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Cortical glucose metabolism in Huntington's disease
Abstract
We measured cortical glucose metabolism with positron emission tomography in 39 patients with Huntington's disease (HD) and in 34 controls. In the 23 patients with symptoms for less than 5 years, there was a 15% decrease in metabolism in frontal and inferior parietal cortex. In 16 patients with symptoms for more than 5 years, all cortical areas (except temporal) were significantly involved, with metabolic rates 25 to 30% below those of controls. These data indicate the presence of a diffuse abnormality of cortical function with early involvement of frontal lobes in HD, suggesting that the clinical manifestations may not be related solely to basal ganglia pathology, even in early disease.
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Positron emission tomography with [18F]-fluorodeoxyglucose reveals a regional decrease of glucose usage in the striatum and cortex of persons symptomatic and at risk for HD.
“Positron emission tomography brain imaging with [18 F]-fluorodeoxyglucose has revealed a regional decrease of glucose usage in the striatum (caudate and putamen) and cortex (frontal and temporal lobes) of persons symptomatic and at risk for HD [3-8].”
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Mitochondrial defect in Huntington's disease caudate nucleus
Gu, M., Gash, M. T., Mann, V. M., Javoy‐Agid, F., Cooper, J. M., & Schapira, A. H. V. (1996) · Annals of Neurology · doi:10.1002/ana.410390317 · Cited by 758
Duan, W., Guo, Z., Jiang, H., Ware, M., Li, X.-J., & Mattson, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536856100 · Cited by 428
Grafton, S. T., Mazziotta, J. C., Pahl, J. J., George-Hyslop, P. S., Haines, J. L., Gusella, J., Hoffman, J. M., Baxter, L. R., & Phelps, M. E. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530350075022 · Cited by 157
Striatal glucose consumption in chorea-free subjects at risk of Huntington's disease
Kuwert, T., Boecker, H., Titz, H., Herzog, H., Wang, B. C., Nayak, U., Feinendegen, L. E., Lange, H. W., & Aulich, A. (1993) · Journal of Neurology · doi:10.1007/bf00870669 · Cited by 99
McClory, H., Williams, D., Sapp, E., Gatune, L. W., Wang, P., DiFiglia, M., & Li, X. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0178-7 · Cited by 60
Metadata
- Authors
- Martin, W. R. W., Clark, C., Ammann, W., Stoessl, A. J., Shtybel, W., & Hayden, M. R.
- Affiliations
- From the Department of Medicine (Neurology) (Dr. Martin), University of Alberta, Edmonton, AB; the Division of Neurology (Dr. Stoessll, St. Joseph's Hospital, London, ON; and the Departments of Psychiatry (Dr. Clark), Radiology (Nuclear Medicine) (Dr. Ammann), and Medical Genetics (Drs. Shtybel and Hayden), University of British Columbia, Vancouver, BC, Canada.
- Venue
- Neurology
- Published
- 1992-01
- Volume
- 42
- Issue
- 1
- Pages
- 223-223
- ISSN
- 0028-3878
- 1526-632X
- Cited by
- 69
- References
- 0
- Language
- en
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