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Frontal lobe degeneration: Clinical, neuropsychological, and SPECT characteristics
Abstract
The clinical, neuropsychological, and cerebral blood flow characteristics of eight patients with frontal lobe degeneration (FLD) were studied. Social withdrawal and behavioral disinhibition were the earliest and most common clinical presentations, and psychiatric symptoms typically preceded the onset of dementia by several years. Neuropsychological testing showed selective impairment of frontal and memory tasks with relative sparing of attention, language, and visuospatial skills. Single-photon emission computerized tomography demonstrated frontal and temporal hypoperfusion with relative sparing of parietal and occipital blood flow. Previous studies suggest that the neuropathologic findings in patients with FLD are varied; some demonstrate frontal gliosis, neuronal loss, and Pick bodies while others show only gliosis and neuronal loss.
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Cited by
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047
Self-citationKnopman, D. S., DeKosky, S. T., Cummings, J. L., Chui, H., Corey–Bloom, J., Relkin, N., Small, G. W., Miller, B., & Stevens, J. C. (2001) · Neurology · doi:10.1212/wnl.56.9.1143 · Cited by 1,410
Self-citationBozeat, S. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.2.178 · Cited by 603
Frontal behavioral inventory: diagnostic criteria for frontal lobe dementi
Kertesz, A., Davidson, W., & Fox, H. (1997) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100021053 · Cited by 571
The temporal variant of frontotemporal dementia
Edwards-Lee, T. (1997) · Brain · doi:10.1093/brain/120.6.1027 · Cited by 373
Metadata
- Authors
- Miller, B. L., Cummings, J. L., Villanueva-Meyer, J., Boone, K., Mehringer, C. M., Lesser, I. M., & Mena, I.
- Venue
- Neurology
- Published
- 1991-09
- Volume
- 41
- Issue
- 9
- Pages
- 1374-1374
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2103588538
- Cited by
- 363
- References
- 0
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Miller, B. L., Cummings, J. L., Villanueva-Meyer, J., Boone, K., Mehringer, C. M., Lesser, I. M., & Mena, I. (1991). Frontal lobe degeneration: Clinical, neuropsychological, and SPECT characteristics. Neurology. https://doi.org/10.1212/wnl.41.9.1374
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
