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Progression after chronic manganese exposure
Abstract
We report a longitudinal follow-up study on six patients with chronic manganese-induced parkinsonism following cessation of manganese exposure. Compared with the 1987 study, their parkinsonian symptoms showed a slow progression, particularly in gait disturbances such as freezing during turning and walking backward with retropulsion. The mean disability scores on the King's College Hospital Rating Scale were 15.0 +/- 4.2 in 1987 and 28.3 +/- 6.7 in 1991 (p = 0.003, paired t test). Review of the video records also confirmed a worsening of parkinsonism, especially in difficulty turning. Three of six patients receiving levodopa treatment had an initial improvement. The response decreased after 2 to 3 years. During the therapy, they did not develop on-off fluctuation or dyskinesia. We conclude that patients with manganese-induced parkinsonism may develop increasing neurologic dysfunction long after cessation of exposure and that their responses to levodopa are different from those of patients with Parkinson's disease.
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Citations
Cited by
Manganese toxicity upon overexposure
Crossgrove, J., & Zheng, W. (2004) · NMR in Biomedicine · doi:10.1002/nbm.931 · Cited by 801
Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors
Klingelhoefer, L., & Reichmann, H. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.197 · Cited by 598
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Mitochondrial dysfunction in Parkinson's disease
Schapira, A. H. V. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402160 · Cited by 175
Targeting the Progression of Parkinsons Disease
George, J., Mok, S., Moses, D., Wilkins, S., Bush, A., Cherny, R., & Finkelstein, D. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602814 · Cited by 77
Metadata
- Authors
- Huang, C.-C., Lu, C.-S., Chu, N.-S., Hochberg, F., Lilienfeld, D., Olanow, W., & Calne, D. B.
- Venue
- Neurology
- Published
- 1993-08
- Volume
- 43
- Issue
- 8
- Pages
- 1479-1479
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2057956755
- Cited by
- 194
- References
- 0
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huang, C.-C., Lu, C.-S., Chu, N.-S., Hochberg, F., Lilienfeld, D., Olanow, W., & Calne, D. B. (1993). Progression after chronic manganese exposure. Neurology. https://doi.org/10.1212/wnl.43.8.1479
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