The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Deconditioning in patients with orthostatic intolerance
Open accessAbstract
OBJECTIVE: To study the frequency and degree of deconditioning, clinical features, and relationship between deconditioning and autonomic parameters in patients with orthostatic intolerance. METHODS: We retrospectively studied all patients seen for orthostatic intolerance at Mayo Clinic between January 2006 and June 2011, who underwent both standardized autonomic and exercise testing. RESULTS: A total of 184 patients (84 with postural orthostatic tachycardia syndrome [POTS] and 100 without orthostatic tachycardia) fulfilled the inclusion criteria. Of these, 89% were women, and median age was 27.5 years (interquartile range [IQR] 22-37 years). Symptom duration was 4 years (IQR 2-7.8). Of the patients, 90% had deconditioning (reduced maximum oxygen uptake [VO(2max)%] <85%) during exercise. This finding was unrelated to age, gender, or duration of illness. The prevalence of deconditioning was similar between those with POTS (95%) and those with orthostatic intolerance (91%). VO(2max)% had a weak correlation with a few autonomic and laboratory parameters but adequate predictors of VO(2max)% could not be identified. CONCLUSION: Reduced VO(2max)% consistent with deconditioning is present in almost all patients with orthostatic intolerance and may play a central role in pathophysiology. This finding provides a strong rationale for retraining in the treatment of orthostatic intolerance. None of the autonomic indices are reliable predictors of deconditioning.
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“The true prevalence of deconditioning in POTS also remains unclear, with studies showing large variations ranging from 20 to 90% of patients depending on site of patient recruitment and exercise protocols (Parsaik et al., 2012;Burkhardt et al., 2011;Arnold et al., 2013).”
From Postural tachycardia syndrome – Diagnosis, physiology, and prognosis (2018) · cites this paper as Parsaik et al., 2012
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“The successful outcomes of interdisciplinary pain programs have been extensively researched for adolescents and adults.189–191”
From Sinus Tachycardia: a Multidisciplinary Expert Focused Review (2022) · cites this paper as [191]
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Heart-rate Recovery Immediately After Exercise as a Predictor of Mortality
Cole, C. R., Blackstone, E. H., Pashkow, F. J., Snader, C. E., & Lauer, M. S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199910283411804 · Cited by 1,935
Postural orthostatic tachycardia syndrome: the Mayo clinic experience
Thieben, M. J., Sandroni, P., Sletten, D. M., Benrud-Larson, L. M., Fealey, R. D., Vernino, S., Low, P. A., Lennon, V. A., & Shen, W.-K. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)61027-6 · Cited by 516
Self-citationPostural tachycardia syndrome (POTS)
LOW, P. A., SANDRONI, P., JOYNER, M., & SHEN, W. (2009) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2008.01407.x · Cited by 358
Self-citationCardiac origins of the postural orthostatic tachycardia syndrome
Fu, Q., VanGundy, T. B., Galbreath, M. M., Shibata, S., Jain, M., Hastings, J. L., Bhella, P. S., & Levine, B. D. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.02.043 · Cited by 329
Autonomic Nervous System Function
Low, P. A. (1993) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199301000-00003 · Cited by 215
Self-citationPostural Tachycardia Syndrome: Clinical Features and Follow-up Study
Sandroni, P., Opfer-Gehrking, T. L., McPhee, B. R., & Low, P. A. (1999) · Mayo Clinic Proceedings · doi:10.4065/74.11.1106 · Cited by 194
Self-citationHEART-RATE RECOVERY IMMEDIATELY AFTER EXERCISE AS A PREDICTOR OF MORTALITY
Ole, C. H. R. C., Lackstone, E. U. H. B., Ashkow, J. P., Nader, C., & Auer, S. (2012) · Cited by 177
Fu, Q., VanGundy, T. B., Shibata, S., Auchus, R. J., Williams, G. H., & Levine, B. D. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.172262 · Cited by 175
Endurance Exercise Training in Orthostatic Intolerance
Winker, R., Barth, A., Bidmon, D., Ponocny, I., Weber, M., Mayr, O., Robertson, D., Diedrich, A., Maier, R., Pilger, A., et al. (2005) · Hypertension · doi:10.1161/01.hyp.0000156540.25707.af · Cited by 156
POTS versus deconditioning: the same or different?
