A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

Maurer, I

doi:10.1016/s0197-4580(00)00112-3

Cited by 475Mitochondrial Function and PathologyAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

Maurer, I·2000·Neurobiology of Aging

DOI 10.1016/s0197-4580(00)00112-3

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Abstract

To assess mitochondrial function and test the hypothesis of an underlying oxidative phosphorylation defect in Alzheimer disease (AD), we evaluated the activities of mitochondrial respiratory chain enzyme complexes I+III, complexes II+III, complex IV (cytochrome c oxidase, COX), succinate dehydrogenase, and citrate synthase in the frontal cortex, temporal cortex, hippocampus, and cerebellum of 23 AD patients and 13 normal human brains. The major finding was a significant decrease in COX activity in AD temporal cortex and hippocampus, both whether activities were expressed per noncollagen protein content (49 +/-4.6 versus 78+/-10.8 nmol/min/mg NCP, P = 0.006; 23+/-1.9 versus 48.6+/-8.1 nmol/min/mg NCP, p = 0.003) or corrected for citrate synthase activity (1.6+/-0.2 versus 3+/-0.4, P = 0.001; 0.76+/-0.1 versus 1.76+/-0.26, P = 0.0009). There were no significant differences in the activities of complexes I+III, II+III, and of succinate dehydrogenase in any of the brain regions examined. Our results suggest a specific defect of COX in the AD brain versus the normal human brain, which may contribute to impaired energy generation. Biochemically, the defect is confined to selected brain regions, suggesting anatomic specificity.

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Authors: Maurer, I.
Affiliations: Friedrich Schiller University Jena (DE)
Corresponding author: Maurer, I
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2000-06
Volume: 21
Issue: 3
Pages: 455-462
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/s0197-4580(00)00112-3
OpenAlex: W2006909664
Cited by: 475
References: 3
Citations by year: 2026: 7 · 2025: 12 · 2024: 10 · 2023: 21 · 2022: 24 · 2021: 23 · 2020: 29 · 2019: 25 · 2018: 22 · 2017: 18 · 2016: 24 · 2015: 19 · 2014: 18 · 2013: 26 · 2012: 22
FWCI: 1.81
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, cytochrome c oxidase, mitochondrial dysfunction, oxidative phosphorylation, respiratory chain complexes, citrate synthase, succinate dehydrogenase, hippocampus, temporal cortex, frontal cortex, cerebellum, brain energy metabolism
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cerebral Cortex, Electron Transport Complex IV, Female, Hippocampus, Humans, Male, Middle Aged, Mitochondria, Oxidative Phosphorylation, Succinate Dehydrogenase

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A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients

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