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Seizures and myoclonus in patients with Alzheimer's disease
Abstract
We reviewed 81 patients with dementia and autopsy findings of Alzheimer's disease (AD) to identify patients with seizures or myoclonus after onset of dementia. Eight (10%) had seizures, and eight others (10%) had myoclonus. The incidence of seizures was 10 times more than expected in a reference population. Seizures occurred in any stage of AD, but myoclonus was often a late manifestation. Both seizures and myoclonus, individually or together, are manifestations of AD and may be seen at any time in the course of the illness.
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“Loss of inhibitory neurons would naturally be expected to disrupt excitatory and inhibitory balance; impaired inhibition may therefore increase the susceptibility of patients with AD to epilepsy, a clinical symptom found in more than 10% of patients88.”
From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [88]
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Бурд, С. Г., Bogolepova, A. N., Лебедева, А. В., Rubleva, Y. V., Коваленко, Е. А., Makhnovich, E. V., Osinovskaya, N. A., Gileva, E. A., Pantina, N. V., Kovaleva, I. I., et al. (2025) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202512511136
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Metadata
- Authors
- Hauser, W. A., Morris, M. L., Heston, L. L., & Anderson, V. E.
- Affiliations
- University of Minnesota (US)
- ORCID
- Hauser, W. Allen
- Venue
- Neurology
- Published
- 1986-09
- Volume
- 36
- Issue
- 9
- Pages
- 1226-1226
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2010891279
- Cited by
- 336
- References
- 0
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 18 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 15 · 2015: 11 · 2014: 7 · 2013: 8 · 2012: 18
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (1-P50-NS16308, P50NS016308)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, seizures, myoclonus, dementia, autopsy findings, seizure incidence, late-stage dementia
- MeSH terms
- Aged, Alzheimer Disease, Epilepsies, Myoclonic, Humans, Middle Aged, Seizures
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