Cited by 57Balance, Gait, and Falls PreventionStroke Rehabilitation and RecoveryNeurological disorders and treatments

Emerging therapies for gait disability and balance impairment: Promises and pitfalls

Open access
Maetzler, Walter, Nieuwhof, Freek, Hasmann, Sandra E., Bloem, Bastiaan R.·2013·Movement Disorders

Abstract

Therapeutic management of gait and balance impairment during aging and neurodegeneration has long been a neglected topic. This has changed considerably during recent years, for several reasons: (1) an increasing recognition that gait and balance deficits are among the most relevant determinants of an impaired quality of life and increased mortality for affected individuals; (2) the arrival of new technology, which has allowed for new insights into the anatomy and functional (dis)integrity of gait and balance circuits; and (3) based in part on these improved insights, the development of new, more specific treatment strategies in the field of pharmacotherapy, deep brain surgery, and physiotherapy. The initial experience with these emerging treatments is encouraging, although much work remains to be done. The objective of this narrative review is to discuss several promising developments in the field of gait and balance treatment. We also address several pitfalls that can potentially hinder a fast and efficient continuation of this vital progress. Important issues that should be considered in future research include a clear differentiation between gait and balance as two distinctive targets for treatment and recognition of compensatory mechanisms as a separate target for therapeutic intervention. © 2013 International Parkinson and Movement Disorder Society

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Registry

Crossref · 10.1002/mds.25682

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111 of 111 references verified0 citation errors · 0 not checkable

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Authors
Maetzler, W., Nieuwhof, F., Hasmann, S. E., & Bloem, B. R.
Affiliations
  • German Center for Neurodegenerative Diseases (DE)
  • Radboud University Nijmegen (NL)
Venue
Movement Disorders
Publisher
Wiley
Published
2013-09-15
Volume
28
Issue
11
Pages
1576-1586
ISSN
  • 0885-3185 (ISSN-L)
  • 1531-8257
OpenAlex
W1877691820
Cited by
57
References
111
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 8 · 2016: 8 · 2015: 13 · 2014: 4 · 2013: 2
FWCI
1.28
Type
journal article
Language
en
Open access
Locations
  • Movement Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • DZNE Pub (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Topics
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
gait disturbance, balance disorders, aging, neurodegeneration, pharmacotherapy, deep brain stimulation, physiotherapy, compensatory mechanisms, quality of life, mortality
MeSH terms
Emergency Medical Services, Postural Balance, Humans, Quality of Life, Sensation Disorders, Gait Disorders, Neurologic

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