Joyner, M. J., & Masuki, S. (2008) · Clinical Autonomic Research · doi:10.1007/s10286-008-0487-7 · Cited by 90
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Research works printed but not linked: 2
- Gibbons CH, Freeman R . Intense cardiovascular exercise as a treatment for non-neuropathic postural tachycardia syndrome (POTS). Neurology 2011; 76: A264.
- Gibbons CH, Freeman R . Intense cardiovascular exercise as a treatment for non-neuropathic postural tachycardia syndrome (POTS). Neurology 2011; 76 (suppl 4): A264.
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Shaw, B. H., Ng, J., & Raj, S. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.99799-0
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Other forms of autonomic dysfunction
Appenzeller, O., Lamotte, G. J., & Coon, E. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-96011-3.00007-3
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Sinus Tachycardias: Inappropriate Sinus Tachycardia and Postural Orthostatic Tachycardia Syndrome
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Yanagimoto, Y., Ishizaki, Y., Terashima, T., Yoshida, R., Ishitani, K., Haraguchi, K., Yamamoto, M., Kubota, M., Adomi, Y., Yamasaki, S., et al. (2025) · Frontiers in Pediatrics · doi:10.3389/fped.2025.1573842 · Cited by 2
Exercise for Postural Orthostatic Tachycardia Syndrome: Challenges and Opportunities to Improve
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Walsh, E. G., Birdee, G. S., Bonnet, K. R., Schlundt, D. G., Broadbent, C., Kelly, E. C., Rogalski, K., Archer, K. R., & Gamboa, A. C. (2025) · Clinical Autonomic Research · doi:10.1007/s10286-025-01166-0 · Cited by 1
Griffith, G. J., Holst, B., Myers, J., & Ward, K. M. (2026) · Pediatric Exercise Science · doi:10.1123/pes.2025-0074
Nocturnal and Diurnal Measures of Autonomic Function in Idiopathic Hypersomnia and Type 1 NarcolepsyPreprint
Zitser, J., Baldelli, L., Taha, H. B., Sibal, O., Chiaro, G., Cecere, A., Barletta, G., Cortelli, P., Guaraldi, P., & Miglis, M. G. (2026) · medRxiv · doi:10.64898/2026.04.09.26349889
Andrade, C., Zamuner, A., Barbic, F., Porta, A., Rigo, S., Shiffer, D., Bringard, A., Fagoni, N., Guido, F., & Furlan, R. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.20327113
Trastornos cardiocirculatorios en la enfermedad de Parkinson
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Metadata
- Authors
- Parsaik, A., Allison, T. G., Singer, W., Sletten, D. M., Joyner, M. J., Benarroch, E. E., Low, P. A., & Sandroni, P.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Venue
- Neurology
- Published
- 2012-10-02
- Volume
- 79
- Issue
- 14
- Pages
- 1435-1439
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3525293
- OpenAlex
- W2102895149
- Cited by
- 111
- References
- 13
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 6 · 2013: 6 · 2012: 4
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Georgia Clinical and Translational Science Alliance
- Rare Diseases Clinical Research Network
- National Institutes of Health (NS4 4233, NS3 2352, RR24150)
- National Institute of Neurological Disorders and Stroke (NS3 2352, P01NS044233, NS-44233, U54NS065736, K23NS075141)
- National Center for Research Resources (UL1RR024150)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- orthostatic intolerance, deconditioning, postural orthostatic tachycardia syndrome, autonomic dysfunction, VO2max, exercise capacity, autonomic function testing
- MeSH terms
- Adult, Blood Pressure, Exercise Test, Female, Heart Rate, Humans, Male, Reflex, Retrospective Studies, Valsalva Maneuver, Cardiovascular Deconditioning, Statistics, Nonparametric, Orthostatic Intolerance, Postural Orthostatic Tachycardia Syndrome, Young Adult
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