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Reduced platelet cytochrome c oxidase activity in Alzheimer's disease
Abstract
We evaluated a simplified method for preparation and analysis of platelet cytochrome c oxidase activity in Alzheimer's disease (AD) and control patients. Mean cytochrome c oxidase activity in controls (n = 17) was 0.233 sec-1/mg whereas mean cytochrome c oxidase activity in Alzheimer patients (n = 19) was 0.193 sec-1/mg, p = 0.033. Complex III (ubiquinol:cytochrome c oxidoreductase), complex II (succinic dehydrogenase), and citrate synthase were all assayed as internal controls and were not significantly different in controls and Alzheimer patients. There is a relatively specific loss of platelet cytochrome c oxidase activity in Alzheimer disease patients.
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Cited by
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Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357
A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease
Swerdlow, R. H., & Khan, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.045 · Cited by 758
Estrogen: A master regulator of bioenergetic systems in the brain and body
Rettberg, J. R., Yao, J., & Brinton, R. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.001 · Cited by 534
A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients
Maurer, I. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00112-3 · Cited by 475
Mitochondrial dysfunction in neurodegenerative disorders
Klemmensen, M. M., Borrowman, S. H., Pearce, C., Pyles, B., & Chandra, B. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2023.10.002 · Cited by 396
Metadata
- Authors
- Parker, W. D., Mahr, N. J., Filley, C. M., Parks, J. K., Hughes, D., Young, D. A., & Cullum, C. M.
- Venue
- Neurology
- Published
- 1994-06
- Volume
- 44
- Issue
- 6
- Pages
- 1086-1086
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1972542632
- Cited by
- 198
- References
- 0
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Parker, W. D., Mahr, N. J., Filley, C. M., Parks, J. K., Hughes, D., Young, D. A., & Cullum, C. M. (1994). Reduced platelet cytochrome c oxidase activity in Alzheimer's disease. Neurology. https://doi.org/10.1212/wnl.44.6.1086
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
