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Periventricular white matter lucencies in senile dementia of the Alzheimer type and in normal aging
Abstract
The significance of periventricular lucencies in the white matter on CT in demented patients is not understood. We studied the relationship of these changes to mental status of subjects with senile dementia of the Alzheimer type. A semiquantitative method showed more numerous and extensive lucencies in demented than in healthy elderly. Neuropathologic examination of five subjects with these changes and confirmed Alzheimer's disease revealed diffuse white matter pallor without infarction. There were no hypertensive vascular changes, although limited hyaline thickening was present.
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“AD subjects show more pervasive white matter change [42–46].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [42]
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White Matter Lesions Double the Risk of Post-Thrombolytic Intracerebral Hemorrhage
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Magnetic resonance findings in patients with early-onset Alzheimer's disease
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BackgroundThe underdiagnosis of the vascular contribution to dementia
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“The frequent appearance of white matter lesions in patients otherwise diagnosed as suffering from AD [3,18] is of special relevance to the present discussion, since these lesions are thought to be predominantly due to vascular lesions, suggesting that vascular factors are involved in classical AD [5].”
BackgroundThe influence of coincidental vascular pathology on symptomatology and course of Alzheimer’s disease
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MethodNeuroimaging Criteria for Vascular Dementia
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NONSPECIFIC LEUKOENCEPHALOPATHY ASSOCIATED WITH AGING
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“Another visual rating scales, the Rezek scale, [21] also measured the lesion size, and it had excellent intra-rater and interrater reliability with kappa values ranging from 0.”
BackgroundClinical Correlates of Alzheimer's Disease With and Without Silent Radiographic Abnormalities
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“WMH have been shown for some time to be greater in volume and severity in Alzheimer’s disease patients than in healthy elderly individuals (Rezek et al., 1987; Scheltens et al., 1992; Barber et al., 1999), and more recently, have been considered by some to be a core feature of”
BackgroundA Population‐Based Study on Motor Performance and White Matter Lesions in Older Women
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In vivo proton magnetic resonance spectroscopy study on premature aging in adult Down's syndrome
Murata, T., Koshino, Y., Omori, M., Murata, I., Nishio, M., Horie, T., Umezawa, Y., Isaki, K., Kimura, H., Itoh, S., et al. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90086-s · Cited by 35
Propionibacterium acnes in the cortex of patients with Alzheimer's disease
Kornhuber, H. H. (1996) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02274902 · Cited by 32
Brain Imaging in Dementia of the Alzheimer Type
Faulstich, M. E. (1991) · International Journal of Neuroscience · doi:10.3109/00207459109150345 · Cited by 32
Leukb‐Araiosis and Cerebral Hypoperfusion Compared in Elderly Normals and Alzheimer's Dementia
Kawamura, J., Meyer, J. S., Terayama, Y., & Weathers, S. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb02138.x · Cited by 31
Does APO epsilon 4 correlate with MRI changes in Alzheimer's disease?
Doody, R. S. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.5.668 · Cited by 30
Research and Alzheimer's disease: an epidemiological perspective
Brayne, C. (1993) · Psychological Medicine · doi:10.1017/s003329170002835x · Cited by 30
“Leukoaraiosis has been found to reflect neuropathology (Janota et al. 1989) and this is bound to cause further confusion in differential diagnosis in the elderly where such lesions are common (Rezek et al. 1987).”
Background
Metadata
- Authors
- Rezek, D. L., Morris, J. C., Fulling, K. H., & Gado, M. H.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Morris, John C.
- Venue
- Neurology
- Published
- 1987-08
- Volume
- 37
- Issue
- 8
- Pages
- 1365-1365
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2136432656
- Cited by
- 173
- References
- 0
- Citations by year
- 2025: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 1
- FWCI
- 14.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5t32ns007205-32)
- National Institute on Aging (P01 AG0 3991, P01AG003991)
- National Institute of Neurological Disorders and Stroke (5 T32 NS07205-04)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- senile dementia of the Alzheimer type, Alzheimer's disease, normal aging, mental status, head CT, neuropathology
- MeSH terms
- Aged, Aging, Alzheimer Disease, Brain, Cerebral Ventricles, Female, Humans, Longitudinal Studies, Male, Tomography, X-Ray Computed
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