Development of amyloid burden in African Green monkeys

Kalinin, Sergey; Willard, Stephanie L.; Shively, Carol A.; Kaplan, Jay R.; Register, Thomas C.; Jorgensen, Matthew J.; Polak, Paul E.; Rubinstein, Israel; Feinstein, Douglas L.

doi:10.1016/j.neurobiolaging.2013.03.023

Cited by 32Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Development of amyloid burden in African Green monkeys

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Kalinin, Sergey, Willard, Stephanie L., Shively, Carol A., Kaplan, Jay R., Register, Thomas C., Jorgensen, Matthew J., Polak, Paul E., Rubinstein, Israel +1 more·2013·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2013.03.023PMC PMC3706498

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Abstract

The vervet is an old world monkey increasingly being used as a model for human diseases. In addition to plaques and tangles, an additional hallmark of Alzheimer's disease is damage to neurons that synthesize noradrenaline (NA). We characterized amyloid burden in the posterior temporal lobe of young and aged vervets, and compared that with changes in NA levels and astrocyte activation. Total amyloid beta (Aβ)40 and Aβ42 levels were increased in the aged group, as were numbers of amyloid plaques detected using antibody 6E10. Low levels of Aβ42 were detected in 1 of 5 younger animals, although diffusely stained plaques were observed in 4 of these. Increased glial fibrillary acidic protein staining and messenger RNA levels were significantly correlated with increased age, as were cortical NA levels. Levels of Aβ42 and Aβ40, and the number of 6E10-positive plaques, were correlated with NA levels. Interestingly messenger RNA levels of glial derived neurotrophic factor, important for noradrenergic neuronal survival, were reduced with age. These findings suggest that amyloid pathology in aged vervets is associated with astrocyte activation and higher NA levels.

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Vervets have evidence of Aβ deposition, gliosis and neuronal dystrophy with age.
“Vervets live to approximately 30 years in captivity and have evidence of Aβ deposition, gliosis and neuronal dystrophy with age [72, 88, 89].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [72]

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Self-citation

Authors: Kalinin, S., Willard, S. L., Shively, C. A., Kaplan, J. R., Register, T. C., Jorgensen, M. J., Polak, P. E., Rubinstein, I., & Feinstein, D. L.
Affiliations: University of Illinois Chicago (US)
Wake Forest University Health Sciences (US)
Corresponding author: Feinstein, Douglas L.
ORCID: Kalinin, Sergey
Shively, Carol A.
Kaplan, Jay R.
Register, Thomas C.
Jorgensen, Matthew J.
Polak, Paul E.
Rubinstein, Israel
Feinstein, Douglas L.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2013-10
Volume: 34
Issue: 10
Pages: 2361-2369
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2013.03.023
PMC: PMC3706498
OpenAlex: W1995510295
Cited by: 32
References: 57
Citations by year: 2025: 3 · 2024: 3 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 2
FWCI: 1.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Department of Veterans Affairs (VA 247-P-0447, VA 240-12-C-0051)
NIH (RR019963, OD010965, RO1-HL87103)
Roena Kulynych Center for Memory and Cognition Research
Claude D. Pepper Older Americans Independence Center of Wake Forest School of Medicine (P30-AG21332)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: amyloid burden, vervet monkey, Alzheimer's disease model, amyloid-beta 42, amyloid plaques, norepinephrine, astrocyte activation, glial fibrillary acidic protein, glial cell line-derived neurotrophic factor, aging, posterior temporal lobe, nonhuman primate model
MeSH terms: Aging, Alzheimer Disease, Animals, Astrocytes, Chlorocebus aethiops, Cerebral Cortex, Disease Models, Animal, Female, Glial Fibrillary Acidic Protein, Norepinephrine, Peptide Fragments, Temporal Lobe, Amyloid beta-Peptides, Brain-Derived Neurotrophic Factor, Plaque, Amyloid

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