The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Antidepressants as Analgesics
Abstract
Depression is a common accompaniment of pain, particularly when pain is unremitting. The use of a variety of antidepressant medications is associated with pain reduction, an effect that is independent of the mood-enhancing qualities of these drugs. This pain relief is a consequence of a wide variety of actions of antidepressants on the neuroregulatory mechanisms associated with pain perception and transmission. The older tricyclic antidepressants (TCAs) and the newer 'balanced' reuptake inhibitors (such as duloxetine) seem to be more efficacious in terms of providing pain relief than the selective serotonin reuptake inhibitors (SSRIs). Unfortunately, adverse effects are not uncommon during antidepressant use, particularly with TCAs. It is now becoming apparent that TCAs can have an analgesic effect when applied topically and that this effect is produced by peripheral mechanisms rather than systemic uptake. Antidepressants remain a major therapeutic tool in the management of chronic pain.
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“Although treatment with antidepressants may be effective in reducing some forms of pain (e.g. those linked to depression or neuropathy) independent of a mood-enhancing effect (Dworkin et al., 2007; McCleane, 2008)”
From Presence and predictors of pain in depression: Results from the FINDER study (2010) · cites this paper as McCleane, 2008
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Metadata
- Authors
- McCleane, G.
- Corresponding author
- McCleane, Gary
- Venue
- CNS Drugs
- Published
- 2008
- Volume
- 22
- Issue
- 2
- Pages
- 139-156
- ISSN
- 1172-7047 (ISSN-L)
- OpenAlex
- W1989133401
- Cited by
- 109
- References
- 158
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 7 · 2013: 7 · 2012: 7
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Drugs (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- antidepressants, analgesia, chronic pain, tricyclic antidepressants, duloxetine, selective serotonin reuptake inhibitors, pain perception, pain transmission, adverse effects
- MeSH terms
- Analgesics, Animals, Antidepressive Agents, Clinical Trials as Topic, Disease Models, Animal, Humans, Pain
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