The DOI matches its Crossref record; 159 of the 159 references it cites were found in a registry or an index.
Role of dopamine in the pathophysiology of Parkinson’s disease
Open accessAbstract
A pathological feature of Parkinson’s disease (PD) is the progressive loss of dopaminergic neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD brains. DA is the neurotransmitter of dopaminergic neurons. Accumulating evidence suggests that DA interacts with environmental and genetic factors to contribute to PD pathophysiology. Disturbances of DA synthesis, storage, transportation and metabolism have been shown to promote neurodegeneration of dopaminergic neurons in various PD models. DA is unstable and can undergo oxidation and metabolism to produce multiple reactive and toxic by-products, including reactive oxygen species, DA quinones, and 3,4-dihydroxyphenylacetaldehyde. Here we summarize and highlight recent discoveries on DA-linked pathophysiologic pathways, and discuss the potential protective and therapeutic strategies to mitigate the complications associated with DA.
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Citations
Cites
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Cited by
Jiao, Y., Yang, L., Wang, R., Song, G., Fu, J., Wang, J., Gao, N., & Wang, H. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16121611 · Cited by 63
Gao, L., Wang, J., & Bi, Y. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s549893 · Cited by 52
“81 Beyond the classical mechanism of neuro-transmitter deficiency, PD pathogenesis involves multifactorial pathological processes, including abnormal aggregation of α-synuclein, neuroinflammatory responses, oxidative stress, and mitochondrial dysfunction.”
Metadata
- Authors
- Zhou, Z. D., Yi, L. X., Wang, D. Q., Lim, T. M., & Tan, E. K.
- Venue
- Translational Neurodegeneration
- Published
- 2023-09-18
- Volume
- 12
- Issue
- 1
- Pages
- 44-44
- ISSN
- 2047-9158 (ISSN-L)
- OpenAlex
- W4386817494
- Cited by
- 308
- References
- 159
- FWCI
- 45.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhou, Z. D., Yi, L. X., Wang, D. Q., Lim, T. M., & Tan, E. K. (2023). Role of dopamine in the pathophysiology of Parkinson’s disease. Translational Neurodegeneration. https://doi.org/10.1186/s40035-023-00378-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
