The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
A meta-regression of the long-term effects of deep brain stimulation on balance and gait in PD
Open accessAbstract
OBJECTIVE: Deep brain stimulation (DBS) alleviates the cardinal Parkinson disease (PD) symptoms of tremor, rigidity, and bradykinesia. However, its effects on postural instability and gait disability (PIGD) are uncertain. Contradictory findings may be due to differences the in stimulation site and the length of time since DBS surgery. This prompted us to conduct the first meta-regression of long-term studies of bilateral DBS in the subthalamic nucleus (STN) and globus pallidus interna (GPi). RESULTS: Eleven articles reported a breakdown of the Unified Parkinson's Disease Rating Scale score before and beyond 3 years postsurgery (mean 4.5 years). Random effects meta-regression revealed that DBS initially improved PIGD compared to the OFF medicated state before surgery, but performance declined over time and extrapolation showed subjects would reach presurgery levels 9 years postsurgery. ON medication, DBS improved PIGD over and above the effect of medication before surgery. Nevertheless, for the STN group, PIGD progressively declined and was worse than presurgery function within 2 years. In contrast, GPi patients showed no significant long-term decline in PIGD in the medicated state. Improvements in cardinal signs with DBS at both sites were maintained across 5 years in the OFF and ON medication states. CONCLUSIONS: DBS alone does not offer the same improvement to PIGD as it does to the cardinal symptoms, suggesting axial and distal control are differentially affected by DBS. GPi DBS in combination with levodopa seemed to preserve PIGD better than did STN DBS, although more studies of GPi DBS and randomized controls are needed.
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How should meta‐regression analyses be undertaken and interpreted?
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Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up
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Postural Orientation and Equilibrium
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A meta‐analysis of six prospective studies of falling in Parkinson's disease
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Cited by
ISway: a sensitive, valid and reliable measure of postural control
Mancini, M., Salarian, A., Carlson-Kuhta, P., Zampieri, C., King, L., Chiari, L., & Horak, F. B. (2012) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/1743-0003-9-59 · Cited by 499
Self-citationTreatment of motor and non-motor features of Parkinson's disease with deep brain stimulation
Fasano, A., Daniele, A., & Albanese, A. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70049-2 · Cited by 437
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Deep Brain Stimulation: A Paradigm Shifting Approach to Treat Parkinson's Disease
Hickey, P., & Stacy, M. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00173 · Cited by 125
Emerging therapies for gait disability and balance impairment: Promises and pitfalls
Maetzler, W., Nieuwhof, F., Hasmann, S. E., & Bloem, B. R. (2013) · Movement Disorders · doi:10.1002/mds.25682 · Cited by 57
Metadata
- Authors
- St. George, R. J., Nutt, J. G., Burchiel, K. J., & Horak, F. B.
- Venue
- Neurology
- Published
- 2010-10-05
- Volume
- 75
- Issue
- 14
- Pages
- 1292-1299
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2058671384
- Cited by
- 305
- References
- 47
- FWCI
- 7.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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