The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Atrial fibrillation and incidence of dementia: A systematic review and meta-analysis
Abstract
BACKGROUND: Previous systematic reviews that examined whether atrial fibrillation (AF) is associated with dementia have relied on different study designs (including retrospective ones) and did not evaluate risk using meta-analysis. METHODS: We searched Medline, Embase, and PsychINFO in September 2010 for published prospective studies reporting on the association between baseline AF and incident dementia. Pooled odds ratios for AF and dementia were calculated using the random effects model, with heterogeneity assessed using I(2). RESULTS: We identified 15 relevant studies covering 46,637 participants, mean age 71.7 years. One study that reported no significant difference in Mini-Mental State Examination scores between patients with or without AF could not be pooled. Meta-analysis of the remaining 14 studies showed that AF was associated with a significant increase in dementia overall (odds ratio [OR] 2.0, 95% confidence interval [CI] 1.4 to 2.7, p < 0.0001), with substantial heterogeneity (I(2) = 75%). When stratified by participants, the association was significant (with little heterogeneity) in studies focusing solely on patients with stroke (7 studies, OR 2.4, 95% CI 1.7 to 3.5, p < 0.001, I(2) = 10%), and of borderline significance (with substantial heterogeneity) for studies in broader populations (7 studies, OR 1.6, 95% CI 1.0 to 2.7, p = 0.05, I(2) = 87%). For conversion of mild cognitive impairment to dementia, one study showed a significant association with AF (OR 4.6, 95% CI 1.7 to 12.5). CONCLUSION: There is consistent evidence supporting an association between AF and increased incidence of dementia in patients with stroke whereas there remains considerable uncertainty about any link in the broader population. The potential association between AF and incident dementia in mild cognitive impairment merits further investigation.
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Cites
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Analysing data and undertaking meta‐analyses
Deeks, J. J., Higgins, J. P., Altman, D. G., & on behalf of the Cochrane Statistical Methods Group (2019) · Cochrane Handbook for Systematic Reviews of Interventions · doi:10.1002/9781119536604.ch10 · Cited by 2,672
Prevalence of Dementia in the United States: The Aging, Demographics, and Memory Study
Plassman, B. L., Langa, K. M., Fisher, G. G., Heeringa, S. G., Weir, D. R., Ofstedal, M. B., Burke, J. R., Hurd, M. D., Potter, G. G., Rodgers, W. L., et al. (2007) · Neuroepidemiology · doi:10.1159/000109998 · Cited by 1,932
The appropriateness of asymmetry tests for publication bias in meta-analyses: A large survey
Ioannidis, J. P. A., & Trikalinos, T. A. (2007) · Canadian Medical Association Journal · doi:10.1503/cmaj.060410 · Cited by 1,052
Cardiovascular risk factors and cognitive decline in middle-aged adults
Knopman, D., Boland, L. L., Mosley, T., Howard, G., Liao, D., Szklo, M., McGovern, P., & Folsom, A. R. (2001) · Neurology · doi:10.1212/wnl.56.1.42 · Cited by 883
Atrial Fibrillation and Dementia in a Population-Based Study: The Rotterdam Study
Ott, A., Breteler, M. M. B., de Bruyne, M. C., van Harskamp, F., Grobbee, D. E., & Hofman, A. (1997) · Stroke · doi:10.1161/01.str.28.2.316 · Cited by 732
Relation of diabetes to mild cognitive impairment
Luchsinger, J. A., Reitz, C., Patel, B., Tang, M.-X., Manly, J. J., & Mayeux, R. (2007) · Archives of Neurology · doi:10.1001/archneur.64.4.570 · Cited by 592
Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia
Bunch, T. J., Weiss, J. P., Crandall, B. G., May, H. T., Bair, T. L., Osborn, J. S., Anderson, J. L., Muhlestein, J. B., Horne, B. D., Lappe, D. L., et al. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2009.12.004 · Cited by 405
Epidemiological Studies of the Effect of Stroke on Incident Dementia: A Systematic Review
Savva, G. M., Stephan, B. C. M., & the Alzheimer’s Society Vascular Dementia Systematic Review Group (2010) · Stroke · doi:10.1161/strokeaha.109.559880 · Cited by 257
Miyasaka, Y., Barnes, M. E., Petersen, R. C., Cha, S. S., Bailey, K. R., Gersh, B. J., Casaclang-Verzosa, G., Abhayaratna, W. P., Seward, J. B., Iwasaka, T., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm012 · Cited by 133
Cited by
Heart Disease and Stroke Statistics—2013 Update: A Report From the American Heart Association
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., Fox, C. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828124ad · Cited by 5,292
Global epidemiology of atrial fibrillation
Rahman, F., Kwan, G. F., & Benjamin, E. J. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.118 · Cited by 731
Deckers, K., van Boxtel, M. P. J., Schiepers, O. J. G., de Vugt, M., Muñoz Sánchez, J. L., Anstey, K. J., Brayne, C., Dartigues, J.-F., Engedal, K., Kivipelto, M., et al. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4245 · Cited by 534
A major role for cardiovascular burden in age-related cognitive decline
Qiu, C., & Fratiglioni, L. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.223 · Cited by 398
Brain in Congenital Heart Disease Across the Lifespan: The Cumulative Burden of Injury
Marelli, A., Miller, S. P., Marino, B. S., Jefferson, A. L., & Newburger, J. W. (2016) · Circulation · doi:10.1161/circulationaha.115.019881 · Cited by 359
Metadata
- Authors
- Kwok, C. S., Loke, Y. K., Hale, R., Potter, J. F., & Myint, P. K.
- Venue
- Neurology
- Published
- 2011-03-08
- Volume
- 76
- Issue
- 10
- Pages
- 914-922
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1990481580
- Cited by
- 283
- References
- 11
- FWCI
- 11.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kwok, C. S., Loke, Y. K., Hale, R., Potter, J. F., & Myint, P. K. (2011). Atrial fibrillation and incidence of dementia: A systematic review and meta-analysis. Neurology. https://doi.org/10.1212/wnl.0b013e31820f2e38
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
