Striatal glucose consumption in chorea-free subjects at risk of Huntington's disease
Abstract
Controversial data have been reported with regard to the diagnostic value of the positron emission tomographic (PET) measurement of striatal glucose consumption (rCMRGlc) in chorea-free subjects at risk of Huntington's disease (HD). For further clarification of this issue we measured striatal and cerebellar rCMRGlc in 27 chorea-free subjects at risk of HD, 20 patients with manifest HD and 20 control subjects, using PET and 18F-fluorodeoxyglucose. In 6 of the at-risk subjects cerebellar ratios of striatal rCMRGlc were decreased below the corresponding 99% confidence limit determined in the controls. This indicates that the PET measurement of rCMRGlc may, indeed, be valuable in establishing the diagnosis of incipient HD in presymptomatic at-risk subjects.
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Glucose metabolism is reduced in the basal ganglia and cerebral cortex of symptomatic HD patients and even presymptomatic gene carriers, as assessed by PET imaging.
“Glucose metabolism is reduced in the basal ganglia and cerebral cortex of symptomatic HD patients and even of presymptomatic gene carriers, as assessed by PET imaging35-37.”
From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [36]
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THÉORIE DE L'ESPRIT et LOBE FRONTAL
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Self-citation
- Authors
- Kuwert, T., Boecker, H., Titz, H., Herzog, H., Wang, B. C., Nayak, U., Feinendegen, L. E., Lange, H. W., & Aulich, A.
- Affiliations
- Forschungszentrum Jülich (DE)
- Heinrich Heine University Düsseldorf (DE)
- Venue
- Journal of Neurology
- Published
- 1993
- Volume
- 241
- Issue
- 1
- Pages
- 31-36
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W1978049342
- Cited by
- 99
- References
- 42
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 10
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- Huntington's disease, 18F-FDG PET, early diagnosis
- MeSH terms
- Adolescent, Adult, Corpus Striatum, Deoxyglucose, Disease Susceptibility, Female, Fluorine Radioisotopes, Glucose, Heterozygote, Humans, Huntington Disease, Male, Middle Aged, Neurologic Examination, Risk, Tomography, Emission-Computed, Fluorodeoxyglucose F18, Genetic Predisposition to Disease
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