The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Cardiovascular effects of human insular cortex stimulation
Abstract
Recent investigations indicate a site of cardiac representation within the left insular cortex of the rat. Moreover, the results of lesion studies suggest left-sided insular dominance for sympathetic cardiovascular effects. It is unclear whether similar representation exists within the human insular cortex. Five epileptic patients underwent intraoperative insular stimulation prior to temporal lobectomy for seizure control. On stimulation of the left insular cortex, bradycardia and depressor responses were more frequently produced than tachycardia and pressor effects (p less than 0.005). The converse applied for the right insular cortex. We believe this to be the first demonstration of cardiovascular changes elicitable during insular stimulation in humans, and of lateralization of such responses for a cortical site. In humans, unlike the rat, there appears to be right-sided dominance for sympathetic effects. These findings may be of relevance in predicting the autonomic effects of stroke in humans and in the explanation of sudden unexpected epileptic death.
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“an area responsible for interoception,20 disgust,21 emotion processing,22 emotion recall9 and anticipation of aversive stimuli.19”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [20]
Citations
Cites
The Cerebral Cortex of Man: A Clinical Study of Localization of Function
(1968) · JAMA · doi:10.1001/jama.1968.03150020096041 · Cited by 1,218
Insula of the old world monkey. III: Efferent cortical output and comments on function
Mesulam, M. ‐., & Mufson, E. J. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902120104 · Cited by 1,013
Mesulam, M. M., & Mufson, E. J. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902120102 · Cited by 660
Kaada, B. R. (1951) · PubMed · Cited by 549
Early mortality following stroke: a prospective review.
Silver, F. L., Norris, J. W., Lewis, A., & Hachinski, V. C. (1984) · Stroke · doi:10.1161/01.str.15.3.492 · Cited by 485
Self-citationAutonomic responses and efferent pathways from the insular cortex in the rat
Yasui, Y., Breder, C. D., Safer, C. B., & Cechetto, D. F. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903030303 · Cited by 480
Lown, B., Temte, J. V., Reich, P., Gaughan, C. E., Regestein, Q. R., & Hai, H. A. (1976) · New England Journal of Medicine · doi:10.1056/nejm197603182941201 · Cited by 374
Cerebrogenic Cardiac Arrhythmias
Oppenheimer, S. M. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530050029008 · Cited by 325
Self-citationInsular cortex stimulation produces lethal cardiac arrhythmias: a mechanism of sudden death?
Oppenheimer, S. M., Wilson, J. X., Guiraudon, C., & Cechetto, D. F. (1991) · Brain Research · doi:10.1016/0006-8993(91)90412-o · Cited by 298
Self-citationCardiac chronotropic organization of the rat insular cortex
Oppenheimer, S. M., & Cechetto, D. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91796-j · Cited by 270
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How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391
Circuitry and functional aspects of the insular lobe in primates including humans
AUGUSTINE, J. (1996) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00011-2 · Cited by 1,776
The Central Autonomic Network: Functional Organization, Dysfunction, and Perspective
BENARROCH, E. E. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62272-1 · Cited by 1,534
Structure and Function of the Human Insula
Uddin, L. Q., Nomi, J. S., Hébert-Seropian, B., Ghaziri, J., & Boucher, O. (2017) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000377 · Cited by 1,262
Metadata
- Authors
- Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Neurology
- Published
- 1992-09
- Volume
- 42
- Issue
- 9
- Pages
- 1727-1727
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2169985903
- Cited by
- 1,272
- References
- 22
- Citations by year
- 2026: 40 · 2025: 31 · 2024: 38 · 2023: 39 · 2022: 47 · 2021: 48 · 2020: 49 · 2019: 64 · 2018: 62 · 2017: 59 · 2016: 63 · 2015: 57 · 2014: 59 · 2013: 50 · 2012: 48
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Keywords
- insula, cardiovascular effects, electrical brain stimulation, bradycardia, tachycardia, hemispheric lateralization, epilepsy, sudden unexpected death in epilepsy
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Blood Pressure, Cardiovascular Physiological Phenomena, Cerebral Cortex, Craniotomy, Epilepsy, Heart Rate, Humans, Male, Chi-Square Distribution
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