The DOI matches its Crossref record.
Amitriptyline, but not lorazepam, relieves postherpetic neuralgia
Abstract
In a double-blind, randomized, crossover study, 58 patients with postherpetic neuralgia received 6-week courses of amitriptyline, 12.5 to 150 mg/d; lorazepam, 0.5 to 6 mg/d; or lactose placebo. Doses were titrated to the maximum level tolerated. Patients rated pain in a diary, using lists of verbal descriptors. Forty-seven percent of patients reported moderate or greater relief with amitriptyline, 16% with placebo, and 15% with lorazepam. Mean amitriptyline dose was 65 mg/d. Greater relief was associated with higher amitriptyline doses, up to the maximum dose of 150 mg/d, and with higher serum tricyclic levels. Lorazepam did not relieve pain and was associated with severe depressive reactions in four patients.
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Cited by
EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision
Attal, N., Cruccu, G., Baron, R., Haanpää, M., Hansson, P., Jensen, T. S., & Nurmikko, T. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.02999.x · Cited by 1,873
Complex Regional Pain Syndromes: Guidelines for Therapy
Stanton-Hicks, M., Baron, R., Boas, R., Gordh, T., Harden, N., Hendler, N., Koltzenburg, M., Raj, P., & Wilder, R. (1998) · The Clinical Journal of Pain · doi:10.1097/00002508-199806000-00012 · Cited by 378
Amitriptyline for neuropathic pain and fibromyalgia in adults
Moore, R. A., Derry, S., Aldington, D., Cole, P., & Wiffen, P. J. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008242.pub2 · Cited by 293
McCleane, G. (2008) · CNS Drugs · doi:10.2165/00023210-200822020-00005 · Cited by 109
Chou, R., Carson, S., & Chan, B. K. S. (2009) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0877-5 · Cited by 57
Metadata
- Authors
- Max, M. B., Schafer, S. C., Culnane, M., Smoller, B., Dubner, R., & Gracely, R. H.
- Venue
- Neurology
- Published
- 1988-09
- Volume
- 38
- Issue
- 9
- Pages
- 1427-1427
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1964941904
- Cited by
- 402
- References
- 0
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
