Mitochondrial dysfunction in Parkinson's disease

The protein kinase complement of the human genome

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

Betarbet, R., Sherer, T., Mackenzie, G., Garcia-Osuna, M., Panov, A., & Greenamyre, J. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,797 · see citing works

Mitochondrial membrane permeabilization in cell death

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

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Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

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Signaling—2000 and Beyond

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788 · see citing works

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

Schapira, A. H. V., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92366-0 · Cited by 1,757 · see citing works

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705 · see citing works

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

Bender, A., Krishnan, K. J., Morris, C. M., Taylor, G. A., Reeve, A. K., Perry, R. H., Jaros, E., Hersheson, J. S., Betts, J., Klopstock, T., et al. (2006) · Nature Genetics · doi:10.1038/ng1769 · Cited by 1,570 · see citing works

Mitochondrial pathology and apoptotic muscle degeneration in <i>Drosophila parkin</i> mutants

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The origins of protein phosphorylation

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Abnormalities of the electron transport chain in idiopathic parkinson's disease

Parker, W. D., Boyson, S. J., & Parks, J. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260606 · Cited by 1,061 · see citing works

Transcriptional Repression of PGC-1α by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration

Cui, L., Jeong, H., Borovecki, F., Parkhurst, C. N., Tanese, N., & Krainc, D. (2006) · Cell · doi:10.1016/j.cell.2006.09.015 · Cited by 1,012 · see citing works

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

Palacino, J. J., Sagi, D., Goldberg, M. S., Krauss, S., Motz, C., Wacker, M., Klose, J., & Shen, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401135200 · Cited by 995 · see citing works

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

Goldberg, M. S., Fleming, S. M., Palacino, J. J., Cepeda, C., Lam, H. A., Bhatnagar, A., Meloni, E. G., Wu, N., Ackerson, L. C., Klapstein, G. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308947200 · Cited by 913 · see citing works

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons

Kraytsberg, Y., Kudryavtseva, E., McKee, A. C., Geula, C., Kowall, N. W., & Khrapko, K. (2006) · Nature Genetics · doi:10.1038/ng1778 · Cited by 884 · see citing works

Anatomic and Disease Specificity of NADH CoQ1 Reductase (Complex I) Deficiency in Parkinson's Disease

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Origin and functional consequences of the complex I defect in Parkinson's disease

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Mitochondrial disease

Schapira, A. H. V. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68970-8 · Cited by 594 · see citing works

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

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Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study

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Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease

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Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons.

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PINK1 mutations are associated with sporadic early‐onset parkinsonism

Valente, E. M., Salvi, S., Ialongo, T., Marongiu, R., Elia, A. E., Caputo, V., Romito, L. M., Albanese, A., Dallapiccola, B., & Bentivoglio, A. R. (2004) · Annals of Neurology · doi:10.1002/ana.20256 · Cited by 506 · see citing works

Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients

Shoffner, J. M., Brown, M. D., Torroni, A., Lott, M. T., Cabell, M. F., Mirra, S. S., Beal, M. F., Yang, C.-C., Gearing, M., Salvo, R., et al. (1993) · Genomics · doi:10.1006/geno.1993.1299 · Cited by 450 · see citing works

Low platelet mitochondrial complex I and complex II/III activity in early untreated parkinson's disease

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Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis

Zhang, L., Shimoji, M., Thomas, B., Moore, D. J., Yu, S.-W., Marupudi, N. I., Torp, R., Torgner, I. A., Ottersen, O. P., Dawson, T. M., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi211 · Cited by 418 · see citing works

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death

Darios, F. D. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg044 · Cited by 401 · see citing works

Neuroprotective Role of the Reaper-Related Serine Protease HtrA2/Omi Revealed by Targeted Deletion in Mice

Martins, L. M., Morrison, A., Klupsch, K., Fedele, V., Moisoi, N., Teismann, P., Abuin, A., Grau, E., Geppert, M., Livi, G. P., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9848-9862.2004 · Cited by 395 · see citing works

Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway

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Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

Beilina, A. G., van der Brug, M., Ahmad, R., Kesavapany, S., Miller, D. W., Petsko, G. A., & Cookson, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500617102 · Cited by 382 · see citing works

Mitochondrial respiratory chain disorders I: mitochondrial DNA defects

Leonard, J., & Schapira, A. H. V. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05225-3 · Cited by 365 · see citing works

Platelet mitochondria function in Parkinson's disease

Krige, D., Carroll, M. T., Cooper, J. A. D., MARSDEN, C. D., & Schapira, A. H. V. (1992) · Annals of Neurology · doi:10.1002/ana.410320612 · Cited by 358 · see citing works

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

Yokota, T., Sugawara, K., Ito, K., Takahashi, R., Ariga, H., & Mizusawa, H. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.056 · Cited by 356 · see citing works

Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system

Betarbet, R. S., Canet-Aviles, R., Sherer, T., Mastroberardino, P. G., McLendon, C., Kim, J.-H., Lund, S. A., Na, H. M., Taylor, G., Bence, N., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.003 · Cited by 342 · see citing works

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

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Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats

Höglinger, G. U., Féger, J., Prigent, A., Michel, P. P., Parain, K., Champy, P., Ruberg, M., Oertel, W. H., & Hirsch, É. C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01533.x · Cited by 331 · see citing works

Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP

Javitch, J. A., & Snyder, S. H. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90740-4 · Cited by 317 · see citing works

Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

Gu, M., Cooper, J. A. D., Taanman, J., & Schapira, A. H. V. (1998) · Annals of Neurology · doi:10.1002/ana.410440207 · Cited by 313 · see citing works

Glutathione peroxidase activity in Parkinson's disease brain

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Parkinsonism Induced By 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine (MPTP): Implications for Treatment and the Pathogenesis of Parkinson’s Disease

Langston, J. W., & Ballard, P. (1984) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100046333 · Cited by 281 · see citing works

Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes

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Parkin enhances mitochondrial biogenesis in proliferating cells

Kuroda, Y., Mitsui, T., Kunishige, M., Shono, M., Akaike, M., Azuma, H., & Matsumoto, T. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl006 · Cited by 268 · see citing works

Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe

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Complex I, iron, and ferritin in Parkinson's disease substantia nigra

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The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis

Xu, J., Zhong, N., Wang, H., Elias, J. E., Kim, C. Y., Woldman, I., Pifl, C., Gygi, S. P., Geula, C., & Yankner, B. A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi134 · Cited by 250 · see citing works

Novel PINK1 mutations in early‐onset parkinsonism

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L166P Mutant DJ-1, Causative for Recessive Parkinson's Disease, Is Degraded through the Ubiquitin-Proteasome System

Miller, D. W., Ahmad, R., Hague, S., Baptista, M. J., Canet-Aviles, R., McLendon, C., Carter, D. M., Zhu, P., Stadler, J., Chandran, J. S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304272200 · Cited by 236 · see citing works

Analysis of Steady-state Protein Phosphorylation in Mitochondria Using a Novel Fluorescent Phosphosensor Dye

Schulenberg, B., Aggeler, R. J., Beechem, J., Capaldi, R., & Patton, W. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c300189200 · Cited by 230 · see citing works

Novel PINK1 mutations in early-onset parkinsonism

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Proteome Analysis Reveals Phosphorylation of ATP Synthase β-Subunit in Human Skeletal Muscle and Proteins with Potential Roles in Type 2 Diabetes

Højlund, K., Wrzesinski, K., Larsen, P. M., Fey, S. J., Roepstorff, P., Handberg, A., Dela, F., Vinten, J., McCormack, J. G., Reynet, C., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212881200 · Cited by 221 · see citing works

Evidence for mitochondrial dysfunction in Parkinson's disease—a critical appraisal

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Progression after chronic manganese exposure

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Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects

Leonard, J. V., & Schapira, A. H. V. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05226-5 · Cited by 195 · see citing works

Mitochondrial involvement in Parkinson's disease

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Mitochondrial DNA haplogroup cluster UKJT reduces the risk of PD

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The Phosphorylation of Subunits of Complex I from Bovine Heart Mitochondria

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Mitochondrial function and parental sex effect in Huntington's disease

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Characterization of dynamic and steady‐state protein phosphorylation using a fluorescent phosphoprotein gel stain and mass spectrometry

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Point mutations of mitochondrial genome in Parkinson's disease

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Identification of 14 new phosphoproteins involved in important plant mitochondrial processes

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Homozygous PINK1 C‐terminus mutation causing early‐onset parkinsonism

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Distinct clustering of point mutations in mitochondrial DNA among patients with mitochondrial encephalomyopathies and with Parkinson's disease

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A Pure Parkinsonian Syndrome Following Acute Carbon Monoxide Intoxication

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Mitochondria and Dopamine

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Mitochondrial DNA analysis in Parkinson's disease

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Mitochondrial ND5 mutations in idiopathic Parkinson’s disease

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mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish

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Interactions of the neurotoxic amine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine with monoamine oxidases

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A Novel Polymerase γ Mutation in a Family With Ophthalmoplegia, Neuropathy, and Parkinsonism

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Generalized mitochondrial dysfunction in Parkinson's disease detected by magnetic resonance spectroscopy of muscle

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Sequence Analysis of the Entire Mitochondrial Genome in Parkinson's Disease

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Melanin Affinity of 1‐Methyl‐4‐phenyl‐1,2,5,6‐tetrahydropyridine, an Inducer of Chronic Parkinsonism in Humans

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Mitochondrial respiratory chain function in multiple system atrophy

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A 31P magnetic resonance spectroscopy study of mitochondrial function in skeletal muscle of patients with Parkinson's disease

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Mitochondrial DNA in Postmortem Brain from Patients with Parkinson's Disease

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Characterization of the Binding of N‐Methyl‐4‐Phenylpyridine, the Toxic Metabolite of the Parkinsonian Neurotoxin N‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine, to Neuromelanin

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Focused proteomics: Monoclonal antibody‐based isolation of the oxidative phosphorylation machinery and detection of phosphoproteins using a fluorescent phosphoprotein gel stain

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Novel mitochondrial DNA mutations in Parkinson's disease

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Carbon-monoxide Encephalopathy

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Analysis of the trinucleotide CAG repeat from the DNA polymerase γ gene (POLG) in patients with Parkinson's disease

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L ‐Dihydroxyphenylalanine and complex I deficiency in Parkinson's disease brain

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Suppression of MPTP-induced dopaminergic neurotoxicity in mice by nomifensine andl-DOPA

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PARKINSONISM FOLLOWING CARBON MONOXID POISONING

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