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Cardiovascular effects of human insular cortex stimulation
Abstract
Recent investigations indicate a site of cardiac representation within the left insular cortex of the rat. Moreover, the results of lesion studies suggest left-sided insular dominance for sympathetic cardiovascular effects. It is unclear whether similar representation exists within the human insular cortex. Five epileptic patients underwent intraoperative insular stimulation prior to temporal lobectomy for seizure control. On stimulation of the left insular cortex, bradycardia and depressor responses were more frequently produced than tachycardia and pressor effects (p less than 0.005). The converse applied for the right insular cortex. We believe this to be the first demonstration of cardiovascular changes elicitable during insular stimulation in humans, and of lateralization of such responses for a cortical site. In humans, unlike the rat, there appears to be right-sided dominance for sympathetic effects. These findings may be of relevance in predicting the autonomic effects of stroke in humans and in the explanation of sudden unexpected epileptic death.
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“an area responsible for interoception,20 disgust,21 emotion processing,22 emotion recall9 and anticipation of aversive stimuli.19”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [20]
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Duffau, H., Capelle, L., Lopes, M., Faillot, T., Sichez, J. P., & Fohanno, D. (2000) · Neurosurgery · doi:10.1097/00006123-200010000-00001 · Cited by 211
Lateralization of affective processing in the insula
Duerden, E. G., Arsalidou, M., Lee, M., & Taylor, M. J. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.014 · Cited by 212
Autonomic symptoms during epileptic seizures.
Baumgartner, C., Lurger, S., & Leutmezer, F. (2001) · Epileptic disorders · doi:10.1684/j.1950-6945.2001.tb00380.x · Cited by 212
Activation of the Insular Cortex During Dynamic Exercise in Humans
WILLIAMSON, J. W., da Nóbrega, A. C. L., McColl, R. W., Mathews, D., Winchester, P., Friberg, L., & Mitchell, J. H. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.277bh.x · Cited by 200
Metadata
- Authors
- Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Neurology
- Published
- 1992-09
- Volume
- 42
- Issue
- 9
- Pages
- 1727-1727
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2169985903
- Cited by
- 1,272
- References
- 22
- Citations by year
- 2026: 40 · 2025: 31 · 2024: 38 · 2023: 39 · 2022: 47 · 2021: 48 · 2020: 49 · 2019: 64 · 2018: 62 · 2017: 59 · 2016: 63 · 2015: 57 · 2014: 59 · 2013: 50 · 2012: 48
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Keywords
- insula, cardiovascular effects, electrical brain stimulation, bradycardia, tachycardia, hemispheric lateralization, epilepsy, sudden unexpected death in epilepsy
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Blood Pressure, Cardiovascular Physiological Phenomena, Cerebral Cortex, Craniotomy, Epilepsy, Heart Rate, Humans, Male, Chi-Square Distribution
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