The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Age and diagnostic performance of Alzheimer disease CSF biomarkers
Open accessAbstract
OBJECTIVES: Core CSF changes in Alzheimer disease (AD) are decreased amyloid β(1-42), increased total tau, and increased phospho-tau, probably indicating amyloid plaque accumulation, axonal degeneration, and tangle pathology, respectively. These biomarkers identify AD already at the predementia stage, but their diagnostic performance might be affected by age-dependent increase of AD-type brain pathology in cognitively unaffected elderly. METHODS: We investigated effects of age on the diagnostic performance of CSF biomarkers in a uniquely large multicenter study population, including a cross-sectional cohort of 529 patients with AD dementia (median age 71, range 43-89 years) and 304 controls (67, 44-91 years), and a longitudinal cohort of 750 subjects without dementia with mild cognitive impairment (69, 43-89 years) followed for at least 2 years, or until dementia diagnosis. RESULTS: The specificities for subjects without AD and the areas under the receiver operating characteristics curves decreased with age. However, the positive predictive value for a combination of biomarkers remained stable, while the negative predictive value decreased only slightly in old subjects, as an effect of the high AD prevalence in older ages. CONCLUSION: Although the diagnostic accuracies for AD decreased with age, the predictive values for a combination of biomarkers remained essentially stable. The findings highlight biomarker variability across ages, but support the use of CSF biomarkers for AD even in older populations.
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Self-citationTowards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative
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Towards Complete and Accurate Reporting of Studies of Diagnostic Accuracy: The STARD Initiative
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Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
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Self-citationRevising the definition of Alzheimer's disease: a new lexicon
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Self-citationCerebrospinal fluid and plasma biomarkers in Alzheimer disease
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Self-citationNeuropathology of older persons without cognitive impairment from two community-based studies
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Winblad, B., Amouyel, P., Andrieu, S., Ballard, C., Brayne, C., Brodaty, H., Cedazo-Minguez, A., Dubois, B., Edvardsson, D., Feldman, H., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00062-4 · Cited by 1,676
Self-citationPlasma phospholipids identify antecedent memory impairment in older adults
Mapstone, M., Cheema, A. K., Fiandaca, M. S., Zhong, X., Mhyre, T. R., MacArthur, L. H., Hall, W. J., Fisher, S. G., Peterson, D. R., Haley, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3466 · Cited by 1,043
Shaw, L. M., Arias, J., Blennow, K., Galasko, D., Molinuevo, J. L., Salloway, S., Schindler, S., Carrillo, M. C., Hendrix, J. A., Ross, A., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.220 · Cited by 266
Self-citationCharacterization of Novel CSF Tau and ptau Biomarkers for Alzheimer’s Disease
Meredith Jr., J. E., Sankaranarayanan, S., Guss, V., Lanzetti, A. J., Berisha, F., Neely, R. J., Slemmon, J. R., Portelius, E., Zetterberg, H., Blennow, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076523 · Cited by 209
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Metadata
- Authors
- Mattsson, N., Rosén, E., Hansson, O., Andreasen, N., Parnetti, L., Jonsson, M., Herukka, S.-K., van der Flier, W. M., Blankenstein, M. A., Ewers, M., Rich, K., Kaiser, E., Verbeek, M. M., Olde Rikkert, M., Tsolaki, M., Mulugeta, E., Aarsland, D., Visser, P. J., Schröder, J., Marcusson, J., de Leon, M., Hampel, H., Scheltens, P., Wallin, A., Eriksdotter-Jönhagen, M., Minthon, L., Winblad, B., Blennow, K., & Zetterberg, H.
- Venue
- Neurology
- Published
- 2012-02-14
- Volume
- 78
- Issue
- 7
- Pages
- 468-476
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2124670646
- Cited by
- 171
- References
- 16
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Mattsson, N., Rosén, E., Hansson, O., Andreasen, N., Parnetti, L., Jonsson, M., Herukka, S.-K., van der Flier, W. M., Blankenstein, M. A., Ewers, M., Rich, K., Kaiser, E., Verbeek, M. M., Olde Rikkert, M., Tsolaki, M., Mulugeta, E., Aarsland, D., Visser, P. J., Schröder, J., . . . Zetterberg, H. (2012). Age and diagnostic performance of Alzheimer disease CSF biomarkers. Neurology. https://doi.org/10.1212/wnl.0b013e3182477eed
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