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Neuroleptic Malignant syndrome caused by dopamine‐depleting drugs in a patient with Huntington disease
Abstract
Prior reports of neuroleptic malignant syndrome (NMS) concerned patients with psychiatric disorders, usually schizophrenia, who were taking dopamine receptor blocking agents. We report the syndrome in a patient with Huntington disease who was treated with dopamine-depleting agents. He had a negative evaluation for malignant hyperthermia (MH), and we suggest that NMS differs from MH. The occurrence of NMS caused by dopamine-depleting agents suggests that anticholinergic properties of phenotiazines are not the only cause. Central dopaminergic systems probably participate in thermoregulation, and dopamine depletion probably plays a pathogenetic role in this syndrome.
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Citations
Cited by
Warren, J. D., Blumbergs, P. C., & Thompson, P. D. (2002) · Muscle & Nerve · doi:10.1002/mus.10053 · Cited by 431
Neuroleptic Malignant Syndrome
Guzé, B. H., & Baxter, L. R. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507183130306 · Cited by 312
Role of dopamine in the pathophysiology of Parkinson’s disease
Zhou, Z. D., Yi, L. X., Wang, D. Q., Lim, T. M., & Tan, E. K. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00378-6 · Cited by 308
Fasano, A., & Bentivoglio, A. R. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560903386292 · Cited by 51
Metadata
- Authors
- Burke, R. E., Fahn, S., Mayeux, R., Weinberg, H., Louis, K., & Willner, J. H.
- Venue
- Neurology
- Published
- 1981-08
- Volume
- 31
- Issue
- 8
- Pages
- 1022-1022
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2061852415
- Cited by
- 171
- References
- 0
- FWCI
- 9.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Neuroleptic Malignant syndrome caused by dopamine‐depleting drugs in a patient with Huntington disease. https://app.cochat.ai/papers/10.1212/wnl.31.8.1022
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- Burke, R. E., Fahn, S., Mayeux, R., Weinberg, H., Louis, K., & Willner, J. H. (1981). Neuroleptic Malignant syndrome caused by dopamine‐depleting drugs in a patient with Huntington disease. Neurology. https://doi.org/10.1212/wnl.31.8.1022
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
