Signaling of Medial Prefrontal Cortex Pyramidal Neurons
Franco, A. P. D., & Newman, E. A. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0990-23.2023 · Cited by 13
Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus
Grella, S. L., & Donaldson, T. N. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1342622 · Cited by 16
Social activity mediates locus coeruleus tangle-related cognition in older adults
Zide, B. S., Donovan, N. J., Lee, S., Nag, S., Bennett, D. A., & Jacobs, H. I. L. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02467-y · Cited by 13
Long‐term exposure to excessive norepinephrine in the brain induces tau aggregation, neuronal death, and cognitive deficits in early tau transgenic mice
Jeong, J., Kim, D. K., Chung, S., Han, J. W., Han, J., & Mook‐Jung, I. (2024) · Aging Cell · doi:10.1111/acel.14420 · Cited by 14
Astroglial Vesicular Trafficking in Neurodegenerative Diseases
Zorec, R., Parpura, V., & Verkhratsky, A. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2055-1 · Cited by 13
Acute Effect of Noradrenergic Modulation on Motor Output Adjustment in Men
Klass, M., Roelands, B., MEEUSEN, R. R., & Duchateau, J. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001622 · Cited by 13
CSF Catecholamine Profile in Subarachnoid Hemorrhage Patients with Neurogenic Cardiomyopathy
Moussouttas, M., Lai, E. W., Dombrowski, K. E., Huynh, T., Khoury, J., Carmona, G. N., DeCaro, M. V., & Pacák, K. (2011) · Neurocritical Care · doi:10.1007/s12028-011-9527-6 · Cited by 13
The blood–brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis
Polak, P. E., Lin, S. X., Pelligrino, D. A., & Feinstein, D. L. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.09.004 · Cited by 13
Severe hypoxia during incremental exercise to exhaustion provokes negative post-exercise affects
Keramidas, M. E., Stavrou, N. A. M., Kounalakis, S. N., Eiken, O., & Mekjavić, I. B. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.021 · Cited by 14
A possible pathway to freezing of gait in Parkinson's disease
Factor, S. A., Weinshenker, D., & McKay, J. L. (2025) · Journal of Parkinson s Disease · doi:10.1177/1877718x241308487 · Cited by 12
The Physio-Pharmacological Role of the NPS/NPSR System in Psychiatric Disorders: A Translational Overview
Ghazal, P. (2016) · Current Protein and Peptide Science · doi:10.2174/1389203717666151218150704 · Cited by 13
The LC-NE system as a potential target for neuromodulation to ameliorate non-motor symptoms in Parkinson's disease
Zaehle, T., Galazky, I., & Krauel, K. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102901 · Cited by 12
Decreased Signal in the Locus Coeruleus Based on Neuromelanin-Sensitive MRI Technique as an Imaging Biomarker for Alzheimer's Disease
Li, M., Liu, S., Zhu, H., Guo, Z., Zhi, Y., Liu, R., Jiang, Z., Liang, X., Hu, H., & Zhu, J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1014485 · Cited by 11
Localization of endogenous amyloid-β to the coeruleo-cortical pathway: consequences of noradrenergic depletion
Ross, J. A., Reyes, B. A. S., THOMAS, S. A., & Bockstaele, E. J. V. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1489-9 · Cited by 12
The Reticular Formation and Some Related Nuclei
ten Donkelaar, H. J. (2011) · Springer eBooks · doi:10.1007/978-3-642-19134-3_5 · Cited by 12
Comparative Analysis of the WISC between Two ADHD Subgroups
Kubo, Y., Kanazawa, T., Kawabata, Y., Tanaka, K., Okayama, T., Fujta, M., Tsutsumi, A., Yokota, S., & Yoneda, H. (2018) · Psychiatry Investigation · doi:10.30773/pi.2017.07.12 · Cited by 11

Authors: Benarroch, E. E.
Affiliations: Mayo Clinic (US)
Corresponding author: Benarroch, Eduardo E.
ORCID: Benarroch, Eduardo E.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-11-17
Volume: 73
Issue: 20
Pages: 1699-1704
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.0b013e3181c2937c
OpenAlex: W1969610953
Cited by: 317
References: 29
Citations by year: 2026: 14 · 2025: 17 · 2024: 17 · 2023: 32 · 2022: 23 · 2021: 24 · 2020: 32 · 2019: 22 · 2018: 32 · 2017: 17 · 2016: 16 · 2015: 13 · 2014: 19 · 2013: 9 · 2012: 13
FWCI: 4.31
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: locus coeruleus, norepinephrine, noradrenergic neurons, noradrenergic neurotransmission
MeSH terms: Alzheimer Disease, Animals, Arousal, Attention, Brain, Humans, Locus Coeruleus, Memory, Neural Pathways, Neurons, Norepinephrine, Parkinson Disease, Stress, Psychological, Prosencephalon

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The locus ceruleus norepinephrine system: Functional organization and potential clinical significance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks