Cited by 174Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record.

Periventricular white matter lucencies in senile dementia of the Alzheimer type and in normal aging

Rezek, Donald L., Morris, John C., Fulling, Keith H., Gado, Mokhtar H.·1987·Neurology

DOI 10.1212/wnl.37.8.1365

Open this paper in CoChat — free account

Abstract

The significance of periventricular lucencies in the white matter on CT in demented patients is not understood. We studied the relationship of these changes to mental status of subjects with senile dementia of the Alzheimer type. A semiquantitative method showed more numerous and extensive lucencies in demented than in healthy elderly. Neuropathologic examination of five subjects with these changes and confirmed Alzheimer's disease revealed diffuse white matter pallor without infarction. There were no hypertensive vascular changes, although limited hyaline thickening was present.

Integrity signals

Registry

Crossref · 10.1212/wnl.37.8.1365

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–174 of 174

A radiologic study of dynamic processes in lacunar dementia.
Tanaka, Y., Tanaka, O., Mizuno, Y., et al. (1989) · Stroke · doi:10.1161/01.str.20.11.1488 · Cited by 29
The Relationship between White Matter Low Attenuation on Brain CT and Vascular Risk Factors: A Memory Clinic Study
Amar, K. A., Lewis, T., Wilcock, G. K., Scott, M., & Bucks, R. S. (1995) · Age and Ageing · doi:10.1093/ageing/24.5.411 · Cited by 28
Leukoaraiosis and intracerebral hematoma.
Selekler, K., & Erzen, C. (1989) · Stroke · doi:10.1161/01.str.20.8.1016 · Cited by 25
Leukoencephalopathy and major depression: A preliminary report
Guzé, B. H., & Szuba, M. P. (1992) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(92)90024-x · Cited by 25
Frontal/Subcortical Features of Normal Aging: An Empirical Analysis
Hinkin, C. H., Cummings, J. L., van Gorp, W. G., et al. (1990) · Canadian Journal on Aging / La Revue canadienne du vieillissement · doi:10.1017/s0714980800013106 · Cited by 24
“Differential changes to the subcortical white matter among the elderly has also been documented using computerized tomography (CT) and magnetic resonance imaging (MRI) (London et al., 1986; Rezak et al., 1987; Salgado et al., 1986).”
Psychiatric correlates of MR deep white matter lesions in probable Alzheimer's disease
López, O. L., Becker, J. T., Reynolds, C. F., Jungreis, C. A., Weinman, S., & DeKosky, S. T. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.2.246 · Cited by 23
Validation Study of a CT-Based Weighted Rating Scale for Subcortical Ischemic Vascular Disease in Patients with Mild Cognitive Deterioration
Geroldi, C., Galluzzi, S., Testa, C., Zanetti, O. O., & Frisoni, G. B. (2003) · European Neurology · doi:10.1159/000070183 · Cited by 24
Relationship between lobar intracerebral hemorrhage and leukoencephalopathy associated with cerebral amyloid angiopathy: Clinicopathological study of 64 Japanese patients
Oide, T., Takahashi, H., Ytitani, C., Ishihara, T., & Ikeda, S. (2003) · Amyloid · doi:10.3109/13506120308998994 · Cited by 23
Hypertension, white matter change and response to cholinesterase inhibitors in Alzheimer's disease
Connelly, P., Prentice, N. P., & Fowler, K. G. (2005) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1331 · Cited by 22
“Neither the presence of vascular risk factors nor the presence of WML implies causation of cognitive deficits by vascular disease since both occur in asymptomatic elderly individuals (Rezek et al., 1987; Leys et al., 1990) and increase in prevalence with increasing age (Rezek et al.”
Background
Magnetic Resonance Imaging of Neurodegenerative Diseases
Hauser, R. A., & Olanow, C. W. (1994) · Journal of Neuroimaging · doi:10.1111/jon199443146 · Cited by 22
Cerebral Blood Flow in White Matter Is Correlated with Systolic Blood Pressure and EEG in Senile Dementia of the Alzheimer Type
Siennicki‐Lantz, A., Lilja, B., Rosén, I., & Elmståhl, S. (1997) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017019 · Cited by 20
The presence of leuko-araiosis in patients with Alzheimer's disease predicts poor tolerance to tacrine, but does not discriminate responders from non-responders
Amar, K. A., Wilcock, G. K., SCOT, M., & Lewis, T. (1997) · Age and Ageing · doi:10.1093/ageing/26.1.25 · Cited by 18
“They are reported to be present in approximately 30% of AD patients, as well as other dementias, especially vascular-type dementia where they are present in approximately 70% of patients [6, 7, 16].”
Background
The Aging Brain and Neurodegenerative Disorders
Braffman, B. H. (2000) · Neuroimaging · doi:10.1007/978-1-4612-1152-5_26 · Cited by 18
Démotivation et dysfonctionnements frontaux chez le sujet âgé : place de la leucoaraïose
Thomas, P., Hazif‐Thomas, C., Saccardy, F., et al. (2004) · L Encéphale · doi:10.1016/s0013-7006(04)95416-4 · Cited by 17
2′,3′-Cyclic nucleotide-3′-phosphodiesterase activity as an index of myelin in the post-mortem brains of patients with Alzheimer's disease
Reinikainen, K. J., Pitkänen, A., & Riekkinen, P. J. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90230-9 · Cited by 16
Alzheimer's disease
Bennett, D. A., & Evans, D. A. (1992) · Disease-a-Month · doi:10.1016/0011-5029(92)90010-m · Cited by 17
Clinical evaluation of the ICD-10 criteria for vascular dementia
Wetterling, T., Kanitz, R.-D., & Borgis, K. (1993) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02191521 · Cited by 16
“Another point of issue is the aetiopathology of leuko-araiosis [3, 7, 20, 23, 27, 55, 60, 77, 78, 81].”
Background
Neuropsychological Assessment
Rue, A. L., Yang, J. A., & Osato, S. S. (1992) · Elsevier eBooks · doi:10.1016/b978-0-12-101277-9.50027-9 · Cited by 14
White matter changes in dementia: does radiology matter?
Bronge, L., & Wahlund, L. (2007) · British Journal of Radiology · doi:10.1259/bjr/35265137 · Cited by 13
Visual rating of magnetic resonance images of human cerebrospinal fluid spaces and white brain matter: Relation to sex and age in healthy volunteers
Agartz, I., Marions, O., Sääf, J., Wahlund, L., & Wetterberg, L. (1992) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(92)90383-b · Cited by 11
Mental disorders in the elderly : a population study in 85-year-olds
Skoog, I. G. (1993) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 11
Elevated Cerebellar Glucose Metabolism in Microvascular White Matter Disease: Normal Aging and Alzheimer's Disease
Klinger, A., de Leon, M. J., GEORGE, A. E., et al. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.80 · Cited by 11
Cerebral White Matter Hyperintensities and Microbleeds in Acute Ischemic Stroke: Impact on Recanalization Therapies. A Review of the Literature
Fladt, J. C., Kronlage, C., & Marchis, G. M. D. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.09.003 · Cited by 10
White-matter lesions on CT in Alzheimer patients
Leys, D., Scheltens, P., & Steinling, M. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb04949.x · Cited by 10
“Firstly, since WMLs are strongly correlated with age in normal subjects (2, 3), the difference between EAD and LAD groups might be secondary to age differences between groups.”
BackgroundMethod
Comparisons of polio-araiosis and leuko-araiosis in dementias of ischemic vascular and alzheimer types
Terayama, Y., Meyer, J. S., Takashima, S., et al. (1993) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/s1052-3057(10)80072-2 · Cited by 10
Magnetic Resonance Imaging Hyperintensities in Alzheimer's Disease
Fazekas, F., Schmidt, R., Offenbacher, H., et al. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530170028012 · Cited by 10
Deep White Matter Lesions Are Associated with Early Recognition of Dementia in Alzheimer’s Disease
Kasahara, H., Ikeda, M., Nagashima, K., Fujita, Y., Makioka, K., Tsukagoshi, S., Yamazaki, T., Takai, E., Sanada, E., Kobayashi, A., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180939 · Cited by 9
“Although such lesions have long been reported in VaD, some studies have demonstrated that they are more severe in patients with AD than in healthy controls [38–41].”
Leuko-araiosis: a reappraisal. I. CT studies
Inzitari, D., & Mascalchi, M. (1990) · Neurological Sciences · doi:10.1007/bf02333853 · Cited by 9
“, 5 with and 5 without LA showed similar histological modifications in the periventricular white matter [49].”
BackgroundInfluential
Leuko-araiosis and stroke: a case-control study
Awada, A. A., & Omojola, M. F. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb00054.x · Cited by 8
Vascular dementia: persisting controversies and questions
Moncayo, J., & Bogousslavsky, J. (1996) · European Journal of Neurology · doi:10.1111/j.1468-1331.1996.tb00221.x · Cited by 8
“In subjects with dementia the prevalence rate of leuko-araiosis has been found to be higher than in normal individuals (George et al., 1986; Rezek et al., 1987).”
Background
Magnetic Resonance Imaging Hyperintensities in Alzheimer's Disease-Reply
Leys, D., Steinling, M., Pruvo, J., Petit, H., Scheltens, P., & Barkhof, F. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530170028013 · Cited by 8
White matter changes in dementia
Joyce, E. M., & Lishman, W. (1988) · Current Opinion in Psychiatry · doi:10.1097/00001504-198807000-00014 · Cited by 7
White Matter Hyperintensities and Medication Adherence
Insel, K. C., Reminger, S. L., & Hsiao, C. (2008) · Biological Research For Nursing · doi:10.1177/1099800408322216 · Cited by 8
A New Visual Rating Scale for White Matter Low Attenuation on CT
Ribeiro, H. K. M., Barnetson, L. P. D., Hogervorst, E., et al. (2001) · European Neurology · doi:10.1159/000052112 · Cited by 7
NEUROIMAGING PREDICTORS OF DEMENTIAIN STROKE PATIENTS
Hénon, H. (2002) · Clinical and Experimental Hypertension · doi:10.1081/ceh-120015344 · Cited by 7
Does white matter and vascular injury from repetitive head impacts lead to a novel pattern on T2 FLAIR MRI? A hypothesis proposal and call for research
Miner, A. E., Groh, J. R., Farris, C. W., Hattiangadi, S., Cui, A., Brickman, A. M., Alshikho, M. J., Rabinovici, G. D., Rosen, H. J., Cobigo, Y., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70085 · Cited by 5
Hemodynamic changes in Alzheimer's and Binswanger's diseases as evaluated by second‐derivative finger photoplethysmography
Iwamoto, T., Kanetaka, H., Takasaki, M., & Takazawa, K. (2003) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1444-1586.2003.00086.x · Cited by 6
Vascular glycosaminoglycans in periventricular leukoencephalopathy
Torack, R. M., & Morris, J. C. (1989) · Acta Neuropathologica · doi:10.1007/bf00687710 · Cited by 6
Self-citation
Cognitive decline and dementia in the elderly hypertensive
Hanon, O., & Leys, D. (2002) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.3317/jraas.2002.028 · Cited by 5
CSF β-endorphin, HVA and 5-HIAA of dementia of the Alzheimer type and Binswanger’s disease in the elderly
Lee, S., Chiba, T., Kitahama, T., et al. (1990) · Springer eBooks · doi:10.1007/978-3-7091-3345-3_5 · Cited by 4
Contribution de l'imagerie morphologique au diagnostic des démences. I — Maladie d'Alzheimer
Scheltens, P., Leys, D., Barkhof, F., Vermersch, P., Steinling, M., Weinstein, H. C., Pruvo, J., & Petit, H. (1994) · La Revue de Médecine Interne · doi:10.1016/s0248-8663(05)81459-6 · Cited by 3
Periventricular lucencies on computed tomography in multiple cerebral infarcts: Correlation with cerebral blood flow measurements
Tachibana, H., Kaku, T., Takeda, M., et al. (1990) · International Journal of Neuroscience · doi:10.3109/00207459008986601 · Cited by 4
Subcortical vascular dementia: Epidemiology and risk factors
Leys, D., & Pasquier, F. (1998) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(98)80040-x · Cited by 5
Vascular Dementia
Leys, D., Englund, E. M., & Erkinjuntti, T. (2003) · Wiley eBooks · doi:10.1002/9780470752340.ch20 · Cited by 4
Alzheimer's disease or A lzheimer's syndrome?: a longitudinal computed tomography neuroradiological follow‐up study of 56 cases diagnosed clinically as A lzheimer's disease
Fujisawa, K., Tsunoda, S., Hino, H., Shibuya, K., Takeda, A., & Aoki, N. (2015) · Psychogeriatrics · doi:10.1111/psyg.12162 · Cited by 3
Rapid cycling bipolar disorder in a case of Binswanger's disease
El‐Shazly, M. (1994) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.930091110 · Cited by 3
[Binswanger's disease: evolution of thought and a proposed diagnostic triad].
Vega, M. G., & Faccio, E. (1995) · PubMed · Cited by 3
Heterogeneity in Alzheimer’s Disease: A European View
Blennow, K., & Wallin, A. (1994) · Springer eBooks · doi:10.1007/978-1-4615-6805-6_8 · Cited by 3
Computed tomography and magnetic resonance imaging in the diagnosis of Alzheimer’s disease
Aichner, F., Felber, S. R., & Birbamer, G. (1994) · Key topics in brain research · doi:10.1007/978-3-7091-9376-1_3 · Cited by 3
Enfermedad de binswanger: evolucion de las ideas y propuesta de un tripode diagnóstico
Vega, M. G., & Faccio, E. (1995) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x1995000300027 · Cited by 3
Structural MRI in Alzheimer’s Disease
Last, B. S., Rizvi, B. M., & Brickman, A. M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190634230.003.0010 · Cited by 3
References
(1994) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1994.tb08108.x · Cited by 2
Leukoaraiosis
Mirsen, T. R., & Merskey, H. (1994) · Springer eBooks · doi:10.1007/978-1-4615-6805-6_39 · Cited by 2
HIPERTENSIÓN ARTERIAL Y DÉFICIT COGNITIVO
Rivas, J. C., & Gaviria, Y. M. (2000) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 2
Diagnostische Wertigkeit von Marklager-Hypodensitäten im CCT
Wetterling, T., Reger, K., & Borgis, H. J. (1989) · Verhandlungen der Deutschen Gesellschaft für Neurologie · doi:10.1007/978-3-642-83771-5_72 · Cited by 1
Development of a CT-based weighted rating scale for subcortical cerebrovascular disease sensitive to mild clinical symptoms
Geroldi, C., Galluzzi, S., Miao, J., et al. (2002) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(02)00298-8 · Cited by 1
“Some scales have been found to be associated with non-cognitive neurological signs [7,8], and only one scale has been shown able to discriminate demented from non-demented patients [9].”
Background
Establishing diagnostic criteria for a registry for dementing diseases
Morris, J. C. (1990) · Aging Clinical and Experimental Research · doi:10.1007/bf03323919 · Cited by 1
Self-citation
Leukoaraiosis and cognitive impairment
Pantoni, L., & Inzitari, D. (2005) · CRC Press eBooks · doi:10.1201/b13239-81 · Cited by 1
Could “Leuko-araïosis” Be Secondary to Wallerian Degeneration in Alzheimer’s Disease?
Leys, D., Pruvo, J. P., Parent, M., Vermersch, P., Soetaert, G., Steinling, M., Delacourte, A., Défossez, A., Rapoport, A., Clarisse, J., et al. (1990) · Springer eBooks · doi:10.1007/978-3-642-75690-0_6 · Cited by 1
Vascular dementia
Peisah, C., Sachdev, P. S., & Brodaty, H. (1993) · International Review of Psychiatry · doi:10.3109/09540269309037800 · Cited by 1
The Vascular Dementias and Cerebrovascular Involvement in Alzheimer’s Disease
Schulz, J. G., & Einhäupl, K. M. (1996) · Springer eBooks · doi:10.1007/978-3-662-03248-0_2
Leukoaraiosis. A Short Review
Kapilamoorthy, T. R., Fiorelli, M., Gupta, A. K., Kesavadas, C., Krishnamoorthy, T., & Bozzao, L. (2005) · Rivista di Neuroradiologia · doi:10.1177/197140090501800212
Dementia and white matter lesions on neuroimaging
KERTESZ, A. E. (1991) · Journal of Neurolinguistics · doi:10.1016/s0911-6044(05)80003-x
Small deep cerebral infarcts: Is there synergism between hypertension and diabetes?
Pullicino, P. M., & Zammit, A. (1993) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/s1052-3057(10)80160-0
Pathological Changes in Neurodegenerative Disease
Mann, D. M. A. (1997) · Springer eBooks · doi:10.1007/978-1-4615-6001-2_3
Lacunar Infarcts andWhiteMatterAttenuation Ophthalmologic andMicrocirculatory Aspects ofthePathophysiology
Rademacher, M., & Wolf, S. (1993)
Consequences of Intracellular Amyloid in Vascular System
D’Andrea, M. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-804256-4.00008-5
La diagnostica neuroradiologica TC nelle demenze
Zanotti, B., Bruseghini, C., & Leonardi, M. (1995) · Rivista di Neuroradiologia · doi:10.1177/197140099500800409
Inquadramento clinico delle demenze
AGNOLI, A., Fabbrini, G., & Martucci, N. (1993) · Rivista di Neuroradiologia · doi:10.1177/19714009930060s120
Invecchiamento cerebrale e patologia neurodegenerativa
Braffman, B. (1993) · Rivista di Neuroradiologia · doi:10.1177/19714009930060s124
Binswanger Disease: The King Khalid University Hospital Experience
Al-Bunyan, M. A. (1993) · Annals of Saudi Medicine · doi:10.5144/0256-4947.1993.429
Y DÉFICIT COGNITIVO
Rivas, J. C., & Gaviria, Y. M. (2000)
Assessing the Relationship of White Matter Hyperintensities and Grey Matter to Neuropsychiatric Symptoms in Alzheimer's Disease and Mild Cognitive Impairment
Misquitta, K. (2017) · TSpace (University of Toronto)
10.1016/s9999-9994(04)95416-5
(2000) · Time to knit · doi:10.1016/s9999-9994(04)95416-5

Authors: Rezek, D. L., Morris, J. C., Fulling, K. H., & Gado, M. H.
Affiliations: Washington University in St. Louis (US)
ORCID: Morris, John C.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1987-08
Volume: 37
Issue: 8
Pages: 1365-1365
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.37.8.1365
OpenAlex: W2136432656
Cited by: 173
References: 0
Citations by year: 2025: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 1
FWCI: 14.04
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5t32ns007205-32)
National Institute on Aging (P01 AG0 3991, P01AG003991)
National Institute of Neurological Disorders and Stroke (5 T32 NS07205-04)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: senile dementia of the Alzheimer type, Alzheimer's disease, normal aging, mental status, head CT, neuropathology
MeSH terms: Aged, Aging, Alzheimer Disease, Brain, Cerebral Ventricles, Female, Humans, Longitudinal Studies, Male, Tomography, X-Ray Computed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Periventricular white matter lucencies in senile dementia of the Alzheimer type and in normal aging

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks