Frontal behavioral inventory: diagnostic criteria for frontal lobe dementi
Open accessAbstract
Objective: To utilize the diagnostic criteria of frontal lobe dementia (FLD). Methods: We studied 12 patients with FLD diagnosed clinically, with radiological confirmation in 10 and autopsy confirmation in 2; sixteen patients with Alzheimer's disease matched for stage and severity to FLD and 11 patients with depressive dementia were used as control groups. A 24-item Frontal Behavioral Inventory (FBI) using the most relevant behavioral manifestations of FLD was administered in these populations. Results: FLD patient scores on the FBI were much higher compared with control groups (AD and DD). Item analysis showed loss of insight, indifference, distractibility, personal neglect and apathy as the most frequent negative symptoms. Perseveration, disinhibition, inappropriateness, impulsivity, and irresponsibility were the most significant positive symptoms. An operational definition of FLD included a minimum FBI score of 27. Only one false positive was shown in the depressive group and none among the AD group, indicating little overlap between patient groups, and a high discriminating value of the FBI. Conclusions: The FBI appears to be a useful diagnostic instrument and a method to operate the behavioral criteria of FLD. Further prospective studies are warranted to establish validity.
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The Frontal Behavioral Inventory covers a range of FTD-related functional and behavioral symptoms, resulting in a positive and a negative symptom score.
“The Frontal Behavioral Inventory (FBI) covers a range of FTD-related functional and behavioral symptoms, resulting in a positive (e.g., impulsivity; hyperorality) and a negative symptom score (e.g., lack of empathy; apathy) (Kertesz et al., 1997).”
From The pursuit for markers of disease progression in behavioral variant frontotemporal dementia: a scoping review to optimize outcome measures for clinical trials (2024) · cites this paper as Kertesz et al., 1997
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- Authors
- Kertesz, A., Davidson, W., & Fox, H.
- Affiliations
- Western University (CA)
- Corresponding author
- Kertesz, Andrew
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 1997-02
- Volume
- 24
- Issue
- 1
- Pages
- 29-36
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W188949016
- Cited by
- 571
- References
- 35
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 27 · 2023: 21 · 2022: 21 · 2021: 29 · 2020: 23 · 2019: 27 · 2018: 29 · 2017: 20 · 2016: 30 · 2015: 26 · 2014: 29 · 2013: 34 · 2012: 21
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Society
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- frontal lobe dementia, Frontal Behavioral Inventory, diagnostic criteria, behavioral symptoms, Alzheimer's disease, perseveration, disinhibition, apathy, personal neglect, impulsivity, differential diagnosis
- MeSH terms
- Aged, Alzheimer Disease, Behavior, Dementia, Depression, Female, Frontal Lobe, Humans, Male, Middle Aged, Personality Inventory, Pilot Projects, Psychiatric Status Rating Scales
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