Cited by 99Genetic Neurodegenerative DiseasesNeurological and metabolic disordersNeurological diseases and metabolism

Striatal glucose consumption in chorea-free subjects at risk of Huntington's disease

Kuwert, T., Boecker, H., Titz, H., Herzog, H., Wang, B. -C., Nayak, U., Feinendegen, L. E., Lange, H. W. +1 more·1993·Journal of Neurology

Abstract

Controversial data have been reported with regard to the diagnostic value of the positron emission tomographic (PET) measurement of striatal glucose consumption (rCMRGlc) in chorea-free subjects at risk of Huntington's disease (HD). For further clarification of this issue we measured striatal and cerebellar rCMRGlc in 27 chorea-free subjects at risk of HD, 20 patients with manifest HD and 20 control subjects, using PET and 18F-fluorodeoxyglucose. In 6 of the at-risk subjects cerebellar ratios of striatal rCMRGlc were decreased below the corresponding 99% confidence limit determined in the controls. This indicates that the PET measurement of rCMRGlc may, indeed, be valuable in establishing the diagnosis of incipient HD in presymptomatic at-risk subjects.

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Crossref · 10.1007/bf00870669

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  • Glucose metabolism is reduced in the basal ganglia and cerebral cortex of symptomatic HD patients and even presymptomatic gene carriers, as assessed by PET imaging.

    “Glucose metabolism is reduced in the basal ganglia and cerebral cortex of symptomatic HD patients and even of presymptomatic gene carriers, as assessed by PET imaging35-37.”

    From Mitochondrial Approaches for Neuroprotection (2008) · cites this paper as [36]

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Authors
Kuwert, T., Boecker, H., Titz, H., Herzog, H., Wang, B. C., Nayak, U., Feinendegen, L. E., Lange, H. W., & Aulich, A.
Affiliations
  • Forschungszentrum Jülich (DE)
  • Heinrich Heine University Düsseldorf (DE)
Venue
Journal of Neurology
Published
1993
Volume
241
Issue
1
Pages
31-36
ISSN
  • 0012-1037 (ISSN-L)
  • 0340-5354
  • 1432-1459
OpenAlex
W1978049342
Cited by
99
References
42
Citations by year
2025: 3 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 10
FWCI
0.83
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
Huntington's disease, 18F-FDG PET, early diagnosis
MeSH terms
Adolescent, Adult, Corpus Striatum, Deoxyglucose, Disease Susceptibility, Female, Fluorine Radioisotopes, Glucose, Heterozygote, Humans, Huntington Disease, Male, Middle Aged, Neurologic Examination, Risk, Tomography, Emission-Computed, Fluorodeoxyglucose F18, Genetic Predisposition to Disease

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